EuRBPDB

Description

Ensembl ID: ENSG00000115183 (Gene tree)
Gene ID: 85461
Gene Symbol: TANC1
Alias: KIAA1728|ROLSB
Full Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 264,030 bases
Position: chr2:158,968,634-159,232,663
Accession: 29364
RBP type: non-canonical RBP
Summary: (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. Diseases associated with TANC1 include Space Motion Sickness and Motion Sickness. An important paralog of this gene is TANC2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464096	TANC1-202	1736	-	-	- (aa)	-	-
ENST00000465963	TANC1-203	2141	-	-	- (aa)	-	-
ENST00000263635	TANC1-201	7470	XM_005246918	ENSP00000263635	1861 (aa)	XP_005246975	Q9C0D5
ENST00000470074	TANC1-204	4351	-	-	- (aa)	-	-
ENST00000496406	TANC1-205	7586	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115183	Cholesterol, HDL	1.59494955062006E-8	17903299
ENSG00000115183	Cholesterol, HDL	1.11848186075955E-7	17903299
ENSG00000115183	Carotid Arteries	1.51492089682447E-6	17903303
ENSG00000115183	Echocardiography	1.20595178081605E-6	17903301
ENSG00000115183	Echocardiography	1.3781352471028E-6	17903301
ENSG00000115183	Echocardiography	1.42263070701378E-5	17903301
ENSG00000115183	Bone Density	2.00708026825075E-7	17903296
ENSG00000115183	Bone Density	3.97074671739406E-9	17903296
ENSG00000115183	Bone Density	6.49981370854495E-7	17903296
ENSG00000115183	Bone Density	2.34240279967447E-8	17903296
ENSG00000115183	Bone Density	9.55301939713069E-8	17903296
ENSG00000115183	Waist Circumference	3.2610000E-005	-
ENSG00000115183	Coronary Artery Disease	7.3720000E-005	-
ENSG00000115183	Platelet Function Tests	1.4227100E-005	-
ENSG00000115183	Child Development Disorders, Pervasive	2.0000000E-005	-
ENSG00000115183	Child Development Disorders, Pervasive	2.4000000E-005	-
ENSG00000115183	Death, Sudden, Cardiac	1E-6	21658281
ENSG00000115183	Prostatic Neoplasms	5E-11	24974847
ENSG00000115183	Electromagnetic Radiation	5E-11	24974847
ENSG00000115183	Heart Rate	7E-7	27798624
ENSG00000115183	Sleep	3E-7	27126917

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115183	rs17494056	2	159196220	C	Resting heart rate	27798624	[0.11-0.26] unit decrease	0.1844	EFO_0004351
ENSG00000115183	rs111640264	2	159207648	A	Night sleep phenotypes	27126917	[0.33-0.73] unit decrease	0.5271	EFO_0007827
ENSG00000115183	rs7582141	2	159042977	T	Response to radiotherapy in prostate cancer (toxicity)	24974847	[NR] unit increase	0.37	GO_0009314\|EFO_0001663
ENSG00000115183	rs34588551	2	159097663	C	Heel bone mineral density	28869591	[0.015-0.035] unit decrease	0.0248973	EFO_0009270
ENSG00000115183	rs34588551	2	159097663	C	Heel bone mineral density	28869591	[0.014-0.027] unit decrease	0.0205898	EFO_0009270
ENSG00000115183	rs890622	2	159108877	C	Nicotine dependence	28440896	[0.041-0.119] unit decrease	0.08	EFO_0003768
ENSG00000115183	rs13022357	2	159213245	?	Sudden cardiac arrest	21658281	[1.38-2.14]	1.72	EFO_0004278
ENSG00000115183	rs34588551	2	159097663	?	Heel bone mineral density	30048462	[0.02-0.028] unit decrease	0.023993	EFO_0009270
ENSG00000115183	rs2069035	2	159163999	?	Heel bone mineral density	30048462	[0.021-0.03] unit decrease	0.0255014	EFO_0009270
ENSG00000115183	rs34324915	2	159126695	A	Heel bone mineral density	30598549	[0.017-0.025] unit decrease	0.0211363	EFO_0009270
ENSG00000115183	rs67674876	2	159116592	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	30126976.	IPI	Function
GO:0007520	myoblast fusion	-	IEA	Process
GO:0008542	visual learning	-	IEA	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043679	axon terminus	-	IEA	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0097062	dendritic spine maintenance	-	IEA	Process