EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000112984 (Gene tree)
Gene ID: 10112
Gene Symbol: KIF20A
Alias: RAB6KIFL
Full Name: kinesin family member 20A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 8,997 bases
Position: chr5:138,178,719-138,187,715
Accession: 9787
RBP type: non-canonical RBP
Summary: (Kinesin Family Member 20A) is a Protein Coding gene. Diseases associated with KIF20A include Familial Isolated Restrictive Cardiomyopathy. Among its related pathways are PLK1 signaling events and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ATPase activity. An important paralog of this gene is KIF23.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25499221	KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.	Neoplasia	2014 Dec	Taniuchi K	doi: 10.1016/j.neo.2014.10.007.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000502338	KIF20A-202	600	-	ENSP00000426704	82 (aa)	-	H0YAC9
ENST00000508792	KIF20A-205	2935	-	ENSP00000420880	872 (aa)	-	O95235
ENST00000503417	KIF20A-203	598	-	-	- (aa)	-	-
ENST00000511638	KIF20A-206	864	-	-	- (aa)	-	-
ENST00000394894	KIF20A-201	3201	-	ENSP00000378356	890 (aa)	-	O95235
ENST00000513276	KIF20A-207	631	-	ENSP00000422928	159 (aa)	-	D6R9E4
ENST00000504621	KIF20A-204	810	-	ENSP00000424056	225 (aa)	-	D6RBN1

Gene Model

Click here to download ENSG00000112984's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112984's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	15843429.	IMP	Process
GO:0001578	microtubule bundle formation	12939256.	IDA	Process
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005215	transporter activity	9438855.	TAS	Function
GO:0005515	protein binding	16431929.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005819	spindle	12939256.	IDA	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0015031	protein transport	-	IEA	Process
GO:0016192	vesicle-mediated transport	9438855.	TAS	Process
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0019901	protein kinase binding	12939256.	IPI	Function
GO:0030496	midbody	15843429.	IDA	Component
GO:0032154	cleavage furrow	-	IDA	Component
GO:0032465	regulation of cytokinesis	12939256.	IDA	Process
GO:0045171	intercellular bridge	-	IDA	Component
GO:0061952	midbody abscission	15843429.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27941992	High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma.	PLoS One	2016 Dec 12	Zhang W	doi: 10.1371/journal.pone.0167449
28070829	Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.	J Neurooncol	2017 Mar	Saito K	doi: 10.1007/s11060-016-2360-1
25953216	Kif20a inhibition reduces migration and invasion of pancreatic cancer cells.	J Surg Res	2015 Jul	Stangel D	doi: 10.1016/j.jss.2015.03.070
22887948	Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.	Proteomics	2012 Aug	Yan GR	doi: 10.1002/pmic.201100652.
28081138	Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.	PLoS One	2017 Jan 12	Liu SL	doi: 10.1371/journal.pone.0169280
29704495	FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A.	Eur J Pharmacol	2018 Aug 15	Xiu G	doi: 10.1016/j.ejphar.2018.04.021
15665285	Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.	Cancer Res	2005 Jan 1	Taniuchi K	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	138187306	Silent	novel	R856R	0.13
BLCA	chr5	138186315	Missense_Mutation	novel	E747K	0.29
BLCA	chr5	138187142	Missense_Mutation	novel	L801P	0.36
BLCA	chr5	138182884	Missense_Mutation	rs768806257	K242N	0.08
BLCA	chr5	138183524	Missense_Mutation	novel	V361A	0.35
BLCA	chr5	138184025	Silent	novel	L424L	0.27
BRCA	chr5	138186353	Missense_Mutation	novel	E759D	0.09
BRCA	chr5	138179666	5'UTR	novel		0.18
BRCA	chr5	138184632	Missense_Mutation	NA	D547N	0.19
BRCA	chr5	138182438	Nonsense_Mutation	NA	S164*	0.21
BRCA	chr5	138185561	Missense_Mutation	novel	R659T	0.1
CESC	chr5	138184599	Missense_Mutation	NA	E536Q	0.42
CESC	chr5	138185521	Missense_Mutation	novel	E646K	0.42
CESC	chr5	138187232	Missense_Mutation	novel	G831V	0.09
COAD	chr5	138184916	Missense_Mutation	NA	E598G	0.29
COAD	chr5	138187163	Missense_Mutation	NA	A808V	0.32
COAD	chr5	138184087	Missense_Mutation	rs781453282	R445H	0.29
COAD	chr5	138186359	Silent	NA	A761A	0.33
COAD	chr5	138181677	Silent	novel	K108K	0.03
COAD	chr5	138187407	Missense_Mutation	NA	K889N	0.34
COAD	chr5	138182346	Missense_Mutation	NA	Q133H	0.31
COAD	chr5	138183332	Silent	rs141701454	C332C	0.1
COAD	chr5	138184332	Silent	NA	V482V	0.16
COAD	chr5	138185705	Missense_Mutation	NA	T707I	0.3
COAD	chr5	138179755	Silent	NA	E25E	0.22
COAD	chr5	138185133	Missense_Mutation	NA	M621T	0.39
COAD	chr5	138185575	Missense_Mutation	NA	A664T	0.3
COAD	chr5	138185959	Splice_Site	novel	X709_splice	0.19
COAD	chr5	138183181	Missense_Mutation	rs775464245	R282Q	0.3
COAD	chr5	138181688	Missense_Mutation	rs752597788	R112Q	0.27
ESCA	chr5	138186376	Missense_Mutation	novel	G767V	0.13
ESCA	chr5	138186052	Frame_Shift_Ins	novel	*L744Ifs2**	0.12
ESCA	chr5	138187225	Missense_Mutation	rs752376351	R829C	0.32
GBM	chr5	138179823	Missense_Mutation	novel	T48I	0.11
GBM	chr5	138182453	Missense_Mutation	rs200872203	T169M	0.66
GBM	chr5	138184546	Missense_Mutation	novel	P518L	0.12
GBM	chr5	138183496	Missense_Mutation	novel	A352P	0.51
GBM	chr5	138179713	Silent	novel	G11G	0.33
GBM	chr5	138186047	Missense_Mutation	novel	Q738K	0.31
GBM	chr5	138184083	Missense_Mutation	novel	L444V	0.16
GBM	chr5	138184265	Missense_Mutation	novel	R460P	0.07
HNSC	chr5	138183300	Nonsense_Mutation	novel	Q322*	0.22
KIRC	chr5	138186390	Missense_Mutation	rs751619840	R772C	0.27
KIRC	chr5	138184944	Splice_Region	NA	C607C	0.36
KIRC	chr5	138186309	Missense_Mutation	rs758407494	R745W	0.04
KIRC	chr5	138187180	Missense_Mutation	NA	Y814H	0.34
KIRC	chr5	138183535	Missense_Mutation	NA	N365D	0.22
LGG	chr5	138185609	Missense_Mutation	rs756187494	R675Q	0.26
LIHC	chr5	138184882	Missense_Mutation	novel	H587D	0.03
LUAD	chr5	138183326	Silent	NA	R330R	0.35
LUAD	chr5	138179726	Missense_Mutation	NA	D16Y	0.07
LUAD	chr5	138181609	Missense_Mutation	novel	G86C	0.31
LUAD	chr5	138184642	Missense_Mutation	novel	E550A	0.21
LUAD	chr5	138185587	Missense_Mutation	novel	S668A	0.31
LUAD	chr5	138183561	Silent	novel	L373L	0.24
LUAD	chr5	138185609	Missense_Mutation	rs756187494	R675Q	0.1
LUAD	chr5	138184942	Missense_Mutation	NA	C607R	0.07
LUAD	chr5	138185637	Silent	rs144189626	A684A	0.1
LUSC	chr5	138184388	Nonsense_Mutation	NA	S501*	0.24
LUSC	chr5	138182958	Missense_Mutation	NA	I267T	0.25
LUSC	chr5	138186351	Missense_Mutation	NA	E759Q	0.61
OV	chr5	138187586	3'UTR	novel		0.33
OV	chr5	138179762	Missense_Mutation	novel	A28S	0.1
OV	chr5	138185946	Splice_Site	novel	X709_splice	0.11
OV	chr5	138187352	Missense_Mutation	rs765098249	R871Q	0.53
OV	chr5	138184031	Missense_Mutation	novel	E426D	0.21
OV	chr5	138184032	Frame_Shift_Ins	novel	*A427Vfs40**	0.19
OV	chr5	138179774	Missense_Mutation	novel	G32W	0.06
OV	chr5	138179776	Silent	novel	G32G	0.04
OV	chr5	138184069	Missense_Mutation	novel	R439P	0.03
PAAD	chr5	138183180	Nonsense_Mutation	rs777958054	R282*	0.23
PRAD	chr5	138184860	Silent	rs114549959	Q579Q	0.29
PRAD	chr5	138183336	Missense_Mutation	NA	D334Y	0.21
PRAD	chr5	138184930	Missense_Mutation	novel	R603W	0.45
SARC	chr5	138187231	Missense_Mutation	novel	G831S	0.11
SARC	chr5	138184557	Missense_Mutation	novel	S522T	0.37
SKCM	chr5	138179665	5'UTR	novel		0.17
SKCM	chr5	138179666	5'UTR	novel		0.17
SKCM	chr5	138185578	Missense_Mutation	NA	H665N	0.07
SKCM	chr5	138184258	Missense_Mutation	NA	P458S	0.17
SKCM	chr5	138181695	Silent	NA	I114I	0.24
STAD	chr5	138184035	Nonsense_Mutation	NA	G428*	0.13
STAD	chr5	138179766	Missense_Mutation	NA	A29V	0.08
STAD	chr5	138179744	Frame_Shift_Ins	novel	*P22Hfs4**	0.18
STAD	chr5	138185640	Silent	NA	S685S	0.37
STAD	chr5	138184635	Missense_Mutation	NA	D548N	0.41
STAD	chr5	138183180	Nonsense_Mutation	rs777958054	R282*	0.33
STAD	chr5	138184104	Missense_Mutation	novel	R451W	0.26
STAD	chr5	138186049	Silent	NA	Q738Q	0.11
STAD	chr5	138187370	Missense_Mutation	rs754343932	R877H	0.25
STAD	chr5	138183724	Frame_Shift_Del	novel	*E394Kfs4**	0.44
STAD	chr5	138183273	Missense_Mutation	novel	L313I	0.38
STAD	chr5	138187204	Missense_Mutation	novel	G822C	0.12
STAD	chr5	138183229	Missense_Mutation	rs144155991	R298H	0.46
STAD	chr5	138183292	Missense_Mutation	rs375379655	P319L	0.29
STAD	chr5	138187357	Silent	novel	L873L	0.06
UCEC	chr5	138183306	Missense_Mutation	rs745761982	R324C	0.28
UCEC	chr5	138182454	Silent	rs375606679	T169T	0.43
UCEC	chr5	138184931	Missense_Mutation	rs564669414	R603Q	0.47
UCEC	chr5	138184386	Missense_Mutation	NA	F500L	0.29
UCEC	chr5	138187650	3'UTR	novel		0.36
UCEC	chr5	138181664	Missense_Mutation	novel	S104Y	0.37
UCEC	chr5	138187444	3'UTR	novel		0.18
UCEC	chr5	138187496	3'UTR	novel		0.37
UCEC	chr5	138187592	3'UTR	rs201817182		0.34
UCEC	chr5	138183273	Missense_Mutation	novel	L313F	0.2
UCEC	chr5	138187401	Silent	novel	G887G	0.15
UCEC	chr5	138185611	Missense_Mutation	rs760158461	R676W	0.53
UCEC	chr5	138185623	Silent	NA	L680L	0.17
UCEC	chr5	138183245	Silent	novel	I303I	0.33
UCEC	chr5	138183293	Silent	rs369402135	P319P	0.29
UCEC	chr5	138184633	Missense_Mutation	novel	D547G	0.21
UCEC	chr5	138187217	Missense_Mutation	novel	A826V	0.41
UCEC	chr5	138184087	Missense_Mutation	rs781453282	R445H	0.35
UCEC	chr5	138187592	3'UTR	rs201817182		0.5
UCEC	chr5	138185516	Missense_Mutation	rs755581965	R644Q	0.5
UCEC	chr5	138187592	3'UTR	rs201817182		0.5
UCEC	chr5	138179793	Missense_Mutation	novel	N38S	0.38
UCEC	chr5	138179793	Missense_Mutation	novel	N38S	0.17
UCEC	chr5	138185175	Missense_Mutation	rs141655710	S635I	0.3
UCEC	chr5	138187592	3'UTR	rs201817182		0.41
UCEC	chr5	138187340	Missense_Mutation	novel	S867I	0.31
UCEC	chr5	138184547	Silent	NA	P518P	0.06
UCEC	chr5	138179700	Missense_Mutation	NA	S7Y	0.34
UCEC	chr5	138187388	Missense_Mutation	novel	S883F	0.16
UCEC	chr5	138182454	Silent	rs375606679	T169T	0.17
UCEC	chr5	138184265	Missense_Mutation	NA	R460H	0.26
UCEC	chr5	138184086	Missense_Mutation	rs771283364	R445C	0.27
UCEC	chr5	138184625	Silent	novel	G544G	0.07
UCS	chr5	138185569	Missense_Mutation	novel	S662P	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0417	0.11554
LAML	DEL	0.089	1.2971e-07
LUAD	DEL	0.2694	7.4776e-05
LUSC	DEL	0.6208	0.002071
MESO	DEL	0.1264	0.20184
PRAD	AMP	0.0285	0.16448
SKCM	DEL	0.2888	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0076	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0058	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
LUSC	0.035	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PAAD	0.00028	Kaplan-Meier Survival Analysis
PCPG	0.041	Kaplan-Meier Survival Analysis
KICH	0.021	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.045	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00077	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742