EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000113522 (Gene tree)
Gene ID: 10111
Gene Symbol: RAD50
Alias: hRad50|RAD50-2
Full Name: RAD50 double strand break repair protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 90,326 bases
Position: chr5:132,556,019-132,646,344
Accession: 9816
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12007281	Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.	Pathobiology	2001	Matsutani N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000378823	RAD50-201	8306	-	ENSP00000368100	1312 (aa)	-	Q92878
ENST00000416135	RAD50-202	923	-	ENSP00000389515	100 (aa)	-	C9JNH8
ENST00000434288	RAD50-204	1052	-	ENSP00000396100	158 (aa)	-	H7C0P8
ENST00000496204	RAD50-208	473	-	-	- (aa)	-	-
ENST00000453394	RAD50-205	2076	-	ENSP00000400049	660 (aa)	-	E7EN38
ENST00000533482	RAD50-209	4373	-	ENSP00000431225	102 (aa)	-	E9PM98
ENST00000455677	RAD50-206	564	-	ENSP00000396860	157 (aa)	-	H7C0V2
ENST00000487596	RAD50-207	738	-	-	- (aa)	-	-
ENST00000423956	RAD50-203	2915	-	ENSP00000390971	551 (aa)	-	E7ESD9

Gene Model

Click here to download ENSG00000113522's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03440	Homologous recombination	KEGG
hsa03450	Non-homologous end-joining	KEGG
hsa04218	Cellular senescence	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113522	Asthma	2E-16	27182965
ENSG00000113522	Venous Thromboembolism	9E-6	28203683
ENSG00000113522	Dermatitis, Atopic	4E-7	25865352
ENSG00000113522	Asthma	3E-7	20159242
ENSG00000113522	Dermatitis, Atopic	2E-18	25574825
ENSG00000113522	Psoriasis	2E-18	25574825
ENSG00000113522	Asthma	2E-7	27611488
ENSG00000113522	Immunoglobulin E	4E-8	18846228
ENSG00000113522	Dermatitis, Atopic	4E-17	26482879
ENSG00000113522	Asthma	8E-7	24241537

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113522	rs2040704	5	132637485	?	Asthma	27611488	[0.12-0.27] unit decrease	0.195	EFO_0000270
ENSG00000113522	rs6596086	5	132616530	?	Inflammatory skin disease	25574825			EFO_0000274\|EFO_0000676
ENSG00000113522	rs6871536	5	132634182	C	Asthma (childhood onset)	24241537	[1.10-1.25]	1.17	EFO_0004591
ENSG00000113522	rs2244012	5	132565533	C	Asthma	20159242	[1.36-1.97]	1.64	EFO_0000270
ENSG00000113522	rs11954099	5	132619836	C	Itch intensity from mosquito bite	28199695	[0.027-0.052] unit decrease	0.0396282	EFO_0008377
ENSG00000113522	rs10479009	5	132619905	G	Neutrophil percentage of white cells	27863252	[0.018-0.036] unit decrease	0.02746763	EFO_0007990
ENSG00000113522	rs2706345	5	132568236	?	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	28203683		1.459854	EFO_0004286
ENSG00000113522	rs9687749	5	132619885	T	Allergic rhinitis	30013184	[1.04-1.09]	1.06	EFO_0005854
ENSG00000113522	rs2040704	5	132637485	?	IgE levels	18846228	[NR] % increase	13.9	EFO_0004579
ENSG00000113522	rs2244012	5	132565533	?	Asthma	27182965	[1.077-1.128]	1.102	EFO_0000270
ENSG00000113522	rs2706345	5	132568236	A	Eosinophil percentage of granulocytes	27863252	[0.067-0.085] unit increase	0.07600837	EFO_0007996
ENSG00000113522	rs2706345	5	132568236	A	Sum eosinophil basophil counts	27863252	[0.067-0.085] unit increase	0.0760465	EFO_0005090\|EFO_0004842
ENSG00000113522	rs2706345	5	132568236	A	Eosinophil percentage of white cells	27863252	[0.068-0.086] unit increase	0.07707069	EFO_0007991
ENSG00000113522	rs2706345	5	132568236	A	Eosinophil counts	27863252	[0.071-0.089] unit increase	0.0799056	EFO_0004842
ENSG00000113522	rs75765453	5	132614533	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000113522	rs2706362	5	132589495	?	Asthma	29785011	[0.078-0.142] unit increase	0.109751	EFO_0000270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113522's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	21873635.	IBA	Function
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	9705271.	IDA	Function
GO:0000019	regulation of mitotic recombination	8756642.	IDA	Process
GO:0000722	telomere maintenance via recombination	21873635.	IBA	Process
GO:0000723	telomere maintenance	10888888.	TAS	Process
GO:0000724	double-strand break repair via homologous recombination	-	TAS	Process
GO:0000729	DNA double-strand break processing	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0000784	nuclear chromosome, telomeric region	10888888.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000794	condensed nuclear chromosome	21873635.	IBA	Component
GO:0003677	DNA binding	15790808.	IDA	Function
GO:0003691	double-stranded telomeric DNA binding	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	15790808.	IMP	Function
GO:0004017	adenylate kinase activity	21873635.	IBA	Function
GO:0005515	protein binding	11096100.18716619.24534091.24651726.27568553.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	9705271.	IDA	Process
GO:0006302	double-strand break repair	9590181.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006310	DNA recombination	9705271.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	17500065.	IDA	Process
GO:0007004	telomere maintenance via telomerase	21873635.	IBA	Process
GO:0007004	telomere maintenance via telomerase	9705271.	IDA	Process
GO:0007131	reciprocal meiotic recombination	8756642.	TAS	Process
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	9705271.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016233	telomere capping	21873635.	IBA	Process
GO:0030674	protein binding, bridging	12152085.	IDA	Function
GO:0030870	Mre11 complex	21873635.	IBA	Component
GO:0030870	Mre11 complex	9590181.19151086.	IDA	Component
GO:0030870	Mre11 complex	27918544.	TAS	Component
GO:0031860	telomeric 3' overhang formation	16374507.	IMP	Process
GO:0031954	positive regulation of protein autophosphorylation	15790808.	IDA	Process
GO:0032206	positive regulation of telomere maintenance	16374507.	IMP	Process
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	15790808.	IMP	Process
GO:0033674	positive regulation of kinase activity	15790808.	IDA	Process
GO:0035861	site of double-strand break	21873635.	IBA	Component
GO:0035861	site of double-strand break	15916964.	IDA	Component
GO:0043047	single-stranded telomeric DNA binding	21873635.	IBA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0046940	nucleoside monophosphate phosphorylation	-	IEA	Process
GO:0051880	G-quadruplex DNA binding	21873635.	IBA	Function
GO:0070192	chromosome organization involved in meiotic cell cycle	21873635.	IBA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1904354	negative regulation of telomere capping	17694070.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17932350	Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.	Cancer Epidemiol Biomarkers Prev	2007 Oct	Hsu HM	-
25528023	INPP4B and RAD50 have an interactive effect on survival after breast cancer.	Breast Cancer Res Treat	2015 Jan	Dai X	doi: 10.1007/s10549-014-3241-y
24894818	Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.	Breast Cancer Res	2014 Jun 3	Damiola F	doi: 10.1186/bcr3669.
24079363	The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.	Mol Cancer	2013 Sep 30	Zi??kowska-Suchanek I	doi: 10.1186/1476-4598-12-113.
18830935	RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer.	Histol Histopathol	2008 Dec	Gao J	doi: 10.14670/HH-23.1495.
19190165	Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.	Cancer Epidemiol Biomarkers Prev	2009 Feb	Uhrhammer N	doi: 10.1158/1055-9965.EPI-08-0971
27798884	High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.	Anticancer Res	2016 Oct	Altan B	-
21356067	Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.	Breast Cancer Res	2011 Feb 28	Kuusisto KM	doi: 10.1186/bcr2832.
20571869	RAD50 gene mutations are not likely a risk factor for breast cancer in Poland.	Breast Cancer Res Treat	2010 Sep	Mosor M	doi: 10.1007/s10549-010-0992-y
16474176	RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.	Carcinogenesis	2006 Aug	Heikkinen K	-
26824983	Genetic instability in the RAD51 and BRCA1 regions in breast cancer.	Cell Mol Biol Lett	2007	Nowacka-Zawisza M	-
19904603	Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer.	Breast Cancer Res Treat	2010 May	Cao AY	doi: 10.1007/s10549-009-0629-1
20682289	Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.	Biochem Biophys Res Commun	2010 Sep 3	Kavitha CV	doi: 10.1016/j.bbrc.2010.07.117
21898661	Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.	Hum Mutat	2012 Jan	Brooks JD	doi: 10.1002/humu.21604
24934408	Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.	Cancer Discov	2014 Sep	Al-Ahmadie H	doi: 10.1158/2159-8290.CD-14-0380
21811815	RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.	Breast Cancer Res Treat	2012 May	He M	doi: 10.1007/s10549-011-1700-2
24642965	RAD50 targeting impairs DNA damage response and sensitizes human breast cancer cells to cisplatin therapy.	Cancer Biol Ther	2014 Jun 1	Flores-P??rez A	doi: 10.4161/cbt.28551
19383352	Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.	Mol Oncol	2008 Dec	Bartkova J	doi: 10.1016/j.molonc.2008.09.007
28073364	Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.	BMC Cancer	2017 Jan 10	Brandt S	doi: 10.1186/s12885-016-3026-2.
30176843	Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis.	BMC Cancer	2018 Sep 3	Ho V	doi: 10.1186/s12885-018-4776-9.
29726012	RAD50 germline mutations are associated with poor survival in BRCA1/2-negative breast cancer patients.	Int J Cancer	2018 Oct 15	Fan C	doi: 10.1002/ijc.31579

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	132592030	Silent	novel	L597L	0.37
ACC	chr5	132604964	Missense_Mutation	novel	S895P	0.2
BLCA	chr5	132595658	Missense_Mutation	novel	Q685H	0.19
BLCA	chr5	132594886	Missense_Mutation	novel	S604F	0.24
BLCA	chr5	132575786	Missense_Mutation	novel	E75Q	0.09
BLCA	chr5	132638172	Silent	rs759971562	L1189L	0.38
BLCA	chr5	132579419	Missense_Mutation	novel	F156L	0.05
BLCA	chr5	132587580	Missense_Mutation	novel	E259Q	0.11
BLCA	chr5	132557310	5'UTR	novel		0.14
BLCA	chr5	132638134	Missense_Mutation	novel	D1177H	0.66
BLCA	chr5	132559359	Missense_Mutation	rs370769989	D69N	0.21
BLCA	chr5	132579397	Frame_Shift_Del	novel	*A149Gfs10**	0.19
BLCA	chr5	132579384	Missense_Mutation	rs534015582	G145R	0.34
BLCA	chr5	132595617	Nonsense_Mutation	rs142947311	Q672*	0.08
BRCA	chr5	132640787	Nonsense_Mutation	novel	*A1246Pfs3**	0.05
BRCA	chr5	132588737	Missense_Mutation	novel	D368H	0.06
BRCA	chr5	132589715	Missense_Mutation	NA	E444K	0.19
BRCA	chr5	132588719	Missense_Mutation	NA	E362Q	0.27
BRCA	chr5	132595662	Missense_Mutation	novel	V687F	0.19
BRCA	chr5	132643269	3'UTR	novel		0.19
BRCA	chr5	132609348	Silent	novel	K996K	0.06
BRCA	chr5	132575784	In_Frame_Del	NA	E75del	0.42
BRCA	chr5	132604825	Silent	NA	L848L	0.29
BRCA	chr5	132587678	Missense_Mutation	NA	E291D	0.2
BRCA	chr5	132618111	Missense_Mutation	rs769003601	R1069I	0.26
BRCA	chr5	132609379	Frame_Shift_Ins	novel	*D1007Vfs23**	0.11
BRCA	chr5	132591375	Missense_Mutation	rs200548021	R535H	0.52
BRCA	chr5	132591261	Missense_Mutation	NA	V497A	0.35
BRCA	chr5	132557198	5'UTR	novel		0.17
BRCA	chr5	132609197	Silent	rs148269640	D970D	0.27
CESC	chr5	132557198	5'UTR	novel		0.2
CESC	chr5	132640734	Silent	NA	I1227I	0.04
CESC	chr5	132580030	In_Frame_Ins	novel	I240_V241insM	0.1
CESC	chr5	132580032	Frame_Shift_Ins	novel	*K242Yfs14**	0.1
CESC	chr5	132591375	Missense_Mutation	rs200548021	R535H	0.38
CESC	chr5	132642265	Silent	novel	S1280S	0.07
CESC	chr5	132580057	Silent	novel	D249D	0.14
CESC	chr5	132557447	Silent	NA	G41G	0.17
CESC	chr5	132588055	Silent	novel	L339L	0.47
CESC	chr5	132579423	Missense_Mutation	novel	H158Y	0.61
CHOL	chr5	132595742	Silent	novel	K713K	0.52
COAD	chr5	132609150	Missense_Mutation	NA	H955N	0.37
COAD	chr5	132579495	Missense_Mutation	novel	A182T	0.31
COAD	chr5	132616063	Nonsense_Mutation	NA	E1033*	0.36
COAD	chr5	132640684	Missense_Mutation	NA	L1211F	0.14
COAD	chr5	132595780	Missense_Mutation	rs28903092	R726H	0.35
COAD	chr5	132642251	Missense_Mutation	NA	L1276F	0.08
COAD	chr5	132579487	Frame_Shift_Del	novel	*S181Qfs9**	0.48
COAD	chr5	132642260	Missense_Mutation	rs786201810	R1279C	0.9
COAD	chr5	132588805	Silent	NA	E390E	0.35
COAD	chr5	132559351	Missense_Mutation	NA	F66S	0.36
COAD	chr5	132608690	Frame_Shift_Del	rs758740142	*N934Ifs6**	0.26
COAD	chr5	132642968	3'UTR	novel		0.46
COAD	chr5	132557342	Missense_Mutation	novel	K6N	0.25
COAD	chr5	132588821	Missense_Mutation	NA	F396L	0.24
COAD	chr5	132591273	Missense_Mutation	NA	K501R	0.11
COAD	chr5	132618111	Missense_Mutation	rs769003601	R1069I	0.25
COAD	chr5	132588789	Missense_Mutation	rs150030986	R385H	0.23
COAD	chr5	132589709	Frame_Shift_Ins	novel	*I442Kfs7**	0.03
COAD	chr5	132595719	Nonsense_Mutation	rs772468452	R706*	0.11
COAD	chr5	132595760	Frame_Shift_Del	NA	*K722Gfs5**	0.35
ESCA	chr5	132637192	Missense_Mutation	rs587780156	R1156H	0.07
ESCA	chr5	132608690	Frame_Shift_Del	rs758740142	*N934Ifs6**	0.46
GBM	chr5	132591404	Missense_Mutation	NA	K545E	0.36
GBM	chr5	132588847	Missense_Mutation	novel	Q404H	0.18
GBM	chr5	132595765	Missense_Mutation	novel	K721T	0.44
GBM	chr5	132603997	Silent	novel	V825V	0.07
GBM	chr5	132588055	Silent	NA	L339L	0.08
HNSC	chr5	132595777	Missense_Mutation	novel	R725L	0.1
HNSC	chr5	132618155	Nonsense_Mutation	rs765931959	E1084*	0.14
HNSC	chr5	132642223	Frame_Shift_Ins	novel	*V1274Dfs4**	0.09
HNSC	chr5	132595719	Nonsense_Mutation	rs772468452	R706*	0.2
HNSC	chr5	132604983	Missense_Mutation	novel	L901S	0.35
HNSC	chr5	132638107	Missense_Mutation	novel	D1168N	0.15
HNSC	chr5	132594951	Missense_Mutation	rs763432574	E626K	0.17
HNSC	chr5	132595781	In_Frame_Del	novel	D727_P734del	0.06
HNSC	chr5	132580043	Missense_Mutation	novel	E245K	0.32
HNSC	chr5	132557270	5'UTR	novel		0.12
HNSC	chr5	132618247	Silent	novel	T1114T	0.31
HNSC	chr5	132575813	Silent	novel	L84L	0.19
HNSC	chr5	132579455	Silent	novel	E168E	0.82
HNSC	chr5	132618183	Missense_Mutation	rs781612348	R1093Q	0.13
HNSC	chr5	132587642	Missense_Mutation	novel	K279N	0.15
KIRC	chr5	132603366	Silent	NA	N758N	0.07
KIRC	chr5	132591362	Frame_Shift_Del	novel	*H531Qfs10**	0.24
KIRC	chr5	132594945	Missense_Mutation	NA	S624G	0.51
KIRP	chr5	132642831	3'UTR	novel		0.67
KIRP	chr5	132618127	Silent	NA	A1074A	0.46
KIRP	chr5	132638150	Missense_Mutation	novel	Y1182S	0.36
LAML	chr5	132592035	Splice_Site	novel	X598_splice	0.08
LAML	chr5	132587602	Missense_Mutation	novel	M266K	0.09
LAML	chr5	132557371	Missense_Mutation	NA	G16E	0.11
LGG	chr5	132579981	Missense_Mutation	rs28903088	R224H	0.32
LGG	chr5	132604845	Missense_Mutation	rs751531030	D855G	0.29
LGG	chr5	132618134	Nonsense_Mutation	rs368980595	R1077*	0.33
LGG	chr5	132595022	Silent	NA	I649I	0.14
LGG	chr5	132637194	Missense_Mutation	novel	G1157R	0.39
LGG	chr5	132557437	Missense_Mutation	rs750480943	N38S	0.42
LIHC	chr5	132618197	Missense_Mutation	rs750947088	R1098W	0.12
LIHC	chr5	132603481	Missense_Mutation	novel	R797G	0.35
LIHC	chr5	132603424	Missense_Mutation	novel	I778V	0.28
LIHC	chr5	132557331	Missense_Mutation	novel	R3G	0.28
LUAD	chr5	132595719	Missense_Mutation	novel	R706G	0.63
LUAD	chr5	132603357	Missense_Mutation	novel	Q755H	0.08
LUAD	chr5	132559359	Missense_Mutation	NA	D69Y	0.25
LUAD	chr5	132557342	Missense_Mutation	novel	K6N	0.24
LUAD	chr5	132587690	Frame_Shift_Ins	novel	*V296Cfs6**	0.13
LUAD	chr5	132587641	Missense_Mutation	novel	K279T	0.2
LUAD	chr5	132616098	Frame_Shift_Ins	novel	*M1045Sfs11**	0.14
LUAD	chr5	132616100	Frame_Shift_Del	novel	*M1045Rfs11**	0.14
LUAD	chr5	132557241	5'UTR	novel		0.08
LUAD	chr5	132580029	Frame_Shift_Ins	novel	*V241Mfs12**	0.06
LUAD	chr5	132580031	Frame_Shift_Ins	novel	*V241Gfs14**	0.06
LUAD	chr5	132579443	Missense_Mutation	novel	W164C	0.3
LUAD	chr5	132638175	Silent	NA	K1190K	0.35
LUAD	chr5	132642317	Missense_Mutation	NA	E1298Q	0.2
LUAD	chr5	132587638	Missense_Mutation	novel	R278L	0.11
LUAD	chr5	132588055	Silent	NA	L339L	0.28
LUAD	chr5	132559359	Missense_Mutation	NA	D69Y	0.7
LUSC	chr5	132609123	Missense_Mutation	novel	D946Y	0.37
LUSC	chr5	132575822	Missense_Mutation	rs143802516	R87C	0.37
LUSC	chr5	132589725	Missense_Mutation	rs786201804	S447L	0.35
LUSC	chr5	132591389	In_Frame_Ins	novel	M540delinsNLPNFV	0.13
LUSC	chr5	132591348	Missense_Mutation	novel	E526V	0.3
LUSC	chr5	132609134	Missense_Mutation	novel	E949D	0.44
LUSC	chr5	132618116	Missense_Mutation	NA	H1071Y	0.58
LUSC	chr5	132579413	Silent	NA	V154V	0.31
LUSC	chr5	132618120	Missense_Mutation	rs761533807	N1072S	0.75
LUSC	chr5	132591933	Silent	novel	T564T	0.47
LUSC	chr5	132640804	Missense_Mutation	novel	E1251Q	0.11
MESO	chr5	132579999	Missense_Mutation	novel	K230R	0.11
MESO	chr5	132588057	Missense_Mutation	rs776934742	N340S	0.19
OV	chr5	132557400	Missense_Mutation	novel	T26A	0.1
OV	chr5	132589678	Missense_Mutation	NA	E431D	0.11
OV	chr5	132642823	3'UTR	novel		0.67
OV	chr5	132595728	Missense_Mutation	novel	P709T	0.04
OV	chr5	132640796	Missense_Mutation	NA	A1248G	0.93
PAAD	chr5	132618294	Splice_Site	novel	X1130_splice	0.06
PCPG	chr5	132595613	Silent	novel	I670I	0.38
PRAD	chr5	132591375	Missense_Mutation	rs200548021	R535H	0.13
READ	chr5	132587638	Missense_Mutation	rs587782307	R278Q	0.27
READ	chr5	132609330	Silent	rs375264148	C990C	0.28
READ	chr5	132618183	Missense_Mutation	rs781612348	R1093Q	0.23
READ	chr5	132640730	Missense_Mutation	novel	G1226V	0.57
READ	chr5	132575893	Missense_Mutation	NA	E110D	0.2
READ	chr5	132587678	Missense_Mutation	NA	E291D	0.2
READ	chr5	132557385	Missense_Mutation	novel	D21Y	0.45
READ	chr5	132579436	Missense_Mutation	novel	S162Y	0.35
READ	chr5	132579887	Missense_Mutation	rs28903087	R193W	0.43
READ	chr5	132589822	Missense_Mutation	novel	Q479H	0.42
READ	chr5	132618164	Missense_Mutation	NA	H1087N	0.09
SARC	chr5	132591992	Missense_Mutation	novel	S584L	0.5
SARC	chr5	132638203	Nonsense_Mutation	rs750586158	R1200*	0.45
SARC	chr5	132591399	Missense_Mutation	rs766041105	K543R	0.39
SARC	chr5	132609141	Frame_Shift_Del	novel	*N953Ifs6**	0.08
SKCM	chr5	132608637	Missense_Mutation	novel	P914L	0.25
SKCM	chr5	132640762	Missense_Mutation	novel	L1237F	0.57
SKCM	chr5	132595589	Silent	rs777890524	A662A	0.43
SKCM	chr5	132587930	Nonsense_Mutation	NA	Q298*	0.33
SKCM	chr5	132588689	Missense_Mutation	NA	R352C	0.57
SKCM	chr5	132640720	Missense_Mutation	NA	L1223F	0.31
SKCM	chr5	132575822	Missense_Mutation	rs143802516	R87C	0.31
SKCM	chr5	132592026	Frame_Shift_Ins	novel	*K596Efs12**	0.13
SKCM	chr5	132580059	Missense_Mutation	NA	P250L	0.32
SKCM	chr5	132557303	5'UTR	novel		0.25
SKCM	chr5	132588689	Missense_Mutation	NA	R352C	0.54
SKCM	chr5	132604970	Missense_Mutation	NA	E897K	0.35
SKCM	chr5	132640798	Missense_Mutation	novel	L1249M	0.38
SKCM	chr5	132595014	Missense_Mutation	novel	E647K	0.12
SKCM	chr5	132579332	Silent	NA	V127V	0.45
STAD	chr5	132595779	Missense_Mutation	rs753002904	R726C	0.26
STAD	chr5	132579367	Frame_Shift_Del	novel	M140*	0.32
STAD	chr5	132618134	Nonsense_Mutation	rs368980595	R1077*	0.27
STAD	chr5	132589823	Missense_Mutation	novel	E480K	0.42
STAD	chr5	132557293	5'UTR	NA		0.08
STAD	chr5	132640773	Silent	NA	E1240E	0.07
STAD	chr5	132608690	Frame_Shift_Del	rs758740142	*N934Ifs6**	0.5
STAD	chr5	132637134	Missense_Mutation	NA	S1137G	0.25
STAD	chr5	132575795	Missense_Mutation	NA	V78M	0.16
STAD	chr5	132591958	Frame_Shift_Del	novel	*K574Nfs24**	0.09
STAD	chr5	132595646	Silent	NA	C681C	0.45
STAD	chr5	132603432	Silent	NA	P780P	0.43
STAD	chr5	132638159	Missense_Mutation	rs747603489	R1185Q	0.27
THCA	chr5	132618259	Frame_Shift_Ins	novel	*K1119Cfs16**	0.05
UCEC	chr5	132604931	Missense_Mutation	rs755939251	R884C	0.34
UCEC	chr5	132640716	Missense_Mutation	novel	F1221L	0.27
UCEC	chr5	132643156	3'UTR	novel		0.21
UCEC	chr5	132643388	3'UTR	novel		0.18
UCEC	chr5	132557310	5'UTR	novel		0.4
UCEC	chr5	132591914	Missense_Mutation	NA	R558M	0.24
UCEC	chr5	132618275	Missense_Mutation	NA	Y1124D	0.4
UCEC	chr5	132618205	Silent	novel	A1100A	0.9
UCEC	chr5	132579317	Splice_Region	rs587782384	K122K	0.08
UCEC	chr5	132595720	Missense_Mutation	rs773566981	R706Q	0.37
UCEC	chr5	132603472	Missense_Mutation	novel	I794L	0.28
UCEC	chr5	132588839	Missense_Mutation	novel	E402Q	0.15
UCEC	chr5	132579486	Frame_Shift_Ins	novel	*S181Ffs7**	0.49
UCEC	chr5	132643393	3'UTR	rs536567192		0.27
UCEC	chr5	132575822	Missense_Mutation	rs143802516	R87C	0.45
UCEC	chr5	132557393	Missense_Mutation	novel	Q23H	0.44
UCEC	chr5	132604829	Missense_Mutation	rs181961360	R850C	0.43
UCEC	chr5	132587571	Missense_Mutation	novel	K256Q	0.2
UCEC	chr5	132588818	Missense_Mutation	novel	N395H	0.24
UCEC	chr5	132618234	Missense_Mutation	novel	V1110G	0.2
UCEC	chr5	132643603	3'UTR	novel		0.21
UCEC	chr5	132557328	Missense_Mutation	novel	S2P	0.06
UCEC	chr5	132603932	Missense_Mutation	NA	D804Y	0.33
UCEC	chr5	132618125	Missense_Mutation	NA	A1074T	0.28
UCEC	chr5	132603379	In_Frame_Ins	novel	R763delinsLISYSPTVQNLLC	0.08
UCEC	chr5	132603941	Silent	NA	R807R	0.44
UCEC	chr5	132575865	Missense_Mutation	NA	V101A	0.26
UCEC	chr5	132579923	Nonsense_Mutation	NA	E205*	0.12
UCEC	chr5	132640694	Missense_Mutation	rs765290694	R1214H	0.42
UCEC	chr5	132579400	Missense_Mutation	NA	V150A	0.22
UCEC	chr5	132557405	Silent	novel	F27F	0.33
UCEC	chr5	132595719	Nonsense_Mutation	rs772468452	R706*	0.42
UCEC	chr5	132604931	Missense_Mutation	rs755939251	R884C	0.41
UCEC	chr5	132618111	Missense_Mutation	rs769003601	R1069I	0.46
UCEC	chr5	132640787	Nonsense_Mutation	novel	*A1246Pfs3**	0.05
UCEC	chr5	132580003	Missense_Mutation	novel	E231D	0.2
UCEC	chr5	132591997	Nonsense_Mutation	novel	E586*	0.31
UCEC	chr5	132642931	3'UTR	novel		0.38
UCEC	chr5	132643036	3'UTR	novel		0.13
UCEC	chr5	132643189	3'UTR	novel		0.33
UCEC	chr5	132579487	Frame_Shift_Del	novel	*S181Qfs9**	0.39
UCEC	chr5	132579896	Missense_Mutation	rs769853458	R196C	0.36
UCEC	chr5	132579429	Nonsense_Mutation	novel	E160*	0.19
UCEC	chr5	132589690	Missense_Mutation	novel	K435N	0.44
UCEC	chr5	132618113	Missense_Mutation	novel	N1070H	0.46
UCEC	chr5	132591251	Missense_Mutation	novel	N494D	0.39
UCEC	chr5	132609141	Frame_Shift_Del	novel	*N953Ifs6**	0.47
UCEC	chr5	132637173	Missense_Mutation	novel	L1150M	0.35
UCEC	chr5	132609165	Missense_Mutation	novel	D960Y	0.59
UCEC	chr5	132616092	Silent	novel	L1042L	0.51
UCEC	chr5	132618183	Missense_Mutation	rs781612348	R1093Q	0.5
UCEC	chr5	132640784	Missense_Mutation	novel	S1244Y	0.41
UCEC	chr5	132559359	Missense_Mutation	rs370769989	D69N	0.43
UCEC	chr5	132608690	Frame_Shift_Del	rs758740142	*N934Ifs6**	0.59
UCEC	chr5	132618141	Missense_Mutation	NA	K1079T	0.21
UCEC	chr5	132557342	Missense_Mutation	novel	K6N	0.21
UCEC	chr5	132587638	Missense_Mutation	rs587782307	R278Q	0.48
UCEC	chr5	132588729	Missense_Mutation	rs146370443	R365Q	0.32
UCEC	chr5	132643106	3'UTR	rs149508378		0.41
UCEC	chr5	132604880	Missense_Mutation	rs753186320	T867A	0.19
UCEC	chr5	132588711	Missense_Mutation	novel	R359H	0.24
UCEC	chr5	132594935	Missense_Mutation	novel	E620D	0.25
UCEC	chr5	132609173	Missense_Mutation	novel	E962D	0.22
UCEC	chr5	132609343	Nonsense_Mutation	novel	E995*	0.15
UCEC	chr5	132618197	Missense_Mutation	rs750947088	R1098W	0.14
UCEC	chr5	132640784	Missense_Mutation	novel	S1244Y	0.17
UCEC	chr5	132638158	Nonsense_Mutation	rs778555849	R1185*	0.53
UCEC	chr5	132595650	Missense_Mutation	rs367925756	V683I	0.12
UCEC	chr5	132638116	Missense_Mutation	NA	E1171K	0.43
UCEC	chr5	132587678	Missense_Mutation	NA	E291D	0.34
UCEC	chr5	132603932	Missense_Mutation	NA	D804Y	0.47
UCEC	chr5	132643318	3'UTR	novel		0.23
UCEC	chr5	132643503	3'UTR	novel		0.53
UCEC	chr5	132640693	Missense_Mutation	rs546479838	R1214C	0.58
UCEC	chr5	132603932	Missense_Mutation	NA	D804Y	0.38
UCEC	chr5	132638090	Missense_Mutation	novel	Y1162C	0.32
UCEC	chr5	132643447	3'UTR	novel		0.42
UCEC	chr5	132559359	Missense_Mutation	rs370769989	D69N	0.29
UCEC	chr5	132640801	Missense_Mutation	novel	V1250I	0.49
UCEC	chr5	132642264	Missense_Mutation	novel	S1280Y	0.15
UCEC	chr5	132580057	Silent	novel	D249D	0.04
UCEC	chr5	132591910	Missense_Mutation	NA	S557P	0.28
UCEC	chr5	132591911	Missense_Mutation	NA	S557Y	0.24
UCEC	chr5	132618182	Nonsense_Mutation	rs121912628	R1093*	0.33
UCEC	chr5	132642305	Missense_Mutation	rs587782339	D1294N	0.24
UCEC	chr5	132589685	Missense_Mutation	novel	D434Y	0.19
UCEC	chr5	132638101	Missense_Mutation	rs587782577	R1166W	0.4
UCEC	chr5	132616126	Frame_Shift_Ins	novel	*K1054Rfs6**	0.08
UCEC	chr5	132579381	Missense_Mutation	novel	L144I	0.06
UCEC	chr5	132579414	Frame_Shift_Ins	novel	*C157Lfs7**	0.27
UCEC	chr5	132603363	Silent	novel	V757V	0.31
UCEC	chr5	132618197	Missense_Mutation	rs750947088	R1098W	0.4
UCEC	chr5	132618091	Missense_Mutation	NA	E1062D	0.18
UCEC	chr5	132603400	Nonsense_Mutation	NA	E770*	0.27
UCEC	chr5	132575891	Nonsense_Mutation	novel	E110*	0.37
UCEC	chr5	132557228	5'UTR	novel		0.29
UCEC	chr5	132557441	Silent	novel	G39G	0.25
UCEC	chr5	132603480	Missense_Mutation	novel	E796D	0.2
UCEC	chr5	132604035	Missense_Mutation	novel	K838T	0.55
UCEC	chr5	132616040	Missense_Mutation	novel	R1025I	0.31
UCEC	chr5	132618209	Missense_Mutation	novel	E1102K	0.3
UCEC	chr5	132603399	Silent	novel	E769E	0.18
UCEC	chr5	132595760	Frame_Shift_Del	NA	*K722Gfs5**	0.53
UCEC	chr5	132587596	Missense_Mutation	novel	K264T	0.35
UCEC	chr5	132591299	Frame_Shift_Ins	novel	*A512Sfs9**	0.36
UCEC	chr5	132618182	Nonsense_Mutation	rs121912628	R1093*	0.52
UCEC	chr5	132642191	Missense_Mutation	rs561655417	R1256C	0.42
UCEC	chr5	132575822	Missense_Mutation	rs143802516	R87C	0.37
UCEC	chr5	132588689	Missense_Mutation	NA	R352C	0.34
UCEC	chr5	132608690	Frame_Shift_Del	rs758740142	*N934Ifs6**	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0417	0.11554
LAML	DEL	0.089	1.2971e-07
LUAD	DEL	0.3023	7.4776e-05
LUSC	DEL	0.6447	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0244	0.16448
STAD	DEL	0.2744	2.8835e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00018	Kaplan-Meier Survival Analysis
MESO	0.00036	Kaplan-Meier Survival Analysis
ACC	0.023	Kaplan-Meier Survival Analysis
SKCM	0.008	Kaplan-Meier Survival Analysis
BRCA	0.04	Kaplan-Meier Survival Analysis
CESC	0.0016	Kaplan-Meier Survival Analysis
READ	0.0056	Kaplan-Meier Survival Analysis
LIHC	0.028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742