EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116161 (Gene tree)
Gene ID: 27101
Gene Symbol: CACYBP
Alias: SIP|S100A6BP
Full Name: calcyclin binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,865 bases
Position: chr1:174,999,163-175,012,027
Accession: 30423
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18985281	Growth hormone-dependent changes in the rat lung proteome during alveorization.	Mol Cell Biochem	2009 Jan	Beyea JA	doi: 10.1007/s11010-008-9933-z

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000426793	CACYBP-204	499	-	ENSP00000403674	50 (aa)	-	B2ZWH1
ENST00000613570	CACYBP-209	2835	-	ENSP00000479414	185 (aa)	-	Q9HB71
ENST00000367679	CACYBP-201	2766	-	ENSP00000356652	228 (aa)	-	Q9HB71
ENST00000406752	CACYBP-203	243	-	ENSP00000384139	80 (aa)	-	Q9HB71
ENST00000473925	CACYBP-207	804	-	-	- (aa)	-	-
ENST00000469173	CACYBP-206	904	-	-	- (aa)	-	-
ENST00000483307	CACYBP-208	688	-	-	- (aa)	-	-
ENST00000405362	CACYBP-202	1059	XM_017001046	ENSP00000385771	185 (aa)	XP_016856535	Q9HB71
ENST00000461977	CACYBP-205	574	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000116161's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04310	Wnt signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116161	rs75035127	1	175004590	A	Feeling miserable	29500382	z score increase	5.8	EFO_0009598

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116161's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116161	CACYBP	98	40.889	FBgn0029882	CG3226	94	40.889	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16085652.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005641	nuclear envelope lumen	-	IEA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007507	heart development	21873635.	IBA	Process
GO:0007568	aging	-	IEA	Process
GO:0015631	tubulin binding	-	IEA	Function
GO:0019005	SCF ubiquitin ligase complex	-	IEA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030877	beta-catenin destruction complex	16085652.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	-	IEA	Function
GO:0042803	protein homodimerization activity	16085652.	IPI	Function
GO:0043005	neuron projection	-	IEA	Component
GO:0044297	cell body	-	IEA	Component
GO:0044548	S100 protein binding	-	IEA	Function
GO:0045740	positive regulation of DNA replication	-	IEA	Process
GO:0055007	cardiac muscle cell differentiation	-	IEA	Process
GO:0060416	response to growth hormone	-	IEA	Process
GO:0060548	negative regulation of cell death	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071277	cellular response to calcium ion	-	IEA	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18443365	Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey.	J Histochem Cytochem	2008 Aug	Zhai H	doi: 10.1369/jhc.2008.950519
22480271	CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells.	Biochem Cell Biol	2012 Aug	Kilanczyk E	doi: 10.1139/o2012-011
22874833	Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.	FASEB J	2012 Nov	Rines AK	doi: 10.1096/fj.12-212282
17400182	Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma.	Biochem Biophys Res Commun	2007 May 18	Sun S	-
20585948	CacyBP/SIP expression is involved in the clinical progression of breast cancer.	World J Surg	2010 Nov	Wang N	doi: 10.1007/s00268-010-0690-2.
23543800	iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis.	Mol Cell Proteomics	2013 Jul	Ghosh D	doi: 10.1074/mcp.M112.023085
18765951	Expression and clinical significance of CacyBP/SIP in pancreatic cancer.	Pancreatology	2008	Chen X	doi: 10.1159/000151774
18171983	Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer.	Mol Cancer Res	2007 Dec	Ning X	doi: 10.1158/1541-7786.MCR-06-0426.
27099442	CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.	World J Gastroenterol	2016 Apr 21	Niu YL	doi: 10.3748/wjg.v22.i15.3992.
25110433	CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.	World J Gastroenterol	2014 Aug 7	Zhai HH	doi: 10.3748/wjg.v20.i29.10062.
23463283	CacyBP/SIP enhances multidrug resistance of pancreatic cancer cells by regulation of P-gp and Bcl-2.	Apoptosis	2013 Jul	Chen X	doi: 10.1007/s10495-013-0831-9.
28196083	CacyBP/SIP promotes the proliferation of colon cancer cells.	PLoS One	2017 Feb 14	Zhai H	doi: 10.1371/journal.pone.0169959
29099417	Cell cycle-dependent translocation and regulatory mechanism of CacyBP/SIP in gastric cancer cells.	Anticancer Drugs	2018 Jan	Chen Y	doi: 10.1097/CAD.0000000000000556.
29534068	The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells.	PLoS One	2018 Mar 13	Feng S	doi: 10.1371/journal.pone.0192208
29197151	Transcriptional regulation of CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression pattern in colorectal cancer HCT116 cells.	IUBMB Life	2018 Jan	Kdzioka B	doi: 10.1002/iub.1698

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	175004920	Intron	novel		0.21
BLCA	chr1	175004770	Missense_Mutation	novel	E58K	0.12
BRCA	chr1	175008650	Silent	rs771316635	V158V	0.38
BRCA	chr1	175004884	Intron	novel		0.28
CESC	chr1	175000069	5'UTR	novel		0.26
CESC	chr1	175000001	5'UTR	novel		0.12
CESC	chr1	175004721	Silent	NA	K41K	0.5
CESC	chr1	175007191	Frame_Shift_Del	NA	*V145Sfs22**	0.31
CESC	chr1	175000004	5'UTR	novel		0.16
COAD	chr1	175010001	Silent	rs776535448	D203D	0.28
COAD	chr1	175008629	Silent	NA	L151L	0.23
COAD	chr1	175007144	Missense_Mutation	NA	M127V	0.32
COAD	chr1	175004929	Intron	novel		0.35
COAD	chr1	175007191	Frame_Shift_Del	NA	*V145Sfs22**	0.25
COAD	chr1	175004829	Missense_Mutation	NA	N77K	0.09
COAD	chr1	175000181	Translation_Start_Site	NA	M1?	0.06
COAD	chr1	175005005	Intron	NA		0.4
ESCA	chr1	175010002	Missense_Mutation	novel	D204N	0.18
GBM	chr1	175004813	Missense_Mutation	novel	T72M	0.72
GBM	chr1	175004958	Intron	novel		0.25
HNSC	chr1	175007146	Missense_Mutation	novel	M127I	0.23
HNSC	chr1	175010168	3'UTR	novel		0.19
HNSC	chr1	175010069	Missense_Mutation	rs780696971	T226M	0.24
HNSC	chr1	175004761	Missense_Mutation	rs11548912	L55F	0.42
HNSC	chr1	175008609	Missense_Mutation	novel	V145I	0.2
HNSC	chr1	175010159	3'UTR	novel		0.62
HNSC	chr1	175008631	Missense_Mutation	novel	I152T	0.61
KIRC	chr1	175004733	Missense_Mutation	NA	Q45H	0.27
KIRC	chr1	175004617	Nonsense_Mutation	NA	Q7*	0.16
KIRC	chr1	175008700	Frame_Shift_Del	novel	*E177Rfs15**	0.26
KIRP	chr1	175009993	Missense_Mutation	NA	D201Y	0.25
LGG	chr1	175004814	Silent	rs759751331	T72T	0.2
LIHC	chr1	175005042	Intron	novel		0.79
LIHC	chr1	175010388	3'UTR	novel		0.31
LUAD	chr1	175000121	5'UTR	novel		0.42
LUAD	chr1	175004703	Missense_Mutation	novel	K35N	0.05
LUAD	chr1	175010166	3'UTR	novel		0.15
LUSC	chr1	175009965	Missense_Mutation	novel	L191F	0.54
LUSC	chr1	175008612	Missense_Mutation	novel	K146Q	0.22
LUSC	chr1	175007146	Missense_Mutation	NA	M127I	0.12
LUSC	chr1	175004824	Missense_Mutation	novel	S76G	0.22
PAAD	chr1	175009974	Silent	novel	V194V	0.28
PCPG	chr1	175008682	Missense_Mutation	novel	V169A	0.24
PRAD	chr1	175010065	Missense_Mutation	NA	D225N	0.28
READ	chr1	175010014	Nonsense_Mutation	novel	R208*	0.37
SKCM	chr1	175008627	Missense_Mutation	NA	L151F	0.22
SKCM	chr1	175010069	Missense_Mutation	rs780696971	T226M	0.13
STAD	chr1	175004892	Intron	novel		0.22
STAD	chr1	175006783	Missense_Mutation	NA	T92A	0.17
STAD	chr1	175007188	Missense_Mutation	NA	S141R	0.35
STAD	chr1	175007191	Frame_Shift_Del	NA	*V145Sfs22**	0.16
UCEC	chr1	175004876	Intron	novel		0.27
UCEC	chr1	175010068	Missense_Mutation	novel	T226A	0.16
UCEC	chr1	175009960	Nonsense_Mutation	novel	G190*	0.18
UCEC	chr1	175007169	Missense_Mutation	novel	P135L	0.51
UCEC	chr1	175010056	Missense_Mutation	novel	A222S	0.2
UCEC	chr1	175007191	Frame_Shift_Del	NA	*V145Sfs22**	0.62
UCEC	chr1	175007156	Missense_Mutation	rs756165044	N131D	0.43
UCEC	chr1	175010032	Missense_Mutation	novel	W214R	0.51
UCEC	chr1	175004783	Missense_Mutation	NA	A62V	0.25
UCEC	chr1	175004938	Intron	novel		0.24
UCEC	chr1	175008639	Missense_Mutation	NA	R155G	0.19
UCEC	chr1	175000175	5'UTR	novel		0.32
UCEC	chr1	175004804	Missense_Mutation	rs377688600	T69M	0.36
UCEC	chr1	175007140	Nonsense_Mutation	novel	Y125*	0.31
UCEC	chr1	175004674	Missense_Mutation	novel	R26C	0.13
UCEC	chr1	175010259	3'UTR	novel		0.33
UCEC	chr1	175004829	Missense_Mutation	NA	N77K	0.33
UCEC	chr1	175004813	Missense_Mutation	novel	T72M	0.05
UCEC	chr1	175007191	Frame_Shift_Del	NA	*V145Sfs22**	0.23
UCEC	chr1	175010030	Missense_Mutation	novel	A213V	0.33
UCEC	chr1	175004626	Missense_Mutation	novel	L10I	0.06
UCEC	chr1	175010248	3'UTR	novel		0.33
UCEC	chr1	175004957	Intron	novel		0.15
UCEC	chr1	175004843	Intron	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
KIRC	AMP	0.0909	0.059566
PAAD	AMP	0.2174	0.085665
SKCM	AMP	0.4932	9.6912e-06
TGCT	AMP	0.3467	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
MESO	0.014	Kaplan-Meier Survival Analysis
HNSC	0.017	Kaplan-Meier Survival Analysis
BRCA	0.0093	Kaplan-Meier Survival Analysis
ESCA	0.0079	Kaplan-Meier Survival Analysis
KIRP	0.00033	Kaplan-Meier Survival Analysis
LAML	0.0042	Kaplan-Meier Survival Analysis
KICH	0.046	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00075	Kaplan-Meier Survival Analysis
LUAD	0.00089	Kaplan-Meier Survival Analysis
UVM	0.041	Kaplan-Meier Survival Analysis
OV	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742