EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113649 (Gene tree)
Gene ID: 10915
Gene Symbol: TCERG1
Alias: CA150|Urn1|TAF2S
Full Name: transcription elongation regulator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 64,652 bases
Position: chr5:146,447,310-146,511,961
Accession: 15630
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10908677	Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II.	Proc Natl Acad Sci U S A	2000 Aug 1	Carty SM	-
19711185	High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations.	J Biomol NMR	2009 Nov	Zeng J	doi: 10.1007/s10858-009-9366-3

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504116	TCERG1-204	564	-	-	- (aa)	-	-
ENST00000511077	TCERG1-211	1846	-	-	- (aa)	-	-
ENST00000394421	TCERG1-202	3633	XM_017008977	ENSP00000377943	1077 (aa)	XP_016864466	O14776
ENST00000507175	TCERG1-207	1984	-	-	- (aa)	-	-
ENST00000510724	TCERG1-210	583	-	-	- (aa)	-	-
ENST00000549332	TCERG1-216	3518	-	ENSP00000450414	1032 (aa)	-	G3V220
ENST00000514719	TCERG1-214	573	-	-	- (aa)	-	-
ENST00000503741	TCERG1-203	578	-	-	- (aa)	-	-
ENST00000509810	TCERG1-209	784	-	-	- (aa)	-	-
ENST00000506524	TCERG1-206	3787	-	-	- (aa)	-	-
ENST00000509787	TCERG1-208	887	-	-	- (aa)	-	-
ENST00000505285	TCERG1-205	486	-	-	- (aa)	-	-
ENST00000514567	TCERG1-213	702	-	-	- (aa)	-	-
ENST00000296702	TCERG1-201	4654	XM_005268365	ENSP00000296702	1098 (aa)	XP_005268422	O14776
ENST00000513298	TCERG1-212	711	-	-	- (aa)	-	-
ENST00000515203	TCERG1-215	576	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000113649's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113649	Blood Pressure	3.8311739E-006	-
ENSG00000113649	Blood Pressure	8.2431889E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113649's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113649	TCERG1	100	97.636	ENSMUSG00000024498	Tcerg1	100	97.636	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	20956529.	IDA	Process
GO:0001103	RNA polymerase II repressing transcription factor binding	20956529.	IPI	Function
GO:0003713	transcription coactivator activity	9315662.	TAS	Function
GO:0003714	transcription corepressor activity	20956529.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	15383276.17500595.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	9315662.	TAS	Process
GO:0042802	identical protein binding	17060612.	IPI	Function
GO:0070064	proline-rich region binding	-	IEA	Function
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process