EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000115970 (Gene tree)
Gene ID: 63892
Gene Symbol: THADA
Alias: FLJ21877|KIAA1767|GITA|ARMC13
Full Name: THADA armadillo repeat containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 365,221 bases
Position: chr2:43,230,836-43,596,056
Accession: 19217
RBP type: non-canonical RBP
Summary: This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497770	THADA-219	390	-	-	- (aa)	-	-
ENST00000469323	THADA-213	547	-	-	- (aa)	-	-
ENST00000462185	THADA-211	544	-	-	- (aa)	-	-
ENST00000402360	THADA-202	2974	-	ENSP00000385441	937 (aa)	-	Q6YHU6
ENST00000405975	THADA-207	6114	XM_006712063	ENSP00000386088	1953 (aa)	XP_006712126	Q6YHU6
ENST00000486735	THADA-218	564	-	-	- (aa)	-	-
ENST00000402796	THADA-203	2749	-	ENSP00000385003	408 (aa)	-	H7BYZ4
ENST00000404790	THADA-205	3043	-	ENSP00000384266	894 (aa)	-	Q6YHU6
ENST00000473004	THADA-214	549	-	-	- (aa)	-	-
ENST00000407351	THADA-208	3678	XM_006712069	ENSP00000386112	1193 (aa)	XP_006712132	H0Y3V5
ENST00000474159	THADA-215	1975	-	ENSP00000445294	348 (aa)	-	F5H3M9
ENST00000467668	THADA-212	382	-	-	- (aa)	-	-
ENST00000408045	THADA-209	5585	-	ENSP00000384172	297 (aa)	-	B6ZDE5
ENST00000485353	THADA-217	698	-	-	- (aa)	-	-
ENST00000436947	THADA-210	611	-	-	- (aa)	-	-
ENST00000403856	THADA-204	6939	-	ENSP00000385469	870 (aa)	-	B5MC89
ENST00000485018	THADA-216	837	-	-	- (aa)	-	-
ENST00000405006	THADA-206	6310	-	ENSP00000385995	1953 (aa)	-	Q6YHU6
ENST00000398653	THADA-201	5900	-	ENSP00000381647	297 (aa)	-	B6ZDE5

Gene Model

Click here to download ENSG00000115970's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115970	Atherosclerosis	7.7375036E-005	-
ENSG00000115970	Thyrotropin	3.4440000E-005	-
ENSG00000115970	Drug Resistance	6E-6	22952603
ENSG00000115970	Inflammatory Bowel Diseases	8E-16	26192919
ENSG00000115970	Inflammatory Bowel Diseases	8E-12	23128233
ENSG00000115970	Hair	1E-7	19896111
ENSG00000115970	Polycystic Ovary Syndrome	2E-23	21151128
ENSG00000115970	Polycystic Ovary Syndrome	3E-23	21151128
ENSG00000115970	Creatinine	7E-7	26831199
ENSG00000115970	Glomerular Filtration Rate	7E-7	26831199
ENSG00000115970	DNA Methylation	8E-7	23725790
ENSG00000115970	Prostatic Neoplasms	4E-6	22219177
ENSG00000115970	Inflammatory Bowel Diseases	6E-9	28067908
ENSG00000115970	Crohn Disease	4E-11	28067908
ENSG00000115970	Crohn Disease	3E-13	26192919
ENSG00000115970	Platelet Count	1E-10	22139419
ENSG00000115970	GRN protein, human	1E-8	22863734
ENSG00000115970	Alopecia	2E-8	27182965
ENSG00000115970	Polycystic Ovary Syndrome	4E-13	22885925
ENSG00000115970	Cleft Lip	9E-8	20023658
ENSG00000115970	Crohn Disease	2E-14	21102463
ENSG00000115970	DNA, Mitochondrial	4E-6	25240745
ENSG00000115970	Prostatic Neoplasms	2E-8	19767753
ENSG00000115970	Polycystic Ovary Syndrome	3E-10	26416764
ENSG00000115970	Age-Related Hearing Impairment 1	4E-9	24939585
ENSG00000115970	Diabetes Mellitus, Type 2	1E-9	18372903

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115970	rs113542380	2	43237679	G	Intraocular pressure	29617998	[0.15-0.25] unit decrease	0.202	EFO_0004695
ENSG00000115970	rs77059113	2	43445369	T	Intraocular pressure	29617998	[0.14-0.24] unit decrease	0.19	EFO_0004695
ENSG00000115970	rs10203174	2	43462891	C	Type 2 diabetes	22885922	[1.10-1.19]	1.14	EFO_0001360
ENSG00000115970	rs13405158	2	43478147	T	Type 2 diabetes	22885922	[1.11-1.22]	1.16	EFO_0001360
ENSG00000115970	rs113542380	2	43237679	A	Mean corpuscular hemoglobin	27863252	[0.043-0.07] unit increase	0.05647488	EFO_0004527
ENSG00000115970	rs113542380	2	43237679	A	Mean corpuscular volume	27863252	[0.046-0.073] unit increase	0.05927439	EFO_0004526
ENSG00000115970	rs183816209	2	43362921	?	Viral capsid antigen IgG seropositivity	29868224	[1.30-2.44]	1.69	EFO_0009272
ENSG00000115970	rs10495903	2	43579779	T	Crohn's disease	21102463	[1.09-1.20]	1.14	EFO_0000384
ENSG00000115970	rs13429458	2	43411699	?	Response to amphetamines	22952603			GO_0042493
ENSG00000115970	rs2888875	2	43560953	A	Glomerular filtration rate (creatinine)	26831199	[0.0025-0.0057] unit increase	0.0041	EFO_0005208\|EFO_0004518
ENSG00000115970	rs17406451	2	43405337	?	Mitochondrial DNA levels	25240745	[NR]		EFO_0006312
ENSG00000115970	rs6732426	2	43360365	T	Hair morphology	19896111			EFO_0005038
ENSG00000115970	rs10495903	2	43579779	A	Crohn's disease	26192919	[1.1-1.17]	1.1337671	EFO_0000384
ENSG00000115970	rs78487399	2	43582208	?	Inflammatory bowel disease	26192919			EFO_0003767
ENSG00000115970	rs11897432	2	43590366	A	DNA methylation (variation)	23725790			GO_0006306
ENSG00000115970	rs7590268	2	43312986	G	Orofacial clefts	22863734	[1.225-1.636]	1.415	EFO_0004625
ENSG00000115970	rs13429458	2	43411699	A	Polycystic ovary syndrome	22885925	[NR]	1.49	EFO_0000660
ENSG00000115970	rs17030845	2	43460740	C	Platelet count	22139419	[2.49-4.67] 10^9/l increase	3.577	EFO_0004309
ENSG00000115970	rs1465618	2	43326810	?	Prostate cancer	19767753	[1.03-1.12]	1.08	EFO_0001663
ENSG00000115970	rs7590268	2	43312986	G	Orofacial clefts	20023658	[1.26-1.59]	1.42	EFO_0003959
ENSG00000115970	rs7578597	2	43505684	C	Type 2 diabetes	28869590	[0.07-0.128] unit decrease	0.099	EFO_0001360
ENSG00000115970	rs7578597	2	43505684	C	Type 2 diabetes	28869590	[0.1-0.17] unit decrease	0.1377	EFO_0001360
ENSG00000115970	rs6761129	2	43508574	C	Heel bone mineral density	28869591	[0.025-0.046] unit decrease	0.0355693	EFO_0009270
ENSG00000115970	rs6761129	2	43508574	C	Heel bone mineral density	28869591	[0.024-0.053] unit decrease	0.0382273	EFO_0009270
ENSG00000115970	rs6743071	2	43359148	T	Type 2 diabetes	29358691		1.1863722	EFO_0001360
ENSG00000115970	rs6740322	2	43334790	A	Coronary artery disease	29212778	[0.024-0.056] unit decrease	0.04	EFO_0000378
ENSG00000115970	rs113542380	2	43237679	?	Intraocular pressure	30054594	[0.11-0.21] unit increase	0.1602	EFO_0004695
ENSG00000115970	rs77972916	2	43534973	A	Granulocyte percentage of myeloid white cells	27863252	[0.03-0.057] unit increase	0.04378274	EFO_0007997
ENSG00000115970	rs78487399	2	43582208	C	Myeloid white cell count	27863252	[0.026-0.05] unit increase	0.03823174	EFO_0007988
ENSG00000115970	rs113542380	2	43237679	A	Immature fraction of reticulocytes	27863252	[0.026-0.053] unit decrease	0.03952053	EFO_0007986
ENSG00000115970	rs10495903	2	43579779	?	Crohn's disease	28067908			EFO_0000384
ENSG00000115970	rs10495903	2	43579779	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000115970	rs113542380	2	43237679	A	Neutrophil count	27863252	[0.032-0.059] unit increase	0.04593845	EFO_0004833
ENSG00000115970	rs113542380	2	43237679	A	Plateletcrit	27863252	[0.069-0.096] unit decrease	0.08249128	EFO_0007985
ENSG00000115970	rs190251311	2	43520702	G	Stromal-cell-derived factor 1 alpha levels	27989323	[0.13-0.41] SD units decrease	0.271	EFO_0008293
ENSG00000115970	rs12478601	2	43494369	C	Polycystic ovary syndrome	21151128	[1.30-1.49]	1.39	EFO_0000660
ENSG00000115970	rs13429458	2	43411699	A	Polycystic ovary syndrome	21151128	[1.39-1.61]	1.49	EFO_0000660
ENSG00000115970	rs7578597	2	43505684	T	Type 2 diabetes	18372903	[1.10-1.20]	1.15	EFO_0001360
ENSG00000115970	rs10495903	2	43579779	T	Inflammatory bowel disease	23128233	[1.041-1.131]	1.086	EFO_0003767
ENSG00000115970	rs78487399	2	43582208	C	Granulocyte count	27863252	[0.028-0.052] unit increase	0.04032608	EFO_0007987
ENSG00000115970	rs78487399	2	43582208	C	Sum neutrophil eosinophil counts	27863252	[0.028-0.052] unit increase	0.03988202	EFO_0004833\|EFO_0004842
ENSG00000115970	rs11694173	2	43363760	?	Male-pattern baldness	27182965	[1.11-1.24]	1.1737089	EFO_0004191
ENSG00000115970	rs78487399	2	43582208	C	Sum basophil neutrophil counts	27863252	[0.029-0.053] unit increase	0.04064826	EFO_0004833\|EFO_0005090
ENSG00000115970	rs17334919	2	43480246	T	Type 2 diabetes	30054458	[0.11-0.16] unit decrease	0.1398	EFO_0001360
ENSG00000115970	rs6761129	2	43508574	?	Heel bone mineral density	30048462	[0.018-0.031] unit decrease	0.0241704	EFO_0009270
ENSG00000115970	rs7590268	2	43312986	?	Nonsyndromic cleft lip with or without cleft palate	30067744			HP_0000175\|EFO_0003959
ENSG00000115970	rs17031076	2	43576329	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000115970	rs113542380	2	43237679	G	Intraocular pressure	29785010	[0.11-0.21] unit decrease	0.16	EFO_0004695
ENSG00000115970	rs7563201	2	43334641	A	Polycystic ovary syndrome	30566500	[0.074-0.142] unit decrease	0.1081	EFO_0000660
ENSG00000115970	rs6732426	2	43360365	T	Male-pattern baldness	28196072	NR unit increase	0.0344078	Orphanet_79364
ENSG00000115970	rs11694173	2	43363760	A	Male-pattern baldness	28196072	NR unit increase	0.04	Orphanet_79364
ENSG00000115970	rs17030818	2	43453179	C	Heel bone mineral density	30598549	[0.019-0.03] unit decrease	0.0245601	EFO_0009270
ENSG00000115970	rs10166054	2	43391901	?	Balding type 1	30595370			EFO_0007825
ENSG00000115970	rs11124931	2	43372113	G	Male-pattern baldness	30573740	[0.021-0.033] unit decrease	0.0270782	EFO_0007825
ENSG00000115970	rs75126888	2	43436868	T	Male-pattern baldness	30573740	[0.029-0.049] unit increase	0.0391562	EFO_0007825
ENSG00000115970	rs13414381	2	43340079	?	Type 2 diabetes	30595370			EFO_0001360
ENSG00000115970	rs11888640	2	43579243	?	Latent autoimmune diabetes	30254083	[1.1-1.27]	1.1833298	EFO_0009706
ENSG00000115970	rs35590893	2	43489794	A	Systolic blood pressure	30224653	[0.16-0.27] mmHg decrease	0.2152	EFO_0006335
ENSG00000115970	rs77881454	2	43530154	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000115970	rs67584485	2	43535056	?	White blood cell count	30595370			EFO_0004308
ENSG00000115970	rs7557989	2	43403518	?	Red blood cell count	30595370			EFO_0004305
ENSG00000115970	rs6544650	2	43389673	?	Hair color	30595370			EFO_0007822
ENSG00000115970	rs6708660	2	43525243	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000115970	rs3764769	2	43505819	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000115970	rs77972916	2	43534973	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000115970	rs77972916	2	43534973	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000115970	rs7609283	2	43438039	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000115970	rs1465618	2	43326810	T	Prostate cancer	29892016	[1.07-1.11]	1.09	EFO_0001663
ENSG00000115970	rs35720761	2	43292838	C	Type 2 diabetes	29632382	[1.05-1.10]	1.08	EFO_0001360
ENSG00000115970	rs35720761	2	43292838	C	Type 2 diabetes (adjusted for BMI)	29632382	[1.05-1.10]	1.07	EFO_0001360
ENSG00000115970	rs35720761	2	43292838	C	Type 2 diabetes	29632382	[1.05-1.10]	1.08	EFO_0001360
ENSG00000115970	rs35720761	2	43292838	C	Type 2 diabetes (adjusted for BMI)	29632382	[1.06-1.10]	1.08	EFO_0001360

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115970's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	28399403.	IMP	Process
GO:0055088	lipid homeostasis	28399403.	IGI	Process
GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	-	ISS	Component
GO:1901895	negative regulation of calcium-transporting ATPase activity	-	ISS	Process
GO:1990845	adaptive thermogenesis	-	ISS	Process