EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000114302 (Gene tree)
Gene ID: 5576
Gene Symbol: PRKAR2A
Alias: PRKAR2
Full Name: protein kinase cAMP-dependent type II regulatory subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 103,250 bases
Position: chr3:48,744,597-48,847,846
Accession: 9391
RBP type: non-canonical RBP
Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000419216	PRKAR2A-203	581	-	ENSP00000411432	114 (aa)	-	C9J830
ENST00000454963	PRKAR2A-206	1849	XM_011533942	ENSP00000394041	404 (aa)	XP_011532244	P13861
ENST00000438535	PRKAR2A-205	624	-	ENSP00000416438	99 (aa)	-	H7C4A9
ENST00000296446	PRKAR2A-202	3318	-	ENSP00000296446	382 (aa)	-	P13861
ENST00000457914	PRKAR2A-207	448	-	ENSP00000409239	92 (aa)	-	H7C330
ENST00000437821	PRKAR2A-204	627	-	ENSP00000400840	200 (aa)	-	H7C1L0
ENST00000265563	PRKAR2A-201	6471	XM_005265315	ENSP00000265563	404 (aa)	XP_005265372	P13861

Gene Model

Click here to download ENSG00000114302's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04910	Insulin signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000114302	rs13094900	3	48800299	?	General cognitive ability	29844566	z-score increase	5.441	EFO_0004337
ENSG00000114302	rs62261502	3	48779705	G	Heel bone mineral density	30598549	[0.04-0.054] unit decrease	0.0470703	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114302's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003091	renal water homeostasis	-	TAS	Process
GO:0004862	cAMP-dependent protein kinase inhibitor activity	21812984.	IDA	Function
GO:0005515	protein binding	9473338.11278869.11414803.12475942.16642035.17911601.20007971.22343722.22976297.24083380.25920809.26496610.27484798.	IPI	Function
GO:0005737	cytoplasm	21423175.	IDA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21423175.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005930	axoneme	12475942.	IDA	Component
GO:0005952	cAMP-dependent protein kinase complex	12475942.	IDA	Component
GO:0007596	blood coagulation	-	TAS	Process
GO:0008603	cAMP-dependent protein kinase regulator activity	21812984.	IDA	Function
GO:0008603	cAMP-dependent protein kinase regulator activity	9003463.	NAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019904	protein domain specific binding	25097019.	IPI	Function
GO:0019934	cGMP-mediated signaling	21873635.	IBA	Process
GO:0030552	cAMP binding	-	IEA	Function
GO:0031588	nucleotide-activated protein kinase complex	21812984.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	21423175.	IDA	Function
GO:0032991	protein-containing complex	25097019.	IDA	Component
GO:0034199	activation of protein kinase A activity	-	TAS	Process
GO:0034236	protein kinase A catalytic subunit binding	17911601.21812984.	IPI	Function
GO:0035556	intracellular signal transduction	2540040.	TAS	Process
GO:0044853	plasma membrane raft	17911601.	IDA	Component
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	21873635.	IBA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071377	cellular response to glucagon stimulus	-	TAS	Process
GO:0097546	ciliary base	-	TAS	Component
GO:2000480	negative regulation of cAMP-dependent protein kinase activity	21812984.	IDA	Process