EuRBPDB

Description

Ensembl ID: ENSG00000114030 (Gene tree)
Gene ID: 3836
Gene Symbol: KPNA1
Alias: SRP1|RCH2|NPI-1|IPOA5
Full Name: karyopherin subunit alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 93,045 bases
Position: chr3:122,421,901-122,514,945
Accession: 6394
RBP type: non-canonical RBP
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8777717	Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.	Immunity	1995 Dec	Spanopoulou E	-
8052633	RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.	Proc Natl Acad Sci U S A	1994 Aug 2	Cortes P	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464940	KPNA1-202	582	-	-	- (aa)	-	-
ENST00000344337	KPNA1-201	6830	XM_005247437	ENSP00000343701	538 (aa)	XP_005247494	P52294
ENST00000476916	KPNA1-206	575	-	ENSP00000417319	169 (aa)	-	C9J352
ENST00000466923	KPNA1-204	3316	-	-	- (aa)	-	-
ENST00000485027	KPNA1-208	1843	-	ENSP00000420013	182 (aa)	-	F2Z3G4
ENST00000470904	KPNA1-205	3060	-	-	- (aa)	-	-
ENST00000465882	KPNA1-203	1062	-	ENSP00000419890	328 (aa)	-	C9JYI4
ENST00000493510	KPNA1-209	596	-	ENSP00000419257	174 (aa)	-	C9JWD9
ENST00000482287	KPNA1-207	727	-	ENSP00000417166	214 (aa)	-	C9J4U1
ENST00000494339	KPNA1-210	1923	-	ENSP00000418394	182 (aa)	-	F2Z3G4

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa05164	Influenza A	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000114030	rs11720985	3	122495198	T	Educational attainment (MTAG)	30038396	[0.0063-0.0117] unit increase	0.009	EFO_0004784
ENSG00000114030	rs11720985	3	122495198	T	Highest math class taken (MTAG)	30038396	[0.0072-0.0142] unit increase	0.0107	EFO_0004875
ENSG00000114030	rs3762637	3	122426477	T	LDL cholesterol levels	28334899	[0.013-0.033] unit increase (EA Beta value)	0.0234	EFO_0004611
ENSG00000114030	rs11720985	3	122495198	T	Educational attainment (years of education)	30038396	[0.0056-0.0114] unit increase	0.0085	EFO_0004784
ENSG00000114030	rs9833415	3	122440993	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000114030	KPNA1	97	45.794	WBGene00002074	ima-3	90	45.738	Caenorhabditis_elegans
ENSG00000114030	KPNA1	98	45.342	FBgn0027338	Kap-alpha3	96	45.753	Drosophila_melanogaster
ENSG00000114030	KPNA1	98	46.417	FBgn0267727	Pen	98	44.361	Drosophila_melanogaster
ENSG00000114030	KPNA1	100	81.227	ENSG00000025800	KPNA6	99	81.041	Homo_sapiens
ENSG00000114030	KPNA1	99	48.308	ENSG00000102753	KPNA3	95	48.350	Homo_sapiens
ENSG00000114030	KPNA1	98	50.153	YNL189W	SRP1	94	51.456	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000018	regulation of DNA recombination	8052633.	TAS	Process
GO:0005515	protein binding	10523667.12011095.15942031.16713569.17310249.18985028.19084525.19412186.21385873.21988832.21994455.22500989.25416956.25599645.26420826.26496610.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	7754385.	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006309	apoptotic DNA fragmentation	-	TAS	Process
GO:0006607	NLS-bearing protein import into nucleus	21873635.	IBA	Process
GO:0008139	nuclear localization sequence binding	21873635.	IBA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0014069	postsynaptic density	-	IEA	Component
GO:0019054	modulation by virus of host process	-	TAS	Process
GO:0030425	dendrite	-	ISS	Component
GO:0043657	host cell	-	IEA	Component
GO:0061608	nuclear import signal receptor activity	-	IEA	Function
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099527	postsynapse to nucleus signaling pathway	21873635.	IBA	Process