EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115275 (Gene tree)
Gene ID: 7841
Gene Symbol: MOGS
Alias: GCS1|CWH41|DER7
Full Name: mannosyl-oligosaccharide glucosidase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 4,354 bases
Position: chr2:74,461,057-74,465,410
Accession: 24862
RBP type: non-canonical RBP
Summary: This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000649854	MOGS-219	2304	-	ENSP00000496797	715 (aa)	-	-
ENST00000462189	MOGS-206	2400	-	-	- (aa)	-	-
ENST00000452063	MOGS-205	2433	-	ENSP00000388201	731 (aa)	-	Q13724
ENST00000648810	MOGS-215	2126	-	ENSP00000496949	562 (aa)	-	UPI000048BAEA
ENST00000647915	MOGS-213	2269	-	ENSP00000498123	53 (aa)	-	-
ENST00000647753	MOGS-211	2445	-	ENSP00000497318	159 (aa)	-	B4E3B8
ENST00000489655	MOGS-209	489	-	-	- (aa)	-	-
ENST00000233616	MOGS-201	2895	-	ENSP00000233616	837 (aa)	-	Q13724
ENST00000448666	MOGS-204	2867	-	ENSP00000410992	837 (aa)	-	C9J8D4
ENST00000649777	MOGS-218	2775	-	-	- (aa)	-	-
ENST00000462443	MOGS-207	2205	-	ENSP00000497265	562 (aa)	-	UPI000048BAEA
ENST00000486036	MOGS-208	811	-	-	- (aa)	-	-
ENST00000647723	MOGS-210	2606	-	ENSP00000497924	208 (aa)	-	-
ENST00000648768	MOGS-214	2862	-	-	- (aa)	-	-
ENST00000649075	MOGS-216	2649	-	ENSP00000497836	294 (aa)	-	-
ENST00000647771	MOGS-212	2469	-	ENSP00000496788	75 (aa)	-	-
ENST00000414701	MOGS-203	520	-	ENSP00000396298	145 (aa)	-	C9JDQ1
ENST00000649601	MOGS-217	2316	-	ENSP00000496796	113 (aa)	-	-
ENST00000650523	MOGS-220	1332	-	ENSP00000497143	428 (aa)	-	-
ENST00000409065	MOGS-202	2668	-	ENSP00000386493	209 (aa)	-	B8ZZE2

Gene Model

Click here to download ENSG00000115275's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00510	N-Glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115275's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115275	MOGS	100	89.726	ENSMUSG00000030036	Mogs	100	86.277	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004573	mannosyl-oligosaccharide glucosidase activity	21873635.	IBA	Function
GO:0004573	mannosyl-oligosaccharide glucosidase activity	-	TAS	Function
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006457	protein folding	-	TAS	Process
GO:0006487	protein N-linked glycosylation	21873635.	IBA	Process
GO:0009311	oligosaccharide metabolic process	-	IEA	Process
GO:0015926	glucosidase activity	7635146.	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0070062	extracellular exosome	19056867.19199708.	HDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	74461318	Missense_Mutation	rs376424106	G824D	0.22
BLCA	chr2	74462141	Nonsense_Mutation	novel	Q550*	0.19
BLCA	chr2	74461797	Silent	rs752336550	L664L	0.07
BLCA	chr2	74461925	Missense_Mutation	NA	E622K	0.19
BLCA	chr2	74461163	3'UTR	novel		0.46
BLCA	chr2	74464607	Silent	NA	F156F	0.32
BLCA	chr2	74464624	Missense_Mutation	NA	H151Y	0.39
BLCA	chr2	74463452	Intron	novel		0.09
BLCA	chr2	74462718	Silent	NA	L357L	0.43
BRCA	chr2	74461781	Missense_Mutation	NA	Q670E	0.17
BRCA	chr2	74462039	Missense_Mutation	novel	D584N	0.07
BRCA	chr2	74462607	Silent	novel	A394A	0.07
BRCA	chr2	74462752	Missense_Mutation	NA	N346S	0.16
BRCA	chr2	74463474	Intron	novel		0.16
CESC	chr2	74461380	Silent	novel	G803G	0.29
CESC	chr2	74461662	Silent	novel	L709L	0.34
CESC	chr2	74461769	Missense_Mutation	rs760636403	R674W	0.41
CESC	chr2	74462262	Silent	NA	H509H	0.3
CESC	chr2	74462926	Missense_Mutation	rs374993988	R288Q	0.45
CESC	chr2	74463250	Missense_Mutation	novel	D239G	0.26
CESC	chr2	74462604	Silent	rs751485436	L395L	0.55
CESC	chr2	74464613	Silent	novel	L154L	0.18
CESC	chr2	74461637	Missense_Mutation	rs747152213	D718N	0.2
CESC	chr2	74464607	Missense_Mutation	novel	F156L	0.19
CESC	chr2	74461155	3'UTR	novel		0.33
CESC	chr2	74461345	Missense_Mutation	rs778832533	R815Q	0.47
COAD	chr2	74463206	Missense_Mutation	rs752804401	A254T	0.37
COAD	chr2	74463476	Intron	novel		0.3
COAD	chr2	74464659	Missense_Mutation	novel	Q139R	0.1
COAD	chr2	74462185	Missense_Mutation	rs199528323	R535Q	0.35
COAD	chr2	74464972	Silent	NA	P92P	0.23
COAD	chr2	74462908	Frame_Shift_Del	rs758620366	*P294Lfs11**	0.44
COAD	chr2	74461551	Silent	NA	D746D	0.31
COAD	chr2	74462762	Missense_Mutation	novel	A343T	0.25
COAD	chr2	74461545	Frame_Shift_Del	NA	*Y749Tfs44**	0.51
COAD	chr2	74462085	Silent	novel	A568A	0.44
COAD	chr2	74461429	Missense_Mutation	NA	L787P	0.23
COAD	chr2	74461631	Missense_Mutation	rs779843206	R720C	0.28
COAD	chr2	74463389	Splice_Region	novel		0.55
COAD	chr2	74461367	Missense_Mutation	novel	Q808K	0.09
COAD	chr2	74462251	Frame_Shift_Del	novel	*P513Qfs7**	0.57
COAD	chr2	74464692	Missense_Mutation	rs779319482	P128L	0.61
COAD	chr2	74462557	Missense_Mutation	NA	V411A	0.28
COAD	chr2	74462808	Missense_Mutation	novel	K327N	0.3
COAD	chr2	74461357	Missense_Mutation	novel	D811G	0.21
COAD	chr2	74461355	Missense_Mutation	rs368859958	R812C	0.25
ESCA	chr2	74464996	Missense_Mutation	novel	D84E	0.19
GBM	chr2	74461306	Missense_Mutation	novel	L828H	0.41
GBM	chr2	74462335	Missense_Mutation	novel	G485V	0.5
GBM	chr2	74461883	Missense_Mutation	novel	A636T	0.16
GBM	chr2	74462651	Missense_Mutation	novel	E380Q	0.07
GBM	chr2	74462951	Missense_Mutation	rs372551243	R280C	0.16
GBM	chr2	74462903	Missense_Mutation	rs752641712	R296C	0.35
GBM	chr2	74462248	Missense_Mutation	novel	T514I	0.28
HNSC	chr2	74461402	Nonsense_Mutation	novel	W796*	0.1
HNSC	chr2	74462894	Missense_Mutation	rs746113375	G299S	0.28
HNSC	chr2	74462413	Missense_Mutation	novel	V459A	0.14
HNSC	chr2	74462227	Missense_Mutation	novel	H521P	0.12
HNSC	chr2	74462206	Missense_Mutation	novel	P528H	0.22
HNSC	chr2	74461682	Missense_Mutation	novel	D703N	0.29
HNSC	chr2	74464626	Missense_Mutation	novel	F150C	0.32
HNSC	chr2	74464958	Missense_Mutation	novel	G97V	0.32
KIRP	chr2	74461472	Missense_Mutation	NA	E773K	0.29
LGG	chr2	74461454	Missense_Mutation	rs558187098	R779W	0.33
LGG	chr2	74461953	Silent	rs756443476	T612T	0.33
LGG	chr2	74462095	Missense_Mutation	rs777861500	R565Q	0.4
LGG	chr2	74462788	Missense_Mutation	novel	F334S	0.08
LGG	chr2	74461400	Missense_Mutation	rs554882882	R797C	0.26
LIHC	chr2	74465241	Missense_Mutation	novel	R3W	0.45
LIHC	chr2	74462179	Missense_Mutation	novel	A537V	0.27
LUAD	chr2	74462958	Silent	novel	V277V	0.14
LUAD	chr2	74463047	Intron	novel		0.05
LUAD	chr2	74463057	Intron	novel		0.08
LUAD	chr2	74462601	Silent	rs535610745	S396S	0.05
LUAD	chr2	74463353	Missense_Mutation	NA	L205V	0.26
LUAD	chr2	74462531	Missense_Mutation	novel	S420A	0.24
LUAD	chr2	74461733	Missense_Mutation	NA	V686I	0.12
LUAD	chr2	74461426	Missense_Mutation	rs199724485	R788H	0.09
LUAD	chr2	74463064	Intron	novel		0.13
LUAD	chr2	74464504	Missense_Mutation	novel	E191Q	0.43
LUAD	chr2	74461852	Missense_Mutation	rs536613092	A646V	0.37
LUAD	chr2	74464618	Missense_Mutation	novel	G153S	0.27
LUAD	chr2	74462630	Missense_Mutation	rs755702841	E387K	0.13
LUSC	chr2	74462228	Missense_Mutation	rs774128079	H521Y	0.29
LUSC	chr2	74461345	Missense_Mutation	novel	R815P	0.44
LUSC	chr2	74463404	Intron	novel		0.19
LUSC	chr2	74463029	Intron	rs778918995		0.2
LUSC	chr2	74462652	Silent	novel	K379K	0.14
LUSC	chr2	74462894	Missense_Mutation	novel	G299C	0.2
LUSC	chr2	74461454	Missense_Mutation	rs558187098	R779W	0.43
LUSC	chr2	74461599	Silent	NA	S730S	0.32
LUSC	chr2	74461600	Missense_Mutation	NA	S730Y	0.33
LUSC	chr2	74462994	Silent	novel	T265T	0.11
LUSC	chr2	74462924	Missense_Mutation	NA	P289S	0.04
LUSC	chr2	74461865	Missense_Mutation	novel	E642Q	0.43
LUSC	chr2	74462713	Missense_Mutation	novel	Q359L	0.29
OV	chr2	74462575	Missense_Mutation	novel	F405C	0.07
OV	chr2	74461466	Frame_Shift_Ins	novel	*P775Lfs21**	0.13
OV	chr2	74461457	Missense_Mutation	novel	A778S	0.17
OV	chr2	74462829	Missense_Mutation	novel	L320F	0.25
OV	chr2	74461557	Missense_Mutation	novel	E744D	0.4
OV	chr2	74461558	Missense_Mutation	novel	E744V	0.36
OV	chr2	74461109	3'UTR	novel		0.43
OV	chr2	74461600	In_Frame_Ins	novel	S730delinsFTGRQP	0.1
OV	chr2	74462195	Missense_Mutation	novel	A532S	0.16
OV	chr2	74461342	Missense_Mutation	NA	G816D	0.07
PAAD	chr2	74461254	3'UTR	novel		0.14
PAAD	chr2	74462145	Silent	novel	L548L	0.16
PAAD	chr2	74464567	Missense_Mutation	novel	T170A	0.16
PAAD	chr2	74461756	Missense_Mutation	rs776932912	R678Q	0.14
PRAD	chr2	74461637	Missense_Mutation	rs747152213	D718N	0.08
PRAD	chr2	74461694	Silent	novel	L699L	0.4
READ	chr2	74461690	Missense_Mutation	rs771226355	R700Q	0.67
READ	chr2	74462951	Missense_Mutation	rs372551243	R280C	0.34
READ	chr2	74464935	Missense_Mutation	novel	F105V	0.24
SKCM	chr2	74462852	Missense_Mutation	novel	G313W	0.14
SKCM	chr2	74462853	Missense_Mutation	novel	S312R	0.14
SKCM	chr2	74463400	Intron	novel		0.3
SKCM	chr2	74461229	3'UTR	novel		0.35
SKCM	chr2	74462109	Silent	novel	Y560Y	0.41
SKCM	chr2	74461273	3'UTR	novel		0.3
SKCM	chr2	74462844	Silent	NA	G315G	0.21
SKCM	chr2	74462814	Silent	NA	T325T	0.32
SKCM	chr2	74462455	Missense_Mutation	novel	P445L	0.3
SKCM	chr2	74463212	Missense_Mutation	NA	D252N	0.23
SKCM	chr2	74462282	Silent	novel	L503L	0.65
SKCM	chr2	74461773	Silent	rs753542237	L672L	0.38
SKCM	chr2	74462457	Silent	novel	F444F	0.6
STAD	chr2	74462543	Missense_Mutation	NA	G416W	0.33
STAD	chr2	74462756	Missense_Mutation	novel	G345R	0.1
STAD	chr2	74462741	Missense_Mutation	NA	P350S	0.27
STAD	chr2	74461988	Nonsense_Mutation	NA	R601*	0.08
STAD	chr2	74462303	Missense_Mutation	NA	A496T	0.15
STAD	chr2	74462696	Missense_Mutation	NA	A365T	0.06
STAD	chr2	74462956	Frame_Shift_Del	rs781260708	*K278Efs5**	0.16
STAD	chr2	74462801	Missense_Mutation	NA	I330V	0.31
STAD	chr2	74461629	Silent	NA	R720R	0.15
STAD	chr2	74462201	Missense_Mutation	rs749160883	D530N	0.38
STAD	chr2	74461353	Silent	rs771882219	R812R	0.26
STAD	chr2	74464539	Missense_Mutation	NA	Q179P	0.22
STAD	chr2	74461708	Missense_Mutation	NA	L694P	0.31
UCEC	chr2	74463155	Intron	novel		0.23
UCEC	chr2	74463534	Intron	novel		0.4
UCEC	chr2	74463244	Missense_Mutation	novel	R241H	0.08
UCEC	chr2	74463075	Intron	novel		0.39
UCEC	chr2	74462301	Silent	novel	A496A	0.36
UCEC	chr2	74461420	Missense_Mutation	NA	N790S	0.5
UCEC	chr2	74461781	Missense_Mutation	NA	Q670E	0.33
UCEC	chr2	74461207	3'UTR	novel		0.19
UCEC	chr2	74462450	Missense_Mutation	novel	G447C	0.19
UCEC	chr2	74462096	Missense_Mutation	rs745841543	R565W	0.22
UCEC	chr2	74463055	Intron	novel		0.12
UCEC	chr2	74461934	Missense_Mutation	novel	G619C	0.25
UCEC	chr2	74461567	Missense_Mutation	rs768870045	R741H	0.38
UCEC	chr2	74463292	Missense_Mutation	novel	G225E	0.58
UCEC	chr2	74462071	Missense_Mutation	NA	L573P	0.09
UCEC	chr2	74461352	Missense_Mutation	novel	D813N	0.23
UCEC	chr2	74462262	Silent	NA	H509H	0.4
UCEC	chr2	74462908	Frame_Shift_Del	rs758620366	*P294Lfs11**	0.37
UCEC	chr2	74462045	Silent	rs563534545	L582L	0.19
UCEC	chr2	74462832	Missense_Mutation	novel	F319L	0.55
UCEC	chr2	74462248	Missense_Mutation	novel	T514I	0.29
UCEC	chr2	74464530	Missense_Mutation	NA	G182V	0.48
UCEC	chr2	74462185	Missense_Mutation	rs199528323	R535Q	0.45
UCEC	chr2	74463052	Intron	novel		0.26
UCEC	chr2	74461236	3'UTR	novel		0.46
UCEC	chr2	74461848	Silent	novel	P647P	0.27
UCEC	chr2	74462101	Missense_Mutation	rs769741414	R563Q	0.35
UCEC	chr2	74462908	Frame_Shift_Del	rs758620366	*P294Lfs11**	0.63
UCEC	chr2	74463428	Intron	novel		0.3
UCEC	chr2	74464549	Missense_Mutation	novel	P176S	0.28
UCEC	chr2	74462908	Frame_Shift_Del	rs758620366	*P294Lfs11**	0.23
UCEC	chr2	74462903	Missense_Mutation	rs752641712	R296C	0.19
UCEC	chr2	74463494	Intron	novel		0.27
UCEC	chr2	74462003	Missense_Mutation	rs371459798	R596W	0.24
UCEC	chr2	74462185	Missense_Mutation	rs199528323	R535Q	0.4
UCEC	chr2	74464701	Missense_Mutation	rs747215720	G125D	0.08
UCEC	chr2	74462202	Silent	rs190772368	D529D	0.2
UCEC	chr2	74462875	Missense_Mutation	novel	K305T	0.34
UCEC	chr2	74462908	Frame_Shift_Del	rs758620366	*P294Lfs11**	0.3
UCEC	chr2	74462272	Missense_Mutation	rs757364620	R506Q	0.36
UCEC	chr2	74463212	Missense_Mutation	NA	D252N	0.38
UCEC	chr2	74462646	Missense_Mutation	novel	K381N	0.41
UCS	chr2	74461859	Missense_Mutation	novel	H644Y	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0727	0.19022

Survival Analysis

Cancer	P-value	Q-value
THYM	0.024	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.026	Kaplan-Meier Survival Analysis
SARC	0.024	Kaplan-Meier Survival Analysis
MESO	0.041	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.03	Kaplan-Meier Survival Analysis
KIRP	0.0046	Kaplan-Meier Survival Analysis
COAD	0.00016	Kaplan-Meier Survival Analysis
PAAD	0.034	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
LIHC	0.0003	Kaplan-Meier Survival Analysis
DLBC	0.031	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
OV	0.028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742