EuRBPDB

Description

Ensembl ID: ENSG00000116489 (Gene tree)
Gene ID: 829
Gene Symbol: CAPZA1
Alias: N
Full Name: capping actin protein of muscle Z-line subunit alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 52,447 bases
Position: chr1:112,619,173-112,671,619
Accession: 1488
RBP type: non-canonical RBP
Summary: CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000476936	CAPZA1-204	867	-	-	- (aa)	-	-
ENST00000263168	CAPZA1-201	3020	XM_011542225	ENSP00000263168	286 (aa)	XP_011540527	P52907
ENST00000498626	CAPZA1-206	650	-	-	- (aa)	-	-
ENST00000485542	CAPZA1-205	739	-	-	- (aa)	-	-
ENST00000476820	CAPZA1-203	278	-	-	- (aa)	-	-
ENST00000466066	CAPZA1-202	765	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116489	Platelet Function Tests	3.3100000E-006	-
ENSG00000116489	Blood Pressure	3E-9	25249183
ENSG00000116489	Blood Pressure	8E-8	25249183
ENSG00000116489	Body Height	2E-12	25282103
ENSG00000116489	Blood Pressure	7E-8	26390057
ENSG00000116489	Blood Pressure	6E-7	26390057
ENSG00000116489	Blood Pressure	8E-6	21572416
ENSG00000116489	Blood Pressure	1E-8	21572416
ENSG00000116489	Hypertension	3E-9	25249183

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116489	rs528855147	1	112641982	T	Intraocular pressure	29617998	[0.091-0.157] unit decrease	0.124	EFO_0004695
ENSG00000116489	rs17030613	1	112648185	A	Intraocular pressure	29617998	[0.081-0.149] unit decrease	0.115	EFO_0004695
ENSG00000116489	rs17030613	1	112648185	A	Diastolic blood pressure	26390057	[0.2-0.44] mmHg decrease	0.3193	EFO_0006336
ENSG00000116489	rs17030613	1	112648185	A	Diastolic blood pressure	26390057	[0.3-0.67] mmHg decrease	0.4884	EFO_0006336
ENSG00000116489	rs10745332	1	112646431	A	Systolic blood pressure	25249183	[0.61-1.31] unit increase	0.96	EFO_0006335
ENSG00000116489	rs10745332	1	112646431	A	Diastolic blood pressure	25249183	[0.33-0.73] unit increase	0.53	EFO_0006336
ENSG00000116489	rs10745332	1	112646431	A	Hypertension	25249183			EFO_0000537
ENSG00000116489	rs2932536	1	112659795	A	Platelet count	27863252	[0.027-0.042] unit decrease	0.03455963	EFO_0004309
ENSG00000116489	rs17030613	1	112648185	C	Blood pressure	21572416	[0.27-0.71] mm Hg increase	0.49	EFO_0006335
ENSG00000116489	rs17030613	1	112648185	C	Blood pressure	21572416	[0.24-0.52] mm Hg increase	0.38	EFO_0006336
ENSG00000116489	rs12120956	1	112659949	A	Height	25282103	[0.017-0.033] unit decrease	0.025	EFO_0004339
ENSG00000116489	rs61818802	1	112639117	C	Intraocular pressure	29785010	[0.066-0.128] unit decrease	0.097	EFO_0004695
ENSG00000116489	rs6690292	1	112645797	C	Chronotype	30696823		1.0250076	EFO_0008328
ENSG00000116489	rs6537747	1	112636975	T	Chronotype	30696823	[0.007-0.0145] unit decrease	0.0107681	EFO_0008328

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	7665558.	TAS	Function
GO:0005515	protein binding	22891260.23178720.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0008290	F-actin capping protein complex	21873635.	IBA	Component
GO:0015629	actin cytoskeleton	7665558.	TAS	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030036	actin cytoskeleton organization	21873635.	IBA	Process
GO:0030479	actin cortical patch	21873635.	IBA	Component
GO:0034329	cell junction assembly	22891260.	IMP	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0045087	innate immune response	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051016	barbed-end actin filament capping	21873635.	IBA	Process
GO:0065003	protein-containing complex assembly	9331217.	TAS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071203	WASH complex	19922875.	IDA	Component