EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116288 (Gene tree)
Gene ID: 11315
Gene Symbol: PARK7
Alias: DJ-1|DJ1|GATD2
Full Name: Parkinsonism associated deglycase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 31,215 bases
Position: chr1:7,954,291-7,985,505
Accession: 16369
RBP type: non-canonical RBP
Summary: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11223268	Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.	Gene	2001 Jan 24	Taira T	-
15935068	DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.	J Neurochem	2005 Jun	Meulener MC	-
14654946	Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.	Int J Oncol	2004 Jan	Grzmil M	-
14583493	Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.	Cancer Res	2003 Oct 15	MacKeigan JP	-
18626009	RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.	Proc Natl Acad Sci U S A	2008 Jul 22	van der Brug MP	doi: 10.1073/pnas.0708518105
29675578	The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.	Mol Neurobiol	2019 Jan	Repici M	doi: 10.1007/s12035-018-1084-y
15790595	The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.	Hum Mol Genet	2005 May 1	Xu J	-
21368136	Multiple coregulatory control of tyrosine hydroxylase gene transcription.	Proc Natl Acad Sci U S A	2011 Mar 8	Reddy SD	doi: 10.1073/pnas.1101193108

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377488	PARK7-202	783	-	ENSP00000366708	189 (aa)	-	Q99497
ENST00000497113	PARK7-210	670	-	-	- (aa)	-	-
ENST00000469225	PARK7-207	711	-	ENSP00000466756	160 (aa)	-	K7EN27
ENST00000493373	PARK7-208	624	-	ENSP00000465404	189 (aa)	-	Q99497
ENST00000493678	PARK7-209	1088	-	ENSP00000418770	189 (aa)	-	Q99497
ENST00000338639	PARK7-201	949	-	ENSP00000340278	189 (aa)	-	Q99497
ENST00000377493	PARK7-204	795	-	ENSP00000466242	169 (aa)	-	K7ELW0
ENST00000460192	PARK7-205	567	-	-	- (aa)	-	-
ENST00000377491	PARK7-203	977	XM_005263424	ENSP00000366711	189 (aa)	XP_005263481	Q99497
ENST00000465354	PARK7-206	949	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000116288's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05012	Parkinson disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116288	Colitis, Ulcerative	6E-14	26192919
ENSG00000116288	Colitis, Ulcerative	5E-9	21297633
ENSG00000116288	Crohn Disease	5E-9	26192919
ENSG00000116288	Inflammatory Bowel Diseases	1E-12	28067908
ENSG00000116288	Stroke	2E-7	24262325
ENSG00000116288	Colitis, Ulcerative	4E-9	28067908
ENSG00000116288	Inflammatory Bowel Diseases	1E-15	23128233
ENSG00000116288	Celiac Disease	9E-8	20190752
ENSG00000116288	Crohn Disease	3E-6	28067908

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116288	rs161802	1	7982766	?	Ischemic stroke	24262325	[1.08-1.16]	1.1111	EFO_0000712
ENSG00000116288	rs3766606	1	7962137	C	Ulcerative colitis	26192919		1.143554	EFO_0000729
ENSG00000116288	rs3766606	1	7962137	A	Crohn's disease	26192919		1.1060587	EFO_0000384
ENSG00000116288	rs17523802	1	7961680	?	Tonsillectomy	28928442	[0.033-0.076] unit increase	0.0545	EFO_0007924
ENSG00000116288	rs3766606	1	7962137	?	Crohn's disease	28067908			EFO_0000384
ENSG00000116288	rs3766606	1	7962137	?	Ulcerative colitis	28067908			EFO_0000729
ENSG00000116288	rs3766606	1	7962137	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000116288	rs35675666	1	7961913	G	Ulcerative colitis	21297633	[1.02-1.15]	1.08	EFO_0000729
ENSG00000116288	rs35675666	1	7961913	G	Inflammatory bowel disease	23128233	[1.07-1.156]	1.112	EFO_0003767

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116288's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116288	PARK7	100	91.534	ENSMUSG00000028964	Park7	100	95.238	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000785	chromatin	16731528.	IDA	Component
GO:0001047	core promoter binding	15790595.	IC	Function
GO:0001933	negative regulation of protein phosphorylation	15983381.	IGI	Process
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	-	ISS	Process
GO:0003690	double-stranded DNA binding	22683601.	IDA	Function
GO:0003697	single-stranded DNA binding	22683601.	IDA	Function
GO:0003713	transcription coactivator activity	15790595.	IGI	Function
GO:0003713	transcription coactivator activity	16731528.	TAS	Function
GO:0003729	mRNA binding	18626009.	IDA	Function
GO:0005102	signaling receptor binding	21785459.	IPI	Function
GO:0005507	copper ion binding	23792957.	IDA	Function
GO:0005515	protein binding	11477070.15790595.15983381.16632486.17510388.19229105.19822128.20127688.21097510.21785459.22683601.23743200.24899725.24947010.25416956.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11477070.12446870.14662519.15790595.15983381.18711745.19822128.22683601.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	12446870.15983381.17510388.18711745.19822128.	IDA	Component
GO:0005739	mitochondrion	15790595.15944198.18711745.19229105.19822128.23743200.	IDA	Component
GO:0005739	mitochondrion	21785459.	IMP	Component
GO:0005747	mitochondrial respiratory chain complex I	19822128.	IDA	Component
GO:0005758	mitochondrial intermembrane space	-	IEA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	14662519.15944198.19229105.22683601.	IDA	Component
GO:0005829	cytosol	21785459.	IMP	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005913	cell-cell adherens junction	25468996.	HDA	Component
GO:0006281	DNA repair	28596309.	IDA	Process
GO:0006469	negative regulation of protein kinase activity	15983381.	IGI	Process
GO:0006508	proteolysis	-	IEA	Process
GO:0006517	protein deglycosylation	25416785.	IDA	Process
GO:0006517	protein deglycosylation	27903648.	IDA	Process
GO:0006517	protein deglycosylation	26995087.	IMP	Process
GO:0006914	autophagy	-	IEA	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0007005	mitochondrion organization	-	ISS	Process
GO:0007265	Ras protein signal transduction	14662519.	TAS	Process
GO:0007338	single fertilization	-	IEA	Process
GO:0008134	transcription factor binding	21097510.	IPI	Function
GO:0008233	peptidase activity	20304780.	IDA	Function
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0009438	methylglyoxal metabolic process	22523093.	IDA	Process
GO:0009438	methylglyoxal metabolic process	27903648.	IDA	Process
GO:0010273	detoxification of copper ion	23792957.	IMP	Process
GO:0010628	positive regulation of gene expression	24252804.	TAS	Process
GO:0010629	negative regulation of gene expression	22683601.	IDA	Process
GO:0016532	superoxide dismutase copper chaperone activity	24567322.	IDA	Function
GO:0016605	PML body	22683601.	IDA	Component
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	24567322.	IDA	Function
GO:0018323	enzyme active site formation via L-cysteine sulfinic acid	-	IEA	Process
GO:0019249	lactate biosynthetic process	22523093.	IDA	Process
GO:0019899	enzyme binding	19703902.19822128.23743200.	IPI	Function
GO:0019900	kinase binding	19229105.	IPI	Function
GO:0019955	cytokine binding	21097510.	IPI	Function
GO:0030073	insulin secretion	-	ISS	Process
GO:0030424	axon	-	ISS	Component
GO:0031397	negative regulation of protein ubiquitination	17015834.24899725.	IDA	Process
GO:0032091	negative regulation of protein binding	11477070.16731528.17015834.24899725.	IDA	Process
GO:0032091	negative regulation of protein binding	15983381.	IGI	Process
GO:0032091	negative regulation of protein binding	21785459.	IMP	Process
GO:0032148	activation of protein kinase B activity	22492997.	IC	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	17015834.	IDA	Process
GO:0032757	positive regulation of interleukin-8 production	21097510.	IDA	Process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	22492997.	IMP	Process
GO:0033234	negative regulation of protein sumoylation	16731528.	IDA	Process
GO:0033864	positive regulation of NAD(P)H oxidase activity	-	ISS	Process
GO:0034599	cellular response to oxidative stress	15983381.19703902.20969476.22683601.	IDA	Process
GO:0034599	cellular response to oxidative stress	24899725.	IMP	Process
GO:0036470	tyrosine 3-monooxygenase activator activity	19703902.	IDA	Function
GO:0036471	cellular response to glyoxal	22523093.	IDA	Process
GO:0036478	L-dopa decarboxylase activator activity	19703902.	IDA	Function
GO:0036524	protein deglycase activity	21873635.	IBA	Function
GO:0036524	protein deglycase activity	25416785.	IDA	Function
GO:0036526	peptidyl-cysteine deglycation	25416785.	IDA	Process
GO:0036527	peptidyl-arginine deglycation	25416785.	IDA	Process
GO:0036528	peptidyl-lysine deglycation	25416785.	IDA	Process
GO:0036529	protein deglycation, glyoxal removal	21873635.	IBA	Process
GO:0036529	protein deglycation, glyoxal removal	25416785.	IDA	Process
GO:0036530	protein deglycation, methylglyoxal removal	25416785.	IDA	Process
GO:0036530	protein deglycation, methylglyoxal removal	27903648.	IDA	Process
GO:0036531	glutathione deglycation	25416785.	IDA	Process
GO:0042593	glucose homeostasis	-	ISS	Process
GO:0042743	hydrogen peroxide metabolic process	20969476.24567322.	IDA	Process
GO:0042802	identical protein binding	15502874.15983381.24947010.	IPI	Function
GO:0042803	protein homodimerization activity	18711745.24144264.24567322.	IDA	Function
GO:0043066	negative regulation of apoptotic process	22523093.	IDA	Process
GO:0043523	regulation of neuron apoptotic process	18711745.20304780.	IDA	Process
GO:0043524	negative regulation of neuron apoptotic process	22511790.	IDA	Process
GO:0044297	cell body	-	IEA	Component
GO:0044388	small protein activating enzyme binding	15983381.	IPI	Function
GO:0044390	ubiquitin-like protein conjugating enzyme binding	15983381.	IPI	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045340	mercury ion binding	23792957.	IDA	Function
GO:0045560	regulation of TRAIL receptor biosynthetic process	21785459.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21097510.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	15790595.17015834.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	16731528.19703902.22492997.	IMP	Process
GO:0046295	glycolate biosynthetic process	22523093.	IDA	Process
GO:0046826	negative regulation of protein export from nucleus	15983381.	IGI	Process
GO:0048471	perinuclear region of cytoplasm	25468996.	IDA	Component
GO:0050681	androgen receptor binding	17510388.	IPI	Function
GO:0050727	regulation of inflammatory response	-	ISS	Process
GO:0050787	detoxification of mercury ion	23792957.	IMP	Process
GO:0050821	protein stabilization	24947010.	IDA	Process
GO:0050821	protein stabilization	17015834.19229105.	IMP	Process
GO:0051091	positive regulation of DNA-binding transcription factor activity	17015834.	IMP	Process
GO:0051091	positive regulation of DNA-binding transcription factor activity	22492997.	TAS	Process
GO:0051444	negative regulation of ubiquitin-protein transferase activity	24899725.	IDA	Process
GO:0051583	dopamine uptake involved in synaptic transmission	-	IEA	Process
GO:0051881	regulation of mitochondrial membrane potential	23743200.	IMP	Process
GO:0051897	positive regulation of protein kinase B signaling	22492997.	IC	Process
GO:0051899	membrane depolarization	-	IEA	Process
GO:0051920	peroxiredoxin activity	-	IEA	Function
GO:0060081	membrane hyperpolarization	-	IEA	Process
GO:0060548	negative regulation of cell death	14749723.	IDA	Process
GO:0060765	regulation of androgen receptor signaling pathway	11477070.	IDA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0070301	cellular response to hydrogen peroxide	14749723.	IDA	Process
GO:0070491	repressing transcription factor binding	15790595.16731528.	IPI	Function
GO:0090073	positive regulation of protein homodimerization activity	24947010.	IDA	Process
GO:0097110	scaffold protein binding	21785459.	IPI	Function
GO:0098793	presynapse	-	IEA	Component
GO:0098869	cellular oxidant detoxification	-	IEA	Process
GO:0106044	guanine deglycation	28596309.	IDA	Process
GO:0106045	guanine deglycation, methylglyoxal removal	28596309.	IDA	Process
GO:0106046	guanine deglycation, glyoxal removal	21873635.	IBA	Process
GO:0106046	guanine deglycation, glyoxal removal	28596309.	IDA	Process
GO:1900182	positive regulation of protein localization to nucleus	21097510.	IDA	Process
GO:1900182	positive regulation of protein localization to nucleus	22492997.	IMP	Process
GO:1901215	negative regulation of neuron death	22683601.	IDA	Process
GO:1901671	positive regulation of superoxide dismutase activity	24567322.	IDA	Process
GO:1901984	negative regulation of protein acetylation	22683601.	IDA	Process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	-	IEA	Process
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	14652021.	IGI	Process
GO:1902903	regulation of supramolecular fiber organization	23626584.	TAS	Process
GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	19822128.	IMP	Process
GO:1903073	negative regulation of death-inducing signaling complex assembly	21785459.	IC	Process
GO:1903094	negative regulation of protein K48-linked deubiquitination	21097510.	IDA	Process
GO:1903122	negative regulation of TRAIL-activated apoptotic signaling pathway	21785459.	IMP	Process
GO:1903135	cupric ion binding	24567322.	IDA	Function
GO:1903136	cuprous ion binding	24144264.24567322.	IDA	Function
GO:1903168	positive regulation of pyrroline-5-carboxylate reductase activity	23743200.	IDA	Process
GO:1903178	positive regulation of tyrosine 3-monooxygenase activity	19703902.	IDA	Process
GO:1903181	positive regulation of dopamine biosynthetic process	16731528.	IC	Process
GO:1903181	positive regulation of dopamine biosynthetic process	19703902.	IDA	Process
GO:1903189	glyoxal metabolic process	22523093.	IDA	Process
GO:1903197	positive regulation of L-dopa biosynthetic process	16731528.	IMP	Process
GO:1903200	positive regulation of L-dopa decarboxylase activity	19703902.	IDA	Process
GO:1903202	negative regulation of oxidative stress-induced cell death	16632486.	IDA	Process
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	22492997.23743200.	IMP	Process
GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	15983381.24947010.	IDA	Process
GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	15790595.	IDA	Process
GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	14652021.	IGI	Process
GO:1903427	negative regulation of reactive oxygen species biosynthetic process	-	ISS	Process
GO:1903428	positive regulation of reactive oxygen species biosynthetic process	-	IEA	Process
GO:1903599	positive regulation of autophagy of mitochondrion	24531622.	NAS	Process
GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	14752510.	IDA	Process
GO:1990381	ubiquitin-specific protease binding	21097510.	IPI	Function
GO:2000157	negative regulation of ubiquitin-specific protease activity	21097510.	IDA	Process
GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	-	IEA	Process
GO:2000679	positive regulation of transcription regulatory region DNA binding	22492997.	IMP	Process
GO:2000825	positive regulation of androgen receptor activity	17510388.	IMP	Process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	21785459.	IMP	Process
GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	21785459.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22526154	DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer.	J Cancer Res Clin Oncol	2012 Sep	Chen Y	doi: 10.1007/s00432-012-1205-3
29147911	DJ-1 as a Therapeutic Target Against Cancer.	Adv Exp Med Biol	2017	Cao J	doi: 10.1007/978-981-10-6583-5_13.
20150646	Prognostic significance of nuclear DJ-1 expression in astrocytoma.	Anticancer Res	2010 Jan	Miyajima Y	-
22404125	High levels of DJ-1 protein in nipple fluid of patients with breast cancer.	Cancer Sci	2012 Jun	Oda M	doi: 10.1111/j.1349-7006.2012.02267.x
22968650	Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas.	Br J Cancer	2012 Oct 23	Shimwell NJ	doi: 10.1038/bjc.2012.405
26334622	Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients.	Tumour Biol	2016 Feb	Fan J	doi: 10.1007/s13277-015-3994-x
28653888	DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.	Tumour Biol	2017 Jun	Han B	doi: 10.1177/1010428317714625.
28580701	Identification of DJ-1 as a contributor to multidrug resistance in human small-cell lung cancer using proteomic analysis.	Int J Exp Pathol	2017 Apr	Gao H	doi: 10.1111/iep.12221
26245297	Status of the Parkinson's disease gene family expression in non-small-cell lung cancer.	World J Surg Oncol	2015 Aug 7	Liu QX	doi: 10.1186/s12957-015-0646-y.
21943684	Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.	Hum Pathol	2012 Apr	Merikallio H	doi: 10.1016/j.humpath.2011.05.024
23592371	DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients.	Breast Cancer Res Treat	2013 May	Kawate T	doi: 10.1007/s10549-013-2523-0
17015834	DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.	Proc Natl Acad Sci U S A	2006 Oct 10	Clements CM	-
26125099	Pleural effusion levels of DJ-1 are increased in elderly lung cancer patients with malignant pleural effusions.	Redox Rep	2015	Vavougios G	doi: 10.1179/1351000215Y.0000000023
24614826	DJ-1 in endometrial cancer: a possible biomarker to improve differential diagnosis between subtypes.	Int J Gynecol Cancer	2014 May	Morelli M	doi: 10.1097/IGC.0000000000000102.
24207095	DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma: a possible role in carcinogenesis.	J Egypt Natl Canc Inst	2013 Dec	Osman WM	doi: 10.1016/j.jnci.2013.08.001
24504364	DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression.	Br J Cancer	2014 Mar 4	Ismail IA	doi: 10.1038/bjc.2014.40
24681255	DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal.	Free Radic Biol Med	2014 Jun	Zhu H	doi: 10.1016/j.freeradbiomed.2014.03.026
21670963	DJ-1 may contribute to metastasis of non-small cell lung cancer.	Mol Biol Rep	2012 Mar	Bai J	doi: 10.1007/s11033-011-1024-7
15766664	DJ-1, a novel regulator of the tumor suppressor PTEN.	Cancer Cell	2005 Mar	Kim RH	-
26261582	Role of DJ-1 siRNA in reverse sensitivity of breast cancer cells to chemotherapy and its possible mechanism.	Int J Clin Exp Pathol	2015 Jun 1	Zhang GQ	-
23727824	Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis.	Int J Gynecol Cancer	2013 Jul	Shu K	doi: 10.1097/IGC.0b013e3182959182.
25867058	High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients.	Cancer Sci	2015 Jul	Kawate T	doi: 10.1111/cas.12673
25892179	DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.	Mol Med Rep	2015 Aug	Zhu XL	doi: 10.3892/mmr.2015.3617
27664330	Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.	Eur J Pharm Sci	2017 Feb 15	Wang L	doi: 10.1016/j.ejps.2016.09.023
28618925	DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer.	Tumour Biol	2017 Jun	Di Cello A	doi: 10.1177/1010428317705746.
27611333	Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.	PLoS One	2016 Sep 9	Kim DK	doi: 10.1371/journal.pone.0162831
27582551	Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer.	Oncotarget	2016 Oct 4	Zhang S	doi: 10.18632/oncotarget.11613.
29147902	Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance.	Adv Exp Med Biol	2017	Kawate T	doi: 10.1007/978-981-10-6583-5_4.
28374920	The clinical significance of DJ-1 and HE4 in patients with endometrial cancer.	J Clin Lab Anal	2018 Jan	Benati M	doi: 10.1002/jcla.22223
28963699	NRG-1 Stimulates Serum DJ-1 Increase in Breast Cancers.	Pathol Oncol Res	2019 Jan	Wang Y	doi: 10.1007/s12253-017-0326-z
30536064	DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicinactivated Autophagy in Human Gastric Cancer Cells.	Curr Med Sci	2018 Dec	Pan XK	doi: 10.1007/s11596-018-1978-y
30894531	Reversible histone glycation is associated with disease-related changes in chromatin architecture.	Nat Commun	2019 Mar 20	Zheng Q	doi: 10.1038/s41467-019-09192-z.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	7969402	Missense_Mutation	novel	E84K	0.45
BLCA	chr1	7962831	Missense_Mutation	novel	E16K	0.16
BLCA	chr1	7965365	Silent	novel	V44V	0.24
BRCA	chr1	7977658	Missense_Mutation	novel	T110N	0.28
BRCA	chr1	7971179	Intron	novel		0.57
CESC	chr1	7985092	3'UTR	rs375081848		0.43
CESC	chr1	7985080	3'UTR	novel		0.27
CESC	chr1	7984957	Missense_Mutation	novel	P158H	0.19
CESC	chr1	7970917	Silent	NA	L92L	0.14
CESC	chr1	7971104	Intron	novel		0.38
COAD	chr1	7985067	3'UTR	novel		0.36
COAD	chr1	7965416	Frame_Shift_Del	NA	*E64Rfs25**	0.24
COAD	chr1	7965416	Frame_Shift_Del	NA	*E64Rfs25**	0.37
COAD	chr1	7965376	Missense_Mutation	rs145727915	R48H	0.28
COAD	chr1	7971141	Intron	novel		0.63
COAD	chr1	7965415	Frame_Shift_Ins	rs759703272	*E64Rfs5**	0.15
GBM	chr1	7985122	3'UTR	novel		0.06
GBM	chr1	7977740	Splice_Site	novel	X137_splice	0.29
GBM	chr1	7984997	Silent	novel	A171A	0.11
HNSC	chr1	7962843	Missense_Mutation	novel	V20I	0.77
HNSC	chr1	7965404	Silent	novel	S57S	0.1
LGG	chr1	7977707	Silent	novel	H126H	0.06
PRAD	chr1	7965393	Missense_Mutation	NA	P54A	0.25
PRAD	chr1	7984867	Intron	novel		0.08
SKCM	chr1	7965374	Silent	NA	S47S	0.37
SKCM	chr1	7962774	5'UTR	novel		0.32
SKCM	chr1	7985158	3'UTR	novel		0.86
STAD	chr1	7965335	Silent	rs374236728	T34T	0.18
THCA	chr1	7985059	3'UTR	novel		0.06
THCA	chr1	7985061	3'UTR	novel		0.04
THCA	chr1	7985088	3'UTR	novel		0.13
THCA	chr1	7985090	3'UTR	novel		0.05
UCEC	chr1	7962808	Missense_Mutation	novel	V8A	0.36
UCEC	chr1	7965416	Frame_Shift_Del	NA	*E64Rfs25**	0.28
UCEC	chr1	7970895	Missense_Mutation	novel	S85Y	0.38
UCEC	chr1	7984979	Silent	rs768890106	A165A	0.28
UCEC	chr1	7971064	Intron	novel		0.3
UCEC	chr1	7970933	Missense_Mutation	rs182164240	R98W	0.25
UCEC	chr1	7984978	Missense_Mutation	rs371514726	A165V	0.3
UCEC	chr1	7962841	Missense_Mutation	rs758016497	T19M	0.19
UCEC	chr1	7971085	Intron	novel		0.04
UCEC	chr1	7977684	Missense_Mutation	novel	F119V	0.34
UCEC	chr1	7985085	3'UTR	novel		0.39
UCEC	chr1	7965338	Silent	novel	V35V	0.39
UCEC	chr1	7971085	Intron	novel		0.08
UCEC	chr1	7971085	Intron	novel		0.07
UCEC	chr1	7984917	Missense_Mutation	rs768782230	R145C	0.82
UVM	chr1	7971029	Intron	novel		0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1153	0.00029523
CHOL	DEL	0.7778	3.3987e-23
DLBC	DEL	0.1458	0.011841
GBM	DEL	0.2149	2.9271e-58
HNSC	DEL	0.1398	7.0766e-07
KIRC	DEL	0.1458	2.3538e-09
KIRP	DEL	0.1771	1.462e-09
LUAD	DEL	0.1434	0.0024765
LUSC	DEL	0.3533	2.5882e-07
MESO	DEL	0.3563	2.434e-07
READ	DEL	0.3818	2.1758e-10
TGCT	DEL	0.1867	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
MESO	0.0077	Kaplan-Meier Survival Analysis
ACC	0.0061	Kaplan-Meier Survival Analysis
ESCA	0.031	Kaplan-Meier Survival Analysis
KIRP	0.0047	Kaplan-Meier Survival Analysis
PCPG	0.03	Kaplan-Meier Survival Analysis
LAML	0.00016	Kaplan-Meier Survival Analysis
KICH	0.021	Kaplan-Meier Survival Analysis
UVM	0.0015	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742