EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000113761 (Gene tree)
Gene ID
23567
Gene Symbol
ZNF346
Alias
JAZ|Zfp346
Full Name
zinc finger protein 346
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
58,510 bases
Position
chr5:177,022,680-177,081,189
Accession
16403
RBP type
canonical RBP
Summary
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000350869zf-metPF12874.78.1e-2614
ENSP00000350869zf-metPF12874.78.1e-2624
ENSP00000350869zf-metPF12874.78.1e-2634
ENSP00000350869zf-metPF12874.78.1e-2644
ENSP00000425725zf-metPF12874.71e-2514
ENSP00000425725zf-metPF12874.71e-2524
ENSP00000425725zf-metPF12874.71e-2534
ENSP00000425725zf-metPF12874.71e-2544
ENSP00000424495zf-metPF12874.71.2e-2514
ENSP00000424495zf-metPF12874.71.2e-2524
ENSP00000424495zf-metPF12874.71.2e-2534
ENSP00000424495zf-metPF12874.71.2e-2544
ENSP00000421212zf-metPF12874.71.2e-2314
ENSP00000421212zf-metPF12874.71.2e-2324
ENSP00000421212zf-metPF12874.71.2e-2334
ENSP00000421212zf-metPF12874.71.2e-2344
ENSP00000423515zf-metPF12874.73.8e-1212
ENSP00000423515zf-metPF12874.73.8e-1222
ENSP00000421089zf-metPF12874.70.0009911
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24521053Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids.Biochemistry2014 Mar 11Burge RGdoi: 10.1021/bi401675h
10488071JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization.J Biol Chem1999 Sep 24Yang M-
11972337The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity.Nucleic Acids Res2002 May 1Mendez-Vidal C-
15254228Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.Mol Cell Biol2004 AugChen T-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000506693ZNF346-2051276-ENSP00000423515196 (aa)-B7Z4J8
ENST00000511834ZNF346-2082306XM_017009294ENSP00000425725310 (aa)XP_016864783D6RJ07
ENST00000510933ZNF346-207586--- (aa)--
ENST00000358149ZNF346-2012314XM_017009295ENSP00000350869294 (aa)XP_016864784Q9UL40
ENST00000508155ZNF346-2061622-ENSP00000421388131 (aa)-B7Z6B6
ENST00000512315ZNF346-2091575-ENSP00000421089118 (aa)-B7Z4N4
ENST00000504600ZNF346-204349--- (aa)--
ENST00000513587ZNF346-210977-ENSP00000423690135 (aa)-B7Z6Q2
ENST00000503039ZNF346-2022774XM_005265860ENSP00000424495319 (aa)XP_005265917Q9UL40
ENST00000503425ZNF346-2031191-ENSP00000421212262 (aa)-Q9UL40
Gene Model
Click here to download ENSG00000113761's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113761Sodium2.7960000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000113761rs349339095177038269TMenopause (age at onset)29773799[0.14-0.26] year increase0.2EFO_0004704
ENSG00000113761rs584005555177027080TUterine fibroids30194396[1.05-1.1]1.07EFO_0000731
ENSG00000113761rs614622835177051625AWord reading30741946unit decrease0.682135EFO_0005300
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113761's network
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000113761ZNF3467551.020ENSAPOG00000006793znf3468151.020Acanthochromis_polyacanthus
ENSG00000113761ZNF34610094.262ENSAMEG00000018208ZNF34610094.262Ailuropoda_melanoleuca
ENSG00000113761ZNF3467456.585ENSACIG00000024439znf3469656.190Amphilophus_citrinellus
ENSG00000113761ZNF3467551.230ENSAOCG00000000231znf3467951.230Amphiprion_ocellaris
ENSG00000113761ZNF3467551.020ENSAPEG00000022103znf3467951.653Amphiprion_percula
ENSG00000113761ZNF3467752.209ENSATEG00000022779znf3467852.209Anabas_testudineus
ENSG00000113761ZNF3467065.625ENSAPLG00000002968ZNF3469965.625Anas_platyrhynchos
ENSG00000113761ZNF3467240.529ENSAPLG00000002674-9440.529Anas_platyrhynchos
ENSG00000113761ZNF3467663.934ENSACAG00000005394ZNF3468563.934Anolis_carolinensis
ENSG00000113761ZNF346100100.000ENSANAG00000030820ZNF346100100.000Aotus_nancymaae
ENSG00000113761ZNF3467552.263ENSACLG00000015637znf3467752.263Astatotilapia_calliptera
ENSG00000113761ZNF3468052.569ENSAMXG00000031057znf3468752.569Astyanax_mexicanus
ENSG00000113761ZNF34610091.935ENSBTAG00000010541ZNF34610091.935Bos_taurus
ENSG00000113761ZNF34610098.333ENSCJAG00000007194ZNF34610098.333Callithrix_jacchus
ENSG00000113761ZNF34610093.226ENSCAFG00000016541ZNF34610093.226Canis_familiaris
ENSG00000113761ZNF34610093.333ENSCAFG00020011793ZNF34610092.857Canis_lupus_dingo
ENSG00000113761ZNF34610092.581ENSCHIG00000019690ZNF34610092.581Capra_hircus
ENSG00000113761ZNF3468190.438ENSTSYG00000011481ZNF34610090.438Carlito_syrichta
ENSG00000113761ZNF3466687.958ENSCAPG00000002243ZNF34610087.958Cavia_aperea
ENSG00000113761ZNF34610089.456ENSCPOG00000002813ZNF34610089.456Cavia_porcellus
ENSG00000113761ZNF34610095.000ENSCCAG00000025324ZNF34610095.902Cebus_capucinus
ENSG00000113761ZNF34610099.180ENSCATG00000032030ZNF34610099.180Cercocebus_atys
ENSG00000113761ZNF34610090.816ENSCLAG00000016325ZNF34610090.816Chinchilla_lanigera
ENSG00000113761ZNF346100100.000ENSCSAG00000009071ZNF34610098.065Chlorocebus_sabaeus
ENSG00000113761ZNF3468092.340ENSCHOG00000001795ZNF3469987.645Choloepus_hoffmanni
ENSG00000113761ZNF3468364.368ENSCPBG00000022601ZNF3469565.323Chrysemys_picta_bellii
ENSG00000113761ZNF346100100.000ENSCANG00000019382ZNF346100100.000Colobus_angolensis_palliatus
ENSG00000113761ZNF34610084.887ENSCGRG00001012343Zfp34610084.887Cricetulus_griseus_chok1gshd
ENSG00000113761ZNF3468187.251ENSCGRG00000005866Zfp34610087.251Cricetulus_griseus_crigri
ENSG00000113761ZNF3468047.410ENSCSEG00000016403znf3467147.581Cynoglossus_semilaevis
ENSG00000113761ZNF3468047.581ENSCVAG00000022651-7447.581Cyprinodon_variegatus
ENSG00000113761ZNF3468051.600ENSDARG00000060695znf3468051.626Danio_rerio
ENSG00000113761ZNF34610087.097ENSDNOG00000040065ZNF34610087.097Dasypus_novemcinctus
ENSG00000113761ZNF3468192.032ENSDORG00000013755Zfp3469992.032Dipodomys_ordii
ENSG00000113761ZNF3465798.462ENSETEG00000008948-7798.462Echinops_telfairi
ENSG00000113761ZNF3467138.125ENSEBUG00000010185-8637.870Eptatretus_burgeri
ENSG00000113761ZNF34610092.903ENSEASG00005012266ZNF34610092.903Equus_asinus_asinus
ENSG00000113761ZNF34610092.903ENSECAG00000008904ZNF34610092.903Equus_caballus
ENSG00000113761ZNF3467682.292ENSEEUG00000014263-9982.292Erinaceus_europaeus
ENSG00000113761ZNF3467950.000ENSELUG00000011376znf3468555.804Esox_lucius
ENSG00000113761ZNF34610095.082ENSFCAG00000038511ZNF34610095.082Felis_catus
ENSG00000113761ZNF3468262.308ENSFALG00000008661ZNF3469062.308Ficedula_albicollis
ENSG00000113761ZNF34610090.816ENSFDAG00000012914ZNF34610090.816Fukomys_damarensis
ENSG00000113761ZNF3467549.367ENSFHEG00000020328znf3467549.367Fundulus_heteroclitus
ENSG00000113761ZNF3467451.271ENSGMOG00000015384znf3469551.271Gadus_morhua
ENSG00000113761ZNF3468363.636ENSGALG00000001144ZNF3469263.636Gallus_gallus
ENSG00000113761ZNF3467446.667ENSGAFG00000007352znf3465646.667Gambusia_affinis
ENSG00000113761ZNF3467551.464ENSGACG00000020800znf3468251.464Gasterosteus_aculeatus
ENSG00000113761ZNF3468563.060ENSGAGG00000011389ZNF3469563.060Gopherus_agassizii
ENSG00000113761ZNF346100100.000ENSGGOG00000015260ZNF346100100.000Gorilla_gorilla
ENSG00000113761ZNF3467552.479ENSHBUG00000020017znf3467752.479Haplochromis_burtoni
ENSG00000113761ZNF34610090.476ENSHGLG00000008069ZNF34610090.476Heterocephalus_glaber_female
ENSG00000113761ZNF34610090.476ENSHGLG00100019075ZNF34610090.476Heterocephalus_glaber_male
ENSG00000113761ZNF3467450.215ENSHCOG00000010725-6250.649Hippocampus_comes
ENSG00000113761ZNF3467848.221ENSIPUG00000006892znf3468447.308Ictalurus_punctatus
ENSG00000113761ZNF34610090.000ENSSTOG00000000428ZNF34610089.796Ictidomys_tridecemlineatus
ENSG00000113761ZNF3468588.400ENSJJAG00000021062Zfp3469792.405Jaculus_jaculus
ENSG00000113761ZNF3467551.667ENSKMAG00000018586znf3467151.667Kryptolebias_marmoratus
ENSG00000113761ZNF3467551.626ENSLBEG00000016036znf3467451.626Labrus_bergylta
ENSG00000113761ZNF3467856.471ENSLACG00000007897ZNF3469357.436Latimeria_chalumnae
ENSG00000113761ZNF3468352.091ENSLOCG00000012305znf3468352.091Lepisosteus_oculatus
ENSG00000113761ZNF34610090.816ENSLAFG00000015514ZNF34610090.816Loxodonta_africana
ENSG00000113761ZNF34610098.361ENSMFAG00000003577ZNF34610098.361Macaca_fascicularis
ENSG00000113761ZNF34610098.361ENSMMUG00000011033ZNF34610098.361Macaca_mulatta
ENSG00000113761ZNF34610098.361ENSMNEG00000030466ZNF34610098.361Macaca_nemestrina
ENSG00000113761ZNF346100100.000ENSMLEG00000041138ZNF346100100.000Mandrillus_leucophaeus
ENSG00000113761ZNF3467549.187ENSMAMG00000020140znf3467749.187Mastacembelus_armatus
ENSG00000113761ZNF3467552.263ENSMZEG00005009446znf3467752.263Maylandia_zebra
ENSG00000113761ZNF3466861.850ENSMGAG00000004440ZNF3466661.850Meleagris_gallopavo
ENSG00000113761ZNF34610084.354ENSMAUG00000010058Zfp34610084.354Mesocricetus_auratus
ENSG00000113761ZNF34610094.245ENSMICG00000007633ZNF34610094.245Microcebus_murinus
ENSG00000113761ZNF34610084.694ENSMOCG00000000856Zfp34610084.694Microtus_ochrogaster
ENSG00000113761ZNF3467950.198ENSMMOG00000014824znf3468050.198Mola_mola
ENSG00000113761ZNF3468062.651ENSMODG00000004918-8962.705Monodelphis_domestica
ENSG00000113761ZNF3467451.064ENSMALG00000010445znf3467151.064Monopterus_albus
ENSG00000113761ZNF3468284.980MGP_CAROLIEiJ_G0018551-9988.889Mus_caroli
ENSG00000113761ZNF34610084.733ENSMUSG00000021481Zfp3469886.920Mus_musculus
ENSG00000113761ZNF34610085.496MGP_PahariEiJ_G0019616Zfp3469986.920Mus_pahari
ENSG00000113761ZNF34610083.969MGP_SPRETEiJ_G0019431Zfp3469986.498Mus_spretus
ENSG00000113761ZNF34610092.857ENSMPUG00000012295ZNF34610092.857Mustela_putorius_furo
ENSG00000113761ZNF34610085.496ENSMLUG00000005597ZNF34610085.496Myotis_lucifugus
ENSG00000113761ZNF3468188.800ENSNGAG00000010928Zfp3469988.800Nannospalax_galili
ENSG00000113761ZNF3467552.263ENSNBRG00000009412znf3467752.263Neolamprologus_brichardi
ENSG00000113761ZNF34610098.387ENSNLEG00000012612ZNF34610098.387Nomascus_leucogenys
ENSG00000113761ZNF3467244.231ENSMEUG00000011779-10049.143Notamacropus_eugenii
ENSG00000113761ZNF34610083.851ENSOPRG00000009768ZNF34610083.851Ochotona_princeps
ENSG00000113761ZNF34610089.032ENSODEG00000009676ZNF34610089.032Octodon_degus
ENSG00000113761ZNF3467552.479ENSONIG00000017316znf3468651.240Oreochromis_niloticus
ENSG00000113761ZNF3468560.294ENSOANG00000008690-9360.294Ornithorhynchus_anatinus
ENSG00000113761ZNF34610090.476ENSOCUG00000013360ZNF34610090.476Oryctolagus_cuniculus
ENSG00000113761ZNF3467239.474ENSORLG00000013862znf3465040.179Oryzias_latipes
ENSG00000113761ZNF3467240.789ENSORLG00020011469znf3465040.789Oryzias_latipes_hni
ENSG00000113761ZNF3467240.435ENSORLG00015018451znf3465240.435Oryzias_latipes_hsok
ENSG00000113761ZNF3467440.000ENSOMEG00000003054znf3465540.000Oryzias_melastigma
ENSG00000113761ZNF34610095.000ENSOGAG00000009061ZNF34610092.308Otolemur_garnettii
ENSG00000113761ZNF34610092.581ENSOARG00000003425ZNF34610092.581Ovis_aries
ENSG00000113761ZNF346100100.000ENSPPAG00000031435ZNF346100100.000Pan_paniscus
ENSG00000113761ZNF34610095.082ENSPPRG00000007029ZNF34610095.082Panthera_pardus
ENSG00000113761ZNF34610095.082ENSPTIG00000013172ZNF34610095.082Panthera_tigris_altaica
ENSG00000113761ZNF346100100.000ENSPTRG00000017573ZNF346100100.000Pan_troglodytes
ENSG00000113761ZNF346100100.000ENSPANG00000023732ZNF346100100.000Papio_anubis
ENSG00000113761ZNF3467454.936ENSPKIG00000009247znf3468850.602Paramormyrops_kingsleyae
ENSG00000113761ZNF3468063.347ENSPSIG00000016116ZNF3469562.353Pelodiscus_sinensis
ENSG00000113761ZNF3466956.701ENSPMGG00000011054znf3469456.701Periophthalmus_magnuspinnatus
ENSG00000113761ZNF34610084.014ENSPEMG00000000913Zfp34610084.014Peromyscus_maniculatus_bairdii
ENSG00000113761ZNF3468063.052ENSPCIG00000000498-8763.052Phascolarctos_cinereus
ENSG00000113761ZNF3468047.410ENSPFOG00000018088znf3468847.410Poecilia_formosa
ENSG00000113761ZNF3468047.410ENSPLAG00000022457znf3467347.410Poecilia_latipinna
ENSG00000113761ZNF3468047.410ENSPMEG00000012817znf3467347.410Poecilia_mexicana
ENSG00000113761ZNF3467645.366ENSPREG00000005815znf3467544.444Poecilia_reticulata
ENSG00000113761ZNF3469895.349ENSPPYG00000016082-10086.395Pongo_abelii
ENSG00000113761ZNF3468895.714ENSPCAG00000009931ZNF3467495.714Procavia_capensis
ENSG00000113761ZNF34610096.403ENSPCOG00000025690ZNF34610096.403Propithecus_coquereli
ENSG00000113761ZNF34610094.262ENSPVAG00000006690ZNF34610094.262Pteropus_vampyrus
ENSG00000113761ZNF3467552.263ENSPNYG00000008154znf3467652.263Pundamilia_nyererei
ENSG00000113761ZNF3467455.128ENSPNAG00000015934znf3468055.128Pygocentrus_nattereri
ENSG00000113761ZNF34610081.973ENSRNOG00000016867Zfp34610081.633Rattus_norvegicus
ENSG00000113761ZNF346100100.000ENSRBIG00000036149ZNF346100100.000Rhinopithecus_bieti
ENSG00000113761ZNF346100100.000ENSRROG00000037944ZNF346100100.000Rhinopithecus_roxellana
ENSG00000113761ZNF34610098.333ENSSBOG00000034067ZNF34610098.333Saimiri_boliviensis_boliviensis
ENSG00000113761ZNF3467764.730ENSSHAG00000011651-9664.730Sarcophilus_harrisii
ENSG00000113761ZNF3467450.862ENSSFOG00015010306znf3467750.862Scleropages_formosus
ENSG00000113761ZNF3467653.175ENSSMAG00000007533znf3467353.175Scophthalmus_maximus
ENSG00000113761ZNF3467545.783ENSSDUG00000000468znf3467743.396Seriola_dumerili
ENSG00000113761ZNF3467550.598ENSSLDG00000016433znf3467847.566Seriola_lalandi_dorsalis
ENSG00000113761ZNF3468263.462ENSSPUG00000006033ZNF3469163.462Sphenodon_punctatus
ENSG00000113761ZNF3467551.639ENSSPAG00000003836znf3467352.033Stegastes_partitus
ENSG00000113761ZNF34610095.082ENSSSCG00000014046ZNF34610095.082Sus_scrofa
ENSG00000113761ZNF3466161.658ENSTGUG00000000442ZNF3469961.658Taeniopygia_guttata
ENSG00000113761ZNF3469543.854ENSTRUG00000004159znf3468844.186Takifugu_rubripes
ENSG00000113761ZNF3466637.788ENSTNIG00000002766-9338.117Tetraodon_nigroviridis
ENSG00000113761ZNF34610091.803ENSTTRG00000002040ZNF34610091.803Tursiops_truncatus
ENSG00000113761ZNF34610094.262ENSUAMG00000027913ZNF34610094.262Ursus_americanus
ENSG00000113761ZNF34610094.309ENSUMAG00000024351ZNF34610094.309Ursus_maritimus
ENSG00000113761ZNF34610093.226ENSVVUG00000001235ZNF34610093.226Vulpes_vulpes
ENSG00000113761ZNF3467179.412ENSXETG00000007230znf3466653.659Xenopus_tropicalis
ENSG00000113761ZNF3465848.214ENSXCOG00000008872-5145.161Xiphophorus_couchianus
ENSG00000113761ZNF3468047.410ENSXMAG00000026755znf3467047.410Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22681889.HDAFunction
GO:0003725double-stranded RNA binding21873635.IBAFunction
GO:0003725double-stranded RNA binding10488071.IDAFunction
GO:0005515protein binding21903422.25416956.IPIFunction
GO:0005634nucleus10488071.IDAComponent
GO:0005730nucleolus10488071.IDAComponent
GO:0005737cytoplasm-IEAComponent
GO:0008270zinc ion binding-IEAFunction
GO:0019899enzyme binding23382074.IPIFunction
GO:0035198miRNA binding28431233.IDAFunction
GO:0043065positive regulation of apoptotic process-IEAProcess

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