EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113742 (Gene tree)
Gene ID: 80315
Gene Symbol: CPEB4
Alias: KIAA1673
Full Name: cytoplasmic polyadenylation element binding protein 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 73,697 bases
Position: chr5:173,888,280-173,961,976
Accession: 21747
RBP type: canonical RBP
Summary: (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000427990	RRM_1	PF00076.22	1.4e-12	1	1
ENSP00000430345	RRM_1	PF00076.22	1.7e-12	1	1
ENSP00000429048	RRM_1	PF00076.22	9.4e-12	1	1
ENSP00000429092	RRM_1	PF00076.22	1.2e-11	1	1
ENSP00000334533	RRM_1	PF00076.22	1.3e-11	1	1
ENSP00000265085	RRM_1	PF00076.22	1.4e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29986574	[The research progress of CPEB4 in tumor].	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi	2018 Jul	-	doi: 10.13201/j.issn.1001-1781.2018.13.021.
25237887	Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival.	PLoS One	2014 Sep 19	Chang YW	doi: 10.1371/journal.pone.0107961
27096214	Cytoplasmic polyadenylation element-binding protein 4 is highly expressed in human glioma.	Neuroreport	2016 May 25	Hu H	doi: 10.1097/WNR.0000000000000577.
26984852	Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension.	Gut	2017 Jul	Garcia-Pras E	doi: 10.1136/gutjnl-2015-311157
22138752	Key contribution of CPEB4-mediated translational control to cancer progression.	Nat Med	2011 Dec 4	Ortiz-Zapater E	doi: 10.1038/nm.2540.
23776146	Specificity factors in cytoplasmic polyadenylation.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Charlesworth A	doi: 10.1002/wrna.1171.
27158894	Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma.	PLoS One	2016 May 9	Tsai LY	doi: 10.1371/journal.pone.0155025
28551384	CPEB4 immunohistochemical expression is associated to prognosis in stage IV colorectal carcinoma.	Pathol Res Pract	2017 Jun	Cortes-Guiral D	doi: 10.1016/j.prp.2017.04.020
17024188	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	EMBO J	2006 Oct 18	Huang YS	-
24926617	p53-directed translational control can shape and expand the universe of p53 target genes.	Cell Death Differ	2014 Oct	Zaccara S	doi: 10.1038/cdd.2014.79
27381259	Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.	Sci Rep	2016 Jul 6	Shin J	doi: 10.1038/srep29395.
28381179	Overexpression of CPEB4 in glioma indicates a poor prognosis by promoting cell migration and invasion.	Tumour Biol	2017 Apr	Zhijun L	doi: 10.1177/1010428317694538.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000265085	CPEB4-201	9483	XM_005265994	ENSP00000265085	729 (aa)	XP_005266051	Q17RY0
ENST00000517880	CPEB4-203	1416	-	ENSP00000427990	322 (aa)	-	Q17RY0
ENST00000334035	CPEB4-202	6705	-	ENSP00000334533	712 (aa)	-	Q17RY0
ENST00000520867	CPEB4-208	2607	-	ENSP00000429092	704 (aa)	-	B7ZLQ8
ENST00000519467	CPEB4-206	1348	-	-	- (aa)	-	-
ENST00000522336	CPEB4-209	1551	-	ENSP00000430345	339 (aa)	-	E5RFP2
ENST00000518141	CPEB4-204	429	-	-	- (aa)	-	-
ENST00000519152	CPEB4-205	441	-	ENSP00000429423	147 (aa)	-	H0YBG1
ENST00000522344	CPEB4-210	481	-	-	- (aa)	-	-
ENST00000519835	CPEB4-207	2257	-	ENSP00000429048	639 (aa)	-	E5RJM0

Gene Model

Click here to download ENSG00000113742's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04114	Oocyte meiosis	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113742	Vitamin K	3.67526393820349E-5	17903293
ENSG00000113742	Hemoglobin A2	5.404e-005	-
ENSG00000113742	Body Mass Index	2E-8	25673412
ENSG00000113742	Waist-Hip Ratio	2E-8	25673412
ENSG00000113742	Waist-Hip Ratio	2E-9	20935629
ENSG00000113742	Prion Diseases	7E-6	22210626
ENSG00000113742	Body Mass Index	2E-13	25673412
ENSG00000113742	Waist-Hip Ratio	2E-13	25673412
ENSG00000113742	Crohn Disease	5E-9	23128233
ENSG00000113742	Body Mass Index	4E-7	25673412
ENSG00000113742	Waist-Hip Ratio	4E-7	25673412
ENSG00000113742	Inflammatory Bowel Diseases	2E-8	26192919
ENSG00000113742	Body Height	2E-6	23251661
ENSG00000113742	Body Mass Index	5E-14	25673412
ENSG00000113742	Waist-Hip Ratio	5E-14	25673412
ENSG00000113742	Body Mass Index	2E-7	25673412
ENSG00000113742	Waist-Hip Ratio	2E-7	25673412
ENSG00000113742	Electrocardiography	3E-8	27659466
ENSG00000113742	Body Mass Index	3E-10	25673412
ENSG00000113742	Waist Circumference	3E-10	25673412
ENSG00000113742	Body Mass Index	3E-8	25673412
ENSG00000113742	Waist-Hip Ratio	3E-8	25673412
ENSG00000113742	Body Mass Index	8E-11	25673412
ENSG00000113742	Waist Circumference	8E-11	25673412
ENSG00000113742	Crohn Disease	9E-12	26192919

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113742	rs10516107	5	173921153	A	Waist-to-hip ratio adjusted for BMI	26426971	units increase	0.024094902	EFO_0007788
ENSG00000113742	rs17076726	5	173936886	T	Mean corpuscular hemoglobin	27863252	[0.021-0.035] unit decrease	0.02763309	EFO_0004527
ENSG00000113742	rs17076724	5	173936664	T	Mean corpuscular volume	27863252	[0.022-0.036] unit decrease	0.02888753	EFO_0004526
ENSG00000113742	rs359466	5	173888863	?	QRS complex (Sokolow-Lyon)	27659466			EFO_0007742\|EFO_0005054
ENSG00000113742	rs56163845	5	173946945	?	Crohn's disease	26192919			EFO_0000384
ENSG00000113742	rs72810983	5	173891251	A	Inflammatory bowel disease	26192919		1.0646069	EFO_0003767
ENSG00000113742	rs17695092	5	173910850	T	Crohn's disease	23128233	[1.055-1.136]	1.095	EFO_0000384
ENSG00000113742	rs1106693	5	173925760	G	Obesity-related traits	23251661	[NR] SD increase	0.02	EFO_0004339
ENSG00000113742	rs17076726	5	173936886	T	Red cell distribution width	27863252	[0.015-0.029] unit increase	0.0218207	EFO_0005192
ENSG00000113742	rs72812846	5	173950633	T	Mosquito bite size	28199695	[0.017-0.041] unit increase	0.0294346	EFO_0008378
ENSG00000113742	rs6861681	5	173935455	A	Waist-hip ratio	20935629	[NR] unit increase	0.02	EFO_0004343
ENSG00000113742	rs17763373	5	173932328	?	Prion diseases	22210626	[NR]	1.5106	EFO_0004720
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for body mass index	25673412	[0.016-0.03] unit increase	0.0232	EFO_0007789
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for body mass index	25673412	[0.02-0.038] unit increase	0.029	EFO_0007789
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.017-0.036] unit increase	0.0269	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.017-0.037] unit increase	0.0269	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.02-0.034] unit increase	0.0271	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.016-0.036] unit increase	0.0259	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.017-0.036] unit increase	0.0265	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for body mass index	25673412	[0.019-0.033] unit increase	0.0263	EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.011-0.026] unit increase	0.0188	EFO_0004318\|EFO_0007788
ENSG00000113742	rs7705502	5	173893812	A	Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.015-0.035] unit increase	0.0248	EFO_0004318\|EFO_0007788
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.014-0.033] unit increase	0.0234	EFO_0004318\|EFO_0007789
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.0096-0.0244] unit increase	0.017	EFO_0004318\|EFO_0007789
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000113742	rs10516107	5	173921153	A	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000113742	rs72812846	5	173950633	A	Diastolic blood pressure	28135244	[0.15-0.27] unit decrease	0.209	EFO_0006336
ENSG00000113742	rs10516107	5	173921153	A	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	26426971			EFO_0007788\|EFO_0008343\|EFO_0008007
ENSG00000113742	rs77822827	5	173951314	?	Heel bone mineral density	30048462	[0.0087-0.0176] unit decrease	0.0131409	EFO_0009270
ENSG00000113742	rs6861681	5	173935455	G	Heel bone mineral density	30598549	[0.0082-0.0161] unit decrease	0.0121868	EFO_0009270
ENSG00000113742	rs7705507	5	173931334	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000113742	rs6864691	5	173931151	?	Red blood cell count	30595370			EFO_0004305
ENSG00000113742	rs72812846	5	173950633	T	Diastolic blood pressure	27841878	unit increase	0.202	EFO_0006336
ENSG00000113742	rs72812846	5	173950633	T	Systolic blood pressure	27841878	unit increase	0.198	EFO_0006335
ENSG00000113742	rs75049939	5	173907216	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000113742	rs55646464	5	173897968	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113742's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000113742	CPEB4	100	88.824	ENSG00000137449	CPEB2	100	98.204
ENSG00000113742	CPEB4	100	85.965	ENSG00000107864	CPEB3	100	58.650

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113742	CPEB4	100	95.031	ENSAPOG00000012405	CPEB4	100	77.959	Acanthochromis_polyacanthus
ENSG00000113742	CPEB4	100	92.901	ENSAPOG00000006896	cpeb4a	100	92.901	Acanthochromis_polyacanthus
ENSG00000113742	CPEB4	100	99.451	ENSAMEG00000011342	CPEB4	100	99.451	Ailuropoda_melanoleuca
ENSG00000113742	CPEB4	100	92.330	ENSACIG00000000739	CPEB4	100	76.153	Amphilophus_citrinellus
ENSG00000113742	CPEB4	100	91.358	ENSACIG00000016815	cpeb4a	100	69.231	Amphilophus_citrinellus
ENSG00000113742	CPEB4	100	92.625	ENSAOCG00000000533	CPEB4	100	77.237	Amphiprion_ocellaris
ENSG00000113742	CPEB4	100	92.901	ENSAOCG00000015830	cpeb4a	100	92.901	Amphiprion_ocellaris
ENSG00000113742	CPEB4	100	92.901	ENSAPEG00000011894	cpeb4a	100	92.901	Amphiprion_percula
ENSG00000113742	CPEB4	100	92.625	ENSAPEG00000017337	CPEB4	100	76.447	Amphiprion_percula
ENSG00000113742	CPEB4	100	95.031	ENSATEG00000010123	CPEB4	100	78.747	Anabas_testudineus
ENSG00000113742	CPEB4	100	92.901	ENSATEG00000001785	cpeb4a	100	70.380	Anabas_testudineus
ENSG00000113742	CPEB4	95	89.216	ENSACAG00000012015	-	100	89.251	Anolis_carolinensis
ENSG00000113742	CPEB4	100	98.447	ENSACAG00000015039	CPEB4	100	95.603	Anolis_carolinensis
ENSG00000113742	CPEB4	100	99.726	ENSANAG00000038371	CPEB4	100	99.726	Aotus_nancymaae
ENSG00000113742	CPEB4	98	95.268	ENSACLG00000009630	CPEB4	100	77.260	Astatotilapia_calliptera
ENSG00000113742	CPEB4	100	92.284	ENSACLG00000001821	cpeb4a	100	69.368	Astatotilapia_calliptera
ENSG00000113742	CPEB4	100	94.720	ENSAMXG00000013453	-	100	86.275	Astyanax_mexicanus
ENSG00000113742	CPEB4	100	92.593	ENSAMXG00000030295	cpeb4a	100	75.691	Astyanax_mexicanus
ENSG00000113742	CPEB4	100	99.588	ENSBTAG00000009995	CPEB4	100	99.588	Bos_taurus
ENSG00000113742	CPEB4	100	99.451	ENSCJAG00000019166	CPEB4	100	99.451	Callithrix_jacchus
ENSG00000113742	CPEB4	100	99.452	ENSCAFG00000016761	CPEB4	100	99.452	Canis_familiaris
ENSG00000113742	CPEB4	100	99.579	ENSCAFG00020011285	CPEB4	100	99.579	Canis_lupus_dingo
ENSG00000113742	CPEB4	100	99.588	ENSCHIG00000011030	CPEB4	100	99.588	Capra_hircus
ENSG00000113742	CPEB4	100	99.705	ENSTSYG00000003136	CPEB4	100	99.588	Carlito_syrichta
ENSG00000113742	CPEB4	69	99.548	ENSCAPG00000009045	-	99	98.673	Cavia_aperea
ENSG00000113742	CPEB4	99	99.055	ENSCPOG00000015530	CPEB4	99	99.365	Cavia_porcellus
ENSG00000113742	CPEB4	100	99.726	ENSCCAG00000037039	CPEB4	100	99.726	Cebus_capucinus
ENSG00000113742	CPEB4	100	100.000	ENSCATG00000014550	CPEB4	100	100.000	Cercocebus_atys
ENSG00000113742	CPEB4	100	99.410	ENSCLAG00000013156	CPEB4	100	99.314	Chinchilla_lanigera
ENSG00000113742	CPEB4	100	100.000	ENSCSAG00000009516	CPEB4	100	100.000	Chlorocebus_sabaeus
ENSG00000113742	CPEB4	100	98.758	ENSCPBG00000007535	CPEB4	100	97.051	Chrysemys_picta_bellii
ENSG00000113742	CPEB4	100	100.000	ENSCANG00000037672	CPEB4	100	100.000	Colobus_angolensis_palliatus
ENSG00000113742	CPEB4	100	99.410	ENSCGRG00001021805	Cpeb4	100	98.628	Cricetulus_griseus_chok1gshd
ENSG00000113742	CPEB4	100	99.410	ENSCGRG00000014167	Cpeb4	100	98.628	Cricetulus_griseus_crigri
ENSG00000113742	CPEB4	100	95.031	ENSCSEG00000014712	CPEB4	100	77.353	Cynoglossus_semilaevis
ENSG00000113742	CPEB4	100	90.029	ENSCSEG00000020154	cpeb4a	100	68.254	Cynoglossus_semilaevis
ENSG00000113742	CPEB4	100	94.410	ENSCVAG00000015292	-	100	77.007	Cyprinodon_variegatus
ENSG00000113742	CPEB4	100	92.901	ENSDARG00000056691	cpeb4a	100	76.006	Danio_rerio
ENSG00000113742	CPEB4	100	84.783	ENSEBUG00000008330	-	95	83.988	Eptatretus_burgeri
ENSG00000113742	CPEB4	100	99.410	ENSEASG00005011952	CPEB4	100	98.903	Equus_asinus_asinus
ENSG00000113742	CPEB4	100	99.379	ENSECAG00000016921	CPEB4	100	98.903	Equus_caballus
ENSG00000113742	CPEB4	100	97.118	ENSEEUG00000010887	CPEB4	100	98.045	Erinaceus_europaeus
ENSG00000113742	CPEB4	94	92.157	ENSELUG00000005282	cpeb4a	99	92.157	Esox_lucius
ENSG00000113742	CPEB4	100	95.031	ENSELUG00000022898	CPEB4	100	81.523	Esox_lucius
ENSG00000113742	CPEB4	100	99.410	ENSFCAG00000031504	CPEB4	100	99.314	Felis_catus
ENSG00000113742	CPEB4	100	96.364	ENSFALG00000008809	CPEB4	100	94.663	Ficedula_albicollis
ENSG00000113742	CPEB4	100	99.451	ENSFDAG00000011935	CPEB4	100	99.451	Fukomys_damarensis
ENSG00000113742	CPEB4	99	72.617	ENSFHEG00000010699	CPEB4	97	75.076	Fundulus_heteroclitus
ENSG00000113742	CPEB4	100	92.901	ENSFHEG00000007532	cpeb4a	100	69.433	Fundulus_heteroclitus
ENSG00000113742	CPEB4	100	87.393	ENSGMOG00000015333	cpeb4a	100	68.800	Gadus_morhua
ENSG00000113742	CPEB4	100	98.758	ENSGALG00000033512	CPEB4	100	96.770	Gallus_gallus
ENSG00000113742	CPEB4	100	92.901	ENSGAFG00000006705	cpeb4a	100	70.069	Gambusia_affinis
ENSG00000113742	CPEB4	100	94.410	ENSGAFG00000004796	CPEB4	100	77.143	Gambusia_affinis
ENSG00000113742	CPEB4	100	92.284	ENSGACG00000018422	cpeb4a	100	81.592	Gasterosteus_aculeatus
ENSG00000113742	CPEB4	100	98.758	ENSGAGG00000019992	CPEB4	100	96.910	Gopherus_agassizii
ENSG00000113742	CPEB4	100	100.000	ENSGGOG00000010097	CPEB4	100	100.000	Gorilla_gorilla
ENSG00000113742	CPEB4	100	94.720	ENSHBUG00000003334	CPEB4	100	77.260	Haplochromis_burtoni
ENSG00000113742	CPEB4	100	92.284	ENSHBUG00000004215	cpeb4a	100	69.471	Haplochromis_burtoni
ENSG00000113742	CPEB4	100	99.588	ENSHGLG00000008897	CPEB4	100	99.588	Heterocephalus_glaber_female
ENSG00000113742	CPEB4	100	96.986	ENSHGLG00100017994	CPEB4	100	96.986	Heterocephalus_glaber_male
ENSG00000113742	CPEB4	100	92.284	ENSHCOG00000003707	cpeb4a	100	92.284	Hippocampus_comes
ENSG00000113742	CPEB4	100	92.625	ENSHCOG00000003846	CPEB4	100	75.826	Hippocampus_comes
ENSG00000113742	CPEB4	100	92.901	ENSIPUG00000010268	cpeb4a	100	76.331	Ictalurus_punctatus
ENSG00000113742	CPEB4	100	94.410	ENSIPUG00000005518	cpeb4	100	76.634	Ictalurus_punctatus
ENSG00000113742	CPEB4	100	98.820	ENSSTOG00000020645	CPEB4	100	98.765	Ictidomys_tridecemlineatus
ENSG00000113742	CPEB4	100	99.410	ENSJJAG00000021518	Cpeb4	100	96.982	Jaculus_jaculus
ENSG00000113742	CPEB4	100	95.031	ENSKMAG00000009453	CPEB4	100	76.285	Kryptolebias_marmoratus
ENSG00000113742	CPEB4	100	92.284	ENSKMAG00000008902	cpeb4a	100	68.006	Kryptolebias_marmoratus
ENSG00000113742	CPEB4	92	87.119	ENSLBEG00000027947	-	100	87.119	Labrus_bergylta
ENSG00000113742	CPEB4	100	92.330	ENSLBEG00000001697	CPEB4	100	77.279	Labrus_bergylta
ENSG00000113742	CPEB4	100	92.901	ENSLBEG00000022823	cpeb4a	100	92.901	Labrus_bergylta
ENSG00000113742	CPEB4	100	95.575	ENSLACG00000016073	CPEB4	100	89.373	Latimeria_chalumnae
ENSG00000113742	CPEB4	93	91.611	ENSLACG00000010027	-	100	90.735	Latimeria_chalumnae
ENSG00000113742	CPEB4	100	92.424	ENSLOCG00000009131	cpeb4a	100	85.535	Lepisosteus_oculatus
ENSG00000113742	CPEB4	100	99.451	ENSLAFG00000016030	CPEB4	100	99.451	Loxodonta_africana
ENSG00000113742	CPEB4	100	100.000	ENSMFAG00000003075	CPEB4	100	100.000	Macaca_fascicularis
ENSG00000113742	CPEB4	100	100.000	ENSMMUG00000019926	CPEB4	100	100.000	Macaca_mulatta
ENSG00000113742	CPEB4	100	100.000	ENSMNEG00000034689	CPEB4	100	100.000	Macaca_nemestrina
ENSG00000113742	CPEB4	100	100.000	ENSMLEG00000029667	CPEB4	100	100.000	Mandrillus_leucophaeus
ENSG00000113742	CPEB4	100	92.284	ENSMAMG00000012163	cpeb4a	100	70.149	Mastacembelus_armatus
ENSG00000113742	CPEB4	100	95.342	ENSMAMG00000021359	CPEB4	100	78.338	Mastacembelus_armatus
ENSG00000113742	CPEB4	100	92.284	ENSMZEG00005008957	cpeb4a	100	92.284	Maylandia_zebra
ENSG00000113742	CPEB4	98	95.268	ENSMZEG00005002361	CPEB4	100	77.260	Maylandia_zebra
ENSG00000113742	CPEB4	100	94.262	ENSMGAG00000003660	CPEB4	100	93.169	Meleagris_gallopavo
ENSG00000113742	CPEB4	100	99.410	ENSMAUG00000011128	Cpeb4	100	98.491	Mesocricetus_auratus
ENSG00000113742	CPEB4	100	99.719	ENSMICG00000029322	CPEB4	100	99.719	Microcebus_murinus
ENSG00000113742	CPEB4	100	99.410	ENSMOCG00000022941	Cpeb4	100	97.942	Microtus_ochrogaster
ENSG00000113742	CPEB4	89	93.684	ENSMMOG00000013833	CPEB4	97	76.149	Mola_mola
ENSG00000113742	CPEB4	99	91.589	ENSMMOG00000009234	cpeb4a	100	69.517	Mola_mola
ENSG00000113742	CPEB4	100	97.811	ENSMODG00000006036	CPEB4	100	97.811	Monodelphis_domestica
ENSG00000113742	CPEB4	100	92.593	ENSMALG00000004737	cpeb4a	100	68.966	Monopterus_albus
ENSG00000113742	CPEB4	100	95.031	ENSMALG00000018742	CPEB4	100	78.231	Monopterus_albus
ENSG00000113742	CPEB4	100	99.410	MGP_CAROLIEiJ_G0016172	Cpeb4	100	98.354	Mus_caroli
ENSG00000113742	CPEB4	100	99.410	ENSMUSG00000020300	Cpeb4	100	98.354	Mus_musculus
ENSG00000113742	CPEB4	100	99.410	MGP_PahariEiJ_G0017307	Cpeb4	100	98.491	Mus_pahari
ENSG00000113742	CPEB4	100	99.410	MGP_SPRETEiJ_G0017016	Cpeb4	100	98.354	Mus_spretus
ENSG00000113742	CPEB4	100	99.588	ENSMPUG00000012687	CPEB4	100	99.588	Mustela_putorius_furo
ENSG00000113742	CPEB4	100	99.379	ENSMLUG00000014640	-	100	99.379	Myotis_lucifugus
ENSG00000113742	CPEB4	100	99.410	ENSNGAG00000010735	Cpeb4	100	98.903	Nannospalax_galili
ENSG00000113742	CPEB4	100	92.284	ENSNBRG00000016474	cpeb4a	100	69.231	Neolamprologus_brichardi
ENSG00000113742	CPEB4	98	95.268	ENSNBRG00000005452	CPEB4	100	76.575	Neolamprologus_brichardi
ENSG00000113742	CPEB4	100	99.844	ENSNLEG00000000487	CPEB4	100	99.844	Nomascus_leucogenys
ENSG00000113742	CPEB4	100	83.621	ENSMEUG00000008074	-	100	84.637	Notamacropus_eugenii
ENSG00000113742	CPEB4	100	96.542	ENSOPRG00000002868	CPEB4	76	98.870	Ochotona_princeps
ENSG00000113742	CPEB4	100	99.588	ENSODEG00000001934	CPEB4	100	99.588	Octodon_degus
ENSG00000113742	CPEB4	100	92.284	ENSONIG00000017682	cpeb4a	100	69.293	Oreochromis_niloticus
ENSG00000113742	CPEB4	100	97.127	ENSOANG00000003990	CPEB4	100	97.127	Ornithorhynchus_anatinus
ENSG00000113742	CPEB4	99	98.630	ENSOCUG00000008971	CPEB4	84	97.872	Oryctolagus_cuniculus
ENSG00000113742	CPEB4	100	92.625	ENSORLG00000001711	CPEB4	100	76.517	Oryzias_latipes
ENSG00000113742	CPEB4	100	91.667	ENSORLG00000007328	cpeb4a	100	91.667	Oryzias_latipes
ENSG00000113742	CPEB4	100	91.667	ENSORLG00020006738	cpeb4a	100	69.051	Oryzias_latipes_hni
ENSG00000113742	CPEB4	100	92.625	ENSORLG00020019628	CPEB4	100	76.253	Oryzias_latipes_hni
ENSG00000113742	CPEB4	100	91.667	ENSORLG00015006236	cpeb4a	100	91.667	Oryzias_latipes_hsok
ENSG00000113742	CPEB4	100	94.720	ENSORLG00015003471	CPEB4	100	77.080	Oryzias_latipes_hsok
ENSG00000113742	CPEB4	100	91.667	ENSOMEG00000011206	cpeb4a	100	91.667	Oryzias_melastigma
ENSG00000113742	CPEB4	100	95.031	ENSOMEG00000000138	CPEB4	100	77.353	Oryzias_melastigma
ENSG00000113742	CPEB4	100	99.314	ENSOGAG00000004243	CPEB4	100	99.314	Otolemur_garnettii
ENSG00000113742	CPEB4	100	99.451	ENSOARG00000004239	CPEB4	100	99.451	Ovis_aries
ENSG00000113742	CPEB4	100	100.000	ENSPPAG00000030599	CPEB4	100	100.000	Pan_paniscus
ENSG00000113742	CPEB4	100	99.588	ENSPPRG00000001603	CPEB4	100	99.588	Panthera_pardus
ENSG00000113742	CPEB4	100	99.451	ENSPTIG00000015408	CPEB4	100	99.451	Panthera_tigris_altaica
ENSG00000113742	CPEB4	100	100.000	ENSPTRG00000017545	CPEB4	100	100.000	Pan_troglodytes
ENSG00000113742	CPEB4	100	100.000	ENSPANG00000009300	CPEB4	100	100.000	Papio_anubis
ENSG00000113742	CPEB4	100	94.099	ENSPKIG00000007012	cpeb4a	100	79.437	Paramormyrops_kingsleyae
ENSG00000113742	CPEB4	100	91.066	ENSPKIG00000009006	CPEB4	100	81.114	Paramormyrops_kingsleyae
ENSG00000113742	CPEB4	100	93.973	ENSPSIG00000009213	CPEB4	100	93.973	Pelodiscus_sinensis
ENSG00000113742	CPEB4	100	93.478	ENSPMGG00000007127	CPEB4	100	76.438	Periophthalmus_magnuspinnatus
ENSG00000113742	CPEB4	99	86.687	ENSPMAG00000004652	cpeb4a	99	86.687	Petromyzon_marinus
ENSG00000113742	CPEB4	100	98.758	ENSPCIG00000015843	CPEB4	100	96.858	Phascolarctos_cinereus
ENSG00000113742	CPEB4	100	87.966	ENSPFOG00000000778	cpeb4a	100	69.108	Poecilia_formosa
ENSG00000113742	CPEB4	100	94.410	ENSPLAG00000017841	CPEB4	100	77.143	Poecilia_latipinna
ENSG00000113742	CPEB4	100	92.901	ENSPLAG00000017182	cpeb4a	100	92.901	Poecilia_latipinna
ENSG00000113742	CPEB4	100	92.901	ENSPMEG00000003483	cpeb4a	100	92.901	Poecilia_mexicana
ENSG00000113742	CPEB4	100	92.035	ENSPMEG00000017399	CPEB4	100	75.658	Poecilia_mexicana
ENSG00000113742	CPEB4	100	92.901	ENSPREG00000019466	cpeb4a	100	69.108	Poecilia_reticulata
ENSG00000113742	CPEB4	100	94.410	ENSPREG00000006171	CPEB4	100	77.143	Poecilia_reticulata
ENSG00000113742	CPEB4	100	100.000	ENSPPYG00000016058	CPEB4	100	100.000	Pongo_abelii
ENSG00000113742	CPEB4	100	97.118	ENSPCAG00000007021	CPEB4	79	99.550	Procavia_capensis
ENSG00000113742	CPEB4	100	99.860	ENSPCOG00000004676	CPEB4	100	99.860	Propithecus_coquereli
ENSG00000113742	CPEB4	100	99.177	ENSPVAG00000007863	CPEB4	100	99.177	Pteropus_vampyrus
ENSG00000113742	CPEB4	99	52.632	ENSPNYG00000000178	cpeb4a	91	60.072	Pundamilia_nyererei
ENSG00000113742	CPEB4	98	85.174	ENSPNYG00000015536	CPEB4	100	72.740	Pundamilia_nyererei
ENSG00000113742	CPEB4	100	92.284	ENSPNAG00000010337	cpeb4a	100	76.406	Pygocentrus_nattereri
ENSG00000113742	CPEB4	100	94.410	ENSPNAG00000027950	CPEB4	100	82.370	Pygocentrus_nattereri
ENSG00000113742	CPEB4	100	99.410	ENSRNOG00000033169	Cpeb4	100	98.903	Rattus_norvegicus
ENSG00000113742	CPEB4	100	100.000	ENSRROG00000029196	CPEB4	100	100.000	Rhinopithecus_roxellana
ENSG00000113742	CPEB4	100	99.726	ENSSBOG00000002632	CPEB4	100	99.726	Saimiri_boliviensis_boliviensis
ENSG00000113742	CPEB4	100	97.544	ENSSHAG00000014932	CPEB4	100	97.544	Sarcophilus_harrisii
ENSG00000113742	CPEB4	100	88.824	ENSSHAG00000009862	-	97	88.824	Sarcophilus_harrisii
ENSG00000113742	CPEB4	100	92.625	ENSSFOG00015017925	cpeb4	100	82.225	Scleropages_formosus
ENSG00000113742	CPEB4	100	93.215	ENSSFOG00015000264	CPEB4	100	81.682	Scleropages_formosus
ENSG00000113742	CPEB4	100	92.920	ENSSMAG00000001696	CPEB4	100	77.207	Scophthalmus_maximus
ENSG00000113742	CPEB4	100	92.901	ENSSMAG00000008812	cpeb4a	100	92.901	Scophthalmus_maximus
ENSG00000113742	CPEB4	100	92.920	ENSSDUG00000020954	CPEB4	100	76.447	Seriola_dumerili
ENSG00000113742	CPEB4	100	92.901	ENSSDUG00000009599	cpeb4a	100	70.645	Seriola_dumerili
ENSG00000113742	CPEB4	100	92.901	ENSSLDG00000003652	cpeb4a	100	92.901	Seriola_lalandi_dorsalis
ENSG00000113742	CPEB4	100	92.920	ENSSLDG00000006601	CPEB4	100	77.237	Seriola_lalandi_dorsalis
ENSG00000113742	CPEB4	100	96.159	ENSSARG00000013389	CPEB4	100	96.159	Sorex_araneus
ENSG00000113742	CPEB4	100	98.137	ENSSPUG00000013161	CPEB4	100	96.307	Sphenodon_punctatus
ENSG00000113742	CPEB4	100	92.593	ENSSPAG00000008532	cpeb4a	100	70.055	Stegastes_partitus
ENSG00000113742	CPEB4	100	95.031	ENSSPAG00000009565	CPEB4	100	77.823	Stegastes_partitus
ENSG00000113742	CPEB4	100	99.410	ENSSSCG00000016981	CPEB4	100	98.903	Sus_scrofa
ENSG00000113742	CPEB4	100	92.760	ENSTGUG00000000329	CPEB4	100	92.213	Taeniopygia_guttata
ENSG00000113742	CPEB4	100	94.410	ENSTRUG00000010692	CPEB4	100	74.454	Takifugu_rubripes
ENSG00000113742	CPEB4	100	89.736	ENSTRUG00000010947	cpeb4a	100	69.241	Takifugu_rubripes
ENSG00000113742	CPEB4	100	88.252	ENSTNIG00000017077	cpeb4a	100	69.323	Tetraodon_nigroviridis
ENSG00000113742	CPEB4	94	88.816	ENSTNIG00000004021	-	100	87.859	Tetraodon_nigroviridis
ENSG00000113742	CPEB4	100	96.982	ENSTBEG00000001429	CPEB4	100	96.982	Tupaia_belangeri
ENSG00000113742	CPEB4	100	98.748	ENSUAMG00000014371	CPEB4	100	98.748	Ursus_americanus
ENSG00000113742	CPEB4	100	91.084	ENSVPAG00000010897	CPEB4	100	91.084	Vicugna_pacos
ENSG00000113742	CPEB4	100	99.588	ENSVVUG00000002022	CPEB4	100	99.588	Vulpes_vulpes
ENSG00000113742	CPEB4	100	92.035	ENSXCOG00000006460	CPEB4	100	75.658	Xiphophorus_couchianus
ENSG00000113742	CPEB4	100	87.021	ENSXCOG00000008579	-	94	83.051	Xiphophorus_couchianus
ENSG00000113742	CPEB4	100	92.901	ENSXCOG00000010345	cpeb4a	100	69.793	Xiphophorus_couchianus
ENSG00000113742	CPEB4	100	92.901	ENSXMAG00000010247	cpeb4a	100	92.901	Xiphophorus_maculatus
ENSG00000113742	CPEB4	100	94.410	ENSXMAG00000000294	CPEB4	100	77.143	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000900	translation repressor activity, mRNA regulatory element binding	21873635.	IBA	Function
GO:0002931	response to ischemia	-	ISS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	21336257.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	20639532.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	20639532.	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005783	endoplasmic reticulum	-	ISS	Component
GO:0006412	translation	-	IEA	Process
GO:0008135	translation factor activity, RNA binding	21873635.	IBA	Function
GO:0014069	postsynaptic density	-	ISS	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030425	dendrite	-	ISS	Component
GO:0030426	growth cone	-	IEA	Component
GO:0035235	ionotropic glutamate receptor signaling pathway	-	ISS	Process
GO:0036294	cellular response to decreased oxygen levels	-	ISS	Process
GO:0042149	cellular response to glucose starvation	-	ISS	Process
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0043022	ribosome binding	21873635.	IBA	Function
GO:0043197	dendritic spine	-	IEA	Component
GO:0043524	negative regulation of neuron apoptotic process	-	ISS	Process
GO:0045202	synapse	21873635.	IBA	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0071230	cellular response to amino acid stimulus	-	ISS	Process
GO:1990124	messenger ribonucleoprotein complex	21873635.	IBA	Component
GO:2000766	negative regulation of cytoplasmic translation	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22138752	Key contribution of CPEB4-mediated translational control to cancer progression.	Nat Med	2011 Dec 4	Ortiz-Zapater E	doi: 10.1038/nm.2540.
26361147	MicroRNA-203-mediated posttranscriptional deregulation of CPEB4 contributes to colorectal cancer progression.	Biochem Biophys Res Commun	2015 Oct 16	Zhong X	doi: 10.1016/j.bbrc.2015.09.008
27771769	High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer.	Virchows Arch	2017 Jan	He X	doi: 10.1007/s00428-016-2037-3
27158894	Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma.	PLoS One	2016 May 9	Tsai LY	doi: 10.1371/journal.pone.0155025
27113098	CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer.	J Formos Med Assoc	2017 Feb	Wu YY	doi: 10.1016/j.jfma.2016.01.009
28536077	CPEB4 promotes cell migration and invasion via upregulating Vimentin expression in breast cancer.	Biochem Biophys Res Commun	2017 Jul 22	Lu R	doi: 10.1016/j.bbrc.2017.05.112
29286212	Knockdown of CPEB4 expression suppresses cell migration and invasion via Akt pathway in non-small cell lung cancer.	Cell Biol Int	2018 Nov	Hu J	doi: 10.1002/cbin.10930

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	173890329	Missense_Mutation	novel	S199L	0.2
BLCA	chr5	173932450	Missense_Mutation	novel	G403V	0.23
BLCA	chr5	173956168	3'UTR	novel		0.53
BLCA	chr5	173889944	Missense_Mutation	NA	Q71E	0.58
BLCA	chr5	173890472	Nonsense_Mutation	novel	Q247*	0.35
BRCA	chr5	173890750	Silent	NA	A339A	0.26
BRCA	chr5	173889882	Missense_Mutation	novel	A50D	0.05
BRCA	chr5	173890294	Silent	novel	A187A	0.13
BRCA	chr5	173953152	Silent	rs775172394	T614T	0.21
BRCA	chr5	173910541	Missense_Mutation	rs148567441	D382N	0.12
BRCA	chr5	173951901	Silent	NA	T581T	0.4
CESC	chr5	173890422	Nonsense_Mutation	NA	S230*	0.16
CESC	chr5	173958691	3'UTR	novel		0.39
CESC	chr5	173956208	3'UTR	novel		0.2
CESC	chr5	173888739	5'UTR	novel		0.36
CESC	chr5	173959835	3'UTR	novel		0.5
CESC	chr5	173949970	Silent	rs146932436	F519F	0.12
CESC	chr5	173889808	Silent	novel	H25H	0.06
CESC	chr5	173889967	Silent	novel	E78E	0.23
CESC	chr5	173957535	3'UTR	novel		0.23
CESC	chr5	173959109	3'UTR	novel		0.71
CESC	chr5	173959232	3'UTR	novel		0.62
CESC	chr5	173890288	Frame_Shift_Del	novel	*D186Pfs10**	0.13
CESC	chr5	173890728	Missense_Mutation	NA	S332L	0.54
CESC	chr5	173957002	3'UTR	novel		0.21
COAD	chr5	173889668	5'UTR	novel		0.15
COAD	chr5	173890782	Missense_Mutation	NA	R350H	0.4
COAD	chr5	173889599	5'UTR	novel		0.3
COAD	chr5	173890782	Missense_Mutation	NA	R350H	0.4
COAD	chr5	173951933	Missense_Mutation	rs752472463	R592Q	0.38
COAD	chr5	173889668	5'UTR	novel		0.22
COAD	chr5	173953274	Splice_Site	NA	X654_splice	0.21
COAD	chr5	173890695	Missense_Mutation	NA	L321P	0.47
COAD	chr5	173890521	Frame_Shift_Del	NA	*H263Qfs6**	0.34
COAD	chr5	173890217	Missense_Mutation	novel	A162T	0.17
COAD	chr5	173889661	5'UTR	novel		0.31
COAD	chr5	173889668	5'UTR	novel		0.16
COAD	chr5	173889667	5'UTR	novel		0.13
COAD	chr5	173951924	Missense_Mutation	NA	R589Q	0.42
COAD	chr5	173910541	Missense_Mutation	rs148567441	D382N	0.08
COAD	chr5	173890206	Missense_Mutation	novel	L158S	0.2
COAD	chr5	173889599	5'UTR	novel		0.27
COAD	chr5	173890558	Silent	NA	A275A	0.35
COAD	chr5	173889897	Missense_Mutation	NA	S55N	0.25
COAD	chr5	173889668	5'UTR	novel		0.26
COAD	chr5	173889668	5'UTR	novel		0.28
ESCA	chr5	173959299	3'UTR	novel		0.23
ESCA	chr5	173956451	3'UTR	novel		0.31
ESCA	chr5	173959603	3'UTR	novel		0.21
ESCA	chr5	173951896	Missense_Mutation	novel	K580E	0.07
ESCA	chr5	173959074	3'UTR	novel		0.19
ESCA	chr5	173958949	3'UTR	novel		0.12
ESCA	chr5	173956257	3'UTR	novel		0.47
GBM	chr5	173951933	Missense_Mutation	rs752472463	R592Q	0.18
GBM	chr5	173889690	5'UTR	novel		0.44
GBM	chr5	173889711	5'UTR	novel		0.19
GBM	chr5	173890551	Frame_Shift_Del	novel	*H273Lfs49**	0.16
GBM	chr5	173889923	Missense_Mutation	novel	A64S	0.36
HNSC	chr5	173949541	Missense_Mutation	novel	P497R	0.18	RRM_1
HNSC	chr5	173953193	Missense_Mutation	novel	A628V	0.06
HNSC	chr5	173910526	Missense_Mutation	novel	R377G	0.64
HNSC	chr5	173932488	Silent	novel	L416L	0.24
HNSC	chr5	173890387	Silent	novel	F218F	0.07
KIRC	chr5	173943035	Missense_Mutation	NA	Y423C	0.34
KIRC	chr5	173945082	Silent	NA	R466R	0.27
KIRC	chr5	173890712	Frame_Shift_Del	novel	L328*	0.23
KIRC	chr5	173890565	Missense_Mutation	novel	L278V	0.1
KIRC	chr5	173890382	Missense_Mutation	novel	G217S	0.36
KIRP	chr5	173890602	Frame_Shift_Del	novel	*S290Ifs32**	0.41
KIRP	chr5	173943036	Nonsense_Mutation	NA	Y423*	0.13
KIRP	chr5	173890151	Missense_Mutation	NA	L140V	0.07
KIRP	chr5	173889597	5'UTR	novel		0.38
KIRP	chr5	173945033	Missense_Mutation	novel	H450R	0.4
LAML	chr5	173890076	Missense_Mutation	novel	S115T	0.08
LGG	chr5	173890568	Frame_Shift_Del	novel	*K280Pfs41**	0.14
LGG	chr5	173953100	Missense_Mutation	rs748691598	A597V	0.12
LGG	chr5	173945078	Frame_Shift_Del	novel	*R466Sfs18**	0.05
LGG	chr5	173890437	Missense_Mutation	NA	H235L	0.15
LGG	chr5	173953274	Splice_Site	NA	X654_splice	0.35
LGG	chr5	173889973	Frame_Shift_Del	novel	*Q83Afs26**	0.2
LIHC	chr5	173889582	5'UTR	novel		0.19
LIHC	chr5	173889740	Missense_Mutation	NA	D3Y	0.39
LIHC	chr5	173889554	5'UTR	novel		0.56
LIHC	chr5	173945131	Missense_Mutation	novel	I483V	0.16	RRM_1
LIHC	chr5	173955950	Missense_Mutation	novel	D668V	0.27
LIHC	chr5	173956286	3'UTR	novel		0.5
LUAD	chr5	173956195	3'UTR	novel		0.22
LUAD	chr5	173889704	5'UTR	novel		0.73
LUAD	chr5	173889773	Missense_Mutation	novel	T14P	0.11
LUAD	chr5	173890334	Missense_Mutation	novel	N201D	0.09
LUAD	chr5	173949507	Splice_Site	novel	X486_splice	0.12
LUAD	chr5	173932494	Missense_Mutation	NA	I418V	0.54
LUAD	chr5	173953136	Missense_Mutation	NA	Y609C	0.14
LUSC	chr5	173890232	Missense_Mutation	NA	G167C	0.21
LUSC	chr5	173889943	Silent	novel	I70I	0.21
LUSC	chr5	173949598	Splice_Site	novel	X516_splice	0.45
LUSC	chr5	173890596	Missense_Mutation	NA	Y288C	0.41
LUSC	chr5	173932483	Missense_Mutation	novel	S414T	0.17
OV	chr5	173890319	Missense_Mutation	NA	P196T	0.33
OV	chr5	173890424	Missense_Mutation	novel	Q231E	0.05
OV	chr5	173889742	Silent	novel	D3D	0.05
PAAD	chr5	173910526	Missense_Mutation	NA	R377C	0.15
PAAD	chr5	173889691	5'UTR	novel		0.17
PAAD	chr5	173889985	Silent	novel	Q84Q	0.09
PAAD	chr5	173951897	Missense_Mutation	novel	K580T	0.09
PRAD	chr5	173890312	Frame_Shift_Ins	novel	*V195Gfs7**	0.08
PRAD	chr5	173890155	Missense_Mutation	novel	T141K	0.06
READ	chr5	173945098	Nonsense_Mutation	NA	R472*	0.26
READ	chr5	173889828	Missense_Mutation	novel	H32R	0.05
READ	chr5	173949528	Missense_Mutation	novel	R493C	0.34	RRM_1
READ	chr5	173889740	Missense_Mutation	novel	D3N	0.08
SARC	chr5	173890253	Missense_Mutation	novel	A174S	0.12
SARC	chr5	173958104	3'UTR	novel		0.44
SARC	chr5	173959641	3'UTR	novel		0.33
SKCM	chr5	173890318	Silent	novel	V195V	0.5
SKCM	chr5	173955925	Missense_Mutation	novel	Y660H	0.35
SKCM	chr5	173945029	Missense_Mutation	rs774341529	L449F	0.3
SKCM	chr5	173889720	5'UTR	novel		0.3
SKCM	chr5	173890639	Silent	novel	G302G	0.34
SKCM	chr5	173890640	Missense_Mutation	novel	G303C	0.34
SKCM	chr5	173951894	Missense_Mutation	NA	R579Q	0.4
SKCM	chr5	173910591	Missense_Mutation	NA	N398K	0.28
SKCM	chr5	173951906	Missense_Mutation	novel	F583C	0.34
SKCM	chr5	173949540	Missense_Mutation	NA	P497S	0.22	RRM_1
STAD	chr5	173956106	Missense_Mutation	NA	R720H	0.32
STAD	chr5	173890678	Silent	novel	R315R	0.26
STAD	chr5	173890791	Missense_Mutation	NA	S353F	0.15
STAD	chr5	173949541	Missense_Mutation	NA	P497H	0.18	RRM_1
STAD	chr5	173889668	5'UTR	novel		0.23
STAD	chr5	173890504	Silent	NA	H257H	0.2
STAD	chr5	173951841	Missense_Mutation	NA	W561C	0.4
STAD	chr5	173889599	5'UTR	novel		0.29
STAD	chr5	173951880	Silent	novel	Q574Q	0.15
STAD	chr5	173889668	5'UTR	novel		0.27
STAD	chr5	173932453	Missense_Mutation	rs142106976	R404H	0.26
STAD	chr5	173889668	5'UTR	novel		0.19
STAD	chr5	173889668	5'UTR	novel		0.28
STAD	chr5	173953256	Missense_Mutation	novel	G649E	0.3
STAD	chr5	173890461	Frame_Shift_Ins	novel	*H246Pfs20**	0.15
STAD	chr5	173951893	Nonsense_Mutation	NA	R579*	0.22
STAD	chr5	173949577	Missense_Mutation	NA	K509R	0.23	RRM_1
STAD	chr5	173953101	Silent	rs770312805	A597A	0.31
STAD	chr5	173890431	Missense_Mutation	NA	H233R	0.05
STAD	chr5	173889668	5'UTR	novel		0.34
STAD	chr5	173890323	Missense_Mutation	rs760479707	A197V	0.1
STAD	chr5	173889604	5'UTR	novel		0.14
STAD	chr5	173889668	5'UTR	novel		0.51
STAD	chr5	173890105	Silent	NA	S124S	0.15
STAD	chr5	173889668	5'UTR	novel		0.35
STAD	chr5	173889668	5'UTR	novel		0.14
STAD	chr5	173956098	Silent	rs746507891	G717G	0.22
THCA	chr5	173910558	Silent	NA	E387E	0.07
THCA	chr5	173890374	Missense_Mutation	novel	V214G	0.41
THYM	chr5	173958884	3'UTR	novel		0.26
UCEC	chr5	173889871	Missense_Mutation	novel	N46K	0.49
UCEC	chr5	173890094	Missense_Mutation	novel	D121N	0.26
UCEC	chr5	173890217	Missense_Mutation	novel	A162T	0.44
UCEC	chr5	173890686	Missense_Mutation	novel	R318H	0.47
UCEC	chr5	173943050	Splice_Site	rs753891353	X428_splice	0.2
UCEC	chr5	173958260	3'UTR	novel		0.32
UCEC	chr5	173958519	3'UTR	rs545104220		0.32
UCEC	chr5	173958894	3'UTR	novel		0.32
UCEC	chr5	173959007	3'UTR	novel		0.06
UCEC	chr5	173960120	3'UTR	novel		0.16
UCEC	chr5	173889735	Translation_Start_Site	NA	M1?	0.44
UCEC	chr5	173945018	Missense_Mutation	NA	G445V	0.4
UCEC	chr5	173953350	Intron	novel		0.29
UCEC	chr5	173956826	3'UTR	novel		0.55
UCEC	chr5	173957642	3'UTR	novel		0.28
UCEC	chr5	173890618	Silent	novel	P295P	0.19
UCEC	chr5	173956902	3'UTR	novel		0.33
UCEC	chr5	173959122	3'UTR	novel		0.42
UCEC	chr5	173951894	Missense_Mutation	NA	R579Q	0.33
UCEC	chr5	173953421	Intron	novel		0.45
UCEC	chr5	173953153	Missense_Mutation	novel	D615N	0.36
UCEC	chr5	173890530	Missense_Mutation	novel	A266V	0.21
UCEC	chr5	173953270	Missense_Mutation	NA	R654W	0.24
UCEC	chr5	173957696	3'UTR	novel		0.29
UCEC	chr5	173890104	Missense_Mutation	novel	S124L	0.04
UCEC	chr5	173890029	Missense_Mutation	NA	S99N	0.22
UCEC	chr5	173950039	Silent	NA	L542L	0.11
UCEC	chr5	173945139	Missense_Mutation	novel	E485D	0.17	RRM_1
UCEC	chr5	173958005	3'UTR	novel		0.26
UCEC	chr5	173890474	Missense_Mutation	NA	Q247H	0.09
UCEC	chr5	173890789	Missense_Mutation	NA	S352R	0.41
UCEC	chr5	173957548	3'UTR	novel		0.49
UCEC	chr5	173943041	Missense_Mutation	rs764316983	R425Q	0.35
UCEC	chr5	173951893	Nonsense_Mutation	NA	R579*	0.1
UCEC	chr5	173890500	Missense_Mutation	novel	P256L	0.26
UCEC	chr5	173958884	3'UTR	novel		0.33
UCEC	chr5	173888613	5'UTR	novel		0.29
UCEC	chr5	173958959	3'UTR	novel		0.47
UCEC	chr5	173955926	Missense_Mutation	novel	Y660S	0.3
UCEC	chr5	173957696	3'UTR	novel		0.4
UCEC	chr5	173958467	3'UTR	novel		0.24
UCEC	chr5	173958658	3'UTR	rs533023959		0.32
UCEC	chr5	173958883	3'UTR	novel		0.35
UCEC	chr5	173958691	3'UTR	novel		0.48
UCEC	chr5	173958275	3'UTR	novel		0.49
UCEC	chr5	173957516	3'UTR	novel		0.39
UCEC	chr5	173959369	3'UTR	novel		0.53
UCEC	chr5	173960166	3'UTR	novel		0.08
UCEC	chr5	173957627	3'UTR	novel		0.53
UCEC	chr5	173888670	5'UTR	novel		0.33
UCEC	chr5	173958658	3'UTR	rs533023959		0.15
UCEC	chr5	173955991	Frame_Shift_Del	novel	*F683Sfs32**	0.25
UCEC	chr5	173945104	Missense_Mutation	NA	V474L	0.41	RRM_1
UCEC	chr5	173890738	Missense_Mutation	NA	K335N	0.32
UCEC	chr5	173888763	5'UTR	novel		0.42
UCEC	chr5	173958018	3'UTR	novel		0.41
UCEC	chr5	173958175	3'UTR	novel		0.53
UCEC	chr5	173959139	3'UTR	novel		0.3
UCEC	chr5	173950054	Silent	novel	S547S	0.23
UCEC	chr5	173955972	Frame_Shift_Ins	novel	*K678Efs9**	0.38
UCEC	chr5	173958691	3'UTR	novel		0.45
UCEC	chr5	173945133	Silent	rs781371312	I483I	0.28
UCEC	chr5	173889711	5'UTR	novel		0.22
UCEC	chr5	173890524	Missense_Mutation	novel	R264I	0.18
UCEC	chr5	173958406	3'UTR	novel		0.41
UCEC	chr5	173890691	Missense_Mutation	novel	G320W	0.45
UCEC	chr5	173958068	3'UTR	novel		0.37
UCEC	chr5	173958811	3'UTR	novel		0.22
UCEC	chr5	173890759	Silent	novel	H342H	0.15
UCEC	chr5	173958928	3'UTR	novel		0.11
UCEC	chr5	173889726	5'UTR	novel		0.38
UCEC	chr5	173888715	5'UTR	novel		0.6
UCEC	chr5	173958673	3'UTR	novel		0.49
UCEC	chr5	173890007	Nonsense_Mutation	NA	E92*	0.3
UCEC	chr5	173959686	3'UTR	novel		0.11
UCEC	chr5	173956081	Missense_Mutation	NA	P712S	0.29
UCEC	chr5	173956175	3'UTR	novel		0.35
UCEC	chr5	173888961	5'UTR	novel		0.36
UCEC	chr5	173889846	Frame_Shift_Del	novel	*S40Afs6**	0.32
UCEC	chr5	173955960	Frame_Shift_Del	novel	*A673Pfs42**	0.3
UCEC	chr5	173889994	Silent	novel	Q87Q	0.11
UCEC	chr5	173890788	Missense_Mutation	NA	S352N	0.22
UCEC	chr5	173956058	Missense_Mutation	NA	R704H	0.53
UCEC	chr5	173951932	Nonsense_Mutation	novel	R592*	0.32
UCEC	chr5	173889668	5'UTR	novel		0.45
UCEC	chr5	173956291	3'UTR	novel		0.31
UCEC	chr5	173953235	Missense_Mutation	NA	R642H	0.29
UCEC	chr5	173955979	Frame_Shift_Del	novel	*K678Nfs37**	0.21
UCEC	chr5	173956242	3'UTR	novel		0.38
UCEC	chr5	173957321	3'UTR	novel		0.48
UCEC	chr5	173910540	Silent	rs569550736	F381F	0.23
UCEC	chr5	173957130	3'UTR	novel		0.36
UCEC	chr5	173958406	3'UTR	novel		0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.5909	2.1944e-60
KIRP	AMP	0.1111	0.069756
KIRP	DEL	0.0347	0.11554
LGG	DEL	0.0955	1.86e-07
LUAD	AMP	0.1705	0.24967
LUSC	DEL	0.6088	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0325	0.16448
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0046	Kaplan-Meier Survival Analysis
ACC	0.0025	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.046	Kaplan-Meier Survival Analysis
LUSC	0.0014	Kaplan-Meier Survival Analysis
PCPG	0.037	Kaplan-Meier Survival Analysis
READ	0.046	Kaplan-Meier Survival Analysis
UVM	0.0041	Kaplan-Meier Survival Analysis