EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113657 (Gene tree)
Gene ID: 1809
Gene Symbol: DPYSL3
Alias: DRP-3|ULIP|CRMP4
Full Name: dihydropyrimidinase like 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 119,453 bases
Position: chr5:147,390,808-147,510,260
Accession: 3015
RBP type: non-canonical RBP
Summary: (Dihydropyrimidinase Like 3) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein binding. An important paralog of this gene is CRMP1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000507309	DPYSL3-204	514	-	-	- (aa)	-	-
ENST00000523458	DPYSL3-209	584	-	ENSP00000428958	75 (aa)	-	H0YB87
ENST00000398514	DPYSL3-202	5309	XM_011537574	ENSP00000381526	570 (aa)	XP_011535876	Q14195
ENST00000519672	DPYSL3-207	572	-	-	- (aa)	-	-
ENST00000343218	DPYSL3-201	5476	-	ENSP00000343690	684 (aa)	-	Q14195
ENST00000512722	DPYSL3-206	539	-	ENSP00000426720	92 (aa)	-	D6RF19
ENST00000508042	DPYSL3-205	746	-	-	- (aa)	-	-
ENST00000520473	DPYSL3-208	838	-	ENSP00000430267	209 (aa)	-	H0YBT4
ENST00000504965	DPYSL3-203	771	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000113657's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113657	Audiometry, Pure-Tone	9.6590774676164E-5	-
ENSG00000113657	Child Development Disorders, Pervasive	2.3000000E-005	-
ENSG00000113657	Sleep	1E-7	27992416

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113657	rs2288802	5	147412461	G	Macrophage inflammatory protein 1a levels	27989323	[0.12-0.31] SD units decrease	0.2188	EFO_0008218
ENSG00000113657	rs35309287	5	147395824	TA	Excessive daytime sleepiness	27992416	[0.042-0.092] unit increase	0.067	EFO_0007875
ENSG00000113657	rs11167990	5	147412193	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113657's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113657	DPYSL3	100	89.130	ENSG00000092964	DPYSL2	99	76.708	Homo_sapiens
ENSG00000113657	DPYSL3	100	89.130	ENSMUSG00000022048	Dpysl2	99	77.408	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005615	extracellular space	-	ISS	Component
GO:0005829	cytosol	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0010976	positive regulation of neuron projection development	-	ISS	Process
GO:0010977	negative regulation of neuron projection development	-	ISS	Process
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	IEA	Function
GO:0017124	SH3 domain binding	-	ISS	Function
GO:0030027	lamellipodium	-	ISS	Component
GO:0030336	negative regulation of cell migration	-	ISS	Process
GO:0030426	growth cone	-	ISS	Component
GO:0031005	filamin binding	25358863.	IPI	Function
GO:0031941	filamentous actin	-	ISS	Component
GO:0035374	chondroitin sulfate binding	-	ISS	Function
GO:0044297	cell body	-	ISS	Component
GO:0045202	synapse	-	IEA	Component
GO:0048666	neuron development	-	IEA	Process
GO:0048678	response to axon injury	-	ISS	Process
GO:0051017	actin filament bundle assembly	-	ISS	Process
GO:0051260	protein homooligomerization	-	ISS	Process
GO:0051491	positive regulation of filopodium assembly	-	ISS	Process
GO:0051764	actin crosslink formation	-	ISS	Process
GO:0070382	exocytic vesicle	-	ISS	Component
GO:0071345	cellular response to cytokine stimulus	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27475326	Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer.	BMC Cancer	2016 Jul 30	Guo H	doi: 10.1186/s12885-016-2593-6.
15933812	HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors.	J Neurooncol	2005 May	Choi YL	-
20543870	Expression profiling identifies new function of collapsin response mediator protein 4 as a metastasis-suppressor in prostate cancer.	Oncogene	2010 Aug 12	Gao X	doi: 10.1038/onc.2010.213
25096402	Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer.	J Exp Clin Cancer Res	2014 Aug 6	Kanda M	doi: 10.1186/s13046-014-0066-9.
22805864	Collapsin response mediator protein 4 expression is associated with liver metastasis and poor survival in pancreatic cancer.	Ann Surg Oncol	2013 Dec	Hiroshima Y	doi: 10.1245/s10434-012-2491-3

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	147393881	3'UTR	novel		0.41
BLCA	chr5	147400707	Missense_Mutation	novel	I365M	0.35
BLCA	chr5	147415814	Missense_Mutation	rs777564671	E125Q	0.11
BLCA	chr5	147399223	Silent	novel	F380F	0.39
BRCA	chr5	147397756	Silent	NA	G457G	0.36
BRCA	chr5	147399234	Missense_Mutation	rs754356799	E377K	0.13
BRCA	chr5	147424921	Missense_Mutation	NA	D28N	0.1
BRCA	chr5	147395710	Silent	NA	L491L	0.19
BRCA	chr5	147400721	Missense_Mutation	NA	R361W	0.16
BRCA	chr5	147400782	Silent	NA	Q340Q	0.26
BRCA	chr5	147418557	Missense_Mutation	rs750296589	G68E	0.22
BRCA	chr5	147415769	Missense_Mutation	novel	D140H	0.05
BRCA	chr5	147405727	Missense_Mutation	NA	E232K	0.42
CESC	chr5	147390980	3'UTR	novel		0.12
CESC	chr5	147453552	Silent	novel	I12I	0.44
CESC	chr5	147415797	Missense_Mutation	NA	K130N	0.11
CESC	chr5	147391274	3'UTR	novel		0.75
CESC	chr5	147391274	3'UTR	novel		0.2
CESC	chr5	147399135	Missense_Mutation	rs757343684	V410I	0.14
CESC	chr5	147418589	Silent	novel	T57T	0.24
CESC	chr5	147391351	3'UTR	novel		0.35
CESC	chr5	147395625	Missense_Mutation	rs751361322	R520W	0.12
CESC	chr5	147399187	Silent	novel	F392F	0.3
CESC	chr5	147391387	3'UTR	novel		0.19
CESC	chr5	147412656	Silent	NA	L191L	0.5
CESC	chr5	147391361	3'UTR	novel		0.09
COAD	chr5	147400778	Missense_Mutation	NA	A342T	0.38
COAD	chr5	147418456	Missense_Mutation	NA	T102A	0.47
COAD	chr5	147395638	Frame_Shift_Del	novel	*A516Qfs15**	0.31
COAD	chr5	147424941	Missense_Mutation	novel	G21V	0.54
COAD	chr5	147395693	Missense_Mutation	NA	G497D	0.78
COAD	chr5	147405695	Silent	NA	I242I	0.41
COAD	chr5	147397674	Missense_Mutation	rs747491194	R485W	0.09
COAD	chr5	147393949	3'UTR	novel		0.23
COAD	chr5	147394056	Silent	NA	S564S	0.34
COAD	chr5	147397674	Missense_Mutation	rs747491194	R485W	0.3
COAD	chr5	147401615	Missense_Mutation	NA	A298V	0.4
COAD	chr5	147399173	Missense_Mutation	novel	R397H	0.12
COAD	chr5	147399190	Silent	novel	I391I	0.05
COAD	chr5	147399123	Missense_Mutation	NA	P414S	0.16
ESCA	chr5	147415848	Silent	novel	E113E	0.1
ESCA	chr5	147393798	3'UTR	novel		0.11
ESCA	chr5	147393786	3'UTR	novel		0.09
ESCA	chr5	147424921	Missense_Mutation	novel	D28H	0.83
GBM	chr5	147415815	Missense_Mutation	novel	R124S	0.14
GBM	chr5	147424882	Silent	novel	L41L	0.07
GBM	chr5	147415797	Missense_Mutation	novel	K130N	0.54
GBM	chr5	147405659	Silent	NA	K254K	0.06
HNSC	chr5	147418546	Missense_Mutation	novel	V72I	0.25
HNSC	chr5	147405629	Silent	novel	I264I	0.18
HNSC	chr5	147399097	Silent	NA	A422A	0.11
HNSC	chr5	147418458	Missense_Mutation	novel	T101I	0.42
HNSC	chr5	147424946	Missense_Mutation	novel	I19M	0.11
HNSC	chr5	147397671	Missense_Mutation	novel	R486G	0.62
KIRC	chr5	147418554	Missense_Mutation	NA	G69V	0.21
KIRC	chr5	147412639	Missense_Mutation	NA	V197A	0.4
KIRP	chr5	147393755	3'UTR	novel		0.43
KIRP	chr5	147453575	Missense_Mutation	novel	G5C	0.09
LAML	chr5	147399143	Missense_Mutation	novel	S407N	0.15
LIHC	chr5	147400833	Missense_Mutation	novel	S323R	0.19
LIHC	chr5	147397727	Missense_Mutation	novel	R467L	0.52
LIHC	chr5	147412681	Missense_Mutation	NA	E183V	0.1
LUAD	chr5	147408744	Missense_Mutation	NA	L225Q	0.14
LUAD	chr5	147400718	Missense_Mutation	NA	M362L	0.38
LUAD	chr5	147400726	Missense_Mutation	NA	E359V	0.5
LUAD	chr5	147399177	Missense_Mutation	novel	P396S	0.05
LUAD	chr5	147412659	Missense_Mutation	novel	E190D	0.33
LUAD	chr5	147400721	Silent	NA	R361R	0.63
LUAD	chr5	147401559	Missense_Mutation	NA	I317F	0.59
LUAD	chr5	147397824	Missense_Mutation	NA	E435K	0.24
LUSC	chr5	147415797	Silent	novel	K130K	0.26
LUSC	chr5	147424965	Splice_Site	novel	X14_splice	0.59
LUSC	chr5	147415821	Missense_Mutation	NA	K122N	0.29
LUSC	chr5	147413605	Silent	novel	S177S	0.29
LUSC	chr5	147395638	Frame_Shift_Del	novel	*A516Qfs15**	0.83
LUSC	chr5	147395639	Missense_Mutation	novel	P515L	0.83
LUSC	chr5	147424956	Missense_Mutation	rs374440794	R16H	0.21
LUSC	chr5	147394050	Missense_Mutation	NA	I566M	0.13
LUSC	chr5	147397761	Missense_Mutation	NA	D456N	0.72
LUSC	chr5	147415758	Missense_Mutation	novel	H143Q	0.16
LUSC	chr5	147393931	3'UTR	novel		0.33
OV	chr5	147399211	Silent	novel	T384T	0.05
OV	chr5	147397727	Missense_Mutation	rs377459296	R467H	0.06
OV	chr5	147415843	Missense_Mutation	novel	S115N	0.17
OV	chr5	147394012	3'UTR	novel		0.07
OV	chr5	147400700	Missense_Mutation	novel	K368Q	0.1
OV	chr5	147400701	Silent	novel	D367D	0.1
OV	chr5	147397723	Nonsense_Mutation	novel	*F468Lfs6**	0.16
READ	chr5	147415746	Silent	rs761152983	S147S	0.36
SARC	chr5	147400833	Splice_Region	rs751007269	S323S	0.13
SARC	chr5	147393949	3'UTR	novel		0.21
SKCM	chr5	147418599	Missense_Mutation	NA	G54E	0.37
SKCM	chr5	147400727	Nonsense_Mutation	novel	E359*	0.23
SKCM	chr5	147397737	Missense_Mutation	NA	G464R	0.24
SKCM	chr5	147400770	Silent	NA	G344G	0.27
SKCM	chr5	147405671	Silent	NA	L250L	0.32
SKCM	chr5	147394025	3'UTR	novel		0.22
SKCM	chr5	147399223	Silent	novel	F380F	0.18
SKCM	chr5	147399168	Missense_Mutation	NA	G399R	0.43
SKCM	chr5	147399101	Missense_Mutation	NA	S421F	0.2
SKCM	chr5	147394001	3'UTR	novel		0.18
SKCM	chr5	147395578	Silent	NA	Q535Q	0.4
SKCM	chr5	147415736	Missense_Mutation	novel	E151K	0.45
SKCM	chr5	147418550	Silent	rs761657413	I70I	0.33
SKCM	chr5	147405727	Missense_Mutation	NA	E232K	0.22
SKCM	chr5	147408751	Missense_Mutation	novel	H223Y	0.28
SKCM	chr5	147395657	Missense_Mutation	NA	T509N	0.46
SKCM	chr5	147418543	Missense_Mutation	novel	H73Y	0.3
STAD	chr5	147395678	Missense_Mutation	novel	P502L	0.32
STAD	chr5	147408790	Missense_Mutation	NA	T210A	0.14
STAD	chr5	147408727	Splice_Site	NA	X230_splice	0.23
STAD	chr5	147395696	Missense_Mutation	NA	R496M	0.26
STAD	chr5	147401614	Silent	rs200777055	A298A	0.35
STAD	chr5	147397844	Missense_Mutation	rs758085369	A428V	0.41
STAD	chr5	147399136	Silent	rs779181977	L409L	0.26
STAD	chr5	147401610	Missense_Mutation	NA	A300T	0.3
STAD	chr5	147399135	Missense_Mutation	rs757343684	V410I	0.37
STAD	chr5	147399234	Missense_Mutation	rs754356799	E377K	0.36
STAD	chr5	147400821	Silent	NA	Q327Q	0.18
STAD	chr5	147408736	Missense_Mutation	NA	P228T	0.05
STAD	chr5	147415807	Missense_Mutation	NA	A127V	0.09
STAD	chr5	147418611	Missense_Mutation	NA	I50S	0.1
STAD	chr5	147408776	Silent	NA	E214E	0.23
STAD	chr5	147400760	Missense_Mutation	novel	F348V	0.4
STAD	chr5	147401614	Silent	rs200777055	A298A	0.22
STAD	chr5	147395638	Frame_Shift_Del	novel	*A516Qfs15**	0.35
STAD	chr5	147405611	Frame_Shift_Del	novel	*G271Efs3**	0.34
STAD	chr5	147412652	Frame_Shift_Del	novel	*A193Pfs25**	0.31
STAD	chr5	147412689	Splice_Site	NA	X181_splice	0.19
STAD	chr5	147405607	Splice_Region	novel		0.25
THYM	chr5	147393670	3'UTR	rs547175352		0.39
UCEC	chr5	147395638	Silent	rs540998273	P515P	0.49
UCEC	chr5	147399175	Silent	novel	P396P	0.08
UCEC	chr5	147394074	Silent	rs763302616	A558A	0.43
UCEC	chr5	147399164	Missense_Mutation	NA	R400I	0.24
UCEC	chr5	147393940	3'UTR	novel		0.32
UCEC	chr5	147394074	Silent	rs763302616	A558A	0.17
UCEC	chr5	147395584	Silent	novel	L533L	0.2
UCEC	chr5	147399223	Silent	novel	F380F	0.32
UCEC	chr5	147401544	Missense_Mutation	NA	A322S	0.36
UCEC	chr5	147393934	3'UTR	novel		0.26
UCEC	chr5	147401603	Missense_Mutation	novel	V302A	0.47
UCEC	chr5	147415836	Silent	rs371548122	T117T	0.5
UCEC	chr5	147393908	3'UTR	novel		0.25
UCEC	chr5	147391421	3'UTR	novel		0.59
UCEC	chr5	147399116	Missense_Mutation	novel	A416D	0.55
UCEC	chr5	147424943	Missense_Mutation	novel	K20N	0.41
UCEC	chr5	147391224	3'UTR	novel		0.22
UCEC	chr5	147394012	3'UTR	novel		0.35
UCEC	chr5	147415791	Nonsense_Mutation	novel	C132*	0.37
UCEC	chr5	147509510	Nonsense_Mutation	novel	E117*	0.46
UCEC	chr5	147393975	3'UTR	novel		0.13
UCEC	chr5	147415807	Missense_Mutation	NA	A127D	0.28
UCEC	chr5	147405613	Missense_Mutation	NA	K270E	0.35
UCEC	chr5	147397734	Frame_Shift_Del	novel	*A465Lfs42**	0.36
UCEC	chr5	147395605	Silent	rs760857578	P526P	0.54
UCEC	chr5	147399106	Silent	rs756560734	I419I	0.39
UCEC	chr5	147401686	Silent	novel	V274V	0.42
UCEC	chr5	147412664	Nonsense_Mutation	novel	G189*	0.31
UCEC	chr5	147395635	Silent	novel	A516A	0.27
UCEC	chr5	147393885	3'UTR	novel		0.42
UCEC	chr5	147405668	Silent	rs768834528	Y251Y	0.27
UCEC	chr5	147391358	3'UTR	novel		0.4
UCEC	chr5	147405610	Frame_Shift_Ins	novel	*G271Rfs7**	0.36
UCEC	chr5	147393835	3'UTR	novel		0.49
UCEC	chr5	147412686	Splice_Region	novel	L181L	0.31
UCEC	chr5	147405611	Frame_Shift_Del	novel	*G271Efs3**	0.38
UCEC	chr5	147399136	Silent	rs779181977	L409L	0.33
UCEC	chr5	147453676	5'UTR	novel		0.46
UCEC	chr5	147393944	3'UTR	novel		0.3
UCEC	chr5	147393969	3'UTR	novel		0.45
UCEC	chr5	147395663	Missense_Mutation	novel	T507I	0.37
UCEC	chr5	147401615	Missense_Mutation	NA	A298V	0.37
UCEC	chr5	147418498	Missense_Mutation	NA	D88Y	0.29
UCEC	chr5	147393950	3'UTR	novel		0.3
UCEC	chr5	147395565	Missense_Mutation	novel	L540M	0.24
UCEC	chr5	147395703	Missense_Mutation	rs776105614	V494I	0.43
UCEC	chr5	147399141	Missense_Mutation	novel	D408N	0.48
UCEC	chr5	147397768	Missense_Mutation	novel	M453I	0.4
UCEC	chr5	147393939	3'UTR	novel		0.28
UCEC	chr5	147399173	Missense_Mutation	novel	R397H	0.23
UCEC	chr5	147415728	Silent	novel	Q153Q	0.17
UCEC	chr5	147418601	Silent	novel	G53G	0.19
UCEC	chr5	147453634	5'UTR	rs367940618		0.3
UCEC	chr5	147408762	Missense_Mutation	novel	G219D	0.38
UCEC	chr5	147415851	Silent	rs771694171	P112P	0.24
UCEC	chr5	147509736	Silent	novel	V41V	0.25
UCEC	chr5	147400833	Splice_Region	rs751007269	S323S	0.42
UCEC	chr5	147395659	Silent	novel	T508T	0.43
UCEC	chr5	147397673	Missense_Mutation	rs775844954	R485Q	0.23
UCEC	chr5	147393919	3'UTR	novel		0.43
UCEC	chr5	147394075	Missense_Mutation	rs766945584	A558V	0.38
UCEC	chr5	147394062	Silent	novel	G562G	0.27
UCEC	chr5	147397828	Silent	NA	I433I	0.15
UCEC	chr5	147424910	Missense_Mutation	novel	F31L	0.53
UCEC	chr5	147415724	Missense_Mutation	rs773851486	L155F	0.1
UCEC	chr5	147391436	3'UTR	novel		0.42
UCEC	chr5	147397674	Missense_Mutation	rs747491194	R485W	0.43
UCEC	chr5	147405644	Silent	novel	S259S	0.37
UCEC	chr5	147399223	Silent	novel	F380F	0.27
UCEC	chr5	147453685	5'UTR	novel		0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0417	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6188	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0264	0.16448
SKCM	DEL	0.297	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0022	Kaplan-Meier Survival Analysis
STAD	0.0051	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.0015	Kaplan-Meier Survival Analysis
ACC	0.0045	Kaplan-Meier Survival Analysis
UCS	0.026	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.00045	Kaplan-Meier Survival Analysis
LAML	0.0076	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0035	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742