EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115091 (Gene tree)
Gene ID: 10096
Gene Symbol: ACTR3
Alias: ARP3
Full Name: actin related protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 72,663 bases
Position: chr2:113,889,934-113,962,596
Accession: 170
RBP type: non-canonical RBP
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24630719	Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.	Cell	2014 Mar 13	Hadziselimovic N	doi: 10.1016/j.cell.2014.01.054.
20004659	Cortactin is implicated in murine zygotic development.	Exp Cell Res	2010 Mar 10	Yu D	doi: 10.1016/j.yexcr.2009.11.018

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489779	ACTR3-207	545	-	-	- (aa)	-	-
ENST00000263238	ACTR3-201	6718	-	ENSP00000263238	418 (aa)	-	P61158
ENST00000484165	ACTR3-206	676	-	-	- (aa)	-	-
ENST00000535589	ACTR3-208	1530	-	ENSP00000444987	367 (aa)	-	B4DXW1
ENST00000443297	ACTR3-203	566	-	ENSP00000403125	84 (aa)	-	F8WDR7
ENST00000478928	ACTR3-205	5965	-	-	- (aa)	-	-
ENST00000446821	ACTR3-204	818	-	ENSP00000394213	41 (aa)	-	F8WE84
ENST00000415792	ACTR3-202	676	-	ENSP00000407912	34 (aa)	-	F8WEW2

Gene Model

Click here to download ENSG00000115091's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115091	Cholesterol, HDL	1.81918986805751E-5	17903299
ENSG00000115091	Compliance	8.848e-005	-
ENSG00000115091	Blood Pressure	4.8700000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115091's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115091	ACTR3	97	84.848	FBgn0262716	Arp3	100	80.622	Drosophila_melanogaster
ENSG00000115091	ACTR3	100	100.000	ENSMUSG00000026341	Actr3	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005200	structural constituent of cytoskeleton	11741539.	IDA	Function
GO:0005515	protein binding	20195357.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16767080.17220302.	IDA	Component
GO:0005737	cytoplasm	17220302.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005885	Arp2/3 protein complex	11741539.17220302.	IDA	Component
GO:0005885	Arp2/3 protein complex	9230079.	TAS	Component
GO:0005903	brush border	-	IEA	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007163	establishment or maintenance of cell polarity	-	IEA	Process
GO:0008356	asymmetric cell division	-	IEA	Process
GO:0015629	actin cytoskeleton	9230079.	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016344	meiotic chromosome movement towards spindle pole	-	IEA	Process
GO:0030027	lamellipodium	9230079.	IDA	Component
GO:0033206	meiotic cytokinesis	-	IEA	Process
GO:0034314	Arp2/3 complex-mediated actin nucleation	11741539.17220302.	IDA	Process
GO:0035861	site of double-strand break	-	ISS	Component
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	17220302.	IDA	Process
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0051015	actin filament binding	11741539.	IDA	Function
GO:0051653	spindle localization	-	IEA	Process
GO:0060271	cilium assembly	20393563.	IMP	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0070358	actin polymerization-dependent cell motility	9230079.	TAS	Process
GO:0071346	cellular response to interferon-gamma	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23320827	CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder.	Cancer Invest	2013 Feb	Yang ZL	doi: 10.3109/07357907.2012.756113
15279900	Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.	Cancer Lett	2004 Aug 30	Kaneda A	-
28170369	LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction.	Med Sci Monit	2017 Feb 7	Liu Y	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	113955632	Missense_Mutation	rs375902041	I363V	0.09
BLCA	chr2	113916973	Missense_Mutation	novel	D64Y	0.74
BRCA	chr2	113934285	Missense_Mutation	NA	L147V	0.13
BRCA	chr2	113942183	Splice_Region	novel		0.11
BRCA	chr2	113942357	Nonsense_Mutation	NA	E286*	0.13
CESC	chr2	113934341	Silent	novel	G165G	0.3
CESC	chr2	113951769	Missense_Mutation	novel	R334H	0.37
COAD	chr2	113942342	Missense_Mutation	NA	I281L	0.37
COAD	chr2	113942309	Missense_Mutation	rs760969306	D270N	0.1
COAD	chr2	113890235	5'UTR	novel		0.37
COAD	chr2	113951767	Silent	novel	R333R	0.33
COAD	chr2	113951543	Missense_Mutation	NA	P308H	0.3
COAD	chr2	113957589	3'UTR	novel		0.15
COAD	chr2	113940075	Missense_Mutation	NA	Q219H	0.17
COAD	chr2	113939979	Silent	NA	G187G	0.11
ESCA	chr2	113958410	3'UTR	novel		0.42
ESCA	chr2	113934315	Missense_Mutation	novel	Q157E	0.12
GBM	chr2	113934338	Silent	rs371867071	T164T	0.06
GBM	chr2	113913203	Nonsense_Mutation	novel	E26*	0.52
GBM	chr2	113927438	Missense_Mutation	novel	D107N	0.29
GBM	chr2	113934329	Silent	novel	R161R	0.3
HNSC	chr2	113957357	Splice_Region	novel		0.15
KIRC	chr2	113927447	Nonsense_Mutation	novel	F110*	0.05
KIRP	chr2	113913211	Missense_Mutation	novel	Q28H	0.34
LGG	chr2	113942278	Silent	NA	I259I	0.42
LIHC	chr2	113934375	Missense_Mutation	NA	V177F	0.2
LUAD	chr2	113942248	Silent	novel	G249G	0.07
LUAD	chr2	113927450	Missense_Mutation	NA	L111V	0.19
LUAD	chr2	113934316	Missense_Mutation	novel	Q157P	0.1
LUAD	chr2	113957534	3'UTR	novel		0.29
LUAD	chr2	113951547	Silent	NA	I309I	0.1
LUSC	chr2	113957442	Missense_Mutation	novel	G415E	0.18
LUSC	chr2	113931375	Silent	NA	P137P	0.45
LUSC	chr2	113942325	Missense_Mutation	novel	R275I	0.21
LUSC	chr2	113942210	Missense_Mutation	novel	D237Y	0.33
LUSC	chr2	113942199	Missense_Mutation	novel	Y233F	0.39
LUSC	chr2	113927361	Missense_Mutation	novel	G81V	0.09
OV	chr2	113934311	Silent	novel	S155S	0.03
PRAD	chr2	113951511	Silent	novel	S297S	0.44
READ	chr2	113942189	Missense_Mutation	rs200071930	R230C	0.26
READ	chr2	113957389	Missense_Mutation	novel	K397N	0.5
READ	chr2	113940000	Silent	NA	P194P	0.45
READ	chr2	113955625	Splice_Region	NA	P360P	0.37
SKCM	chr2	113913220	Silent	NA	I31I	0.26
SKCM	chr2	113942183	Splice_Region	novel		0.25
SKCM	chr2	113934307	Missense_Mutation	NA	T154I	0.18
STAD	chr2	113942214	Missense_Mutation	NA	L238S	0.34
STAD	chr2	113957497	3'UTR	novel		0.34
STAD	chr2	113942222	Nonsense_Mutation	NA	E241*	0.32
STAD	chr2	113913200	Missense_Mutation	novel	T25A	0.06
STAD	chr2	113957572	3'UTR	novel		0.57
THCA	chr2	113957534	3'UTR	novel		0.13
UCEC	chr2	113942222	Nonsense_Mutation	NA	E241*	0.37
UCEC	chr2	113958221	3'UTR	novel		0.41
UCEC	chr2	113942294	Missense_Mutation	novel	K265E	0.28
UCEC	chr2	113951780	Missense_Mutation	novel	D338Y	0.25
UCEC	chr2	113934329	Silent	novel	R161R	0.24
UCEC	chr2	113942222	Nonsense_Mutation	NA	E241*	0.16
UCEC	chr2	113913203	Nonsense_Mutation	novel	E26*	0.04
UCEC	chr2	113942210	Missense_Mutation	novel	D237Y	0.15
UCEC	chr2	113958477	3'UTR	novel		0.41
UCEC	chr2	113955672	Missense_Mutation	novel	A376E	0.46
UCEC	chr2	113916885	Splice_Region	rs201769858	C34C	0.16
UCEC	chr2	113916955	Missense_Mutation	novel	L58I	0.3
UCEC	chr2	113958456	3'UTR	novel		0.4
UCEC	chr2	113940040	Silent	rs779420771	L208L	0.3
UCEC	chr2	113931332	Missense_Mutation	novel	R123M	0.46
UCEC	chr2	113957565	3'UTR	novel		0.09
UCEC	chr2	113942309	Missense_Mutation	rs760969306	D270N	0.09
UCEC	chr2	113957771	3'UTR	novel		0.48
UCEC	chr2	113958157	3'UTR	novel		0.38
UCEC	chr2	113958334	3'UTR	novel		0.21
UCEC	chr2	113957871	3'UTR	novel		0.09
UCEC	chr2	113958480	3'UTR	novel		0.53
UCEC	chr2	113957823	3'UTR	novel		0.33
UCEC	chr2	113958475	3'UTR	novel		0.24
UCEC	chr2	113958221	3'UTR	novel		0.27
UCEC	chr2	113942210	Missense_Mutation	novel	D237Y	0.54
UCEC	chr2	113957452	Silent	rs779301166	S418S	0.5
UCEC	chr2	113957633	3'UTR	rs189795162		0.4
UCEC	chr2	113942293	Missense_Mutation	novel	K264N	0.17
UCEC	chr2	113958477	3'UTR	novel		0.24
UCEC	chr2	113890154	5'UTR	novel		0.5
UCEC	chr2	113957476	3'UTR	novel		0.27
UCEC	chr2	113957916	3'UTR	novel		0.23
UCEC	chr2	113934343	Missense_Mutation	rs375240866	T166M	0.31
UCEC	chr2	113940007	Nonsense_Mutation	novel	G197*	0.1
UCEC	chr2	113942344	Frame_Shift_Ins	novel	*H284Sfs6**	0.26
UCEC	chr2	113958480	3'UTR	novel		0.14
UCEC	chr2	113890242	5'UTR	novel		0.29
UCEC	chr2	113934355	Missense_Mutation	novel	S170N	0.24
UCS	chr2	113934339	Missense_Mutation	novel	G165S	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1778	0.15279
PAAD	DEL	0.038	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.024	Kaplan-Meier Survival Analysis
MESO	0.0024	Kaplan-Meier Survival Analysis
ACC	0.00037	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.00021	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
KIRP	0.0019	Kaplan-Meier Survival Analysis
COAD	0.027	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
CESC	0.00013	Kaplan-Meier Survival Analysis
KICH	0.0047	Kaplan-Meier Survival Analysis
UCEC	0.00074	Kaplan-Meier Survival Analysis
LIHC	0.0016	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0041	Kaplan-Meier Survival Analysis
UVM	0.0015	Kaplan-Meier Survival Analysis
OV	0.031	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742