EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115484 (Gene tree)
Gene ID: 10575
Gene Symbol: CCT4
Alias: Cctd
Full Name: chaperonin containing TCP1 subunit 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 20,716 bases
Position: chr2:61,868,089-61,888,804
Accession: 1617
RBP type: non-canonical RBP
Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8626763	Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.	J Biol Chem	1996 Feb 23	Wu-Baer F	-
10839988	Enzymic methylation of arginyl residues in -gly-arg-gly- peptides.	Biochem J	2000 Jun 15	Hyun YL	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461370	CCT4-202	388	-	-	- (aa)	-	-
ENST00000461540	CCT4-203	638	-	-	- (aa)	-	-
ENST00000544079	CCT4-204	2261	-	ENSP00000443061	509 (aa)	-	P50991
ENST00000394440	CCT4-201	2520	-	ENSP00000377958	539 (aa)	-	P50991

Gene Model

Click here to download ENSG00000115484's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115484	rs62149891	2	61877999	A	Plasma free amino acid levels	30659259	[0.15-0.31] unit decrease	0.23	EFO_0009771\|EFO_0005134
ENSG00000115484	rs62149891	2	61877999	A	Plasma free amino acid levels	30659259	[0.15-0.31] unit decrease	0.23	EFO_0005134\|EFO_0009775

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115484's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115484	CCT4	97	64.436	WBGene00000379	cct-4	95	64.981	Caenorhabditis_elegans
ENSG00000115484	CCT4	96	70.213	FBgn0032444	CCT4	97	70.155	Drosophila_melanogaster
ENSG00000115484	CCT4	100	96.660	ENSMUSG00000007739	Cct4	100	96.660	Mus_musculus
ENSG00000115484	CCT4	96	59.579	YDL143W	CCT4	98	59.579	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002199	zona pellucida receptor complex	-	IEA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	16085932.24846140.25467444.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005813	centrosome	20080638.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.	IDA	Component
GO:0005832	chaperonin-containing T-complex	25467444.	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042995	cell projection	-	IEA	Component
GO:0044297	cell body	-	IEA	Component
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0051973	positive regulation of telomerase activity	25467444.	IMP	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0090666	scaRNA localization to Cajal body	25467444.	IMP	Process
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	IMP	Process