EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116030 (Gene tree)
Gene ID: 7341
Gene Symbol: SUMO1
Alias: PIC1|GMP1|SMT3C|SUMO-1|SMT3H3|OFC10|UBL1
Full Name: small ubiquitin like modifier 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 32,429 bases
Position: chr2:202,206,180-202,238,608
Accession: 12502
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19946338	Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.	Oncogene	2010 Feb 18	Oh SM	doi: 10.1038/onc.2009.411
17587596	The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons.	J Struct Biol	2007 Sep	Casafont I	-
25800734	The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.	Nucleic Acids Res	2015 Apr 20	Liu HW	doi: 10.1093/nar/gkv246

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409712	SUMO1-209	761	-	ENSP00000386296	77 (aa)	-	B9A032
ENST00000469034	SUMO1-210	511	-	-	- (aa)	-	-
ENST00000409627	SUMO1-208	722	-	ENSP00000386500	73 (aa)	-	F8WBI1
ENST00000409498	SUMO1-207	779	-	ENSP00000386472	62 (aa)	-	B8ZZ67
ENST00000409181	SUMO1-204	784	-	ENSP00000386753	58 (aa)	-	B8ZZJ0
ENST00000392246	SUMO1-203	1536	-	ENSP00000376077	101 (aa)	-	P63165
ENST00000392245	SUMO1-202	1071	-	ENSP00000376076	101 (aa)	-	P63165
ENST00000392244	SUMO1-201	831	-	ENSP00000376075	76 (aa)	-	P63165
ENST00000409205	SUMO1-205	534	-	ENSP00000386267	62 (aa)	-	B8ZZ67
ENST00000409368	SUMO1-206	1187	-	ENSP00000387204	146 (aa)	-	B8ZZN6

Gene Model

Click here to download ENSG00000116030's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116030	rs6755690	2	202225870	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116030's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116030	SUMO1	100	100.000	ENSMUSG00000026021	Sumo1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0000792	heterochromatin	-	IEA	Component
GO:0001222	transcription corepressor binding	17081986.	IPI	Function
GO:0001650	fibrillar center	-	IEA	Component
GO:0001741	XY body	-	IEA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	9885291.11112409.11735126.11948183.12072434.14516784.15296745.15983381.16154161.16189514.16494873.16732283.17000644.17036045.17066076.17081985.17081986.17099698.17099700.17491593.17535915.17942705.17956732.18264111.18408014.18617892.19684601.19779455.20016594.20016603.20164921.20224576.20414307.20498050.20534433.20661221.20802522.21057547.21212807.21242980.21722636.21811235.21880768.21965678.21988832.22555612.22748127.22878415.23395904.24434214.24819975.25416956.25497731.25910212.26496610.26871637.29656893.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9412458.24651376.	IDA	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	9019411.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	19223394.	IDA	Component
GO:0006281	DNA repair	8812453.	TAS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0008022	protein C-terminus binding	15959518.	IDA	Function
GO:0008022	protein C-terminus binding	17081986.	IMP	Function
GO:0008076	voltage-gated potassium channel complex	19223394.	IDA	Component
GO:0008134	transcription factor binding	-	ISS	Function
GO:0015459	potassium channel regulator activity	19223394.	IDA	Function
GO:0016032	viral process	-	IEA	Process
GO:0016604	nuclear body	24651376.	IDA	Component
GO:0016605	PML body	21873635.	IBA	Component
GO:0016605	PML body	22406621.	IDA	Component
GO:0016605	PML body	9412458.	IDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0016925	protein sumoylation	21873635.	IBA	Process
GO:0016925	protein sumoylation	11889051.14752048.15572661.15637059.15959518.17696781.19223394.21965678.24651376.	IDA	Process
GO:0016925	protein sumoylation	17081986.	IMP	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0019899	enzyme binding	11889051.15959518.	IPI	Function
GO:0030425	dendrite	-	IEA	Component
GO:0030578	PML body organization	-	IEA	Process
GO:0030674	protein binding, bridging	17081986.	IMP	Function
GO:0031334	positive regulation of protein complex assembly	18579533.	IDA	Process
GO:0031386	protein tag	21873635.	IBA	Function
GO:0031510	SUMO activating enzyme complex	15660128.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	18408734.	IPI	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	18408734.	IDA	Process
GO:0032880	regulation of protein localization	15637059.	TAS	Process
GO:0034605	cellular response to heat	11514557.	IDA	Process
GO:0035259	glucocorticoid receptor binding	17081986.	IPI	Function
GO:0043392	negative regulation of DNA binding	16626738.	IDA	Process
GO:0043392	negative regulation of DNA binding	15637059.	IMP	Process
GO:0043433	negative regulation of DNA-binding transcription factor activity	12072434.	IMP	Process
GO:0044388	small protein activating enzyme binding	15660128.	IPI	Function
GO:0044389	ubiquitin-like protein ligase binding	21873635.	IBA	Function
GO:0045202	synapse	-	IEA	Component
GO:0045759	negative regulation of action potential	19223394.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	15572661.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	12072434.	IMP	Process
GO:0050821	protein stabilization	21968017.	IDA	Process
GO:0060021	roof of mouth development	-	ISS	Process
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	-	TAS	Process
GO:0071276	cellular response to cadmium ion	11514557.	IDA	Process
GO:0086004	regulation of cardiac muscle cell contraction	-	IEA	Process
GO:0090204	protein localization to nuclear pore	-	IEA	Process
GO:0097165	nuclear stress granule	11514557.	IDA	Component
GO:1901896	positive regulation of calcium-transporting ATPase activity	-	IEA	Process
GO:1902260	negative regulation of delayed rectifier potassium channel activity	19223394.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29393359	Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.	Int J Oncol	2018 Mar	Shen Y	doi: 10.3892/ijo.2018.4263
24344134	PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.	J Biol Chem	2014 Feb 7	Wang W	doi: 10.1074/jbc.M113.508515
17671677	Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis.	Int J Oncol	2007 Sep	Katayama A	-
19287951	BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers.	Oncogene	2007 Sep 6	Yuli C	-
25241153	Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer.	Arch Dermatol Res	2014 Nov	Oliveira Alves MG	doi: 10.1007/s00403-014-1500-8
17932034	Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.	J Biol Chem	2007 Dec 28	Bawa-Khalfe T	-
23996296	Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association.	Med Oncol	2013 Dec	Mei D	doi: 10.1007/s12032-013-0709-2
24819975	Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α.	FEBS J	2014 Jul	Zhou Q	doi: 10.1111/febs.12840
20932933	Small ubiquitin-related modifier-1: Wrestling with protein regulation.	Int J Biochem Cell Biol	2011 Jan	Barry J	doi: 10.1016/j.biocel.2010.09.022
15123625	Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification.	J Biol Chem	2004 Jul 9	Ohshima T	-
28222440	SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells.	Cell Physiol Biochem	2017	Jin L	doi: 10.1159/000460836

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	202207177	Intron	novel		0.26
BLCA	chr2	202207263	Nonsense_Mutation	novel	S99*	0.2
BLCA	chr2	202238437	Splice_Region	novel		0.43
BLCA	chr2	202210799	Missense_Mutation	NA	P58L	0.58
BRCA	chr2	202214373	Nonsense_Mutation	NA	S50*	0.27
BRCA	chr2	202220089	Silent	NA	T10T	0.32
CESC	chr2	202210755	Missense_Mutation	novel	D73N	0.1
CESC	chr2	202220071	Missense_Mutation	NA	K16N	0.04
CESC	chr2	202214434	Missense_Mutation	NA	D30H	0.13
CESC	chr2	202239628	5'Flank	novel		0.25
CESC	chr2	202220093	Nonsense_Mutation	NA	S9*	0.16
COAD	chr2	202207280	Silent	novel	E93E	0.07
COAD	chr2	202207233	Intron	novel		0.37
COAD	chr2	202207150	Intron	novel		0.22
ESCA	chr2	202206752	3'UTR	novel		0.35
ESCA	chr2	202220076	Frame_Shift_Del	novel	*D15Ifs24**	0.3
GBM	chr2	202220059	Missense_Mutation	NA	E20D	0.16
KIRC	chr2	202207234	Intron	rs760066247		0.11
LIHC	chr2	202238562	5'UTR	novel		0.31
LUAD	chr2	202207177	Intron	novel		0.08
LUAD	chr2	202207317	Frame_Shift_Del	novel	*G81Efs7**	0.12
LUAD	chr2	202207185	Intron	novel		0.26
LUAD	chr2	202207294	Missense_Mutation	novel	E89Q	0.12
LUAD	chr2	202220100	Missense_Mutation	novel	K7E	0.27
LUSC	chr2	202207207	Intron	novel		0.38
LUSC	chr2	202220106	Frame_Shift_Del	novel	*E5Rfs34**	0.5
LUSC	chr2	202210786	Silent	novel	L62L	0.17
LUSC	chr2	202207232	Intron	novel		0.11
READ	chr2	202214360	Silent	novel	R54R	0.15
SKCM	chr2	202207274	Silent	novel	T95T	0.26
SKCM	chr2	202210799	Missense_Mutation	NA	P58L	0.31
STAD	chr2	202210764	Missense_Mutation	novel	R70G	0.2
STAD	chr2	202207233	Intron	novel		0.23
UCEC	chr2	202207221	Intron	novel		0.22
UCEC	chr2	202210792	Silent	novel	N60N	0.22
UCEC	chr2	202210806	Missense_Mutation	NA	G56S	0.39
UCEC	chr2	202207232	Intron	novel		0.5
UCEC	chr2	202206962	Intron	novel		0.43
UCEC	chr2	202206683	3'UTR	novel		0.37
UCEC	chr2	202214377	Nonsense_Mutation	novel	E49*	0.43
UCEC	chr2	202207274	Silent	novel	T95T	0.22
UCEC	chr2	202238580	5'UTR	novel		0.34
UCEC	chr2	202220080	Missense_Mutation	novel	L13F	0.05
UCEC	chr2	202210763	Missense_Mutation	novel	R70I	0.37
UCEC	chr2	202207233	Intron	novel		0.5
UCEC	chr2	202210752	Missense_Mutation	novel	N74D	0.19
UCEC	chr2	202210737	Nonsense_Mutation	NA	E79*	0.43
UCEC	chr2	202206847	Intron	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
KIRC	0.035	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0048	Kaplan-Meier Survival Analysis
SKCM	0.0083	Kaplan-Meier Survival Analysis
KIRP	0.0037	Kaplan-Meier Survival Analysis
PAAD	0.0053	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
UCEC	0.0042	Kaplan-Meier Survival Analysis
LIHC	0.013	Kaplan-Meier Survival Analysis
CHOL	0.048	Kaplan-Meier Survival Analysis
THCA	0.038	Kaplan-Meier Survival Analysis
LUAD	0.037	Kaplan-Meier Survival Analysis
OV	0.0029	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742