EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116120 (Gene tree)
Gene ID: 10056
Gene Symbol: FARSB
Alias: PheHB|FRSB|FARSLB
Full Name: phenylalanyl-tRNA synthetase subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 85,820 bases
Position: chr2:222,570,536-222,656,355
Accession: 17800
RBP type: canonical RBP
Summary: This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000281828	B3_4	PF03483.17	1.8e-25	1	1
ENSP00000281828	B5	PF03484.15	7.5e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000281828	FARSB-201	3369	XM_006712169	ENSP00000281828	589 (aa)	XP_006712232	Q9NSD9

Gene Model

Click here to download ENSG00000116120's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116120	Arteries	2.7930000E-005	-
ENSG00000116120	Arteries	2.1820000E-005	-
ENSG00000116120	Arteries	8.9610000E-005	-
ENSG00000116120	Platelet Function Tests	7.1900000E-006	-
ENSG00000116120	Chin	2E-17	27182965
ENSG00000116120	Schizophrenia	2E-6	25781172
ENSG00000116120	Herpesvirus 1, Human	2E-6	25781172

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116120	rs10170846	2	222652986	?	Schizophrenia (inflammation and infection response interaction)	25781172			EFO_0000692\|EFO_0007050
ENSG00000116120	rs150779234	2	222642575	C	Platelet-derived growth factor BB levels	27989323	[0.13-0.31] SD units decrease	0.2171	EFO_0008264

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116120's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116120	FARSB	100	76.102	ENSAPOG00000013072	farsb	100	72.203	Acanthochromis_polyacanthus
ENSG00000116120	FARSB	100	94.907	ENSAMEG00000005984	FARSB	100	94.907	Ailuropoda_melanoleuca
ENSG00000116120	FARSB	100	74.068	ENSACIG00000021623	farsb	100	74.068	Amphilophus_citrinellus
ENSG00000116120	FARSB	100	75.593	ENSAOCG00000004912	farsb	100	73.051	Amphiprion_ocellaris
ENSG00000116120	FARSB	100	75.424	ENSAPEG00000001153	farsb	100	71.525	Amphiprion_percula
ENSG00000116120	FARSB	100	76.949	ENSATEG00000021441	farsb	70	76.949	Anabas_testudineus
ENSG00000116120	FARSB	99	82.021	ENSAPLG00000010292	FARSB	99	82.021	Anas_platyrhynchos
ENSG00000116120	FARSB	100	81.864	ENSACAG00000004769	FARSB	98	81.864	Anolis_carolinensis
ENSG00000116120	FARSB	100	97.114	ENSANAG00000024637	FARSB	100	97.114	Aotus_nancymaae
ENSG00000116120	FARSB	100	76.610	ENSACLG00000013951	farsb	100	74.336	Astatotilapia_calliptera
ENSG00000116120	FARSB	85	74.200	ENSAMXG00000033881	farsb	100	74.200	Astyanax_mexicanus
ENSG00000116120	FARSB	100	93.888	ENSBTAG00000011649	FARSB	100	93.888	Bos_taurus
ENSG00000116120	FARSB	96	93.262	ENSBTAG00000045523	-	100	93.262	Bos_taurus
ENSG00000116120	FARSB	100	59.291	WBGene00001498	fars-3	100	59.291	Caenorhabditis_elegans
ENSG00000116120	FARSB	100	97.623	ENSCJAG00000012181	FARSB	100	97.623	Callithrix_jacchus
ENSG00000116120	FARSB	100	95.076	ENSCAFG00000016094	-	100	95.076	Canis_familiaris
ENSG00000116120	FARSB	100	92.203	ENSCAFG00020026684	FARSB	100	95.027	Canis_lupus_dingo
ENSG00000116120	FARSB	100	93.888	ENSCHIG00000014275	FARSB	100	93.888	Capra_hircus
ENSG00000116120	FARSB	100	94.058	ENSTSYG00000008461	FARSB	100	94.058	Carlito_syrichta
ENSG00000116120	FARSB	96	86.585	ENSCAPG00000016436	FARSB	99	86.585	Cavia_aperea
ENSG00000116120	FARSB	100	93.888	ENSCPOG00000013109	FARSB	100	93.888	Cavia_porcellus
ENSG00000116120	FARSB	100	92.869	ENSCCAG00000025840	FARSB	100	92.869	Cebus_capucinus
ENSG00000116120	FARSB	100	99.151	ENSCATG00000036168	FARSB	100	99.151	Cercocebus_atys
ENSG00000116120	FARSB	100	93.888	ENSCLAG00000011954	FARSB	100	93.888	Chinchilla_lanigera
ENSG00000116120	FARSB	100	99.151	ENSCSAG00000007806	FARSB	100	99.151	Chlorocebus_sabaeus
ENSG00000116120	FARSB	81	94.382	ENSCHOG00000011785	FARSB	81	94.382	Choloepus_hoffmanni
ENSG00000116120	FARSB	100	83.051	ENSCPBG00000019346	FARSB	98	83.051	Chrysemys_picta_bellii
ENSG00000116120	FARSB	99	57.930	ENSCING00000004180	-	99	57.930	Ciona_intestinalis
ENSG00000116120	FARSB	99	59.866	ENSCSAVG00000005346	-	99	59.866	Ciona_savignyi
ENSG00000116120	FARSB	97	98.594	ENSCANG00000036239	FARSB	100	98.594	Colobus_angolensis_palliatus
ENSG00000116120	FARSB	100	94.907	ENSCGRG00001022928	Farsb	100	94.907	Cricetulus_griseus_chok1gshd
ENSG00000116120	FARSB	100	94.907	ENSCGRG00000001513	Farsb	100	94.907	Cricetulus_griseus_crigri
ENSG00000116120	FARSB	100	75.763	ENSCSEG00000005415	farsb	100	73.171	Cynoglossus_semilaevis
ENSG00000116120	FARSB	76	76.444	ENSCVAG00000018815	farsb	98	76.444	Cyprinodon_variegatus
ENSG00000116120	FARSB	100	75.804	ENSDARG00000016864	farsb	100	75.804	Danio_rerio
ENSG00000116120	FARSB	100	92.360	ENSDNOG00000002511	FARSB	100	92.360	Dasypus_novemcinctus
ENSG00000116120	FARSB	100	94.397	ENSDORG00000011102	Farsb	100	94.397	Dipodomys_ordii
ENSG00000116120	FARSB	100	62.331	FBgn0039175	beta-PheRS	100	62.331	Drosophila_melanogaster
ENSG00000116120	FARSB	97	88.225	ENSETEG00000015080	FARSB	100	88.225	Echinops_telfairi
ENSG00000116120	FARSB	100	65.254	ENSEBUG00000006846	farsb	100	65.254	Eptatretus_burgeri
ENSG00000116120	FARSB	100	95.246	ENSEASG00005011297	FARSB	100	95.246	Equus_asinus_asinus
ENSG00000116120	FARSB	100	91.967	ENSECAG00000023086	FARSB	99	95.221	Equus_caballus
ENSG00000116120	FARSB	100	72.156	ENSEEUG00000007441	FARSB	100	72.156	Erinaceus_europaeus
ENSG00000116120	FARSB	97	75.874	ENSELUG00000014767	farsb	99	75.874	Esox_lucius
ENSG00000116120	FARSB	100	94.058	ENSFCAG00000026772	FARSB	100	94.058	Felis_catus
ENSG00000116120	FARSB	97	82.105	ENSFALG00000006739	FARSB	96	82.105	Ficedula_albicollis
ENSG00000116120	FARSB	100	94.567	ENSFDAG00000008871	FARSB	100	94.567	Fukomys_damarensis
ENSG00000116120	FARSB	100	76.102	ENSFHEG00000020939	farsb	98	76.296	Fundulus_heteroclitus
ENSG00000116120	FARSB	92	73.013	ENSGMOG00000013047	farsb	100	73.013	Gadus_morhua
ENSG00000116120	FARSB	100	82.034	ENSGALG00000005236	FARSB	100	82.034	Gallus_gallus
ENSG00000116120	FARSB	100	75.338	ENSGAFG00000020900	farsb	100	66.216	Gambusia_affinis
ENSG00000116120	FARSB	92	75.231	ENSGACG00000000261	farsb	100	75.231	Gasterosteus_aculeatus
ENSG00000116120	FARSB	100	83.220	ENSGAGG00000016575	FARSB	98	83.220	Gopherus_agassizii
ENSG00000116120	FARSB	100	76.441	ENSHBUG00000022379	farsb	100	74.746	Haplochromis_burtoni
ENSG00000116120	FARSB	100	94.737	ENSHGLG00000015965	FARSB	100	94.737	Heterocephalus_glaber_female
ENSG00000116120	FARSB	100	94.737	ENSHGLG00100001035	FARSB	100	94.737	Heterocephalus_glaber_male
ENSG00000116120	FARSB	91	70.709	ENSHCOG00000016462	farsb	100	70.709	Hippocampus_comes
ENSG00000116120	FARSB	100	76.949	ENSIPUG00000002754	farsb	100	76.949	Ictalurus_punctatus
ENSG00000116120	FARSB	100	96.265	ENSSTOG00000016169	FARSB	100	96.265	Ictidomys_tridecemlineatus
ENSG00000116120	FARSB	100	94.397	ENSJJAG00000003267	Farsb	100	94.397	Jaculus_jaculus
ENSG00000116120	FARSB	100	68.081	ENSKMAG00000005363	farsb	100	68.081	Kryptolebias_marmoratus
ENSG00000116120	FARSB	100	76.102	ENSLBEG00000018127	farsb	70	76.102	Labrus_bergylta
ENSG00000116120	FARSB	100	80.508	ENSLACG00000002551	FARSB	100	80.508	Latimeria_chalumnae
ENSG00000116120	FARSB	100	79.287	ENSLOCG00000004136	farsb	100	79.287	Lepisosteus_oculatus
ENSG00000116120	FARSB	100	94.228	ENSLAFG00000015659	FARSB	100	94.228	Loxodonta_africana
ENSG00000116120	FARSB	100	98.981	ENSMFAG00000036645	FARSB	100	98.981	Macaca_fascicularis
ENSG00000116120	FARSB	100	95.586	ENSMMUG00000007685	FARSB	100	95.586	Macaca_mulatta
ENSG00000116120	FARSB	100	98.812	ENSMNEG00000030672	FARSB	100	98.812	Macaca_nemestrina
ENSG00000116120	FARSB	100	99.151	ENSMLEG00000042060	FARSB	100	99.151	Mandrillus_leucophaeus
ENSG00000116120	FARSB	100	77.288	ENSMAMG00000011835	farsb	100	71.186	Mastacembelus_armatus
ENSG00000116120	FARSB	96	74.291	ENSMZEG00005004544	farsb	100	74.291	Maylandia_zebra
ENSG00000116120	FARSB	95	81.607	ENSMGAG00000004670	FARSB	100	81.607	Meleagris_gallopavo
ENSG00000116120	FARSB	72	84.375	ENSMAUG00000017805	Farsb	100	84.375	Mesocricetus_auratus
ENSG00000116120	FARSB	100	96.774	ENSMICG00000002495	FARSB	100	96.774	Microcebus_murinus
ENSG00000116120	FARSB	100	92.699	ENSMOCG00000003181	Farsb	100	92.699	Microtus_ochrogaster
ENSG00000116120	FARSB	100	70.270	ENSMMOG00000006265	farsb	100	70.270	Mola_mola
ENSG00000116120	FARSB	100	88.983	ENSMODG00000021192	FARSB	100	88.983	Monodelphis_domestica
ENSG00000116120	FARSB	94	75.451	ENSMALG00000021188	farsb	92	75.451	Monopterus_albus
ENSG00000116120	FARSB	100	93.548	MGP_CAROLIEiJ_G0014310	Farsb	100	93.671	Mus_caroli
ENSG00000116120	FARSB	100	93.548	ENSMUSG00000026245	Farsb	100	94.093	Mus_musculus
ENSG00000116120	FARSB	100	94.397	MGP_PahariEiJ_G0027548	Farsb	100	94.515	Mus_pahari
ENSG00000116120	FARSB	100	93.718	MGP_SPRETEiJ_G0015116	Farsb	100	94.515	Mus_spretus
ENSG00000116120	FARSB	100	94.567	ENSMPUG00000016677	FARSB	100	94.567	Mustela_putorius_furo
ENSG00000116120	FARSB	100	95.586	ENSMLUG00000010904	FARSB	100	95.586	Myotis_lucifugus
ENSG00000116120	FARSB	100	93.548	ENSNGAG00000014602	Farsb	100	93.548	Nannospalax_galili
ENSG00000116120	FARSB	100	76.610	ENSNBRG00000003198	farsb	100	72.496	Neolamprologus_brichardi
ENSG00000116120	FARSB	100	99.660	ENSNLEG00000009638	FARSB	100	99.660	Nomascus_leucogenys
ENSG00000116120	FARSB	100	77.966	ENSMEUG00000010798	FARSB	100	77.966	Notamacropus_eugenii
ENSG00000116120	FARSB	89	77.698	ENSOPRG00000003292	FARSB	89	77.698	Ochotona_princeps
ENSG00000116120	FARSB	100	92.699	ENSODEG00000005451	FARSB	100	92.699	Octodon_degus
ENSG00000116120	FARSB	100	76.271	ENSONIG00000014639	farsb	100	76.271	Oreochromis_niloticus
ENSG00000116120	FARSB	91	83.955	ENSOANG00000015387	FARSB	100	83.955	Ornithorhynchus_anatinus
ENSG00000116120	FARSB	92	95.000	ENSOCUG00000007828	FARSB	95	95.000	Oryctolagus_cuniculus
ENSG00000116120	FARSB	100	75.424	ENSORLG00000009135	farsb	100	73.051	Oryzias_latipes
ENSG00000116120	FARSB	100	75.254	ENSORLG00015001072	farsb	100	67.288	Oryzias_latipes_hsok
ENSG00000116120	FARSB	100	75.763	ENSOMEG00000019009	farsb	100	72.203	Oryzias_melastigma
ENSG00000116120	FARSB	100	88.610	ENSOGAG00000010125	FARSB	100	88.610	Otolemur_garnettii
ENSG00000116120	FARSB	100	94.058	ENSOARG00000020329	FARSB	100	94.058	Ovis_aries
ENSG00000116120	FARSB	100	99.491	ENSPPAG00000039268	FARSB	100	99.491	Pan_paniscus
ENSG00000116120	FARSB	100	93.888	ENSPPRG00000010687	FARSB	100	93.888	Panthera_pardus
ENSG00000116120	FARSB	100	93.548	ENSPTIG00000004299	FARSB	100	93.548	Panthera_tigris_altaica
ENSG00000116120	FARSB	100	99.491	ENSPTRG00000012974	FARSB	100	99.491	Pan_troglodytes
ENSG00000116120	FARSB	100	99.151	ENSPANG00000016304	FARSB	100	99.151	Papio_anubis
ENSG00000116120	FARSB	100	75.085	ENSPKIG00000006661	farsb	100	75.085	Paramormyrops_kingsleyae
ENSG00000116120	FARSB	99	81.664	ENSPSIG00000006248	FARSB	99	81.664	Pelodiscus_sinensis
ENSG00000116120	FARSB	83	74.743	ENSPMGG00000002815	farsb	99	74.743	Periophthalmus_magnuspinnatus
ENSG00000116120	FARSB	100	93.039	ENSPEMG00000003131	Farsb	100	93.039	Peromyscus_maniculatus_bairdii
ENSG00000116120	FARSB	100	88.305	ENSPCIG00000019458	FARSB	100	88.305	Phascolarctos_cinereus
ENSG00000116120	FARSB	100	76.271	ENSPLAG00000001104	farsb	100	70.141	Poecilia_latipinna
ENSG00000116120	FARSB	100	76.441	ENSPMEG00000017658	farsb	100	70.318	Poecilia_mexicana
ENSG00000116120	FARSB	100	75.932	ENSPREG00000010583	farsb	100	70.508	Poecilia_reticulata
ENSG00000116120	FARSB	100	99.660	ENSPPYG00000013221	FARSB	100	99.660	Pongo_abelii
ENSG00000116120	FARSB	85	85.972	ENSPCAG00000002757	FARSB	85	85.972	Procavia_capensis
ENSG00000116120	FARSB	69	82.286	ENSPCOG00000028852	FARSB	100	82.286	Propithecus_coquereli
ENSG00000116120	FARSB	100	95.416	ENSPVAG00000006985	FARSB	100	95.416	Pteropus_vampyrus
ENSG00000116120	FARSB	100	64.915	ENSPNYG00000011433	farsb	100	64.915	Pundamilia_nyererei
ENSG00000116120	FARSB	100	77.119	ENSPNAG00000021802	farsb	100	77.119	Pygocentrus_nattereri
ENSG00000116120	FARSB	100	93.379	ENSRNOG00000014119	Farsb	100	93.379	Rattus_norvegicus
ENSG00000116120	FARSB	92	99.259	ENSRBIG00000033191	FARSB	98	98.529	Rhinopithecus_bieti
ENSG00000116120	FARSB	100	99.151	ENSRROG00000029388	FARSB	100	99.151	Rhinopithecus_roxellana
ENSG00000116120	FARSB	100	45.649	YLR060W	FRS1	100	45.649	Saccharomyces_cerevisiae
ENSG00000116120	FARSB	100	88.625	ENSSBOG00000019084	FARSB	100	88.625	Saimiri_boliviensis_boliviensis
ENSG00000116120	FARSB	92	81.967	ENSSHAG00000015752	FARSB	100	81.967	Sarcophilus_harrisii
ENSG00000116120	FARSB	100	74.873	ENSSFOG00015007850	farsb	100	74.873	Scleropages_formosus
ENSG00000116120	FARSB	100	76.441	ENSSMAG00000020668	farsb	100	75.085	Scophthalmus_maximus
ENSG00000116120	FARSB	100	77.703	ENSSDUG00000009685	farsb	100	73.993	Seriola_dumerili
ENSG00000116120	FARSB	100	77.365	ENSSLDG00000025206	farsb	100	73.818	Seriola_lalandi_dorsalis
ENSG00000116120	FARSB	61	91.837	ENSSARG00000005655	-	66	91.837	Sorex_araneus
ENSG00000116120	FARSB	95	77.580	ENSSPUG00000002245	FARSB	100	77.580	Sphenodon_punctatus
ENSG00000116120	FARSB	100	76.102	ENSSPAG00000007367	farsb	69	76.102	Stegastes_partitus
ENSG00000116120	FARSB	100	93.209	ENSSSCG00000016226	-	100	93.209	Sus_scrofa
ENSG00000116120	FARSB	100	85.763	ENSSSCG00000032016	-	100	85.763	Sus_scrofa
ENSG00000116120	FARSB	97	81.579	ENSTGUG00000007788	FARSB	99	81.579	Taeniopygia_guttata
ENSG00000116120	FARSB	100	75.424	ENSTRUG00000009483	farsb	70	75.424	Takifugu_rubripes
ENSG00000116120	FARSB	100	75.593	ENSTNIG00000014310	farsb	100	75.593	Tetraodon_nigroviridis
ENSG00000116120	FARSB	100	66.214	ENSTBEG00000003136	FARSB	100	66.214	Tupaia_belangeri
ENSG00000116120	FARSB	88	93.970	ENSTTRG00000009082	FARSB	88	93.970	Tursiops_truncatus
ENSG00000116120	FARSB	85	91.000	ENSUAMG00000024613	FARSB	99	91.000	Ursus_americanus
ENSG00000116120	FARSB	100	94.907	ENSUMAG00000017995	FARSB	100	94.907	Ursus_maritimus
ENSG00000116120	FARSB	92	90.388	ENSVPAG00000006844	FARSB	100	90.388	Vicugna_pacos
ENSG00000116120	FARSB	100	94.737	ENSVVUG00000024025	FARSB	100	94.737	Vulpes_vulpes
ENSG00000116120	FARSB	100	78.680	ENSXETG00000002934	farsb	100	78.680	Xenopus_tropicalis
ENSG00000116120	FARSB	100	75.593	ENSXMAG00000008280	farsb	100	67.742	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0004826	phenylalanine-tRNA ligase activity	21873635.	IBA	Function
GO:0004826	phenylalanine-tRNA ligase activity	20223217.	IDA	Function
GO:0005515	protein binding	20223217.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	10049785.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	10049785.	TAS	Process
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006432	phenylalanyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006432	phenylalanyl-tRNA aminoacylation	20223217.	IDA	Process
GO:0009328	phenylalanine-tRNA ligase complex	21873635.	IBA	Component
GO:0009328	phenylalanine-tRNA ligase complex	20223217.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0051290	protein heterotetramerization	20223217.	IDA	Process