EuRBPDB

Description

Ensembl ID: ENSG00000112977 (Gene tree)
Gene ID: 1611
Gene Symbol: DAP
Alias: N
Full Name: death associated protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 82,046 bases
Position: chr5:10,679,230-10,761,275
Accession: 2672
RBP type: non-canonical RBP
Summary: This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20048748	Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase.	Acta Pharmacol Sin	2010 Jan	Wu J	doi: 10.1038/aps.2009.183.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508253	DAP-203	785	-	-	- (aa)	-	-
ENST00000230895	DAP-201	2339	-	ENSP00000230895	102 (aa)	-	P51397
ENST00000432074	DAP-202	1048	-	ENSP00000394163	204 (aa)	-	B4DQ75
ENST00000508646	DAP-204	277	-	-	- (aa)	-	-
ENST00000510546	DAP-205	780	-	-	- (aa)	-	-
ENST00000514882	DAP-206	562	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000112977	Heart Failure	5E-6	23934736
ENSG00000112977	Colitis, Ulcerative	1E-7	26192919
ENSG00000112977	Crohn Disease	4E-7	28067908
ENSG00000112977	Colitis, Ulcerative	6E-12	21297633
ENSG00000112977	Inflammatory Bowel Diseases	1E-8	23128233
ENSG00000112977	Inflammatory Bowel Diseases	3E-14	26192919
ENSG00000112977	Crohn Disease	1E-12	26192919
ENSG00000112977	Inflammatory Bowel Diseases	5E-6	28067908
ENSG00000112977	Gastrointestinal Microbiome	4E-6	27694959

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000112977	rs267939	5	10752203	C	Gut microbiota (functional units)	27694959	Z-score decrease	4.6339774	EFO_0007874
ENSG00000112977	rs2930047	5	10695414	G	Ulcerative colitis	26192919	[1.05-1.1]	1.0703659	EFO_0000729
ENSG00000112977	rs2930047	5	10695414	G	Crohn's disease	26192919	[1.07-1.12]	1.0912733	EFO_0000384
ENSG00000112977	rs3776414	5	10689450	?	Inflammatory bowel disease	26192919			EFO_0003767
ENSG00000112977	rs3756407	5	10701402	A	Metabolite levels (Pyroglutamine)	23934736	[0.2-0.08] unit increase	0.14	EFO_0005408
ENSG00000112977	rs2930047	5	10695414	?	Crohn's disease	28067908			EFO_0000384
ENSG00000112977	rs2930047	5	10695414	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000112977	rs267939	5	10752203	C	Ulcerative colitis	21297633	[1.06-1.15]	1.1	EFO_0000729
ENSG00000112977	rs2930047	5	10695414	C	Inflammatory bowel disease	23128233	[1.034-1.096]	1.065	EFO_0003767
ENSG00000112977	rs3822411	5	10684830	C	Sum eosinophil basophil counts	27863252	[0.015-0.03] unit increase	0.02229396	EFO_0005090\|EFO_0004842
ENSG00000112977	rs755546258	5	10698974	T	Height	28270201	[0.053-0.111] m decrease	0.08185815	EFO_0004339
ENSG00000112977	rs5745297	5	10680885	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0006914	autophagy	-	IEA	Process
GO:0006915	apoptotic process	7828849.	IGI	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	1087798.	IMP	Process
GO:0010507	negative regulation of autophagy	21873635.	IBA	Process
GO:0010507	negative regulation of autophagy	20537536.	IMP	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	1087798.	IMP	Process
GO:0034198	cellular response to amino acid starvation	21873635.	IBA	Process
GO:0034198	cellular response to amino acid starvation	20537536.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	1087798.	IMP	Process
GO:0070513	death domain binding	21873635.	IBA	Function
GO:0070513	death domain binding	1087798.	IPI	Function
GO:0097190	apoptotic signaling pathway	21873635.	IBA	Process
GO:0097190	apoptotic signaling pathway	1087798.7828849.	IMP	Process