EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116350 (Gene tree)
Gene ID: 6429
Gene Symbol: SRSF4
Alias: SRP75|SFRS4
Full Name: serine and arginine rich splicing factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 34,388 bases
Position: chr1:29,147,738-29,182,125
Accession: 10786
RBP type: canonical RBP
Summary: This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000485813	RRM_1	PF00076.22	4.8e-31	1	2
ENSP00000485813	RRM_1	PF00076.22	4.8e-31	2	2
ENSP00000362900	RRM_1	PF00076.22	1e-30	1	2
ENSP00000362900	RRM_1	PF00076.22	1e-30	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12083511	Identification of new poly(A) polymerase-inhibitory proteins capable of regulating pre-mRNA polyadenylation.	J Mol Biol	2002 May 17	Ko B	-
22436691	The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.	Genome Biol	2012	Anko ML	doi: 10.1186/gb-2012-13-3-r17.
26260686	Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.	Nat Commun	2015 Aug 11	Hauer C	doi: 10.1038/ncomms8921.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000605204	SRSF4-206	1399	-	ENSP00000473728	160 (aa)	-	S4R2X6
ENST00000622143	SRSF4-207	614	-	-	- (aa)	-	-
ENST00000497015	SRSF4-205	516	-	-	- (aa)	-	-
ENST00000634348	SRSF4-208	8128	-	-	- (aa)	-	-
ENST00000466448	SRSF4-202	1264	XM_011541951	ENSP00000485813	378 (aa)	XP_011540253	A0A0D9SEM4
ENST00000477193	SRSF4-203	206	-	-	- (aa)	-	-
ENST00000373795	SRSF4-201	2387	-	ENSP00000362900	494 (aa)	-	Q08170
ENST00000489898	SRSF4-204	393	-	ENSP00000487379	45 (aa)	-	A0A0D9SGD2

Gene Model

Click here to download ENSG00000116350's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116350	Platelet Function Tests	3.3544280E-012	-
ENSG00000116350	Platelet Function Tests	6.9142470E-012	-
ENSG00000116350	Intelligence Tests	5.6152700E-005	-
ENSG00000116350	Child Development Disorders, Pervasive	2.5662800E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116350's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000116350	SRSF4	89	69.388	ENSG00000124193	SRSF6	61	78.409
ENSG00000116350	SRSF4	60	44.770	ENSG00000136450	SRSF1	84	44.828

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116350	SRSF4	73	78.788	ENSAPOG00000023399	-	84	67.041	Acanthochromis_polyacanthus
ENSG00000116350	SRSF4	92	80.519	ENSAMEG00000000594	SRSF4	64	95.370	Ailuropoda_melanoleuca
ENSG00000116350	SRSF4	53	87.500	ENSACIG00000018649	srsf4	90	85.950	Amphilophus_citrinellus
ENSG00000116350	SRSF4	57	81.982	ENSATEG00000005680	srsf4	60	84.916	Anabas_testudineus
ENSG00000116350	SRSF4	76	88.235	ENSAPLG00000006595	-	57	83.071	Anas_platyrhynchos
ENSG00000116350	SRSF4	100	98.750	ENSANAG00000037134	SRSF4	100	98.750	Aotus_nancymaae
ENSG00000116350	SRSF4	53	95.833	ENSACLG00000021269	-	98	59.887	Astatotilapia_calliptera
ENSG00000116350	SRSF4	53	87.500	ENSACLG00000003395	srsf4	97	68.872	Astatotilapia_calliptera
ENSG00000116350	SRSF4	76	67.647	ENSAMXG00000034811	srsf4	100	66.535	Astyanax_mexicanus
ENSG00000116350	SRSF4	92	90.022	ENSBTAG00000013309	SRSF4	92	88.503	Bos_taurus
ENSG00000116350	SRSF4	100	98.750	ENSCJAG00000047192	SRSF4	100	98.750	Callithrix_jacchus
ENSG00000116350	SRSF4	85	88.605	ENSCAFG00000011669	SRSF4	90	87.442	Canis_familiaris
ENSG00000116350	SRSF4	85	89.486	ENSCAFG00020023963	SRSF4	88	88.679	Canis_lupus_dingo
ENSG00000116350	SRSF4	95	86.275	ENSCHIG00000022096	SRSF4	99	86.275	Capra_hircus
ENSG00000116350	SRSF4	100	96.774	ENSTSYG00000007903	SRSF4	100	96.774	Carlito_syrichta
ENSG00000116350	SRSF4	92	79.212	ENSCAPG00000014747	SRSF4	91	79.121	Cavia_aperea
ENSG00000116350	SRSF4	93	83.190	ENSCPOG00000036234	SRSF4	92	84.848	Cavia_porcellus
ENSG00000116350	SRSF4	100	98.750	ENSCCAG00000033585	SRSF4	100	98.750	Cebus_capucinus
ENSG00000116350	SRSF4	100	100.000	ENSCATG00000031440	SRSF4	100	100.000	Cercocebus_atys
ENSG00000116350	SRSF4	93	87.013	ENSCLAG00000009008	SRSF4	92	86.304	Chinchilla_lanigera
ENSG00000116350	SRSF4	100	99.190	ENSCSAG00000001022	SRSF4	100	99.190	Chlorocebus_sabaeus
ENSG00000116350	SRSF4	85	94.366	ENSCHOG00000013858	SRSF4	92	85.545	Choloepus_hoffmanni
ENSG00000116350	SRSF4	74	98.305	ENSCPBG00000009020	SRSF4	65	90.184	Chrysemys_picta_bellii
ENSG00000116350	SRSF4	67	61.290	ENSCING00000020631	-	90	52.344	Ciona_intestinalis
ENSG00000116350	SRSF4	78	44.410	ENSCING00000024718	-	56	60.417	Ciona_intestinalis
ENSG00000116350	SRSF4	100	100.000	ENSCANG00000028667	SRSF4	100	100.000	Colobus_angolensis_palliatus
ENSG00000116350	SRSF4	76	91.176	ENSCGRG00001021115	Srsf4	92	82.751	Cricetulus_griseus_chok1gshd
ENSG00000116350	SRSF4	76	91.176	ENSCGRG00000014137	Srsf4	91	79.621	Cricetulus_griseus_crigri
ENSG00000116350	SRSF4	53	83.333	ENSCSEG00000010058	srsf4	75	82.927	Cynoglossus_semilaevis
ENSG00000116350	SRSF4	73	69.697	ENSDARG00000105293	srsf4	79	83.333	Danio_rerio
ENSG00000116350	SRSF4	92	84.681	ENSDNOG00000047961	SRSF4	64	96.308	Dasypus_novemcinctus
ENSG00000116350	SRSF4	74	99.435	ENSDORG00000002459	Srsf4	92	78.214	Dipodomys_ordii
ENSG00000116350	SRSF4	92	72.472	ENSETEG00000009774	SRSF4	92	76.754	Echinops_telfairi
ENSG00000116350	SRSF4	60	74.074	ENSEBUG00000001681	srsf4	67	64.246	Eptatretus_burgeri
ENSG00000116350	SRSF4	58	96.154	ENSEBUG00000003129	srsf4	69	63.291	Eptatretus_burgeri
ENSG00000116350	SRSF4	92	93.939	ENSEASG00005010168	SRSF4	92	93.939	Equus_asinus_asinus
ENSG00000116350	SRSF4	92	93.939	ENSECAG00000021350	SRSF4	92	93.939	Equus_caballus
ENSG00000116350	SRSF4	92	90.769	ENSEEUG00000008479	SRSF4	92	89.670	Erinaceus_europaeus
ENSG00000116350	SRSF4	56	88.000	ENSELUG00000017551	srsf4	93	72.308	Esox_lucius
ENSG00000116350	SRSF4	92	92.527	ENSFCAG00000027821	SRSF4	92	91.429	Felis_catus
ENSG00000116350	SRSF4	76	85.294	ENSFALG00000001346	SRSF4	74	72.676	Ficedula_albicollis
ENSG00000116350	SRSF4	76	91.176	ENSFDAG00000007332	SRSF4	92	82.824	Fukomys_damarensis
ENSG00000116350	SRSF4	69	77.419	ENSFHEG00000007472	srsf4	90	86.905	Fundulus_heteroclitus
ENSG00000116350	SRSF4	58	88.462	ENSGMOG00000012906	srsf4	81	66.667	Gadus_morhua
ENSG00000116350	SRSF4	92	73.026	ENSGALG00000050314	SRSF4	61	84.828	Gallus_gallus
ENSG00000116350	SRSF4	76	70.588	ENSGAFG00000018496	srsf4	72	86.765	Gambusia_affinis
ENSG00000116350	SRSF4	56	84.000	ENSGACG00000002389	srsf4	73	69.421	Gasterosteus_aculeatus
ENSG00000116350	SRSF4	74	98.305	ENSGAGG00000014836	SRSF4	65	89.877	Gopherus_agassizii
ENSG00000116350	SRSF4	100	100.000	ENSGGOG00000002444	SRSF4	100	100.000	Gorilla_gorilla
ENSG00000116350	SRSF4	53	87.500	ENSHBUG00000016897	-	79	86.207	Haplochromis_burtoni
ENSG00000116350	SRSF4	53	95.833	ENSHBUG00000011326	-	76	66.544	Haplochromis_burtoni
ENSG00000116350	SRSF4	95	87.234	ENSHGLG00000011842	SRSF4	92	85.683	Heterocephalus_glaber_female
ENSG00000116350	SRSF4	95	87.234	ENSHGLG00100017279	SRSF4	92	85.683	Heterocephalus_glaber_male
ENSG00000116350	SRSF4	71	71.875	ENSHCOG00000012540	srsf4	98	69.549	Hippocampus_comes
ENSG00000116350	SRSF4	92	90.652	ENSSTOG00000015908	SRSF4	92	90.652	Ictidomys_tridecemlineatus
ENSG00000116350	SRSF4	76	91.176	ENSJJAG00000022153	Srsf4	92	74.074	Jaculus_jaculus
ENSG00000116350	SRSF4	69	77.419	ENSKMAG00000013631	srsf4	81	74.879	Kryptolebias_marmoratus
ENSG00000116350	SRSF4	84	89.906	ENSLAFG00000002575	SRSF4	86	88.991	Loxodonta_africana
ENSG00000116350	SRSF4	100	100.000	ENSMFAG00000041784	SRSF4	100	100.000	Macaca_fascicularis
ENSG00000116350	SRSF4	100	100.000	ENSMMUG00000007110	SRSF4	100	100.000	Macaca_mulatta
ENSG00000116350	SRSF4	100	100.000	ENSMNEG00000034931	SRSF4	100	100.000	Macaca_nemestrina
ENSG00000116350	SRSF4	100	100.000	ENSMLEG00000031619	SRSF4	100	100.000	Mandrillus_leucophaeus
ENSG00000116350	SRSF4	62	82.143	ENSMAMG00000004888	srsf4	97	75.794	Mastacembelus_armatus
ENSG00000116350	SRSF4	53	87.500	ENSMZEG00005026275	srsf4	97	68.872	Maylandia_zebra
ENSG00000116350	SRSF4	53	87.500	ENSMZEG00005025078	-	78	86.207	Maylandia_zebra
ENSG00000116350	SRSF4	92	73.026	ENSMGAG00000002400	SRSF4	61	85.172	Meleagris_gallopavo
ENSG00000116350	SRSF4	93	86.393	ENSMAUG00000021940	Srsf4	92	84.211	Mesocricetus_auratus
ENSG00000116350	SRSF4	100	95.210	ENSMICG00000043567	SRSF4	100	90.854	Microcebus_murinus
ENSG00000116350	SRSF4	93	82.751	ENSMOCG00000013319	Srsf4	92	83.406	Microtus_ochrogaster
ENSG00000116350	SRSF4	70	85.507	ENSMMOG00000013653	srsf4	96	66.406	Mola_mola
ENSG00000116350	SRSF4	76	91.176	ENSMODG00000011052	SRSF4	90	95.172	Monodelphis_domestica
ENSG00000116350	SRSF4	69	80.645	ENSMALG00000013392	srsf4	66	86.441	Monopterus_albus
ENSG00000116350	SRSF4	76	73.529	ENSMALG00000010062	-	90	76.190	Monopterus_albus
ENSG00000116350	SRSF4	81	100.000	MGP_CAROLIEiJ_G0026555	Srsf4	92	83.589	Mus_caroli
ENSG00000116350	SRSF4	93	83.766	ENSMUSG00000028911	Srsf4	92	83.991	Mus_musculus
ENSG00000116350	SRSF4	93	85.371	MGP_PahariEiJ_G0028887	Srsf4	92	85.526	Mus_pahari
ENSG00000116350	SRSF4	93	82.468	MGP_SPRETEiJ_G0027535	Srsf4	92	83.114	Mus_spretus
ENSG00000116350	SRSF4	92	87.284	ENSMPUG00000015470	SRSF4	92	87.931	Mustela_putorius_furo
ENSG00000116350	SRSF4	76	91.176	ENSMLUG00000014770	SRSF4	92	86.739	Myotis_lucifugus
ENSG00000116350	SRSF4	92	86.184	ENSNGAG00000012225	Srsf4	92	85.526	Nannospalax_galili
ENSG00000116350	SRSF4	53	87.500	ENSNBRG00000014840	-	81	86.207	Neolamprologus_brichardi
ENSG00000116350	SRSF4	100	98.988	ENSNLEG00000009916	SRSF4	100	98.988	Nomascus_leucogenys
ENSG00000116350	SRSF4	92	87.719	ENSOPRG00000010098	SRSF4	93	86.842	Ochotona_princeps
ENSG00000116350	SRSF4	76	91.176	ENSODEG00000003230	SRSF4	92	84.698	Octodon_degus
ENSG00000116350	SRSF4	76	91.176	ENSOANG00000015169	SRSF4	58	72.500	Ornithorhynchus_anatinus
ENSG00000116350	SRSF4	92	87.609	ENSOCUG00000001837	SRSF4	93	85.652	Oryctolagus_cuniculus
ENSG00000116350	SRSF4	92	93.860	ENSOGAG00000015515	SRSF4	92	92.763	Otolemur_garnettii
ENSG00000116350	SRSF4	76	91.176	ENSOARG00000002451	SRSF4	84	69.259	Ovis_aries
ENSG00000116350	SRSF4	100	100.000	ENSPPAG00000028357	SRSF4	100	100.000	Pan_paniscus
ENSG00000116350	SRSF4	92	92.527	ENSPPRG00000016248	SRSF4	92	91.429	Panthera_pardus
ENSG00000116350	SRSF4	100	100.000	ENSPTRG00000000445	SRSF4	100	100.000	Pan_troglodytes
ENSG00000116350	SRSF4	100	100.000	ENSPANG00000021937	SRSF4	100	100.000	Papio_anubis
ENSG00000116350	SRSF4	53	83.333	ENSPMGG00000013436	srsf4	95	81.102	Periophthalmus_magnuspinnatus
ENSG00000116350	SRSF4	88	80.275	ENSPEMG00000003365	Srsf4	91	81.235	Peromyscus_maniculatus_bairdii
ENSG00000116350	SRSF4	51	73.913	ENSPMAG00000009397	srsf4	89	55.859	Petromyzon_marinus
ENSG00000116350	SRSF4	76	70.588	ENSPFOG00000001306	srsf4	66	69.685	Poecilia_formosa
ENSG00000116350	SRSF4	76	70.588	ENSPLAG00000008812	srsf4	64	75.956	Poecilia_latipinna
ENSG00000116350	SRSF4	69	77.419	ENSPMEG00000023638	srsf4	53	85.246	Poecilia_mexicana
ENSG00000116350	SRSF4	76	70.588	ENSPREG00000009639	srsf4	76	65.950	Poecilia_reticulata
ENSG00000116350	SRSF4	100	98.785	ENSPPYG00000001629	SRSF4	100	98.785	Pongo_abelii
ENSG00000116350	SRSF4	92	88.132	ENSPCAG00000009879	SRSF4	92	89.231	Procavia_capensis
ENSG00000116350	SRSF4	100	90.854	ENSPCOG00000027341	SRSF4	100	90.854	Propithecus_coquereli
ENSG00000116350	SRSF4	67	79.167	ENSPVAG00000012500	SRSF4	67	79.167	Pteropus_vampyrus
ENSG00000116350	SRSF4	56	65.233	ENSPNYG00000003796	srsf4	80	66.667	Pundamilia_nyererei
ENSG00000116350	SRSF4	64	79.310	ENSPNAG00000023844	srsf4	53	83.616	Pygocentrus_nattereri
ENSG00000116350	SRSF4	76	91.176	ENSRNOG00000010007	Srsf4	92	85.120	Rattus_norvegicus
ENSG00000116350	SRSF4	100	99.375	ENSRBIG00000035789	SRSF4	100	99.375	Rhinopithecus_bieti
ENSG00000116350	SRSF4	100	99.375	ENSRROG00000029463	SRSF4	100	99.375	Rhinopithecus_roxellana
ENSG00000116350	SRSF4	100	96.800	ENSSBOG00000027098	SRSF4	100	96.800	Saimiri_boliviensis_boliviensis
ENSG00000116350	SRSF4	76	91.176	ENSSHAG00000012407	SRSF4	100	88.356	Sarcophilus_harrisii
ENSG00000116350	SRSF4	69	90.323	ENSSFOG00015020292	srsf4	82	85.965	Scleropages_formosus
ENSG00000116350	SRSF4	60	63.300	ENSSDUG00000007387	srsf4	80	68.939	Seriola_dumerili
ENSG00000116350	SRSF4	50	74.694	ENSSARG00000001277	SRSF4	52	81.013	Sorex_araneus
ENSG00000116350	SRSF4	73	84.848	ENSSPUG00000019124	-	92	92.683	Sphenodon_punctatus
ENSG00000116350	SRSF4	76	85.294	ENSSPUG00000015318	-	67	83.792	Sphenodon_punctatus
ENSG00000116350	SRSF4	60	81.481	ENSSPAG00000014538	srsf4	83	85.950	Stegastes_partitus
ENSG00000116350	SRSF4	96	90.756	ENSSSCG00000003589	SRSF4	94	89.783	Sus_scrofa
ENSG00000116350	SRSF4	76	88.235	ENSTGUG00000000765	SRSF4	57	82.609	Taeniopygia_guttata
ENSG00000116350	SRSF4	53	83.333	ENSTRUG00000011891	srsf4	62	80.729	Takifugu_rubripes
ENSG00000116350	SRSF4	71	81.250	ENSTNIG00000005573	srsf4	60	71.901	Tetraodon_nigroviridis
ENSG00000116350	SRSF4	92	91.648	ENSTTRG00000002572	SRSF4	92	91.648	Tursiops_truncatus
ENSG00000116350	SRSF4	92	89.417	ENSUAMG00000006106	SRSF4	92	88.889	Ursus_americanus
ENSG00000116350	SRSF4	85	89.252	ENSVVUG00000012690	SRSF4	90	87.850	Vulpes_vulpes
ENSG00000116350	SRSF4	69	77.419	ENSXCOG00000018826	srsf4	89	81.513	Xiphophorus_couchianus
ENSG00000116350	SRSF4	53	100.000	ENSXCOG00000003212	-	55	78.191	Xiphophorus_couchianus
ENSG00000116350	SRSF4	91	68.293	ENSXMAG00000021549	-	83	74.747	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000375	RNA splicing, via transesterification reactions	8321209.	TAS	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	22365833.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006397	mRNA processing	8321209.	TAS	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008380	RNA splicing	8321209.	TAS	Process
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0032868	response to insulin	-	IEA	Process
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:0048025	negative regulation of mRNA splicing, via spliceosome	15009664.	IDA	Process
GO:1990825	sequence-specific mRNA binding	-	IEA	Function