EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000114127 (Gene tree)
Gene ID: 54464
Gene Symbol: XRN1
Alias: 1-Sep
Full Name: 5'-3' exoribonuclease 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 141,456 bases
Position: chr3:142,306,607-142,448,062
Accession: 30654
RBP type: canonical RBP
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000418404	XRN_N	PF03159.18	1.8e-96	1	1
ENSP00000376707	XRN_N	PF03159.18	1.5e-95	1	1
ENSP00000264951	XRN_N	PF03159.18	2.2e-95	1	1
ENSP00000420634	XRN_N	PF03159.18	1.5e-36	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22383165	The 5' - 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development.	Wiley Interdiscip Rev RNA	2012 Jul-Aug	Jones CI	doi: 10.1002/wrna.1109
30301774	A Musashi Splice Variant and Its Interaction Partners Influence Temperature Acclimation in Chlamydomonas.	Plant Physiol	2018 Dec	Li W	doi: 10.1104/pp.18.00972
23068615	Novel interaction of two clock-relevant RNA-binding proteins C3 and XRN1 in Chlamydomonas reinhardtii.	FEBS Lett	2012 Nov 16	Dathe H	doi: 10.1016/j.febslet.2012.09.046
25110015	Regulation of miRNA strand selection: follow the leader?	Biochem Soc Trans	2014 Aug	Meijer HA	doi: 10.1042/BST20140142.
25855736	Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5' Untranslated Region.	J Virol	2015 Jun	Thibault PA	doi: 10.1128/JVI.03631-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000472625	XRN1-209	420	-	-	- (aa)	-	-
ENST00000392981	XRN1-202	5383	XM_017006640	ENSP00000376707	1694 (aa)	XP_016862129	Q8IZH2
ENST00000468894	XRN1-207	318	-	-	- (aa)	-	-
ENST00000264951	XRN1-201	10143	XM_011512919	ENSP00000264951	1706 (aa)	XP_011511221	Q8IZH2
ENST00000477237	XRN1-211	686	-	ENSP00000420634	165 (aa)	-	C9JCZ8
ENST00000465507	XRN1-205	322	-	-	- (aa)	-	-
ENST00000470537	XRN1-208	669	-	-	- (aa)	-	-
ENST00000465074	XRN1-204	643	-	-	- (aa)	-	-
ENST00000463916	XRN1-203	2075	-	ENSP00000418404	459 (aa)	-	Q8IZH2
ENST00000467077	XRN1-206	674	-	-	- (aa)	-	-
ENST00000472697	XRN1-210	2652	-	-	- (aa)	-	-
ENST00000489241	XRN1-213	393	-	ENSP00000419219	63 (aa)	-	H7C583
ENST00000498077	XRN1-214	5600	-	ENSP00000419683	1160 (aa)	-	H7C5E4
ENST00000486211	XRN1-212	1180	-	ENSP00000420786	107 (aa)	-	F8WDA0

Gene Model

Click here to download ENSG00000114127's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000114127	Platelet Function Tests	1.7736100E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000114127	rs140269075	3	142424267	G	Mosquito bite size	28199695	[0.045-0.107] unit decrease	0.0759293	EFO_0008378
ENSG00000114127	rs73238169	3	142380525	G	Heel bone mineral density	30598549	[0.014-0.025] unit increase	0.0192047	EFO_0009270
ENSG00000114127	rs11709758	3	142385585	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114127's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000114127	XRN1	96	50.820	ENSG00000088930	XRN2	71	39.912

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000114127	XRN1	96	96.117	ENSAPOG00000000622	xrn1	100	69.800	Acanthochromis_polyacanthus
ENSG00000114127	XRN1	100	96.970	ENSAMEG00000012538	XRN1	100	91.354	Ailuropoda_melanoleuca
ENSG00000114127	XRN1	97	94.231	ENSACIG00000001057	xrn1	99	72.254	Amphilophus_citrinellus
ENSG00000114127	XRN1	96	96.117	ENSAOCG00000014097	xrn1	95	69.076	Amphiprion_ocellaris
ENSG00000114127	XRN1	96	96.117	ENSAPEG00000006620	xrn1	98	62.720	Amphiprion_percula
ENSG00000114127	XRN1	96	95.146	ENSATEG00000009752	xrn1	99	70.714	Anabas_testudineus
ENSG00000114127	XRN1	100	92.727	ENSAPLG00000004905	XRN1	100	76.016	Anas_platyrhynchos
ENSG00000114127	XRN1	96	97.087	ENSACAG00000004985	XRN1	100	72.185	Anolis_carolinensis
ENSG00000114127	XRN1	100	100.000	ENSANAG00000029013	XRN1	100	96.458	Aotus_nancymaae
ENSG00000114127	XRN1	96	95.146	ENSACLG00000004806	xrn1	99	60.307	Astatotilapia_calliptera
ENSG00000114127	XRN1	100	91.667	ENSAMXG00000019370	xrn1	100	91.667	Astyanax_mexicanus
ENSG00000114127	XRN1	100	98.788	ENSBTAG00000011524	XRN1	100	91.857	Bos_taurus
ENSG00000114127	XRN1	95	80.392	WBGene00012730	xrn-1	80	39.084	Caenorhabditis_elegans
ENSG00000114127	XRN1	100	98.788	ENSCJAG00000001872	XRN1	100	96.281	Callithrix_jacchus
ENSG00000114127	XRN1	100	98.182	ENSCAFG00000007783	XRN1	100	92.966	Canis_familiaris
ENSG00000114127	XRN1	100	98.182	ENSCAFG00020009120	XRN1	99	94.286	Canis_lupus_dingo
ENSG00000114127	XRN1	100	98.182	ENSCHIG00000019192	XRN1	99	89.936	Capra_hircus
ENSG00000114127	XRN1	100	99.394	ENSTSYG00000002705	XRN1	100	93.864	Carlito_syrichta
ENSG00000114127	XRN1	73	100.000	ENSCAPG00000004604	-	99	76.783	Cavia_aperea
ENSG00000114127	XRN1	96	100.000	ENSCPOG00000035199	-	100	100.000	Cavia_porcellus
ENSG00000114127	XRN1	100	100.000	ENSCCAG00000034800	XRN1	99	98.415	Cebus_capucinus
ENSG00000114127	XRN1	100	100.000	ENSCATG00000041794	XRN1	100	97.580	Cercocebus_atys
ENSG00000114127	XRN1	100	99.394	ENSCLAG00000001451	XRN1	99	96.038	Chinchilla_lanigera
ENSG00000114127	XRN1	100	100.000	ENSCSAG00000011265	XRN1	100	97.540	Chlorocebus_sabaeus
ENSG00000114127	XRN1	72	98.701	ENSCHOG00000013961	-	62	98.701	Choloepus_hoffmanni
ENSG00000114127	XRN1	96	85.437	ENSCING00000001334	-	95	70.109	Ciona_intestinalis
ENSG00000114127	XRN1	96	86.408	ENSCSAVG00000008584	-	98	44.917	Ciona_savignyi
ENSG00000114127	XRN1	100	100.000	ENSCANG00000037495	XRN1	100	97.655	Colobus_angolensis_palliatus
ENSG00000114127	XRN1	100	98.788	ENSCGRG00001019411	Xrn1	99	95.721	Cricetulus_griseus_chok1gshd
ENSG00000114127	XRN1	100	98.788	ENSCGRG00000012464	Xrn1	99	95.721	Cricetulus_griseus_crigri
ENSG00000114127	XRN1	96	96.117	ENSCSEG00000021285	xrn1	99	92.727	Cynoglossus_semilaevis
ENSG00000114127	XRN1	96	95.146	ENSCVAG00000013089	xrn1	99	71.605	Cyprinodon_variegatus
ENSG00000114127	XRN1	96	96.117	ENSDARG00000091652	xrn1	98	79.325	Danio_rerio
ENSG00000114127	XRN1	96	98.058	ENSDNOG00000034202	-	100	98.058	Dasypus_novemcinctus
ENSG00000114127	XRN1	100	100.000	ENSDORG00000013833	Xrn1	100	86.690	Dipodomys_ordii
ENSG00000114127	XRN1	98	67.619	FBgn0020261	pcm	76	39.846	Drosophila_melanogaster
ENSG00000114127	XRN1	86	100.000	ENSETEG00000003978	XRN1	88	99.194	Echinops_telfairi
ENSG00000114127	XRN1	100	98.788	ENSEASG00005002687	XRN1	99	95.721	Equus_asinus_asinus
ENSG00000114127	XRN1	100	98.788	ENSECAG00000008301	XRN1	100	92.736	Equus_caballus
ENSG00000114127	XRN1	100	99.394	ENSEEUG00000011323	XRN1	92	82.600	Erinaceus_europaeus
ENSG00000114127	XRN1	96	96.117	ENSELUG00000000169	xrn1	100	61.241	Esox_lucius
ENSG00000114127	XRN1	100	99.394	ENSFCAG00000027589	XRN1	100	96.522	Felis_catus
ENSG00000114127	XRN1	100	92.727	ENSFALG00000007021	XRN1	100	74.733	Ficedula_albicollis
ENSG00000114127	XRN1	100	98.788	ENSFDAG00000020494	XRN1	99	95.563	Fukomys_damarensis
ENSG00000114127	XRN1	96	95.146	ENSFHEG00000017255	-	100	95.146	Fundulus_heteroclitus
ENSG00000114127	XRN1	100	79.518	ENSFHEG00000017356	-	98	69.854	Fundulus_heteroclitus
ENSG00000114127	XRN1	96	94.175	ENSGMOG00000006396	xrn1	83	68.201	Gadus_morhua
ENSG00000114127	XRN1	96	96.117	ENSGALG00000002706	XRN1	100	74.902	Gallus_gallus
ENSG00000114127	XRN1	96	94.175	ENSGAFG00000006293	-	100	94.175	Gambusia_affinis
ENSG00000114127	XRN1	96	96.117	ENSGACG00000014328	xrn1	100	60.068	Gasterosteus_aculeatus
ENSG00000114127	XRN1	96	96.117	ENSGAGG00000017535	XRN1	99	77.939	Gopherus_agassizii
ENSG00000114127	XRN1	100	99.394	ENSGGOG00000008047	XRN1	100	99.055	Gorilla_gorilla
ENSG00000114127	XRN1	97	95.192	ENSHBUG00000005908	xrn1	98	72.279	Haplochromis_burtoni
ENSG00000114127	XRN1	100	98.788	ENSHGLG00000014476	XRN1	99	96.513	Heterocephalus_glaber_female
ENSG00000114127	XRN1	100	98.788	ENSHGLG00100015130	XRN1	99	96.513	Heterocephalus_glaber_male
ENSG00000114127	XRN1	96	96.117	ENSHCOG00000013992	-	90	96.117	Hippocampus_comes
ENSG00000114127	XRN1	96	96.117	ENSHCOG00000014062	xrn1	99	69.531	Hippocampus_comes
ENSG00000114127	XRN1	96	95.146	ENSIPUG00000015229	xrn1	99	62.486	Ictalurus_punctatus
ENSG00000114127	XRN1	100	99.394	ENSSTOG00000013552	XRN1	99	97.306	Ictidomys_tridecemlineatus
ENSG00000114127	XRN1	100	98.788	ENSJJAG00000010863	Xrn1	99	93.548	Jaculus_jaculus
ENSG00000114127	XRN1	96	94.175	ENSKMAG00000021356	xrn1	94	76.160	Kryptolebias_marmoratus
ENSG00000114127	XRN1	98	95.238	ENSLBEG00000018656	xrn1	99	95.238	Labrus_bergylta
ENSG00000114127	XRN1	96	98.058	ENSLACG00000009020	XRN1	100	69.454	Latimeria_chalumnae
ENSG00000114127	XRN1	96	96.117	ENSLOCG00000007944	xrn1	100	65.495	Lepisosteus_oculatus
ENSG00000114127	XRN1	100	98.788	ENSLAFG00000015426	XRN1	100	95.978	Loxodonta_africana
ENSG00000114127	XRN1	100	100.000	ENSMFAG00000032599	XRN1	100	97.580	Macaca_fascicularis
ENSG00000114127	XRN1	100	100.000	ENSMMUG00000014038	XRN1	100	97.639	Macaca_mulatta
ENSG00000114127	XRN1	100	100.000	ENSMNEG00000034217	XRN1	100	97.462	Macaca_nemestrina
ENSG00000114127	XRN1	100	100.000	ENSMLEG00000041349	-	100	99.129	Mandrillus_leucophaeus
ENSG00000114127	XRN1	96	95.146	ENSMAMG00000013219	xrn1	94	76.907	Mastacembelus_armatus
ENSG00000114127	XRN1	96	95.146	ENSMZEG00005015099	xrn1	99	60.193	Maylandia_zebra
ENSG00000114127	XRN1	94	83.295	ENSMGAG00000006333	XRN1	100	74.826	Meleagris_gallopavo
ENSG00000114127	XRN1	99	97.170	ENSMAUG00000014268	-	100	97.170	Mesocricetus_auratus
ENSG00000114127	XRN1	100	100.000	ENSMICG00000048948	XRN1	100	100.000	Microcebus_murinus
ENSG00000114127	XRN1	100	97.576	ENSMOCG00000008665	Xrn1	99	94.612	Microtus_ochrogaster
ENSG00000114127	XRN1	100	80.723	ENSMMOG00000020896	-	96	68.081	Mola_mola
ENSG00000114127	XRN1	96	100.000	ENSMODG00000021236	XRN1	100	82.030	Monodelphis_domestica
ENSG00000114127	XRN1	96	95.146	ENSMALG00000004098	xrn1	100	57.414	Monopterus_albus
ENSG00000114127	XRN1	100	98.788	MGP_CAROLIEiJ_G0032535	Xrn1	100	100.000	Mus_caroli
ENSG00000114127	XRN1	100	98.788	ENSMUSG00000032410	Xrn1	100	100.000	Mus_musculus
ENSG00000114127	XRN1	100	98.788	MGP_PahariEiJ_G0015404	Xrn1	100	100.000	Mus_pahari
ENSG00000114127	XRN1	100	98.788	MGP_SPRETEiJ_G0033678	Xrn1	100	100.000	Mus_spretus
ENSG00000114127	XRN1	100	98.788	ENSMPUG00000012040	XRN1	100	93.146	Mustela_putorius_furo
ENSG00000114127	XRN1	100	98.182	ENSMLUG00000016885	XRN1	100	88.915	Myotis_lucifugus
ENSG00000114127	XRN1	96	99.029	ENSNGAG00000023964	Xrn1	99	91.284	Nannospalax_galili
ENSG00000114127	XRN1	97	95.192	ENSNBRG00000001531	-	100	95.192	Neolamprologus_brichardi
ENSG00000114127	XRN1	100	100.000	ENSNLEG00000004726	XRN1	100	98.229	Nomascus_leucogenys
ENSG00000114127	XRN1	96	99.029	ENSMEUG00000014473	-	80	99.029	Notamacropus_eugenii
ENSG00000114127	XRN1	96	99.029	ENSOPRG00000007337	-	78	84.480	Ochotona_princeps
ENSG00000114127	XRN1	96	100.000	ENSODEG00000008804	-	100	100.000	Octodon_degus
ENSG00000114127	XRN1	96	95.146	ENSONIG00000016673	xrn1	99	64.581	Oreochromis_niloticus
ENSG00000114127	XRN1	100	96.364	ENSOANG00000006735	XRN1	100	77.258	Ornithorhynchus_anatinus
ENSG00000114127	XRN1	100	99.394	ENSOCUG00000001861	XRN1	100	90.029	Oryctolagus_cuniculus
ENSG00000114127	XRN1	96	96.117	ENSORLG00000013005	xrn1	100	60.939	Oryzias_latipes
ENSG00000114127	XRN1	96	96.117	ENSORLG00020005559	xrn1	100	61.316	Oryzias_latipes_hni
ENSG00000114127	XRN1	96	96.117	ENSORLG00015022523	xrn1	100	61.035	Oryzias_latipes_hsok
ENSG00000114127	XRN1	96	96.117	ENSOMEG00000015397	xrn1	99	72.535	Oryzias_melastigma
ENSG00000114127	XRN1	100	99.394	ENSOGAG00000000170	XRN1	100	90.978	Otolemur_garnettii
ENSG00000114127	XRN1	100	98.788	ENSOARG00000006343	XRN1	99	92.258	Ovis_aries
ENSG00000114127	XRN1	100	100.000	ENSPPAG00000010180	XRN1	100	99.233	Pan_paniscus
ENSG00000114127	XRN1	100	99.394	ENSPPRG00000007125	XRN1	100	93.333	Panthera_pardus
ENSG00000114127	XRN1	100	98.788	ENSPTIG00000021081	XRN1	100	93.392	Panthera_tigris_altaica
ENSG00000114127	XRN1	100	100.000	ENSPTRG00000015482	XRN1	100	99.233	Pan_troglodytes
ENSG00000114127	XRN1	100	100.000	ENSPANG00000010638	XRN1	100	97.521	Papio_anubis
ENSG00000114127	XRN1	96	96.117	ENSPKIG00000011903	-	79	96.117	Paramormyrops_kingsleyae
ENSG00000114127	XRN1	96	96.117	ENSPSIG00000018050	XRN1	100	76.528	Pelodiscus_sinensis
ENSG00000114127	XRN1	96	96.117	ENSPMGG00000002648	xrn1	98	78.650	Periophthalmus_magnuspinnatus
ENSG00000114127	XRN1	100	98.788	ENSPEMG00000020610	Xrn1	99	95.404	Peromyscus_maniculatus_bairdii
ENSG00000114127	XRN1	99	71.856	ENSPMAG00000002975	xrn1	91	78.161	Petromyzon_marinus
ENSG00000114127	XRN1	98	97.143	ENSPCIG00000028735	XRN1	99	89.664	Phascolarctos_cinereus
ENSG00000114127	XRN1	96	95.146	ENSPFOG00000013932	xrn1	99	64.630	Poecilia_formosa
ENSG00000114127	XRN1	96	95.146	ENSPLAG00000021653	xrn1	99	64.013	Poecilia_latipinna
ENSG00000114127	XRN1	96	95.146	ENSPMEG00000003076	xrn1	95	64.457	Poecilia_mexicana
ENSG00000114127	XRN1	96	95.146	ENSPREG00000021147	xrn1	100	60.912	Poecilia_reticulata
ENSG00000114127	XRN1	100	99.394	ENSPPYG00000014172	XRN1	100	98.359	Pongo_abelii
ENSG00000114127	XRN1	100	96.970	ENSPCAG00000005638	XRN1	100	81.594	Procavia_capensis
ENSG00000114127	XRN1	100	98.182	ENSPCOG00000013089	XRN1	99	97.087	Propithecus_coquereli
ENSG00000114127	XRN1	100	96.970	ENSPVAG00000016265	XRN1	96	92.028	Pteropus_vampyrus
ENSG00000114127	XRN1	96	95.146	ENSPNYG00000010570	xrn1	99	60.517	Pundamilia_nyererei
ENSG00000114127	XRN1	96	94.175	ENSPNAG00000023531	xrn1	99	60.472	Pygocentrus_nattereri
ENSG00000114127	XRN1	100	98.788	ENSRNOG00000042951	Xrn1	100	86.828	Rattus_norvegicus
ENSG00000114127	XRN1	100	100.000	ENSRBIG00000041227	XRN1	100	97.071	Rhinopithecus_bieti
ENSG00000114127	XRN1	100	100.000	ENSRROG00000033764	-	100	100.000	Rhinopithecus_roxellana
ENSG00000114127	XRN1	100	59.813	YGL173C	XRN1	81	34.513	Saccharomyces_cerevisiae
ENSG00000114127	XRN1	100	99.394	ENSSBOG00000029561	XRN1	100	96.045	Saimiri_boliviensis_boliviensis
ENSG00000114127	XRN1	100	95.152	ENSSHAG00000016207	XRN1	100	81.254	Sarcophilus_harrisii
ENSG00000114127	XRN1	96	95.146	ENSSFOG00015024211	xrn1	100	61.197	Scleropages_formosus
ENSG00000114127	XRN1	96	96.117	ENSSMAG00000016534	xrn1	98	72.132	Scophthalmus_maximus
ENSG00000114127	XRN1	96	96.117	ENSSDUG00000010306	xrn1	97	72.019	Seriola_dumerili
ENSG00000114127	XRN1	96	96.117	ENSSLDG00000021543	xrn1	100	71.429	Seriola_lalandi_dorsalis
ENSG00000114127	XRN1	100	96.970	ENSSARG00000007741	-	83	84.917	Sorex_araneus
ENSG00000114127	XRN1	96	96.117	ENSSPUG00000010754	-	100	96.117	Sphenodon_punctatus
ENSG00000114127	XRN1	100	93.939	ENSSPUG00000010779	-	95	86.583	Sphenodon_punctatus
ENSG00000114127	XRN1	100	82.530	ENSSPAG00000009856	-	96	76.065	Stegastes_partitus
ENSG00000114127	XRN1	100	92.727	ENSTGUG00000008498	XRN1	100	77.017	Taeniopygia_guttata
ENSG00000114127	XRN1	96	93.204	ENSTRUG00000004895	xrn1	96	75.157	Takifugu_rubripes
ENSG00000114127	XRN1	95	94.118	ENSTNIG00000017615	xrn1	100	58.945	Tetraodon_nigroviridis
ENSG00000114127	XRN1	100	96.364	ENSTBEG00000003256	XRN1	89	87.241	Tupaia_belangeri
ENSG00000114127	XRN1	100	98.182	ENSTTRG00000012914	XRN1	100	88.746	Tursiops_truncatus
ENSG00000114127	XRN1	96	100.000	ENSUAMG00000001608	XRN1	99	94.286	Ursus_americanus
ENSG00000114127	XRN1	100	99.394	ENSUMAG00000013625	XRN1	100	94.204	Ursus_maritimus
ENSG00000114127	XRN1	100	98.182	ENSVPAG00000004690	XRN1	100	90.328	Vicugna_pacos
ENSG00000114127	XRN1	100	98.788	ENSVVUG00000024461	XRN1	99	96.672	Vulpes_vulpes
ENSG00000114127	XRN1	96	97.087	ENSXETG00000000619	xrn1	99	88.542	Xenopus_tropicalis
ENSG00000114127	XRN1	96	95.146	ENSXCOG00000007917	xrn1	100	60.897	Xiphophorus_couchianus
ENSG00000114127	XRN1	96	95.146	ENSXMAG00000018320	xrn1	98	72.046	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	-	IEA	Component
GO:0000956	nuclear-transcribed mRNA catabolic process	17545563.	IMP	Process
GO:0002151	G-quadruplex RNA binding	-	ISS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004534	5'-3' exoribonuclease activity	26950371.	IMP	Function
GO:0004534	5'-3' exoribonuclease activity	-	ISS	Function
GO:0005515	protein binding	15687258.20584987.21876179.23125361.23756462.29033321.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016075	rRNA catabolic process	20368444.	IMP	Process
GO:0017148	negative regulation of translation	-	IEA	Process
GO:0030425	dendrite	-	IEA	Component
GO:0032211	negative regulation of telomere maintenance via telomerase	26950371.	IC	Process
GO:0033574	response to testosterone	-	IEA	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0045202	synapse	-	IEA	Component
GO:0051880	G-quadruplex DNA binding	-	ISS	Function
GO:0070034	telomerase RNA binding	26950371.	IC	Function
GO:0071028	nuclear mRNA surveillance	17545563.	IMP	Process
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process
GO:0071409	cellular response to cycloheximide	-	IEA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	ISS	Process
GO:1905795	cellular response to puromycin	-	IEA	Process