EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113272 (Gene tree)
Gene ID: 54974
Gene Symbol: THG1L
Alias: ICF45|FLJ11601|FLJ20546|IHG-1|hTHG1
Full Name: tRNA-histidine guanylyltransferase 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 10,252 bases
Position: chr5:157,731,197-157,741,448
Accession: 26053
RBP type: canonical RBP
Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000231198	Thg1	PF04446.12	2.1e-49	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31000629	Chemical footprinting and kinetic assays reveal dual functions for highly conserved eukaryotic tRNAHis guanylyltransferase residues.	J Biol Chem	2019 May 31	Matlock AO	doi: 10.1074/jbc.RA119.007939

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000523575	THG1L-203	576	-	ENSP00000431090	34 (aa)	-	H0YC78
ENST00000231198	THG1L-201	3107	XM_017009603	ENSP00000231198	298 (aa)	XP_016865092	Q9NWX6
ENST00000521655	THG1L-202	919	-	ENSP00000428387	124 (aa)	-	E5RIQ8

Gene Model

Click here to download ENSG00000113272's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113272	rs2270813	5	157737881	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113272's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113272	THG1L	94	70.968	ENSAPOG00000002190	thg1l	93	70.968	Acanthochromis_polyacanthus
ENSG00000113272	THG1L	100	91.275	ENSAMEG00000006356	THG1L	100	91.275	Ailuropoda_melanoleuca
ENSG00000113272	THG1L	93	71.480	ENSACIG00000015946	thg1l	93	71.480	Amphilophus_citrinellus
ENSG00000113272	THG1L	94	70.968	ENSAOCG00000015583	thg1l	93	70.968	Amphiprion_ocellaris
ENSG00000113272	THG1L	94	70.609	ENSAPEG00000011671	thg1l	93	70.609	Amphiprion_percula
ENSG00000113272	THG1L	91	73.063	ENSATEG00000001426	thg1l	98	72.340	Anabas_testudineus
ENSG00000113272	THG1L	94	84.375	ENSAPLG00000013772	THG1L	99	82.278	Anas_platyrhynchos
ENSG00000113272	THG1L	91	81.550	ENSACAG00000003330	THG1L	88	81.550	Anolis_carolinensis
ENSG00000113272	THG1L	100	95.638	ENSANAG00000031173	-	100	95.638	Aotus_nancymaae
ENSG00000113272	THG1L	98	95.902	ENSANAG00000025715	-	99	85.274	Aotus_nancymaae
ENSG00000113272	THG1L	96	67.596	ENSACLG00000001490	thg1l	95	67.596	Astatotilapia_calliptera
ENSG00000113272	THG1L	98	66.781	ENSAMXG00000042416	thg1l	95	66.781	Astyanax_mexicanus
ENSG00000113272	THG1L	100	89.262	ENSBTAG00000010359	THG1L	100	89.262	Bos_taurus
ENSG00000113272	THG1L	100	96.309	ENSCJAG00000018973	THG1L	100	96.309	Callithrix_jacchus
ENSG00000113272	THG1L	100	89.933	ENSCAFG00000017348	THG1L	100	89.933	Canis_familiaris
ENSG00000113272	THG1L	100	89.933	ENSCAFG00020025580	THG1L	100	89.933	Canis_lupus_dingo
ENSG00000113272	THG1L	100	89.597	ENSCHIG00000011287	THG1L	100	89.597	Capra_hircus
ENSG00000113272	THG1L	100	92.282	ENSTSYG00000001547	THG1L	100	92.282	Carlito_syrichta
ENSG00000113272	THG1L	94	81.250	ENSCAPG00000013412	THG1L	100	92.308	Cavia_aperea
ENSG00000113272	THG1L	100	87.248	ENSCPOG00000037046	THG1L	100	87.248	Cavia_porcellus
ENSG00000113272	THG1L	100	95.973	ENSCCAG00000024953	THG1L	100	95.973	Cebus_capucinus
ENSG00000113272	THG1L	100	96.980	ENSCATG00000040510	THG1L	100	96.980	Cercocebus_atys
ENSG00000113272	THG1L	100	87.248	ENSCLAG00000013903	THG1L	100	87.248	Chinchilla_lanigera
ENSG00000113272	THG1L	100	97.315	ENSCSAG00000010572	THG1L	100	97.315	Chlorocebus_sabaeus
ENSG00000113272	THG1L	98	89.344	ENSCHOG00000007378	THG1L	100	69.388	Choloepus_hoffmanni
ENSG00000113272	THG1L	94	84.375	ENSCPBG00000001551	THG1L	90	84.644	Chrysemys_picta_bellii
ENSG00000113272	THG1L	79	59.184	ENSCING00000013151	-	86	61.111	Ciona_intestinalis
ENSG00000113272	THG1L	89	54.717	ENSCSAVG00000001943	-	99	54.717	Ciona_savignyi
ENSG00000113272	THG1L	100	96.980	ENSCANG00000039650	THG1L	100	96.980	Colobus_angolensis_palliatus
ENSG00000113272	THG1L	100	84.228	ENSCGRG00001019597	Thg1l	99	86.809	Cricetulus_griseus_chok1gshd
ENSG00000113272	THG1L	100	84.228	ENSCGRG00000003459	Thg1l	99	86.809	Cricetulus_griseus_crigri
ENSG00000113272	THG1L	94	65.603	ENSCSEG00000019947	thg1l	94	65.603	Cynoglossus_semilaevis
ENSG00000113272	THG1L	94	68.683	ENSCVAG00000011708	thg1l	94	68.683	Cyprinodon_variegatus
ENSG00000113272	THG1L	91	70.111	ENSDARG00000038360	thg1l	91	70.111	Danio_rerio
ENSG00000113272	THG1L	100	84.228	ENSDNOG00000002215	THG1L	100	84.228	Dasypus_novemcinctus
ENSG00000113272	THG1L	100	81.544	ENSDORG00000007564	Thg1l	100	81.544	Dipodomys_ordii
ENSG00000113272	THG1L	89	54.717	FBgn0283659	THG	86	54.717	Drosophila_melanogaster
ENSG00000113272	THG1L	98	84.553	ENSETEG00000000463	THG1L	100	89.431	Echinops_telfairi
ENSG00000113272	THG1L	88	66.667	ENSEBUG00000006216	thg1l	99	57.875	Eptatretus_burgeri
ENSG00000113272	THG1L	100	90.604	ENSEASG00005000757	THG1L	100	90.604	Equus_asinus_asinus
ENSG00000113272	THG1L	100	90.604	ENSECAG00000013378	THG1L	100	90.604	Equus_caballus
ENSG00000113272	THG1L	100	85.906	ENSEEUG00000001923	THG1L	100	85.906	Erinaceus_europaeus
ENSG00000113272	THG1L	93	70.036	ENSELUG00000005532	thg1l	92	70.036	Esox_lucius
ENSG00000113272	THG1L	100	90.268	ENSFCAG00000022752	THG1L	91	90.268	Felis_catus
ENSG00000113272	THG1L	82	92.857	ENSFALG00000008475	THG1L	93	81.250	Ficedula_albicollis
ENSG00000113272	THG1L	100	89.597	ENSFDAG00000009417	THG1L	100	89.597	Fukomys_damarensis
ENSG00000113272	THG1L	97	65.000	ENSFHEG00000007339	thg1l	79	62.400	Fundulus_heteroclitus
ENSG00000113272	THG1L	90	74.254	ENSGMOG00000015482	thg1l	99	74.254	Gadus_morhua
ENSG00000113272	THG1L	94	84.375	ENSGALG00000003722	THG1L	94	83.273	Gallus_gallus
ENSG00000113272	THG1L	89	71.591	ENSGAFG00000006870	thg1l	87	71.324	Gambusia_affinis
ENSG00000113272	THG1L	99	67.797	ENSGACG00000018445	thg1l	99	67.797	Gasterosteus_aculeatus
ENSG00000113272	THG1L	94	81.250	ENSGAGG00000016997	THG1L	99	85.660	Gopherus_agassizii
ENSG00000113272	THG1L	100	98.993	ENSGGOG00000008668	THG1L	100	98.993	Gorilla_gorilla
ENSG00000113272	THG1L	96	68.070	ENSHBUG00000004025	thg1l	95	68.070	Haplochromis_burtoni
ENSG00000113272	THG1L	100	87.919	ENSHGLG00000008948	THG1L	100	87.919	Heterocephalus_glaber_female
ENSG00000113272	THG1L	100	87.919	ENSHGLG00100007419	THG1L	100	87.919	Heterocephalus_glaber_male
ENSG00000113272	THG1L	91	70.741	ENSHCOG00000002622	thg1l	90	70.741	Hippocampus_comes
ENSG00000113272	THG1L	91	71.691	ENSIPUG00000006310	thg1l	99	72.491	Ictalurus_punctatus
ENSG00000113272	THG1L	100	90.604	ENSSTOG00000014243	THG1L	100	90.604	Ictidomys_tridecemlineatus
ENSG00000113272	THG1L	100	85.570	ENSJJAG00000022909	Thg1l	100	85.570	Jaculus_jaculus
ENSG00000113272	THG1L	99	67.458	ENSKMAG00000009156	thg1l	98	67.458	Kryptolebias_marmoratus
ENSG00000113272	THG1L	90	69.888	ENSLBEG00000022336	thg1l	99	69.888	Labrus_bergylta
ENSG00000113272	THG1L	90	72.491	ENSLBEG00000013870	THG1L	89	72.491	Labrus_bergylta
ENSG00000113272	THG1L	90	75.836	ENSLACG00000015528	THG1L	86	75.836	Latimeria_chalumnae
ENSG00000113272	THG1L	99	69.128	ENSLOCG00000009255	thg1l	96	69.128	Lepisosteus_oculatus
ENSG00000113272	THG1L	100	89.933	ENSLAFG00000004926	THG1L	100	89.933	Loxodonta_africana
ENSG00000113272	THG1L	100	97.315	ENSMFAG00000041928	THG1L	100	98.611	Macaca_fascicularis
ENSG00000113272	THG1L	100	97.315	ENSMNEG00000038597	THG1L	100	97.315	Macaca_nemestrina
ENSG00000113272	THG1L	100	97.315	ENSMLEG00000025109	THG1L	100	97.315	Mandrillus_leucophaeus
ENSG00000113272	THG1L	91	72.426	ENSMAMG00000012302	thg1l	91	72.426	Mastacembelus_armatus
ENSG00000113272	THG1L	96	67.247	ENSMZEG00005008770	thg1l	96	67.247	Maylandia_zebra
ENSG00000113272	THG1L	94	84.375	ENSMGAG00000004968	THG1L	91	83.273	Meleagris_gallopavo
ENSG00000113272	THG1L	100	84.228	ENSMAUG00000012121	Thg1l	98	86.752	Mesocricetus_auratus
ENSG00000113272	THG1L	100	90.268	ENSMICG00000038734	THG1L	90	90.268	Microcebus_murinus
ENSG00000113272	THG1L	99	85.714	ENSMOCG00000005041	Thg1l	97	88.696	Microtus_ochrogaster
ENSG00000113272	THG1L	91	70.480	ENSMMOG00000009355	thg1l	90	70.480	Mola_mola
ENSG00000113272	THG1L	90	84.758	ENSMODG00000008328	THG1L	95	84.758	Monodelphis_domestica
ENSG00000113272	THG1L	94	68.459	ENSMALG00000005060	thg1l	93	68.459	Monopterus_albus
ENSG00000113272	THG1L	100	82.215	MGP_CAROLIEiJ_G0016236	Thg1l	99	86.383	Mus_caroli
ENSG00000113272	THG1L	100	82.215	ENSMUSG00000011254	Thg1l	99	86.383	Mus_musculus
ENSG00000113272	THG1L	100	81.208	MGP_PahariEiJ_G0017372	Thg1l	99	85.532	Mus_pahari
ENSG00000113272	THG1L	100	82.215	MGP_SPRETEiJ_G0017077	Thg1l	99	86.383	Mus_spretus
ENSG00000113272	THG1L	100	90.604	ENSMPUG00000013462	THG1L	100	90.604	Mustela_putorius_furo
ENSG00000113272	THG1L	100	89.933	ENSMLUG00000015926	THG1L	100	89.933	Myotis_lucifugus
ENSG00000113272	THG1L	100	81.544	ENSNGAG00000012087	Thg1l	99	86.383	Nannospalax_galili
ENSG00000113272	THG1L	96	68.070	ENSNBRG00000017747	thg1l	95	68.070	Neolamprologus_brichardi
ENSG00000113272	THG1L	100	97.987	ENSNLEG00000004166	THG1L	100	97.987	Nomascus_leucogenys
ENSG00000113272	THG1L	100	90.940	ENSOPRG00000013774	THG1L	100	90.940	Ochotona_princeps
ENSG00000113272	THG1L	100	84.899	ENSODEG00000009719	THG1L	100	84.899	Octodon_degus
ENSG00000113272	THG1L	93	70.397	ENSONIG00000017663	thg1l	91	70.397	Oreochromis_niloticus
ENSG00000113272	THG1L	94	87.500	ENSOANG00000005074	THG1L	98	80.546	Ornithorhynchus_anatinus
ENSG00000113272	THG1L	100	90.940	ENSOCUG00000001053	THG1L	100	90.940	Oryctolagus_cuniculus
ENSG00000113272	THG1L	93	69.314	ENSORLG00000007424	thg1l	93	69.314	Oryzias_latipes
ENSG00000113272	THG1L	93	69.314	ENSORLG00020006322	thg1l	92	69.314	Oryzias_latipes_hni
ENSG00000113272	THG1L	93	69.314	ENSORLG00015006415	thg1l	93	69.314	Oryzias_latipes_hsok
ENSG00000113272	THG1L	94	69.965	ENSOMEG00000011477	thg1l	95	70.940	Oryzias_melastigma
ENSG00000113272	THG1L	100	91.275	ENSOGAG00000009057	THG1L	100	91.275	Otolemur_garnettii
ENSG00000113272	THG1L	100	89.262	ENSOARG00000012620	THG1L	100	89.262	Ovis_aries
ENSG00000113272	THG1L	100	98.993	ENSPPAG00000042438	THG1L	100	98.993	Pan_paniscus
ENSG00000113272	THG1L	100	90.268	ENSPPRG00000007563	THG1L	100	90.268	Panthera_pardus
ENSG00000113272	THG1L	90	93.309	ENSPTIG00000013921	THG1L	100	93.309	Panthera_tigris_altaica
ENSG00000113272	THG1L	100	98.993	ENSPTRG00000017473	THG1L	100	98.993	Pan_troglodytes
ENSG00000113272	THG1L	100	96.644	ENSPANG00000025147	THG1L	100	96.644	Papio_anubis
ENSG00000113272	THG1L	93	73.188	ENSPKIG00000002407	thg1l	90	73.188	Paramormyrops_kingsleyae
ENSG00000113272	THG1L	94	84.375	ENSPSIG00000005072	THG1L	99	84.434	Pelodiscus_sinensis
ENSG00000113272	THG1L	75	80.645	ENSPMGG00000020712	thg1l	94	62.718	Periophthalmus_magnuspinnatus
ENSG00000113272	THG1L	99	85.135	ENSPEMG00000022707	Thg1l	97	87.931	Peromyscus_maniculatus_bairdii
ENSG00000113272	THG1L	82	67.857	ENSPMAG00000000881	thg1l	85	69.945	Petromyzon_marinus
ENSG00000113272	THG1L	96	83.624	ENSPCIG00000018471	THG1L	100	85.648	Phascolarctos_cinereus
ENSG00000113272	THG1L	95	69.149	ENSPLAG00000019419	thg1l	98	68.905	Poecilia_latipinna
ENSG00000113272	THG1L	95	69.858	ENSPMEG00000017466	thg1l	95	69.858	Poecilia_mexicana
ENSG00000113272	THG1L	95	69.504	ENSPMEG00000017382	-	95	69.504	Poecilia_mexicana
ENSG00000113272	THG1L	89	70.833	ENSPREG00000019678	thg1l	92	70.588	Poecilia_reticulata
ENSG00000113272	THG1L	100	98.322	ENSPPYG00000015993	THG1L	100	98.322	Pongo_abelii
ENSG00000113272	THG1L	100	90.604	ENSPCAG00000016378	THG1L	100	90.604	Procavia_capensis
ENSG00000113272	THG1L	100	90.940	ENSPCOG00000028595	THG1L	100	90.940	Propithecus_coquereli
ENSG00000113272	THG1L	94	84.375	ENSPVAG00000006279	THG1L	100	70.940	Pteropus_vampyrus
ENSG00000113272	THG1L	96	67.596	ENSPNYG00000000169	thg1l	96	67.596	Pundamilia_nyererei
ENSG00000113272	THG1L	91	72.325	ENSPNAG00000013944	thg1l	91	72.325	Pygocentrus_nattereri
ENSG00000113272	THG1L	99	85.085	ENSRNOG00000005539	Thg1l	99	85.085	Rattus_norvegicus
ENSG00000113272	THG1L	100	96.309	ENSRBIG00000037537	THG1L	100	97.685	Rhinopithecus_bieti
ENSG00000113272	THG1L	100	96.309	ENSRROG00000045380	THG1L	100	96.309	Rhinopithecus_roxellana
ENSG00000113272	THG1L	74	52.688	YGR024C	-	91	52.093	Saccharomyces_cerevisiae
ENSG00000113272	THG1L	100	96.644	ENSSBOG00000024790	THG1L	100	96.644	Saimiri_boliviensis_boliviensis
ENSG00000113272	THG1L	96	80.139	ENSSHAG00000016908	THG1L	85	80.139	Sarcophilus_harrisii
ENSG00000113272	THG1L	91	74.265	ENSSFOG00015017619	thg1l	87	74.265	Scleropages_formosus
ENSG00000113272	THG1L	92	70.073	ENSSMAG00000008988	thg1l	92	70.073	Scophthalmus_maximus
ENSG00000113272	THG1L	91	70.588	ENSSDUG00000009841	thg1l	98	69.362	Seriola_dumerili
ENSG00000113272	THG1L	91	70.588	ENSSLDG00000003416	thg1l	91	70.588	Seriola_lalandi_dorsalis
ENSG00000113272	THG1L	98	87.705	ENSSARG00000012216	THG1L	100	88.163	Sorex_araneus
ENSG00000113272	THG1L	94	81.250	ENSSPUG00000007060	THG1L	100	78.067	Sphenodon_punctatus
ENSG00000113272	THG1L	91	72.059	ENSSPAG00000008744	thg1l	91	72.059	Stegastes_partitus
ENSG00000113272	THG1L	100	91.275	ENSSSCG00000036047	THG1L	100	91.275	Sus_scrofa
ENSG00000113272	THG1L	82	92.857	ENSTGUG00000000618	THG1L	100	81.752	Taeniopygia_guttata
ENSG00000113272	THG1L	92	67.273	ENSTRUG00000009758	thg1l	90	67.647	Takifugu_rubripes
ENSG00000113272	THG1L	92	67.273	ENSTNIG00000017067	thg1l	92	67.273	Tetraodon_nigroviridis
ENSG00000113272	THG1L	100	52.013	ENSTBEG00000000788	-	100	52.013	Tupaia_belangeri
ENSG00000113272	THG1L	100	89.933	ENSTTRG00000006448	THG1L	100	89.933	Tursiops_truncatus
ENSG00000113272	THG1L	100	90.940	ENSUAMG00000013357	THG1L	100	90.940	Ursus_americanus
ENSG00000113272	THG1L	100	91.275	ENSUMAG00000000769	THG1L	100	91.275	Ursus_maritimus
ENSG00000113272	THG1L	94	81.250	ENSVPAG00000007839	THG1L	81	89.627	Vicugna_pacos
ENSG00000113272	THG1L	100	90.268	ENSVVUG00000004234	THG1L	100	90.268	Vulpes_vulpes
ENSG00000113272	THG1L	94	78.125	ENSXETG00000007902	thg1l	91	74.721	Xenopus_tropicalis
ENSG00000113272	THG1L	89	71.970	ENSXMAG00000008240	thg1l	92	71.956	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21059936.	TAS	Function
GO:0000287	magnesium ion binding	21059936.	IDA	Function
GO:0005515	protein binding	21044950.25416956.	IPI	Function
GO:0005524	ATP binding	21059936.	IDA	Function
GO:0005525	GTP binding	21059936.	IDA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006400	tRNA modification	-	ISS	Process
GO:0006400	tRNA modification	-	TAS	Process
GO:0008033	tRNA processing	21873635.	IBA	Process
GO:0008033	tRNA processing	21059936.	IDA	Process
GO:0008193	tRNA guanylyltransferase activity	21873635.	IBA	Function
GO:0008193	tRNA guanylyltransferase activity	21059936.	IDA	Function
GO:0008193	tRNA guanylyltransferase activity	-	ISS	Function
GO:0016779	nucleotidyltransferase activity	21059936.	EXP	Function
GO:0042802	identical protein binding	21059936.21516116.25416956.	IPI	Function
GO:0051289	protein homotetramerization	21059936.	IDA	Process
GO:0051289	protein homotetramerization	21059936.	IPI	Process
GO:0099116	tRNA 5'-end processing	-	IEA	Process