EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116062 (Gene tree)
Gene ID: 2956
Gene Symbol: MSH6
Alias: GTBP
Full Name: mutS homolog 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 114,572 bases
Position: chr2:47,695,530-47,810,101
Accession: 7329
RBP type: non-canonical RBP
Summary: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000455383	MSH6-206	578	-	ENSP00000397484	115 (aa)	-	C9J8Y8
ENST00000540021	MSH6-210	3930	-	ENSP00000446475	1230 (aa)	-	P52701
ENST00000622629	MSH6-215	4324	-	ENSP00000482078	327 (aa)	-	A0A087WYT6
ENST00000420813	MSH6-203	491	-	ENSP00000390382	101 (aa)	-	C9JH55
ENST00000493177	MSH6-208	813	-	-	- (aa)	-	-
ENST00000607272	MSH6-212	2219	-	-	- (aa)	-	-
ENST00000454137	MSH6-205	725	-	-	- (aa)	-	-
ENST00000445503	MSH6-204	4158	-	ENSP00000405294	160 (aa)	-	F8WAX8
ENST00000456246	MSH6-207	846	-	ENSP00000410570	104 (aa)	-	F8W7G9
ENST00000606499	MSH6-211	833	-	ENSP00000475605	51 (aa)	-	U3KQ72
ENST00000411819	MSH6-202	548	-	ENSP00000406248	151 (aa)	-	C9J7Y7
ENST00000616033	MSH6-214	3429	-	ENSP00000480261	1067 (aa)	-	A0A087WWJ1
ENST00000538136	MSH6-209	4055	-	ENSP00000438580	1058 (aa)	-	P52701
ENST00000234420	MSH6-201	7476	XM_024452819	ENSP00000234420	1360 (aa)	XP_024308587	P52701
ENST00000614496	MSH6-213	4150	XM_024452822	ENSP00000477844	1058 (aa)	XP_024308590	P52701

Gene Model

Click here to download ENSG00000116062's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01524	Platinum drug resistance	KEGG
hsa03430	Mismatch repair	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05210	Colorectal cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116062	Platelet Function Tests	1.7351700E-005	-
ENSG00000116062	Platelet Function Tests	2.2146622E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116062	rs1800932	2	47790942	A	Menopause (age at onset)	26414677	[0.11-0.23] years decrease	0.17	EFO_0004704
ENSG00000116062	rs2098242	2	47729680	T	HIV-associated neurocognitive disorder (mild neurocognitive disorder)	28447399	[NR]	3.179	EFO_0007948\|EFO_0007982
ENSG00000116062	rs3136302	2	47794240	G	Heel bone mineral density	30598549	[0.0071-0.0143] unit decrease	0.0107039	EFO_0009270
ENSG00000116062	rs3136247	2	47785960	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000116062	rs76928871	2	47778682	?	Age at menopause	30595370			EFO_0004704
ENSG00000116062	rs3136272	2	47789757	T	General risk tolerance (MTAG)	30643258	[0.005-0.0098] unit decrease	0.0074	EFO_0008579
ENSG00000116062	rs3136302	2	47794240	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116062's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116062	MSH6	99	46.201	FBgn0036486	Msh6	91	43.594	Drosophila_melanogaster
ENSG00000116062	MSH6	100	96.078	ENSMUSG00000005370	Msh6	100	85.337	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	16403449.	IDA	Function
GO:0000400	four-way junction DNA binding	21873635.	IBA	Function
GO:0000400	four-way junction DNA binding	12034830.	IDA	Function
GO:0000710	meiotic mismatch repair	21873635.	IBA	Process
GO:0000710	meiotic mismatch repair	-	ISS	Process
GO:0000790	nuclear chromatin	-	IEA	Component
GO:0003682	chromatin binding	-	IEA	Function
GO:0003684	damaged DNA binding	21873635.	IBA	Function
GO:0003690	double-stranded DNA binding	11809883.	IDA	Function
GO:0005515	protein binding	8942985.9774676.10856833.11005803.11801590.14657349.16403449.19377479.25241761.26496610.	IPI	Function
GO:0005515	protein binding	16403449.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	15105434.	IDA	Function
GO:0005634	nucleus	26300262.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006281	DNA repair	8942985.	IDA	Process
GO:0006290	pyrimidine dimer repair	21873635.	IBA	Process
GO:0006298	mismatch repair	21873635.	IBA	Process
GO:0006298	mismatch repair	10871409.23622243.	IDA	Process
GO:0006298	mismatch repair	23603115.	IGI	Process
GO:0006298	mismatch repair	8782829.	IMP	Process
GO:0006298	mismatch repair	-	TAS	Process
GO:0007095	mitotic G2 DNA damage checkpoint	21873635.	IBA	Process
GO:0008094	DNA-dependent ATPase activity	21873635.	IBA	Function
GO:0008340	determination of adult lifespan	-	ISS	Process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	21873635.	IBA	Process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	ISS	Process
GO:0009411	response to UV	21873635.	IBA	Process
GO:0009411	response to UV	-	ISS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016446	somatic hypermutation of immunoglobulin genes	-	ISS	Process
GO:0016447	somatic recombination of immunoglobulin gene segments	-	ISS	Process
GO:0016887	ATPase activity	16403449.	IDA	Function
GO:0019899	enzyme binding	26300262.	IPI	Function
GO:0030983	mismatched DNA binding	23622243.	IDA	Function
GO:0030983	mismatched DNA binding	8942985.11756455.11801590.	IDA	Function
GO:0032137	guanine/thymine mispair binding	21873635.	IBA	Function
GO:0032137	guanine/thymine mispair binding	8942985.11809883.	IDA	Function
GO:0032142	single guanine insertion binding	8942985.	IDA	Function
GO:0032143	single thymine insertion binding	21873635.	IBA	Function
GO:0032143	single thymine insertion binding	8942985.	IDA	Function
GO:0032300	mismatch repair complex	21873635.	IBA	Component
GO:0032301	MutSalpha complex	21873635.	IBA	Component
GO:0032301	MutSalpha complex	8942985.23622243.	IDA	Component
GO:0032357	oxidized purine DNA binding	11756455.11801590.	IDA	Function
GO:0032405	MutLalpha complex binding	21873635.	IBA	Function
GO:0032405	MutLalpha complex binding	16403449.	IDA	Function
GO:0032876	negative regulation of DNA endoreduplication	21873635.	IBA	Process
GO:0035064	methylated histone binding	21873635.	IBA	Function
GO:0035064	methylated histone binding	23622243.	IDA	Function
GO:0036297	interstrand cross-link repair	21873635.	IBA	Process
GO:0042803	protein homodimerization activity	8942985.	IPI	Function
GO:0043111	replication fork arrest	21873635.	IBA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043531	ADP binding	21873635.	IBA	Function
GO:0043531	ADP binding	15105434.	IDA	Function
GO:0043570	maintenance of DNA repeat elements	21873635.	IBA	Process
GO:0043570	maintenance of DNA repeat elements	16388310.	IMP	Process
GO:0045190	isotype switching	-	ISS	Process
GO:0045830	positive regulation of isotype switching	-	IEA	Process
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:0045910	negative regulation of DNA recombination	17715146.	IDA	Process
GO:0051096	positive regulation of helicase activity	21873635.	IBA	Process
GO:0051096	positive regulation of helicase activity	17715146.	IDA	Process
GO:0097193	intrinsic apoptotic signaling pathway	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24323032	Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing.	J Clin Oncol	2014 Jan 10	Buchanan DD	doi: 10.1200/JCO.2013.51.2129
27803051	Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer.	Carcinogenesis	2017 Jan	Wilczak W	doi: 10.1093/carcin/bgw116
19635727	Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds.	J Med Genet	2010 Feb	Grindedal EM	doi: 10.1136/jmg.2009.068130
27261338	Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.	Gut	2017 Sep	Mller P	doi: 10.1136/gutjnl-2016-311403
15805151	No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer.	J Med Genet	2005 Apr	Vahteristo P	-
25503122	Expression of MSH2 and MSH6 on a tissue microarray in patients with osteosarcoma.	Anticancer Res	2014 Dec	Jentzsch T	-
29342268	Reduced Expression of Mismatch Repair Genes MSH6/MSH2 Directly Promotes Pituitary Tumor Growth via the ATR-Chk1 Pathway.	J Clin Endocrinol Metab	2018 Mar 1	Uraki S	doi: 10.1210/jc.2017-02332.
28387323	CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.	Sci Rep	2017 Apr 7	Cheng DD	doi: 10.1038/srep46238.
19861671	Risk of pancreatic cancer in families with Lynch syndrome.	JAMA	2009 Oct 28	Kastrinos F	doi: 10.1001/jama.2009.1529.
18269114	Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts.	Ulster Med J	2008 Jan	Devlin LA	-
21642682	Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.	JAMA	2011 Jun 8	Bonadona V	doi: 10.1001/jama.2011.743.
15855819	Defective DNA mismatch repair in long-term (> or =3 years) survivors with pancreatic cancer.	Pancreatology	2005	Maple JT	-
28176205	Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens.	Fam Cancer	2017 Jul	Akbari MR	doi: 10.1007/s10689-017-9973-1.
30136158	Whole exome sequencing of breast cancer (TNBC) cases from India: association of MSH6 and BRIP1 variants with TNBC risk and oxidative DNA damage.	Mol Biol Rep	2018 Oct	Aravind Kumar M	doi: 10.1007/s11033-018-4307-4
29345684	MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer.	Genet Med	2018 Oct	Roberts ME	doi: 10.1038/gim.2017.254
23434150	Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?	Eur J Cancer	2013 May	Win AK	doi: 10.1016/j.ejca.2013.01.029
23313663	Benzo[α]pyrene repressed DNA mismatch repair in human breast cancer cells.	Toxicology	2013 Feb 8	Chen Y	doi: 10.1016/j.tox.2013.01.003
25255306	Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer.	Nat Commun	2014 Sep 25	Pritchard CC	doi: 10.1038/ncomms5988.
26544533	Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.	Pediatr Blood Cancer	2016 Mar	Baris HN	doi: 10.1002/pbc.25818
18790734	Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.	J Biol Chem	2008 Nov 14	Cyr JL	doi: 10.1074/jbc.M806018200
19707776	Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins.	Int J Colorectal Dis	2010 Jan	Molaei M	doi: 10.1007/s00384-009-0784-1
19787250	Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.	Int J Oncol	2009 Nov	Kawaguchi M	-
15098177	Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history.	Am J Hum Genet	2004 Jun	Buttin BM	-
17498565	A new interphase fluorescence in situ hybridization approach for genomic rearrangements involving MLH1 and MSH6 in hereditary nonpolyposis colorectal cancer-suspected mutation-negative patients.	Cancer Genet Cytogenet	2007 May	Koehler U	-
17854147	Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families.	World J Gastroenterol	2007 Oct 7	Yan SY	-
20495877	Magnetic resonance colonography for colorectal cancer screening in patients with Lynch syndrome gene mutation.	Fam Cancer	2010 Dec	Lim EJ	doi: 10.1007/s10689-010-9350-9.
19582761	MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer.	Mol Carcinog	2009 Nov	Curtin K	doi: 10.1002/mc.20566.
16106253	The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers.	Br J Cancer	2005 Aug 22	Lawes DA	-
21334712	Challenging cases encountered in colorectal cancer screening for Lynch syndrome reveal novel findings: nucleolar MSH6 staining and impact of prior chemoradiation therapy.	Hum Pathol	2011 Sep	Radu OM	doi: 10.1016/j.humpath.2010.11.016
22495361	MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry.	Appl Immunohistochem Mol Morphol	2012 Oct	Okkels H	doi: 10.1097/PAI.0b013e318249739b.
20872076	Hereditary prostate cancer as a feature of Lynch syndrome.	Fam Cancer	2011 Mar	Bauer CM	doi: 10.1007/s10689-010-9388-8.
19924528	Association of rare MSH6 variants with familial breast cancer.	Breast Cancer Res Treat	2010 Sep	Wasielewski M	doi: 10.1007/s10549-009-0634-4
19492230	Meta-analysis of MSH6 gene mutation frequency in colorectal and endometrial cancers.	J Toxicol Environ Health A	2009	Zhao YS	doi: 10.1080/15287390902841003.
14974087	Eight novel MSH6 germline mutations in patients with familial and nonfamilial colorectal cancer selected by loss of protein expression in tumor tissue.	Hum Mutat	2004 Mar	Plaschke J	-
25664706	Lymph node yield after colectomy for cancer: is absence of mismatch repair a factor?	Dis Colon Rectum	2015 Mar	Samdani T	doi: 10.1097/DCR.0000000000000262.
21559014	Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes.	Br J Cancer	2011 Jun 28	Win AK	doi: 10.1038/bjc.2011.172
23301373	Status of mismatch repair genes hMSH2 and hMSH6 in colorectal cancer in Saudi patients: an immunohistochemical analysis.	East Mediterr Health J	2012 Nov	Alkhalidi H	-
17920897	Recently identified colon cancer predispositions: MYH and MSH6 mutations.	Semin Oncol	2007 Oct	Kastrinos F	-
15571801	Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer.	Cancer Genet Cytogenet	2004 Dec	Rey JM	-
12019211	Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome.	Hum Mol Genet	2002 May 15	Kariola R	-
19685280	Association of MUTYH and MSH6 germline mutations in colorectal cancer patients.	Fam Cancer	2009	Gir??ldez MD	doi: 10.1007/s10689-009-9282-4
27013479	Frequent mismatch-repair defects link prostate cancer to Lynch syndrome.	BMC Urol	2016 Mar 24	Dominguez-Valentin M	doi: 10.1186/s12894-016-0130-1.
16902769	Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.	J Cancer Res Clin Oncol	2007 Jan	Chaksangchaichot P	-
24622885	Association between MSH6 G39E polymorphism and cancer susceptibility: a meta-analysis of 7,046 cases and 34,554 controls.	Tumour Biol	2014 Jun	Li Z	doi: 10.1007/s13277-014-1798-z
21710692	Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer.	J Pathol	2011 Oct	Moelans CB	doi: 10.1002/path.2930
14767555	Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1.	Int J Oncol	2004 Mar	Yabuta T	-
11807791	Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation.	Int J Cancer	2002 Feb 10	Plaschke J	-
22484182	Thirty-nine-year-old with familial colon cancer, and variant of undetermined significance in MSH6.	Semin Oncol	2012 Apr	Adonizio C	doi: 10.1053/j.seminoncol.2012.01.013.
12920072	Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome.	J Med Genet	2003 Aug	Plaschke J	-
27468915	First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome.	Fam Cancer	2017 Jan	Ziada-Bouchaar H	doi: 10.1007/s10689-016-9917-1.
29442465	Polymorphism of Gly39Glu (c.116G>A) hMSH6 is associated with sporadic colorectal cancer development in the Polish population: Preliminary results.	Adv Clin Exp Med	2017 Dec	Zelga P	doi: 10.17219/acem/64877.
28451866	The 116G>A MSH6 and IVS1-1121C>T PMS2 Genes Polymorphisms Modulate the Risk of the Sporadic Colorectal Cancer Development in Polish Population.	Pathol Oncol Res	2018 Apr	Zelga P	doi: 10.1007/s12253-017-0231-5
28466842	Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.	Nat Commun	2017 May 3	Haraldsdottir S	doi: 10.1038/ncomms14755.
30486602	The Tendency of Having MSH2 and MSH6 Microsatellite Instability among Clinicopathological Features in Patients with Colorectal Cancer	Asian Pac J Cancer Prev	2018 Nov 29	Arshita N	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	47783223	5'UTR	novel		0.07
ACC	chr2	47799466	Nonsense_Mutation	rs587779212	R495*	0.92
BLCA	chr2	47805664	Silent	novel	L1201L	0.06
BLCA	chr2	47800341	Silent	novel	Y786Y	0.44
BLCA	chr2	47800075	Nonsense_Mutation	novel	Q698*	0.28
BLCA	chr2	47807939	3'UTR	novel		0.56
BLCA	chr2	47800050	Missense_Mutation	NA	F689L	0.24
BLCA	chr2	47791023	Silent	novel	F119F	0.06
BLCA	chr2	47806840	Missense_Mutation	novel	T1355A	0.39
BLCA	chr2	47799068	In_Frame_Del	novel	T363del	0.16
BLCA	chr2	47798940	Silent	rs375210430	T319T	0.1
BLCA	chr2	47800621	Missense_Mutation	NA	D880Y	0.16
BLCA	chr2	47806650	Missense_Mutation	rs773763465	R1334W	0.21
BLCA	chr2	47800459	Missense_Mutation	novel	H826N	0.65
BLCA	chr2	47799442	Missense_Mutation	novel	E487K	0.29
BLCA	chr2	47798738	Nonsense_Mutation	rs267608048	S252*	0.19
BLCA	chr2	47800411	Missense_Mutation	novel	E810K	0.38
BRCA	chr2	47807681	3'UTR	novel		0.3
BRCA	chr2	47800445	Missense_Mutation	novel	L821P	0.24
BRCA	chr2	47806545	Missense_Mutation	novel	G1299C	0.11
BRCA	chr2	47800960	Missense_Mutation	NA	E993K	0.23
BRCA	chr2	47799310	Missense_Mutation	novel	G443R	0.19
BRCA	chr2	47799609	Silent	novel	L542L	0.09
BRCA	chr2	47801129	Missense_Mutation	NA	S1049F	0.16
BRCA	chr2	47799370	Nonsense_Mutation	NA	E463*	0.21
BRCA	chr2	47799772	Missense_Mutation	NA	E597Q	0.13
BRCA	chr2	47806650	Missense_Mutation	rs773763465	R1334W	0.22
BRCA	chr2	47800747	Nonsense_Mutation	rs587779246	R922*	0.29
BRCA	chr2	47800075	Missense_Mutation	rs63750832	Q698E	0.24
BRCA	chr2	47807147	3'UTR	novel		0.44
BRCA	chr2	47800059	Missense_Mutation	NA	K692N	0.13
CESC	chr2	47799846	Silent	NA	L621L	0.27
CESC	chr2	47805701	Nonsense_Mutation	NA	E1214*	0.34
CESC	chr2	47800333	Missense_Mutation	novel	N784H	0.12
CESC	chr2	47798875	Nonsense_Mutation	rs146816935	R298*	0.25
COAD	chr2	47803500	Frame_Shift_Ins	rs748452299	*F1088Lfs5**	0.23
COAD	chr2	47800819	Nonsense_Mutation	NA	E946*	0.38
COAD	chr2	47806614	Nonsense_Mutation	NA	E1322*	0.43
COAD	chr2	47791054	Missense_Mutation	novel	H130N	0.24
COAD	chr2	47808059	3'UTR	novel		0.2
COAD	chr2	47808059	3'UTR	novel		0.33
COAD	chr2	47798680	Missense_Mutation	NA	P233S	0.32
COAD	chr2	47800134	Silent	novel	V717V	0.16
COAD	chr2	47803433	Silent	novel	C1062C	0.32
COAD	chr2	47798676	Silent	novel	V231V	0.17
COAD	chr2	47795959	Missense_Mutation	novel	A175T	0.25
COAD	chr2	47800215	Silent	novel	E744E	0.05
COAD	chr2	47806898	3'UTR	novel		0.32
COAD	chr2	47803552	Frame_Shift_Ins	NA	*G1105Wfs3**	0.27
COAD	chr2	47798717	Frame_Shift_Ins	NA	*R248Tfs8**	0.29
COAD	chr2	47799065	Missense_Mutation	rs63750440	R361H	0.3
COAD	chr2	47798725	Nonsense_Mutation	rs63749980	R248*	0.29
COAD	chr2	47800626	Frame_Shift_Del	novel	*F882Lfs24**	0.31
COAD	chr2	47799353	Missense_Mutation	NA	A457D	0.23
COAD	chr2	47800827	Silent	NA	E948E	0.3
COAD	chr2	47801002	Missense_Mutation	novel	W1007R	0.05
COAD	chr2	47803531	Missense_Mutation	rs63750253	R1095H	0.34
COAD	chr2	47806280	Missense_Mutation	novel	C1241W	0.14
COAD	chr2	47801053	Missense_Mutation	rs370505117	R1024W	0.36
COAD	chr2	47800178	Missense_Mutation	rs749746725	R732Q	0.23
COAD	chr2	47800608	Missense_Mutation	NA	M875I	0.4
COAD	chr2	47803547	Silent	rs540252208	T1100T	0.34
COAD	chr2	47800819	Nonsense_Mutation	NA	E946*	0.21
COAD	chr2	47803634	Silent	NA	C1129C	0.22
COAD	chr2	47791042	In_Frame_Ins	novel	S126delinsYIT	0.07
COAD	chr2	47803552	Frame_Shift_Ins	NA	*G1105Wfs3**	0.23
COAD	chr2	47804948	Silent	rs398123231	Y1159Y	0.35
COAD	chr2	47803474	Missense_Mutation	rs779617676	R1076H	0.13
ESCA	chr2	47806470	Missense_Mutation	novel	E1274Q	0.63
ESCA	chr2	47798985	Missense_Mutation	novel	K334N	0.08
ESCA	chr2	47783138	5'UTR	novel		0.27
ESCA	chr2	47807305	3'UTR	novel		0.31
ESCA	chr2	47795994	Frame_Shift_Ins	novel	*I188Rfs25**	0.29
ESCA	chr2	47798773	Missense_Mutation	novel	E264K	0.3
ESCA	chr2	47803444	Missense_Mutation	rs372103816	Y1066C	0.19
GBM	chr2	47798940	Silent	rs375210430	T319T	0.07
GBM	chr2	47806952	3'UTR	novel		0.05
GBM	chr2	47799761	Frame_Shift_Del	novel	*V594Ffs16**	0.04
GBM	chr2	47799236	Missense_Mutation	novel	S418Y	0.29
GBM	chr2	47799428	Missense_Mutation	rs773226008	R482Q	0.54
GBM	chr2	47800215	Missense_Mutation	novel	E744D	0.06
GBM	chr2	47803547	Silent	rs540252208	T1100T	0.22
GBM	chr2	47799094	Missense_Mutation	novel	E371K	0.21
GBM	chr2	47799931	Missense_Mutation	novel	G650C	0.21
GBM	chr2	47799337	Missense_Mutation	rs780734507	M452V	0.07
GBM	chr2	47799764	Frame_Shift_Del	novel	*L595Yfs15**	0.2
GBM	chr2	47806340	Silent	novel	A1261A	0.04
GBM	chr2	47798948	Missense_Mutation	NA	A322V	0.25
GBM	chr2	47796061	Nonsense_Mutation	rs747477669	E209*	0.28
GBM	chr2	47800414	Missense_Mutation	novel	L811V	0.05
HNSC	chr2	47799562	Frame_Shift_Del	novel	E528*	0.12
HNSC	chr2	47799644	Missense_Mutation	rs730881791	R554H	0.33
HNSC	chr2	47807972	3'UTR	novel		0.19
HNSC	chr2	47798925	Missense_Mutation	rs150440246	S314R	0.28
KICH	chr2	47803552	Frame_Shift_Ins	NA	*G1105Wfs3**	0.72
KIRC	chr2	47801222	Intron	novel		0.38
KIRC	chr2	47799250	Missense_Mutation	NA	L423I	0.3
KIRC	chr2	47805678	Missense_Mutation	novel	A1206E	0.33
KIRP	chr2	47798745	Frame_Shift_Ins	novel	*E255Gfs3**	0.15
KIRP	chr2	47799986	Missense_Mutation	NA	S668C	0.37
LAML	chr2	47800401	Silent	rs770992427	S806S	0.43
LAML	chr2	47800324	Missense_Mutation	rs587779235	P781T	0.07
LGG	chr2	47783274	Missense_Mutation	novel	S14Y	0.22
LGG	chr2	47799151	Missense_Mutation	rs147737737	D390N	0.12
LIHC	chr2	47799908	Missense_Mutation	NA	Y642C	0.5
LIHC	chr2	47800156	Missense_Mutation	rs148898662	I725V	0.43
LIHC	chr2	47791099	Nonsense_Mutation	novel	K145*	0.44
LIHC	chr2	47783390	Frame_Shift_Del	novel	*A53Gfs23**	0.17
LUAD	chr2	47803672	Missense_Mutation	rs267608089	T1142M	0.13
LUAD	chr2	47799827	Missense_Mutation	rs730881793	C615F	0.04
LUAD	chr2	47800058	Missense_Mutation	novel	K692T	0.04
LUAD	chr2	47799657	Silent	novel	V558V	0.52
LUAD	chr2	47805671	Missense_Mutation	NA	A1204P	0.23
LUAD	chr2	47806277	Silent	rs786203260	K1240K	0.15
LUAD	chr2	47806620	Frame_Shift_Ins	novel	*E1324Vfs18**	0.08
LUAD	chr2	47806622	Silent	novel	E1324E	0.05
LUAD	chr2	47783343	Missense_Mutation	rs763104308	A37V	0.24
LUAD	chr2	47800033	Silent	novel	L684L	0.15
LUAD	chr2	47799248	Missense_Mutation	NA	D422G	0.06
LUAD	chr2	47806297	Missense_Mutation	rs786204182	T1247S	0.08
LUAD	chr2	47800717	Missense_Mutation	NA	W912R	0.29
LUSC	chr2	47800048	Missense_Mutation	NA	F689V	0.22
LUSC	chr2	47783202	5'UTR	novel		0.44
LUSC	chr2	47798872	Missense_Mutation	NA	A297T	0.39
LUSC	chr2	47791072	Missense_Mutation	novel	D136N	0.17
LUSC	chr2	47799505	Missense_Mutation	novel	V508L	0.11
LUSC	chr2	47783299	In_Frame_Del	novel	A25_S28del	0.29
LUSC	chr2	47798994	Silent	NA	L337L	0.18
LUSC	chr2	47805664	Silent	rs761458936	L1201L	0.06
LUSC	chr2	47806231	Missense_Mutation	rs63750370	T1225M	0.2
LUSC	chr2	47800879	Missense_Mutation	novel	T966A	0.14
MESO	chr2	47783400	Missense_Mutation	novel	G56E	0.63
OV	chr2	47800329	Silent	NA	L782L	0.37
OV	chr2	47800056	Silent	novel	L691L	0.08
OV	chr2	47806216	Missense_Mutation	novel	A1220G	0.06
OV	chr2	47801115	Nonsense_Mutation	NA	Y1044*	0.32
OV	chr2	47799667	Missense_Mutation	novel	D562N	0.03
PAAD	chr2	47806936	3'UTR	novel		0.05
PAAD	chr2	47791039	Nonsense_Mutation	novel	K125*	0.28
PAAD	chr2	47799483	Silent	novel	A500A	0.23
PAAD	chr2	47803531	Missense_Mutation	rs63750253	R1095H	0.23
PAAD	chr2	47806257	Nonsense_Mutation	NA	E1234*	0.19
PCPG	chr2	47804963	Silent	novel	V1164V	0.07
PRAD	chr2	47800821	Missense_Mutation	novel	E946D	0.25
PRAD	chr2	47799130	Missense_Mutation	NA	R383G	0.29
PRAD	chr2	47783182	5'UTR	novel		0.5
PRAD	chr2	47798940	Silent	rs375210430	T319T	0.39
PRAD	chr2	47799438	Silent	novel	Q485Q	0.48
PRAD	chr2	47799727	Frame_Shift_Del	novel	*F582Lfs4**	0.4
READ	chr2	47799273	Silent	NA	G430G	0.22
READ	chr2	47803550	Missense_Mutation	rs370353868	K1101N	0.27
READ	chr2	47800918	Missense_Mutation	NA	L979V	0.1
READ	chr2	47803598	Frame_Shift_Ins	novel	*E1119Rfs27**	0.34
READ	chr2	47799793	Nonsense_Mutation	novel	E604*	0.36
READ	chr2	47800851	Missense_Mutation	novel	E956D	0.43
READ	chr2	47795977	Missense_Mutation	rs569728764	E181K	0.41
READ	chr2	47806254	Missense_Mutation	NA	K1233Q	0.35
SARC	chr2	47803500	Frame_Shift_Ins	rs748452299	*F1088Lfs5**	0.3
SARC	chr2	47807259	3'UTR	novel		0.18
SKCM	chr2	47783120	5'UTR	novel		0.27
SKCM	chr2	47800013	Missense_Mutation	NA	S677I	0.22
SKCM	chr2	47791026	Silent	novel	I120I	0.34
SKCM	chr2	47791027	Missense_Mutation	rs763593669	R121C	0.34
SKCM	chr2	47800752	Silent	novel	K923K	0.26
SKCM	chr2	47803450	Missense_Mutation	rs398123230	R1068Q	0.39
SKCM	chr2	47799402	Silent	novel	L473L	0.28
SKCM	chr2	47799403	Missense_Mutation	novel	V474M	0.3
SKCM	chr2	47801040	Silent	novel	I1019I	0.33
SKCM	chr2	47798899	Missense_Mutation	novel	G306R	0.22
SKCM	chr2	47798900	Missense_Mutation	novel	G306E	0.21
SKCM	chr2	47803613	Silent	NA	Q1122Q	0.21
SKCM	chr2	47795900	Missense_Mutation	NA	K155R	0.11
SKCM	chr2	47799572	Missense_Mutation	novel	D530V	0.42
STAD	chr2	47800668	Frame_Shift_Del	NA	*N897Ifs9**	0.27
STAD	chr2	47783363	Missense_Mutation	novel	P44T	0.19
STAD	chr2	47803553	Frame_Shift_Del	novel	*F1104Lfs11**	0.25
STAD	chr2	47798999	Missense_Mutation	NA	A339D	0.18
STAD	chr2	47798839	Missense_Mutation	NA	E286K	0.27
STAD	chr2	47799172	Missense_Mutation	rs587779913	Y397H	0.33
STAD	chr2	47807941	3'UTR	novel		0.57
STAD	chr2	47791049	Missense_Mutation	NA	R128H	0.17
STAD	chr2	47798940	Silent	rs375210430	T319T	0.31
STAD	chr2	47801207	Intron	novel		0.25
STAD	chr2	47798865	Silent	novel	V294V	0.37
STAD	chr2	47801011	Missense_Mutation	NA	T1010A	0.18
STAD	chr2	47804974	Missense_Mutation	novel	T1168I	0.23
STAD	chr2	47798789	Missense_Mutation	rs587779322	T269S	0.1
STAD	chr2	47800910	Missense_Mutation	rs63751113	R976H	0.34
STAD	chr2	47800729	Missense_Mutation	novel	F916L	0.32
STAD	chr2	47799983	Missense_Mutation	NA	D667V	0.19
STAD	chr2	47800586	Missense_Mutation	rs780280765	M868T	0.22
STAD	chr2	47803553	Frame_Shift_Del	novel	*F1104Lfs11**	0.2
TGCT	chr2	47799710	Missense_Mutation	novel	D576A	0.35
THYM	chr2	47807218	3'UTR	novel		0.37
UCEC	chr2	47803553	Frame_Shift_Del	novel	*F1104Lfs11**	0.23
UCEC	chr2	47799904	Nonsense_Mutation	NA	E641*	0.31
UCEC	chr2	47803547	Silent	rs540252208	T1100T	0.63
UCEC	chr2	47799428	Missense_Mutation	rs773226008	R482Q	0.31
UCEC	chr2	47800862	Missense_Mutation	NA	N960T	0.16
UCEC	chr2	47803547	Silent	rs540252208	T1100T	0.34
UCEC	chr2	47806333	Missense_Mutation	novel	N1259T	0.04
UCEC	chr2	47801022	Missense_Mutation	NA	K1013N	0.15
UCEC	chr2	47798940	Silent	rs375210430	T319T	0.33
UCEC	chr2	47801022	Missense_Mutation	NA	K1013N	0.32
UCEC	chr2	47799088	Missense_Mutation	novel	T369A	0.11
UCEC	chr2	47807516	3'UTR	novel		0.3
UCEC	chr2	47807588	3'UTR	novel		0.27
UCEC	chr2	47799151	Missense_Mutation	rs147737737	D390N	0.43
UCEC	chr2	47800705	Nonsense_Mutation	NA	E908*	0.45
UCEC	chr2	47800183	Missense_Mutation	rs587780671	V734M	0.48
UCEC	chr2	47799636	Silent	novel	G551G	0.39
UCEC	chr2	47799854	Missense_Mutation	novel	G624D	0.45
UCEC	chr2	47799954	Silent	novel	Q657Q	0.41
UCEC	chr2	47803474	Missense_Mutation	rs779617676	R1076H	0.42
UCEC	chr2	47806614	Nonsense_Mutation	NA	E1322*	0.4
UCEC	chr2	47783245	Missense_Mutation	novel	Q4H	0.42
UCEC	chr2	47795996	Missense_Mutation	NA	K187T	0.31
UCEC	chr2	47800859	Missense_Mutation	rs757653982	R959H	0.3
UCEC	chr2	47783110	5'UTR	novel		0.67
UCEC	chr2	47795957	Missense_Mutation	novel	R174K	0.15
UCEC	chr2	47803547	Silent	rs540252208	T1100T	0.04
UCEC	chr2	47795969	Missense_Mutation	rs786204186	R178H	0.23
UCEC	chr2	47799568	Missense_Mutation	NA	G529C	0.24
UCEC	chr2	47806257	Nonsense_Mutation	NA	E1234*	0.44
UCEC	chr2	47806502	Silent	rs2229018	T1284T	0.23
UCEC	chr2	47806803	Silent	NA	R1342R	0.05
UCEC	chr2	47799466	Nonsense_Mutation	rs587779212	R495*	0.36
UCEC	chr2	47800672	Missense_Mutation	NA	N897H	0.09
UCEC	chr2	47800859	Missense_Mutation	rs757653982	R959H	0.29
UCEC	chr2	47801022	Missense_Mutation	NA	K1013N	0.12
UCEC	chr2	47803552	Frame_Shift_Ins	NA	*G1105Wfs3**	0.34
UCEC	chr2	47799964	Missense_Mutation	novel	G661S	0.24
UCEC	chr2	47800819	Nonsense_Mutation	NA	E946*	0.28
UCEC	chr2	47806614	Nonsense_Mutation	NA	E1322*	0.14
UCEC	chr2	47783329	Silent	rs553046896	G32G	0.38
UCEC	chr2	47783332	Frame_Shift_Del	novel	*A34Pfs47**	0.38
UCEC	chr2	47800729	Frame_Shift_Del	novel	F916*	0.4
UCEC	chr2	47800996	Nonsense_Mutation	rs63750563	R1005*	0.19
UCEC	chr2	47801146	Frame_Shift_Ins	novel	*V1056Sfs10**	0.38
UCEC	chr2	47807555	3'UTR	novel		0.27
UCEC	chr2	47800231	Missense_Mutation	NA	T750P	0.15
UCEC	chr2	47800910	Missense_Mutation	rs63751113	R976H	0.36
UCEC	chr2	47807381	3'UTR	novel		0.3
UCEC	chr2	47801066	Missense_Mutation	NA	S1028L	0.33
UCEC	chr2	47801181	Intron	NA		0.44
UCEC	chr2	47799904	Missense_Mutation	novel	E641K	0.22
UCEC	chr2	47799122	Missense_Mutation	novel	D380A	0.55
UCEC	chr2	47803547	Silent	rs540252208	T1100T	0.13
UCEC	chr2	47807218	3'UTR	novel		0.32
UCEC	chr2	47783215	5'UTR	novel		0.29
UCEC	chr2	47803465	Frame_Shift_Ins	novel	*M1074Yfs19**	0.26
UCEC	chr2	47805629	Frame_Shift_Del	novel	*F1191Lfs4**	0.23
UCEC	chr2	47799065	Missense_Mutation	rs63750440	R361H	0.39
UCEC	chr2	47798812	Nonsense_Mutation	novel	E277*	0.46
UCEC	chr2	47807329	3'UTR	novel		0.07
UCEC	chr2	47799250	Missense_Mutation	novel	L423F	0.31
UCEC	chr2	47799613	Nonsense_Mutation	novel	E544*	0.38
UCEC	chr2	47807322	3'UTR	novel		0.25
UCEC	chr2	47806282	Missense_Mutation	rs63750119	R1242H	0.29
UCEC	chr2	47798717	Frame_Shift_Ins	NA	*R248Tfs8**	0.86
UCEC	chr2	47800832	Missense_Mutation	NA	S950I	0.24
UCEC	chr2	47803582	Missense_Mutation	novel	D1112A	0.42
UCEC	chr2	47805677	Missense_Mutation	novel	A1206S	0.42
UCEC	chr2	47791113	Missense_Mutation	novel	K149N	0.39
UCEC	chr2	47798940	Silent	rs375210430	T319T	0.35
UCEC	chr2	47800910	Missense_Mutation	rs63751113	R976H	0.48
UCEC	chr2	47803614	Missense_Mutation	novel	E1123K	0.45
UCEC	chr2	47805674	Missense_Mutation	novel	T1205A	0.44
UCEC	chr2	47807178	3'UTR	novel		0.16
UCEC	chr2	47801213	Intron	novel		0.2
UCEC	chr2	47800859	Missense_Mutation	rs757653982	R959H	0.25
UCEC	chr2	47803474	Missense_Mutation	rs779617676	R1076H	0.29
UCEC	chr2	47799101	Missense_Mutation	NA	L373P	0.12
UCEC	chr2	47800677	Silent	rs769668106	P898P	0.08
UCEC	chr2	47798900	Missense_Mutation	novel	G306E	0.15
UCEC	chr2	47807329	3'UTR	novel		0.39
UCEC	chr2	47790930	Silent	novel	C88C	0.28
UCEC	chr2	47798870	Missense_Mutation	novel	V296A	0.2
UCEC	chr2	47803480	Missense_Mutation	rs376452612	V1078A	0.4
UCEC	chr2	47807698	3'UTR	novel		0.42
UCEC	chr2	47804931	Missense_Mutation	novel	A1154T	0.22
UCEC	chr2	47799014	Missense_Mutation	novel	Q344P	0.38
UCEC	chr2	47799151	Missense_Mutation	rs147737737	D390N	0.15
UCEC	chr2	47800547	Missense_Mutation	novel	I855N	0.35
UCEC	chr2	47806614	Nonsense_Mutation	NA	E1322*	0.19
UCEC	chr2	47807462	3'UTR	novel		0.17
UCEC	chr2	47799065	Missense_Mutation	rs63750440	R361H	0.59
UCEC	chr2	47798718	Frame_Shift_Del	novel	*K247Nfs32**	0.31
UCEC	chr2	47798985	Missense_Mutation	novel	K334N	0.24
UCEC	chr2	47800298	Missense_Mutation	rs63750725	R772Q	0.42
UCEC	chr2	47803621	Missense_Mutation	novel	G1125D	0.34
UCEC	chr2	47799108	Missense_Mutation	novel	E375D	0.35
UCEC	chr2	47799428	Missense_Mutation	rs773226008	R482Q	0.31
UCEC	chr2	47800996	Nonsense_Mutation	rs63750563	R1005*	0.38
UCEC	chr2	47806257	Nonsense_Mutation	NA	E1234*	0.41
UCEC	chr2	47806350	Nonsense_Mutation	novel	G1265*	0.44
UCEC	chr2	47799438	Missense_Mutation	novel	Q485H	0.48
UCEC	chr2	47806257	Nonsense_Mutation	NA	E1234*	0.43
UCEC	chr2	47799627	Missense_Mutation	novel	D548E	0.38
UCEC	chr2	47806614	Nonsense_Mutation	NA	E1322*	0.38
UCEC	chr2	47807329	3'UTR	novel		0.48
UCEC	chr2	47800819	Nonsense_Mutation	NA	E946*	0.29
UCEC	chr2	47808039	3'UTR	novel		0.06
UCEC	chr2	47800819	Nonsense_Mutation	NA	E946*	0.38
UCEC	chr2	47800542	Missense_Mutation	novel	K853N	0.29
UCEC	chr2	47803473	Missense_Mutation	rs63750617	R1076C	0.35
UCEC	chr2	47807268	3'UTR	novel		0.28
UCEC	chr2	47807622	3'UTR	novel		0.35
UCEC	chr2	47806585	Missense_Mutation	novel	V1312A	0.46
UCEC	chr2	47798987	Frame_Shift_Del	NA	*T336Ffs11**	0.41
UCEC	chr2	47783369	Missense_Mutation	novel	G46R	0.31
UCEC	chr2	47807258	3'UTR	novel		0.26
UCEC	chr2	47800587	Missense_Mutation	rs749508276	M868I	0.3
UCEC	chr2	47799367	Frame_Shift_Ins	novel	*P462Hfs21**	0.07
UCEC	chr2	47803550	Missense_Mutation	rs370353868	K1101N	0.57
UCEC	chr2	47806546	Missense_Mutation	NA	G1299D	0.53
UCEC	chr2	47790963	Missense_Mutation	rs63751258	K99N	0.31
UCEC	chr2	47799878	Missense_Mutation	rs750800736	K632T	0.26
UCEC	chr2	47800813	Missense_Mutation	NA	I944V	0.43
UCEC	chr2	47799613	Nonsense_Mutation	novel	E544*	0.37
UCEC	chr2	47799644	Missense_Mutation	rs730881791	R554H	0.53
UCEC	chr2	47800372	Missense_Mutation	novel	D797Y	0.48
UCEC	chr2	47800946	Missense_Mutation	rs115386788	R988H	0.32
UCEC	chr2	47803474	Missense_Mutation	rs779617676	R1076H	0.55
UCEC	chr2	47806282	Missense_Mutation	rs63750119	R1242H	0.32
UCEC	chr2	47799455	Missense_Mutation	rs759643679	M491T	0.07
UCEC	chr2	47806269	Missense_Mutation	NA	T1238A	0.29
UCEC	chr2	47799105	Missense_Mutation	novel	K374N	0.41
UCEC	chr2	47799777	Missense_Mutation	novel	K598N	0.37
UCEC	chr2	47800215	Silent	novel	E744E	0.36
UCEC	chr2	47804952	Missense_Mutation	novel	P1161S	0.07
UCS	chr2	47803501	Frame_Shift_Del	rs770288143	*F1088Sfs2**	0.49
UCS	chr2	47791001	Missense_Mutation	rs587779934	N112S	0.4
UCS	chr2	47799571	Missense_Mutation	novel	D530Y	0.4
UCS	chr2	47808094	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0707	0.2014
TGCT	AMP	0.2467	0.0050216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.002	Kaplan-Meier Survival Analysis
SARC	0.0012	Kaplan-Meier Survival Analysis
MESO	0.0053	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.023	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
LUSC	0.032	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.018	Kaplan-Meier Survival Analysis
BLCA	0.012	Kaplan-Meier Survival Analysis
CESC	0.011	Kaplan-Meier Survival Analysis
READ	0.0077	Kaplan-Meier Survival Analysis
KICH	0.0097	Kaplan-Meier Survival Analysis
UCEC	0.00059	Kaplan-Meier Survival Analysis
LIHC	0.0017	Kaplan-Meier Survival Analysis
DLBC	0.046	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.043	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742