EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000115241 (Gene tree)
Gene ID: 5496
Gene Symbol: PPM1G
Alias: PP2CG|PP2Cgamma
Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1G
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,494 bases
Position: chr2:27,381,194-27,409,687
Accession: 9278
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000472077	PPM1G-202	3752	-	-	- (aa)	-	-
ENST00000484925	PPM1G-203	836	-	-	- (aa)	-	-
ENST00000344034	PPM1G-201	2311	-	ENSP00000342778	546 (aa)	-	O15355

Gene Model

Click here to download ENSG00000115241's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115241	Platelet Function Tests	4.6500000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115241's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004722	protein serine/threonine phosphatase activity	20801214.	IDA	Function
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	17572683.21044950.22190034.28330616.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006470	protein dephosphorylation	9276438.	TAS	Process
GO:0007050	cell cycle arrest	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0035970	peptidyl-threonine dephosphorylation	20801214.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	27385080	Missense_Mutation	novel	E140Q	0.28
BLCA	chr2	27386139	Intron	novel		0.19
BLCA	chr2	27383462	Missense_Mutation	novel	E369Q	0.17
BLCA	chr2	27393196	Intron	novel		0.31
BLCA	chr2	27381607	Nonsense_Mutation	rs375191761	R545*	0.22
BLCA	chr2	27381468	3'UTR	novel		1
BLCA	chr2	27387125	Missense_Mutation	NA	E52K	0.36
BLCA	chr2	27381734	Silent	novel	I502I	0.19
BLCA	chr2	27387061	Intron	novel		0.28
BLCA	chr2	27392988	Intron	novel		0.24
BLCA	chr2	27381525	3'UTR	novel		0.13
BLCA	chr2	27386197	Silent	novel	Q91Q	0.14
BLCA	chr2	27393125	Intron	novel		0.21
BLCA	chr2	27386013	Intron	novel		0.19
BLCA	chr2	27384756	Frame_Shift_Del	novel	*D246Sfs3**	0.75
BLCA	chr2	27384717	Missense_Mutation	novel	E261K	0.27
BLCA	chr2	27385758	Missense_Mutation	NA	D133V	0.33
BRCA	chr2	27386392	Intron	novel		0.09
BRCA	chr2	27381601	Nonstop_Mutation	novel	547Qext9	0.05
BRCA	chr2	27392856	Intron	novel		0.25
BRCA	chr2	27392857	Intron	novel		0.25
BRCA	chr2	27383976	Silent	novel	V314V	0.4
BRCA	chr2	27384722	Missense_Mutation	NA	D259G	0.37
BRCA	chr2	27387003	Intron	novel		0.24
BRCA	chr2	27383440	Missense_Mutation	NA	R376H	0.04
CESC	chr2	27384904	Missense_Mutation	NA	E198D	0.26
CESC	chr2	27385904	Intron	novel		0.32
CESC	chr2	27381746	Missense_Mutation	NA	M498I	0.1
CESC	chr2	27393007	Intron	novel		0.27
CESC	chr2	27393237	Intron	novel		0.17
CESC	chr2	27384726	Missense_Mutation	NA	E258Q	0.14
COAD	chr2	27384751	Silent	novel	P249P	0.36
COAD	chr2	27386128	Intron	novel		0.28
COAD	chr2	27383389	Frame_Shift_Del	novel	*G393Afs25**	0.08
COAD	chr2	27385992	Intron	novel		0.46
COAD	chr2	27386263	Silent	rs138207162	L69L	0.28
COAD	chr2	27385467	Intron	novel		0.77
COAD	chr2	27386138	Intron	novel		0.06
COAD	chr2	27386181	Intron	novel		0.51
COAD	chr2	27383508	Frame_Shift_Del	novel	*S354Lfs7**	0.39
COAD	chr2	27384009	Missense_Mutation	novel	E303D	0.06
COAD	chr2	27385331	Intron	novel		0.57
COAD	chr2	27385566	Intron	novel		0.56
COAD	chr2	27385621	Intron	novel		0.44
ESCA	chr2	27393174	Intron	novel		0.39
ESCA	chr2	27393362	Intron	novel		0.33
GBM	chr2	27386156	Intron	novel		0.12
GBM	chr2	27387071	Intron	novel		0.11
GBM	chr2	27393312	Intron	novel		0.27
GBM	chr2	27384002	Missense_Mutation	novel	E306K	0.12
GBM	chr2	27381558	3'UTR	novel		0.06
GBM	chr2	27393094	Intron	novel		0.28
GBM	chr2	27381571	3'UTR	novel		0.09
GBM	chr2	27393274	Intron	novel		0.12
GBM	chr2	27385934	Intron	novel		0.12
GBM	chr2	27381598	3'UTR	novel		0.1
HNSC	chr2	27393077	Intron	novel		0.39
HNSC	chr2	27381578	3'UTR	novel		0.24
HNSC	chr2	27386197	Silent	novel	Q91Q	0.21
HNSC	chr2	27382180	Silent	novel	I460I	0.27
KICH	chr2	27385023	Missense_Mutation	NA	R159C	0.95
KIRP	chr2	27381639	Frame_Shift_Del	novel	*N534Mfs112**	0.46
LIHC	chr2	27385664	Intron	novel		0.48
LIHC	chr2	27393091	Intron	novel		0.35
LUAD	chr2	27393218	Intron	novel		0.5
LUAD	chr2	27384698	Missense_Mutation	rs150808424	A267V	0.11
LUAD	chr2	27386047	Intron	novel		0.23
LUAD	chr2	27393354	Intron	novel		0.27
LUAD	chr2	27383411	Missense_Mutation	NA	M386V	0.11
LUAD	chr2	27385837	Missense_Mutation	NA	T107S	0.14
LUAD	chr2	27381725	Missense_Mutation	novel	F505L	0.12
LUAD	chr2	27385718	Intron	novel		0.14
LUAD	chr2	27393254	Intron	novel		0.26
LUAD	chr2	27384862	Silent	NA	T212T	0.21
LUAD	chr2	27392885	Intron	novel		0.19
LUAD	chr2	27384929	Missense_Mutation	NA	A190V	0.1
LUSC	chr2	27381692	Missense_Mutation	novel	E516D	0.23
LUSC	chr2	27383568	Silent	novel	V333V	0.64
OV	chr2	27382577	Silent	NA	N410N	0.54
OV	chr2	27384041	Missense_Mutation	novel	E293Q	0.14
OV	chr2	27393223	Intron	novel		0.07
OV	chr2	27393225	Intron	novel		0.02
OV	chr2	27386897	Intron	novel		0.25
OV	chr2	27384933	Missense_Mutation	novel	E189Q	0.04
OV	chr2	27386152	Intron	novel		0.11
OV	chr2	27387019	Intron	novel		0.41
OV	chr2	27386154	Intron	novel		0.09
OV	chr2	27393278	Intron	NA		0.18
OV	chr2	27385155	Intron	novel		0.17
OV	chr2	27381660	Missense_Mutation	novel	S527F	0.19
PAAD	chr2	27384839	Missense_Mutation	novel	R220H	0.04
PAAD	chr2	27382494	Missense_Mutation	novel	I438N	0.27
PAAD	chr2	27386069	Intron	novel		0.17
PRAD	chr2	27393130	Intron	novel		0.11
READ	chr2	27381628	Missense_Mutation	rs770886509	D538N	0.18
READ	chr2	27385735	Intron	novel		0.22
READ	chr2	27381535	3'UTR	novel		0.1
READ	chr2	27384730	Missense_Mutation	novel	F256L	0.11
READ	chr2	27386168	Intron	novel		0.17
READ	chr2	27385627	Intron	novel		0.48
SKCM	chr2	27382155	Missense_Mutation	NA	L469F	0.26
SKCM	chr2	27384853	Silent	novel	S215S	0.5
SKCM	chr2	27386141	Intron	novel		0.28
SKCM	chr2	27392826	Intron	novel		0.45
SKCM	chr2	27384881	Missense_Mutation	novel	P206L	0.71
SKCM	chr2	27385732	Intron	novel		0.25
SKCM	chr2	27385733	Intron	novel		0.24
SKCM	chr2	27383415	Silent	NA	V384V	0.34
SKCM	chr2	27386368	Intron	novel		0.29
SKCM	chr2	27382475	Splice_Site	NA	X444_splice	0.31
SKCM	chr2	27381524	3'UTR	novel		0.28
SKCM	chr2	27386381	Intron	novel		0.21
STAD	chr2	27385022	Missense_Mutation	rs768747491	R159H	0.16
STAD	chr2	27386445	Intron	novel		0.36
STAD	chr2	27392982	Intron	novel		0.2
STAD	chr2	27393007	Intron	novel		0.17
STAD	chr2	27385797	Missense_Mutation	NA	R120Q	0.18
STAD	chr2	27385927	Intron	novel		0.17
STAD	chr2	27381681	Missense_Mutation	NA	R520Q	0.31
STAD	chr2	27385566	Intron	novel		0.75
STAD	chr2	27385797	Missense_Mutation	NA	R120Q	0.24
STAD	chr2	27393007	Intron	novel		0.18
STAD	chr2	27384859	Silent	rs373757292	G213G	0.17
STAD	chr2	27385966	Intron	novel		0.16
STAD	chr2	27393038	Intron	novel		0.42
STAD	chr2	27393130	Intron	novel		0.1
STAD	chr2	27383588	Missense_Mutation	novel	S327R	0.4
STAD	chr2	27393007	Intron	novel		0.3
STAD	chr2	27387053	Intron	novel		0.19
THYM	chr2	27385622	Intron	novel		0.3
UCEC	chr2	27384736	Silent	NA	S254S	0.35
UCEC	chr2	27385771	Nonsense_Mutation	NA	E129*	0.33
UCEC	chr2	27385941	Intron	novel		0.35
UCEC	chr2	27386035	Intron	novel		0.25
UCEC	chr2	27385080	Nonsense_Mutation	NA	E140*	0.15
UCEC	chr2	27392977	Intron	novel		0.11
UCEC	chr2	27381630	Missense_Mutation	novel	S537N	0.39
UCEC	chr2	27382134	Missense_Mutation	novel	V476M	0.08
UCEC	chr2	27384903	Missense_Mutation	novel	T199A	0.04
UCEC	chr2	27393059	Intron	novel		0.49
UCEC	chr2	27384749	Missense_Mutation	rs772264870	R250Q	0.35
UCEC	chr2	27381787	Missense_Mutation	novel	A485T	0.46
UCEC	chr2	27381254	3'UTR	novel		0.35
UCEC	chr2	27381681	Missense_Mutation	NA	R520Q	0.31
UCEC	chr2	27385847	Silent	novel	A103A	0.26
UCEC	chr2	27385717	Intron	novel		0.33
UCEC	chr2	27385915	Intron	novel		0.09
UCEC	chr2	27385023	Missense_Mutation	NA	R159C	0.09
UCEC	chr2	27385557	Intron	novel		0.35
UCEC	chr2	27392880	Intron	novel		0.45
UCEC	chr2	27381681	Missense_Mutation	NA	R520Q	0.07
UCEC	chr2	27392894	Intron	novel		0.44
UCEC	chr2	27381469	3'UTR	novel		0.53
UCEC	chr2	27384000	Missense_Mutation	NA	E306D	0.32
UCEC	chr2	27385848	Missense_Mutation	novel	A103G	0.12
UCEC	chr2	27384003	Missense_Mutation	novel	D305E	0.45
UCEC	chr2	27382515	Missense_Mutation	novel	D431G	0.45
UCEC	chr2	27384884	Missense_Mutation	novel	G205V	0.43
UCEC	chr2	27385074	Missense_Mutation	novel	A142T	0.33
UCEC	chr2	27387123	Missense_Mutation	novel	E52D	0.5
UCEC	chr2	27392849	Intron	novel		0.48
UCEC	chr2	27381439	3'UTR	novel		0.6
UCEC	chr2	27409354	Silent	novel	L23L	0.31
UCEC	chr2	27409486	5'UTR	novel		0.46
UCEC	chr2	27381759	Missense_Mutation	novel	G494E	0.06
UCEC	chr2	27384883	Silent	rs372242443	G205G	0.32
UCEC	chr2	27386897	Intron	novel		0.42
UCEC	chr2	27384754	Silent	novel	L248L	0.33
UCEC	chr2	27385924	Intron	novel		0.36
UCEC	chr2	27381221	3'UTR	novel		0.47
UCEC	chr2	27393339	Intron	novel		0.43
UCEC	chr2	27383441	Missense_Mutation	NA	R376C	0.27
UCEC	chr2	27386046	Intron	novel		0.27
UCEC	chr2	27381606	Missense_Mutation	novel	R545Q	0.28
UCEC	chr2	27381722	Silent	rs114495106	K506K	0.46
UCEC	chr2	27384005	Missense_Mutation	novel	D305N	0.38
UCEC	chr2	27386159	Intron	novel		0.33
UCEC	chr2	27386872	Intron	novel		0.92
UCEC	chr2	27392894	Intron	novel		0.19
UCEC	chr2	27386182	Intron	novel		0.48
UCEC	chr2	27381648	Frame_Shift_Ins	novel	*A531Gfs2**	0.31
UCEC	chr2	27384093	Splice_Site	novel	X276_splice	0.26
UCEC	chr2	27392894	Intron	novel		0.18
UCEC	chr2	27382507	Nonsense_Mutation	NA	E434*	0.29
UCEC	chr2	27386331	Intron	novel		0.06
UCEC	chr2	27393006	Intron	novel		0.36
UCEC	chr2	27384084	Silent	rs372867701	S278S	0.46
UCEC	chr2	27384689	Missense_Mutation	novel	E270A	0.13
UCEC	chr2	27384966	Missense_Mutation	novel	G178C	0.19
UCEC	chr2	27383428	Missense_Mutation	NA	A380V	0.12
UCEC	chr2	27384788	Missense_Mutation	NA	A237D	0.33
UCEC	chr2	27383496	Silent	novel	G357G	0.48
UCEC	chr2	27381218	3'UTR	novel		0.34
UCEC	chr2	27382213	Silent	novel	S449S	0.42
UCEC	chr2	27384048	Missense_Mutation	novel	E290D	0.31
UCEC	chr2	27385075	Missense_Mutation	novel	E141D	0.16
UCEC	chr2	27386032	Intron	novel		0.18
UCEC	chr2	27387097	Missense_Mutation	novel	G61V	0.34
UCEC	chr2	27393257	Intron	novel		0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2271	0.099937
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0978	0.2014
TGCT	AMP	0.2733	0.0050216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
STAD	0.011	Kaplan-Meier Survival Analysis
SARC	0.0025	Kaplan-Meier Survival Analysis
MESO	0.00069	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.014	Kaplan-Meier Survival Analysis
LUSC	0.00085	Kaplan-Meier Survival Analysis
KIRP	0.0038	Kaplan-Meier Survival Analysis
LAML	0.00096	Kaplan-Meier Survival Analysis
KICH	0.05	Kaplan-Meier Survival Analysis
GBM	0.04	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.039	Kaplan-Meier Survival Analysis
LGG	0.00043	Kaplan-Meier Survival Analysis
LUAD	0.00056	Kaplan-Meier Survival Analysis
OV	0.00025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742