EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000114353 (Gene tree)
Gene ID: 2771
Gene Symbol: GNAI2
Alias: GIP|GNAI2B
Full Name: G protein subunit alpha i2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 33,064 bases
Position: chr3:50,226,292-50,259,355
Accession: 4385
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000266027	GNAI2-201	2169	-	ENSP00000266027	303 (aa)	-	P04899
ENST00000446079	GNAI2-206	2086	-	ENSP00000406065	146 (aa)	-	F8WBG4
ENST00000492383	GNAI2-212	989	-	-	- (aa)	-	-
ENST00000468422	GNAI2-208	531	-	-	- (aa)	-	-
ENST00000490122	GNAI2-210	2445	-	-	- (aa)	-	-
ENST00000480090	GNAI2-209	284	-	-	- (aa)	-	-
ENST00000313601	GNAI2-202	2464	-	ENSP00000312999	355 (aa)	-	P04899
ENST00000491100	GNAI2-211	3886	-	-	- (aa)	-	-
ENST00000440628	GNAI2-204	1663	-	ENSP00000395736	303 (aa)	-	P04899
ENST00000441156	GNAI2-205	2168	-	ENSP00000394321	142 (aa)	-	F8WE78
ENST00000451956	GNAI2-207	1486	-	ENSP00000406369	318 (aa)	-	P04899
ENST00000422163	GNAI2-203	2407	-	ENSP00000406871	339 (aa)	-	P04899

Gene Model

Click here to download ENSG00000114353's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04360	Axon guidance	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04540	Gap junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04724	Glutamatergic synapse	KEGG
hsa04725	Cholinergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04727	GABAergic synapse	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04923	Regulation of lipolysis in adipocytes	KEGG
hsa04924	Renin secretion	KEGG
hsa04926	Relaxin signaling pathway	KEGG
hsa04928	Parathyroid hormone synthesis, secretion and action	KEGG
hsa04934	Cushing syndrome	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05012	Parkinson disease	KEGG
hsa05030	Cocaine addiction	KEGG
hsa05032	Morphine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05133	Pertussis	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000114353	rs2298952	3	50249521	A	Cognitive performance	30038396	[0.019-0.038] unit decrease	0.0283	EFO_0008354
ENSG00000114353	rs2097247	3	50253470	T	Feeling tense	29500382	z score increase	5.94	EFO_0009596
ENSG00000114353	rs181394846	3	50255960	C	Macrophage inflammatory protein 1b levels	27989323	[0.14-0.27] SD units decrease	0.2059	EFO_0008219
ENSG00000114353	rs62260798	3	50236846	T	Morning person	30696823		1.0527	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114353's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000114353	GNAI2	100	98.310	ENSMUSG00000032562	Gnai2	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001664	G protein-coupled receptor binding	21873635.	IBA	Function
GO:0001973	adenosine receptor signaling pathway	21873635.	IBA	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	16189514.16782902.18599439.23773523.25241761.25416956.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	17635935.	IDA	Component
GO:0005813	centrosome	17635935.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005834	heterotrimeric G-protein complex	21873635.	IBA	Component
GO:0005886	plasma membrane	17635935.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007165	signal transduction	7961880.9637720.	TAS	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	21873635.	IBA	Process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	-	IEA	Process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	21873635.	IBA	Process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007194	negative regulation of adenylate cyclase activity	9637720.	TAS	Process
GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	-	IEA	Process
GO:0007214	gamma-aminobutyric acid signaling pathway	21873635.	IBA	Process
GO:0007584	response to nutrient	8587610.	TAS	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	21079996.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030335	positive regulation of cell migration	-	IEA	Process
GO:0030425	dendrite	-	IEA	Component
GO:0030496	midbody	17635935.	IDA	Component
GO:0031683	G-protein beta/gamma-subunit complex binding	21873635.	IBA	Function
GO:0032930	positive regulation of superoxide anion generation	-	IEA	Process
GO:0033864	positive regulation of NAD(P)H oxidase activity	-	IEA	Process
GO:0035810	positive regulation of urine volume	-	IEA	Process
GO:0035815	positive regulation of renal sodium excretion	-	IEA	Process
GO:0044297	cell body	-	IEA	Component
GO:0045121	membrane raft	-	IEA	Component
GO:0045955	negative regulation of calcium ion-dependent exocytosis	-	IEA	Process
GO:0046628	positive regulation of insulin receptor signaling pathway	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050805	negative regulation of synaptic transmission	-	IEA	Process
GO:0051301	cell division	17635935.	IMP	Process
GO:0051924	regulation of calcium ion transport	-	IEA	Process
GO:0070062	extracellular exosome	12519789.19056867.19199708.20458337.	HDA	Component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	Process
GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	-	IEA	Process
GO:1903561	extracellular vesicle	24769233.	HDA	Component
GO:1903614	negative regulation of protein tyrosine phosphatase activity	-	IEA	Process
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IEA	Process
GO:2000179	positive regulation of neural precursor cell proliferation	-	IEA	Process
GO:2001234	negative regulation of apoptotic signaling pathway	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24423449	Suppression of GNAI2 message in ovarian cancer.	J Ovarian Res	2014 Jan 14	Raymond JR Jr	doi: 10.1186/1757-2215-7-6.
22936789	The essential role of Giα2 in prostate cancer cell migration.	Mol Cancer Res	2012 Oct	Zhong M	doi: 10.1158/1541-7786.MCR-12-0219
27811362	MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival.	Oncotarget	2016 Dec 6	Fu X	doi: 10.18632/oncotarget.13017.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	50257657	Missense_Mutation	novel	I345M	0.09
BLCA	chr3	50253084	Missense_Mutation	novel	D122H	0.4
BLCA	chr3	50256222	Silent	novel	Q165Q	0.15
BLCA	chr3	50253075	Missense_Mutation	rs150943193	V119M	0.41
BLCA	chr3	50252404	Missense_Mutation	novel	H57D	0.39
BRCA	chr3	50257511	Missense_Mutation	novel	Y297H	0.38
BRCA	chr3	50256768	Silent	rs781916903	I213I	0.15
BRCA	chr3	50236444	Missense_Mutation	NA	L37M	0.4
BRCA	chr3	50246954	Intron	novel		0.21
BRCA	chr3	50252240	Intron	novel		0.06
BRCA	chr3	50256835	Missense_Mutation	novel	A236S	0.1
BRCA	chr3	50252527	Missense_Mutation	NA	P98S	0.4
BRCA	chr3	50257630	Silent	novel	V336V	0.14
CESC	chr3	50258663	3'UTR	novel		0.47
CESC	chr3	50236236	5'UTR	novel		0.67
CESC	chr3	50251871	Intron	novel		0.17
CESC	chr3	50251479	Intron	novel		0.5
CESC	chr3	50259064	3'UTR	novel		0.38
CESC	chr3	50256202	Missense_Mutation	rs781807470	D159N	0.21
CESC	chr3	50258964	3'UTR	novel		0.37
COAD	chr3	50257500	Missense_Mutation	novel	G293E	0.3
COAD	chr3	50257588	Silent	rs377114196	T322T	0.42
COAD	chr3	50252439	Silent	NA	Q68Q	0.16
COAD	chr3	50252435	Missense_Mutation	rs781986131	R67Q	0.09
COAD	chr3	50256270	Silent	NA	K181K	0.2
COAD	chr3	50257677	Missense_Mutation	NA	C352Y	0.29
COAD	chr3	50257604	Missense_Mutation	novel	T328S	0.08
COAD	chr3	50252524	Missense_Mutation	rs782148570	D97N	0.39
ESCA	chr3	50258979	3'UTR	novel		0.29
ESCA	chr3	50256816	Silent	rs587657823	S229S	0.42
GBM	chr3	50257082	Missense_Mutation	novel	E290V	0.24
GBM	chr3	50257502	Missense_Mutation	novel	A294P	0.16
GBM	chr3	50257626	Missense_Mutation	novel	F335Y	0.28
HNSC	chr3	50256207	Silent	novel	L160L	0.13
HNSC	chr3	50252397	Splice_Region	novel	K54K	0.24
HNSC	chr3	50256276	Silent	novel	T183T	0.44
KIRC	chr3	50256823	Missense_Mutation	NA	D232Y	0.29
KIRC	chr3	50257057	In_Frame_Ins	novel	S282delinsIKR	0.1
KIRC	chr3	50257058	Missense_Mutation	NA	S282N	0.07
KIRC	chr3	50253029	Silent	rs781903414	D103D	0.11
KIRP	chr3	50257012	Missense_Mutation	novel	L267I	0.74
KIRP	chr3	50256848	Missense_Mutation	NA	E240A	0.41
LAML	chr3	50257575	Missense_Mutation	novel	K318M	0.1
LGG	chr3	50256276	Silent	novel	T183T	0.31
LGG	chr3	50256810	Silent	novel	A227A	0.2
LUAD	chr3	50251747	Intron	novel		0.29
LUSC	chr3	50252511	Missense_Mutation	novel	Q92H	0.33
LUSC	chr3	50257627	Silent	rs781851724	F335F	0.33
LUSC	chr3	50257716	Splice_Site	novel		0.28
LUSC	chr3	50252348	Intron	novel		0.12
OV	chr3	50253055	Missense_Mutation	novel	C112Y	0.07
OV	chr3	50258669	3'UTR	rs587711926		0.45
OV	chr3	50257030	Frame_Shift_Del	novel	*D273Pfs3**	0.15
OV	chr3	50251645	Intron	novel		0.07
OV	chr3	50253060	Missense_Mutation	rs368004918	A114T	0.18
PAAD	chr3	50253060	Missense_Mutation	rs368004918	A114T	0.15
PRAD	chr3	50252481	Missense_Mutation	NA	M82I	0.36
PRAD	chr3	50253106	Missense_Mutation	rs782279425	R129Q	0.3
READ	chr3	50252310	Intron	novel		0.35
READ	chr3	50256759	Missense_Mutation	NA	K210N	0.26
READ	chr3	50256966	Silent	rs781818717	F251F	0.25
SKCM	chr3	50252384	Intron	novel		0.52
SKCM	chr3	50252531	Missense_Mutation	novel	S99Y	0.17
SKCM	chr3	50256262	Missense_Mutation	rs137853226	R179C	0.28
SKCM	chr3	50256262	Missense_Mutation	rs137853226	R179C	0.36
SKCM	chr3	50257063	Silent	rs142945610	L284L	0.47
SKCM	chr3	50256262	Missense_Mutation	rs137853226	R179C	0.32
SKCM	chr3	50256261	Silent	novel	T178T	0.49
SKCM	chr3	50256262	Missense_Mutation	rs137853226	R179C	0.48
SKCM	chr3	50251667	Intron	novel		0.45
SKCM	chr3	50252528	Missense_Mutation	novel	P98L	0.37
SKCM	chr3	50252074	Intron	novel		0.15
SKCM	chr3	50256272	Missense_Mutation	NA	T182I	0.58
SKCM	chr3	50256273	Silent	novel	T182T	0.6
SKCM	chr3	50252091	Intron	novel		0.4
SKCM	chr3	50252529	Silent	NA	P98P	0.2
SKCM	chr3	50253122	Silent	rs781916310	D134D	0.11
SKCM	chr3	50252091	Intron	novel		0.31
SKCM	chr3	50256810	Silent	NA	A227A	0.46
SKCM	chr3	50256189	Splice_Region	novel		0.53
SKCM	chr3	50256272	Missense_Mutation	NA	T182I	0.44
STAD	chr3	50252447	Missense_Mutation	rs138213627	A71V	0.33
STAD	chr3	50256257	Missense_Mutation	rs782599019	R177Q	0.29
STAD	chr3	50252418	Silent	novel	Y61Y	0.43
STAD	chr3	50256784	Missense_Mutation	rs782631757	V219I	0.15
STAD	chr3	50256804	Silent	rs141703681	C225C	0.06
STAD	chr3	50256283	Missense_Mutation	NA	V186M	0.3
UCEC	chr3	50258760	3'UTR	novel		0.3
UCEC	chr3	50259210	3'UTR	novel		0.46
UCEC	chr3	50252163	Intron	novel		0.47
UCEC	chr3	50258828	3'UTR	novel		0.45
UCEC	chr3	50256222	Missense_Mutation	novel	Q165H	0.17
UCEC	chr3	50256740	Missense_Mutation	novel	G204D	0.34
UCEC	chr3	50252515	Missense_Mutation	rs183955200	D94N	0.48
UCEC	chr3	50256238	Missense_Mutation	NA	T171A	0.38
UCEC	chr3	50257645	Silent	rs147937896	T341T	0.29
UCEC	chr3	50258592	3'UTR	novel		0.19
UCEC	chr3	50252128	Silent	novel	I49I	0.24
UCEC	chr3	50252231	Intron	novel		0.41
UCEC	chr3	50253132	Nonsense_Mutation	NA	Q138*	0.27
UCEC	chr3	50258899	3'UTR	novel		0.4
UCEC	chr3	50258860	3'UTR	novel		0.35
UCEC	chr3	50252341	Intron	novel		0.4
UCEC	chr3	50253074	Silent	novel	G118G	0.52
UCEC	chr3	50257600	Silent	rs587605417	C326C	0.3
UCEC	chr3	50252342	Intron	novel		0.31
UCEC	chr3	50256211	Missense_Mutation	novel	R162C	0.38
UCEC	chr3	50256936	Splice_Site	novel	X242_splice	0.31
UCEC	chr3	50256937	Missense_Mutation	NA	N242H	0.5
UCEC	chr3	50258974	3'UTR	rs782202930		0.37
UCEC	chr3	50257601	Missense_Mutation	rs782786744	A327T	0.37
UCEC	chr3	50259210	3'UTR	novel		0.45
UCEC	chr3	50257646	Missense_Mutation	novel	D342N	0.44
UCEC	chr3	50251478	Intron	novel		0.29
UCEC	chr3	50257568	Missense_Mutation	novel	D316Y	0.36
UCEC	chr3	50256823	Missense_Mutation	NA	D232Y	0.43
UCEC	chr3	50252448	Silent	rs782465410	A71A	0.25
UCEC	chr3	50256840	Missense_Mutation	novel	E237D	0.26
UCEC	chr3	50256966	Silent	rs781818717	F251F	0.17
UCEC	chr3	50251662	Intron	novel		0.49
UCEC	chr3	50253140	Frame_Shift_Ins	novel	*G142Wfs26**	0.43
UCEC	chr3	50251662	Intron	novel		0.34
UCS	chr3	50253150	Frame_Shift_Del	novel	*S144Qfs14**	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2824	4.5968e-31
CHOL	DEL	0.7778	0.016387
DLBC	DEL	0.1042	0.18166
GBM	DEL	0.0763	0.056565
KIRP	AMP	0.2326	0.14801
LGG	DEL	0.0799	0.00089193
LUAD	DEL	0.3391	0.0021265
PAAD	DEL	0.1902	0.030662
SARC	DEL	0.2218	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.12	0.23596
TGCT	DEL	0.1867	0.08422
THCA	DEL	0.006	0.221
THYM	DEL	0.0732	0.037527
UCS	DEL	0.4643	0.19877
UVM	DEL	0.5375	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.02	Kaplan-Meier Survival Analysis
SKCM	0.0012	Kaplan-Meier Survival Analysis
LUSC	0.023	Kaplan-Meier Survival Analysis
BRCA	0.00016	Kaplan-Meier Survival Analysis
ESCA	0.034	Kaplan-Meier Survival Analysis
TGCT	0.047	Kaplan-Meier Survival Analysis
PAAD	0.028	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
READ	0.019	Kaplan-Meier Survival Analysis
LAML	0.0084	Kaplan-Meier Survival Analysis
UCEC	0.031	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis
LGG	0.0046	Kaplan-Meier Survival Analysis
CHOL	0.042	Kaplan-Meier Survival Analysis
UVM	0.0052	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742