EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact

  • Description
  • RBDs
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115211 (Gene tree)
Gene ID
8890
Gene Symbol
EIF2B4
Alias
EIF2Bdelta|EIF-2B|DKFZP586J0119|EIF2B
Full Name
eukaryotic translation initiation factor 2B subunit delta
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
6,135 bases
Position
chr2:27,364,352-27,370,486
Accession
3260
RBP type
canonical RBP
Summary
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000477710IF-2BPF01008.175.7e-9011
ENSP00000394397IF-2BPF01008.175.9e-9011
ENSP00000233552IF-2BPF01008.175.9e-9011
ENSP00000394869IF-2BPF01008.176.6e-9011
ENSP00000429323IF-2BPF01008.176.6e-9011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000622434EIF2B4-2121771-ENSP00000479991228 (aa)-A0A087WW69
ENST00000445933EIF2B4-2051608-ENSP00000394397522 (aa)-Q9UI10
ENST00000478311EIF2B4-209607--- (aa)--
ENST00000417567EIF2B4-203761-ENSP00000406631194 (aa)-H7C2L8
ENST00000493344EIF2B4-2101949XM_011533147ENSP00000429323544 (aa)XP_011531449E7ERK9
ENST00000418146EIF2B4-204742-ENSP0000040795612 (aa)-F8WEV6
ENST00000616081EIF2B4-2111754-ENSP00000477710520 (aa)-A0A087WTA5
ENST00000475582EIF2B4-2084293--- (aa)--
ENST00000451130EIF2B4-2061633XM_006712132ENSP00000394869543 (aa)XP_006712195Q9UI10
ENST00000347454EIF2B4-2011792-ENSP00000233552523 (aa)-Q9UI10
ENST00000405940EIF2B4-2021570-ENSP00000384375235 (aa)-F8W8L6
ENST00000462749EIF2B4-2071089--- (aa)--
Gene Model
Click here to download ENSG00000115211's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115211Insulin-Like Growth Factor I1.5840000E-00627329260
ENSG00000115211Immunoglobulins4E-623382691
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000115211rs1058065227364857GIgG glycosylation23382691[0.31-0.77] unit increase0.54EFO_0005193
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115211's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115211EIF2B49563.532ENSAPOG00000019798eif2b49563.724Acanthochromis_polyacanthus
ENSG00000115211EIF2B410091.031ENSAMEG00000001525EIF2B410091.031Ailuropoda_melanoleuca
ENSG00000115211EIF2B49560.976ENSACIG00000003490eif2b49961.914Amphilophus_citrinellus
ENSG00000115211EIF2B47972.258ENSAOCG00000024037eif2b48268.397Amphiprion_ocellaris
ENSG00000115211EIF2B49561.524ENSAPEG00000002245eif2b48168.397Amphiprion_percula
ENSG00000115211EIF2B49565.051ENSATEG00000005544eif2b49864.444Anabas_testudineus
ENSG00000115211EIF2B48471.005ENSAPLG00000006467EIF2B49571.005Anas_platyrhynchos
ENSG00000115211EIF2B48465.760ENSACAG00000015672EIF2B49965.760Anolis_carolinensis
ENSG00000115211EIF2B410096.768ENSANAG00000029808EIF2B410096.768Aotus_nancymaae
ENSG00000115211EIF2B49861.152ENSACLG00000012164eif2b49960.478Astatotilapia_calliptera
ENSG00000115211EIF2B49561.101ENSAMXG00000019282eif2b49961.670Astyanax_mexicanus
ENSG00000115211EIF2B410091.412ENSBTAG00000019510EIF2B410091.412Bos_taurus
ENSG00000115211EIF2B410096.578ENSCJAG00000001028EIF2B410096.578Callithrix_jacchus
ENSG00000115211EIF2B410092.190ENSCAFG00000004888EIF2B410092.190Canis_familiaris
ENSG00000115211EIF2B410092.190ENSCAFG00020024261EIF2B410092.190Canis_lupus_dingo
ENSG00000115211EIF2B410089.908ENSCHIG00000025344EIF2B410089.908Capra_hircus
ENSG00000115211EIF2B49978.958ENSTSYG00000001021EIF2B49879.423Carlito_syrichta
ENSG00000115211EIF2B49081.064ENSCAPG00000013775EIF2B410081.064Cavia_aperea
ENSG00000115211EIF2B410088.952ENSCPOG00000007756EIF2B410088.952Cavia_porcellus
ENSG00000115211EIF2B410095.810ENSCCAG00000030083EIF2B410095.810Cebus_capucinus
ENSG00000115211EIF2B410098.662ENSCATG00000007827EIF2B410098.662Cercocebus_atys
ENSG00000115211EIF2B410091.412ENSCLAG00000006807EIF2B410091.412Chinchilla_lanigera
ENSG00000115211EIF2B410098.662ENSCSAG00000009830EIF2B410098.662Chlorocebus_sabaeus
ENSG00000115211EIF2B48468.506ENSCPBG00000018751EIF2B49868.506Chrysemys_picta_bellii
ENSG00000115211EIF2B49248.765ENSCING00000014451-9051.620Ciona_intestinalis
ENSG00000115211EIF2B48352.164ENSCSAVG00000007311-9152.164Ciona_savignyi
ENSG00000115211EIF2B410098.470ENSCANG00000028972EIF2B410098.470Colobus_angolensis_palliatus
ENSG00000115211EIF2B410089.885ENSCGRG00001016291Eif2b410089.885Cricetulus_griseus_chok1gshd
ENSG00000115211EIF2B410089.885ENSCGRG00000013057Eif2b410089.885Cricetulus_griseus_crigri
ENSG00000115211EIF2B49860.714ENSCSEG00000013734eif2b49862.548Cynoglossus_semilaevis
ENSG00000115211EIF2B48468.707ENSCVAG00000023159eif2b49963.035Cyprinodon_variegatus
ENSG00000115211EIF2B49563.477ENSDARG00000014004eif2b410062.051Danio_rerio
ENSG00000115211EIF2B410090.440ENSDNOG00000017797EIF2B410090.440Dasypus_novemcinctus
ENSG00000115211EIF2B410091.810ENSDORG00000006779Eif2b410091.810Dipodomys_ordii
ENSG00000115211EIF2B48147.113FBgn0034858eIF2Bdelta7047.113Drosophila_melanogaster
ENSG00000115211EIF2B410089.122ENSETEG00000003035EIF2B410089.122Echinops_telfairi
ENSG00000115211EIF2B48257.812ENSEBUG00000008859eif2b48457.812Eptatretus_burgeri
ENSG00000115211EIF2B410091.927ENSEASG00005009222EIF2B410091.927Equus_asinus_asinus
ENSG00000115211EIF2B47585.657ENSEEUG00000003530EIF2B47485.657Erinaceus_europaeus
ENSG00000115211EIF2B47972.258ENSELUG00000005290eif2b49067.500Esox_lucius
ENSG00000115211EIF2B410091.031ENSFCAG00000015153EIF2B410091.031Felis_catus
ENSG00000115211EIF2B48470.252ENSFALG00000011165EIF2B49470.252Ficedula_albicollis
ENSG00000115211EIF2B410091.794ENSFDAG00000020829EIF2B410091.794Fukomys_damarensis
ENSG00000115211EIF2B48369.374ENSFHEG00000019524eif2b49563.443Fundulus_heteroclitus
ENSG00000115211EIF2B48369.355ENSGMOG00000013084eif2b48168.694Gadus_morhua
ENSG00000115211EIF2B46372.644ENSGALG00000033575EIF2B49972.644Gallus_gallus
ENSG00000115211EIF2B49564.648ENSGAFG00000003304eif2b49364.648Gambusia_affinis
ENSG00000115211EIF2B48368.966ENSGACG00000010680eif2b49662.405Gasterosteus_aculeatus
ENSG00000115211EIF2B410099.809ENSGGOG00000010979EIF2B410099.809Gorilla_gorilla
ENSG00000115211EIF2B49562.572ENSHBUG00000012690eif2b49961.495Haplochromis_burtoni
ENSG00000115211EIF2B410090.095ENSHGLG00000009335EIF2B410090.095Heterocephalus_glaber_female
ENSG00000115211EIF2B410090.095ENSHGLG00100005657EIF2B410090.095Heterocephalus_glaber_male
ENSG00000115211EIF2B49563.147ENSHCOG00000006727eif2b49961.923Hippocampus_comes
ENSG00000115211EIF2B49564.522ENSIPUG00000016608eif2b49664.660Ictalurus_punctatus
ENSG00000115211EIF2B410092.366ENSSTOG00000011369EIF2B410092.366Ictidomys_tridecemlineatus
ENSG00000115211EIF2B410089.695ENSJJAG00000016213Eif2b410089.695Jaculus_jaculus
ENSG00000115211EIF2B49562.500ENSKMAG00000013298eif2b49662.956Kryptolebias_marmoratus
ENSG00000115211EIF2B49562.162ENSLBEG00000001764eif2b49663.006Labrus_bergylta
ENSG00000115211EIF2B49550.741ENSLACG00000000493EIF2B48355.134Latimeria_chalumnae
ENSG00000115211EIF2B49863.346ENSLOCG00000016732eif2b49863.346Lepisosteus_oculatus
ENSG00000115211EIF2B410090.458ENSLAFG00000005588EIF2B410090.458Loxodonta_africana
ENSG00000115211EIF2B410098.662ENSMFAG00000044359EIF2B410098.662Macaca_fascicularis
ENSG00000115211EIF2B410098.470ENSMMUG00000008287EIF2B410098.470Macaca_mulatta
ENSG00000115211EIF2B410098.470ENSMNEG00000037675EIF2B410098.470Macaca_nemestrina
ENSG00000115211EIF2B410098.470ENSMLEG00000005358EIF2B410098.470Mandrillus_leucophaeus
ENSG00000115211EIF2B49861.194ENSMAMG00000017128eif2b49962.873Mastacembelus_armatus
ENSG00000115211EIF2B49562.572ENSMZEG00005016074eif2b49961.495Maylandia_zebra
ENSG00000115211EIF2B48470.548ENSMGAG00000014076EIF2B410070.548Meleagris_gallopavo
ENSG00000115211EIF2B410089.560ENSMAUG00000010426Eif2b410089.560Mesocricetus_auratus
ENSG00000115211EIF2B410093.702ENSMICG00000015857EIF2B410093.702Microcebus_murinus
ENSG00000115211EIF2B410088.168ENSMOCG00000013193Eif2b410088.168Microtus_ochrogaster
ENSG00000115211EIF2B48467.946ENSMMOG00000015638eif2b48867.946Mola_mola
ENSG00000115211EIF2B49980.000ENSMODG00000015669EIF2B49980.306Monodelphis_domestica
ENSG00000115211EIF2B49858.392ENSMALG00000003249eif2b49959.123Monopterus_albus
ENSG00000115211EIF2B410087.023MGP_CAROLIEiJ_G0027083Eif2b410095.364Mus_caroli
ENSG00000115211EIF2B410087.595ENSMUSG00000029145Eif2b49994.156Mus_musculus
ENSG00000115211EIF2B49982.533MGP_PahariEiJ_G0029298-9283.292Mus_pahari
ENSG00000115211EIF2B410087.595MGP_SPRETEiJ_G0028078Eif2b410094.156Mus_spretus
ENSG00000115211EIF2B410091.587ENSMPUG00000009756EIF2B410091.587Mustela_putorius_furo
ENSG00000115211EIF2B410088.359ENSMLUG00000001360EIF2B410087.786Myotis_lucifugus
ENSG00000115211EIF2B410089.885ENSNGAG00000008465Eif2b410089.885Nannospalax_galili
ENSG00000115211EIF2B49562.764ENSNBRG00000019417eif2b49962.115Neolamprologus_brichardi
ENSG00000115211EIF2B49999.119ENSNLEG00000003362EIF2B410092.545Nomascus_leucogenys
ENSG00000115211EIF2B49581.563ENSMEUG00000001480EIF2B410081.563Notamacropus_eugenii
ENSG00000115211EIF2B410078.476ENSOPRG00000010788EIF2B410078.476Ochotona_princeps
ENSG00000115211EIF2B48389.145ENSODEG00000012702-9389.145Octodon_degus
ENSG00000115211EIF2B49563.410ENSONIG00000015313eif2b49962.313Oreochromis_niloticus
ENSG00000115211EIF2B410086.949ENSOCUG00000017076EIF2B410086.949Oryctolagus_cuniculus
ENSG00000115211EIF2B49563.743ENSORLG00000016283eif2b49962.289Oryzias_latipes
ENSG00000115211EIF2B49564.327ENSORLG00020004784eif2b49962.852Oryzias_latipes_hni
ENSG00000115211EIF2B49564.133ENSORLG00015022950eif2b49962.664Oryzias_latipes_hsok
ENSG00000115211EIF2B49564.717ENSOMEG00000015664eif2b49664.717Oryzias_melastigma
ENSG00000115211EIF2B410092.220ENSOGAG00000012346EIF2B410092.220Otolemur_garnettii
ENSG00000115211EIF2B410092.366ENSOARG00000019282EIF2B49392.366Ovis_aries
ENSG00000115211EIF2B410099.618ENSPPAG00000026873EIF2B410099.618Pan_paniscus
ENSG00000115211EIF2B410091.221ENSPPRG00000001067EIF2B410091.221Panthera_pardus
ENSG00000115211EIF2B410090.649ENSPTIG00000009354EIF2B410090.649Panthera_tigris_altaica
ENSG00000115211EIF2B410099.426ENSPTRG00000011765EIF2B410099.426Pan_troglodytes
ENSG00000115211EIF2B410098.662ENSPANG00000016996EIF2B410098.662Papio_anubis
ENSG00000115211EIF2B49564.764ENSPKIG00000004903eif2b49464.764Paramormyrops_kingsleyae
ENSG00000115211EIF2B49160.455ENSPSIG00000004201EIF2B410061.355Pelodiscus_sinensis
ENSG00000115211EIF2B410088.000ENSPEMG00000012796Eif2b410088.000Peromyscus_maniculatus_bairdii
ENSG00000115211EIF2B47960.000ENSPMAG00000008657eif2b49962.982Petromyzon_marinus
ENSG00000115211EIF2B49981.538ENSPCIG00000013400EIF2B49982.766Phascolarctos_cinereus
ENSG00000115211EIF2B49563.514ENSPFOG00000009151eif2b48268.934Poecilia_formosa
ENSG00000115211EIF2B49563.514ENSPLAG00000020127eif2b48268.934Poecilia_latipinna
ENSG00000115211EIF2B49562.984ENSPMEG00000017928eif2b49663.760Poecilia_mexicana
ENSG00000115211EIF2B49562.451ENSPREG00000019206eif2b49663.443Poecilia_reticulata
ENSG00000115211EIF2B49998.678ENSPPYG00000012550EIF2B410092.586Pongo_abelii
ENSG00000115211EIF2B410090.840ENSPCAG00000000729EIF2B410090.840Procavia_capensis
ENSG00000115211EIF2B410093.511ENSPCOG00000020804EIF2B410093.511Propithecus_coquereli
ENSG00000115211EIF2B410092.748ENSPVAG00000015177EIF2B410092.748Pteropus_vampyrus
ENSG00000115211EIF2B49562.572ENSPNYG00000007166eif2b49561.923Pundamilia_nyererei
ENSG00000115211EIF2B49563.477ENSPNAG00000005962eif2b49862.523Pygocentrus_nattereri
ENSG00000115211EIF2B410085.878ENSRNOG00000005301Eif2b410085.878Rattus_norvegicus
ENSG00000115211EIF2B410098.662ENSRBIG00000039637EIF2B410098.662Rhinopithecus_bieti
ENSG00000115211EIF2B410098.662ENSRROG00000043825EIF2B410098.662Rhinopithecus_roxellana
ENSG00000115211EIF2B46136.870YGR083CGCD25836.870Saccharomyces_cerevisiae
ENSG00000115211EIF2B410096.198ENSSBOG00000030402EIF2B410096.198Saimiri_boliviensis_boliviensis
ENSG00000115211EIF2B49980.192ENSSHAG00000013540EIF2B49980.688Sarcophilus_harrisii
ENSG00000115211EIF2B410061.792ENSSFOG00015019463eif2b48860.141Scleropages_formosus
ENSG00000115211EIF2B49561.877ENSSMAG00000011712eif2b49662.500Scophthalmus_maximus
ENSG00000115211EIF2B49564.202ENSSDUG00000014451eif2b49863.447Seriola_dumerili
ENSG00000115211EIF2B49564.202ENSSLDG00000013386eif2b49863.447Seriola_lalandi_dorsalis
ENSG00000115211EIF2B410083.015ENSSARG00000006628EIF2B410082.443Sorex_araneus
ENSG00000115211EIF2B49563.127ENSSPAG00000012973eif2b49663.443Stegastes_partitus
ENSG00000115211EIF2B410087.890ENSSSCG00000023140EIF2B410088.778Sus_scrofa
ENSG00000115211EIF2B49568.008ENSTGUG00000014831EIF2B410068.675Taeniopygia_guttata
ENSG00000115211EIF2B49562.695ENSTRUG00000007639eif2b49663.672Takifugu_rubripes
ENSG00000115211EIF2B48369.655ENSTNIG00000016343eif2b49169.655Tetraodon_nigroviridis
ENSG00000115211EIF2B47990.968ENSTBEG00000012929EIF2B410089.297Tupaia_belangeri
ENSG00000115211EIF2B410091.794ENSTTRG00000012518EIF2B410091.794Tursiops_truncatus
ENSG00000115211EIF2B410090.840ENSUAMG00000007042EIF2B410090.840Ursus_americanus
ENSG00000115211EIF2B410090.840ENSUMAG00000020349EIF2B410090.840Ursus_maritimus
ENSG00000115211EIF2B410091.392ENSVVUG00000016505EIF2B410091.392Vulpes_vulpes
ENSG00000115211EIF2B49855.249ENSXETG00000020959eif2b47961.894Xenopus_tropicalis
ENSG00000115211EIF2B48967.024ENSXCOG00000005204eif2b49567.024Xiphophorus_couchianus
ENSG00000115211EIF2B49563.953ENSXMAG00000004149eif2b49664.202Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001541ovarian follicle development15507143.IMPProcess
GO:0003743translation initiation factor activity16289705.IDAFunction
GO:0005085guanyl-nucleotide exchange factor activity11323413.IDAFunction
GO:0005085guanyl-nucleotide exchange factor activity15054402.IMPFunction
GO:0005515protein binding15060152.25416956.25910212.28169297.IPIFunction
GO:0005737cytoplasm11323413.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005851eukaryotic translation initiation factor 2B complex11323413.15060152.IDAComponent
GO:0006413translational initiation16289705.IDAProcess
GO:0006417regulation of translation12556349.NASProcess
GO:0009408response to heat-ISSProcess
GO:0009408response to heat12499492.TASProcess
GO:0009749response to glucose-ISSProcess
GO:0014003oligodendrocyte development15217090.IMPProcess
GO:0031369translation initiation factor binding-ISSFunction
GO:0042552myelination14566705.IMPProcess
GO:0043434response to peptide hormone-ISSProcess
GO:0050852T cell receptor signaling pathway8626696.IDAProcess

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us