EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000116584 (Gene tree)
Gene ID: 9181
Gene Symbol: ARHGEF2
Alias: LFP40|GEF-H1|KIAA0651|P40
Full Name: Rho/Rac guanine nucleotide exchange factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 60,431 bases
Position: chr1:155,946,640-156,007,070
Accession: 682
RBP type: non-canonical RBP
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12215442	Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA.	J Biol Chem	2002 Nov 8	Ge W	-
30637779	Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms.	Hepatology	2019 Jan 13	Chen H	doi: 10.1002/hep.30500
15866167	Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.	Dev Cell	2005 May	Aijaz S	-
23536706	Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.	Mol Biol Cell	2013 May	Ueda S	doi: 10.1091/mbc.E12-11-0782

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000470541	ARHGEF2-208	1877	-	ENSP00000476689	263 (aa)	-	V9GYF0
ENST00000474428	ARHGEF2-212	742	-	-	- (aa)	-	-
ENST00000609126	ARHGEF2-219	490	-	-	- (aa)	-	-
ENST00000495070	ARHGEF2-216	571	-	ENSP00000476532	83 (aa)	-	V9GY94
ENST00000609707	ARHGEF2-220	692	-	ENSP00000476699	178 (aa)	-	V9GYF5
ENST00000368315	ARHGEF2-204	1645	-	ENSP00000357298	264 (aa)	-	Q5VY93
ENST00000497907	ARHGEF2-217	764	-	ENSP00000476724	214 (aa)	-	V9GYG5
ENST00000465079	ARHGEF2-207	693	-	-	- (aa)	-	-
ENST00000470874	ARHGEF2-209	372	-	ENSP00000477448	59 (aa)	-	V9GZ58
ENST00000462460	ARHGEF2-206	4438	XM_011510136	ENSP00000476916	1031 (aa)	XP_011508438	V9GYM8
ENST00000313695	ARHGEF2-202	4080	XM_005245589	ENSP00000315325	958 (aa)	XP_005245646	Q92974
ENST00000608543	ARHGEF2-218	820	-	-	- (aa)	-	-
ENST00000423422	ARHGEF2-205	420	-	ENSP00000476518	7 (aa)	-	A0A1Y8EN19
ENST00000470975	ARHGEF2-210	638	-	-	- (aa)	-	-
ENST00000361247	ARHGEF2-203	4149	XM_005245587	ENSP00000354837	986 (aa)	XP_005245644	Q92974
ENST00000477754	ARHGEF2-214	883	-	-	- (aa)	-	-
ENST00000487755	ARHGEF2-215	2176	-	-	- (aa)	-	-
ENST00000313667	ARHGEF2-201	2958	XM_005245588	ENSP00000314787	985 (aa)	XP_005245645	Q92974
ENST00000476273	ARHGEF2-213	668	-	-	- (aa)	-	-
ENST00000471589	ARHGEF2-211	892	-	ENSP00000477299	229 (aa)	-	V9GZ14

Gene Model

Click here to download ENSG00000116584's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116584	Vitamin B 12	3.6160000E-005	-
ENSG00000116584	Amyotrophic Lateral Sclerosis	1E-6	22959728
ENSG00000116584	Age of Onset	1E-6	22959728

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116584	rs2364403	1	155957961	A	Amyotrophic lateral sclerosis (age of onset)	22959728			EFO_0000253\|EFO_0004847
ENSG00000116584	rs4330912	1	155999637	G	Birth weight	27680694	[0.013-0.029] unit increase	0.021	EFO_0004344

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116584's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000132	establishment of mitotic spindle orientation	-	IEA	Process
GO:0000902	cell morphogenesis	11912491.	IMP	Process
GO:0002102	podosome	-	IEA	Component
GO:0005089	Rho guanyl-nucleotide exchange factor activity	9857026.	IDA	Function
GO:0005515	protein binding	14970201.15161933.19043560.21887730.25416956.25609649.	IPI	Function
GO:0005737	cytoplasm	21887730.	IDA	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005819	spindle	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	21887730.	IDA	Component
GO:0005874	microtubule	9857026.	IDA	Component
GO:0005923	bicellular tight junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006886	intracellular protein transport	9857026.	NAS	Process
GO:0007015	actin filament organization	9857026.	IMP	Process
GO:0007026	negative regulation of microtubule depolymerization	11912491.	IMP	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0008017	microtubule binding	9857026.	IDA	Function
GO:0008134	transcription factor binding	-	ISS	Function
GO:0008270	zinc ion binding	11912491.	NAS	Function
GO:0017048	Rho GTPase binding	9857026.	IDA	Function
GO:0030676	Rac guanyl-nucleotide exchange factor activity	9857026.	IDA	Function
GO:0031410	cytoplasmic vesicle	-	IEA	Component
GO:0031982	vesicle	21887730.	IDA	Component
GO:0032587	ruffle membrane	19043560.	IDA	Component
GO:0032755	positive regulation of interleukin-6 production	21887730.	IDA	Process
GO:0032760	positive regulation of tumor necrosis factor production	21887730.	IDA	Process
GO:0032991	protein-containing complex	21887730.	IDA	Component
GO:0035023	regulation of Rho protein signal transduction	11912491.	NAS	Process
GO:0035556	intracellular signal transduction	-	IEA	Process
GO:0042127	regulation of cell proliferation	9857026.	TAS	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043065	positive regulation of apoptotic process	-	TAS	Process
GO:0043198	dendritic shaft	-	IEA	Component
GO:0045087	innate immune response	-	IEA	Process
GO:0045666	positive regulation of neuron differentiation	28453519.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21887730.	IDA	Process
GO:0048365	Rac GTPase binding	9857026.	IDA	Function
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	21887730.	IDA	Process
GO:0050768	negative regulation of neurogenesis	-	IEA	Process
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	19043560.21887730.	IDA	Process
GO:0055059	asymmetric neuroblast division	28453519.	IDA	Process
GO:0060546	negative regulation of necroptotic process	-	ISS	Process
GO:0071225	cellular response to muramyl dipeptide	21887730.	IDA	Process
GO:0071356	cellular response to tumor necrosis factor	-	ISS	Process
GO:0071474	cellular hyperosmotic response	-	ISS	Process
GO:0071802	negative regulation of podosome assembly	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099092	postsynaptic density, intracellular component	-	IEA	Component
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	ISS	Process
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	-	ISS	Process
GO:2001224	positive regulation of neuron migration	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27573550	miR-194 is a negative regulator of GEF-H1 pathway in melanoma.	Oncol Rep	2016 Oct	Guo B	doi: 10.3892/or.2016.5020
25687035	Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer.	Int J Biochem Cell Biol	2015 Apr	Zhu X	doi: 10.1016/j.biocel.2015.02.005
22002306	Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling.	Oncogene	2012 Jun 21	Liao YC	doi: 10.1038/onc.2011.476
16778209	Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells.	Cancer Res	2006 Jun 15	Mizuarai S	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	155952179	Nonsense_Mutation	NA	R681*	0.11
BLCA	chr1	155952627	Splice_Site	NA	X662_splice	0.37
BLCA	chr1	155965313	Silent	novel	L190L	0.32
BLCA	chr1	155950969	Missense_Mutation	novel	E855Q	0.54
BLCA	chr1	155962199	Silent	rs756510235	L375L	0.37
BLCA	chr1	155950844	Missense_Mutation	novel	S896R	0.33
BLCA	chr1	155952775	Missense_Mutation	novel	G613W	0.11
BLCA	chr1	155965749	Nonsense_Mutation	novel	E118*	0.17
BLCA	chr1	155957863	Missense_Mutation	rs756219943	S522L	0.25
BRCA	chr1	155966414	Splice_Site	novel	X114_splice	0.1
BRCA	chr1	155963083	Silent	NA	V275V	0.22
BRCA	chr1	155950867	Missense_Mutation	rs760566971	A889T	0.26
BRCA	chr1	155951218	Missense_Mutation	NA	E772K	0.21
BRCA	chr1	155952749	Silent	NA	F621F	0.67
BRCA	chr1	155952633	Missense_Mutation	rs749849556	R660H	0.08
BRCA	chr1	155952664	Missense_Mutation	rs768385602	R650C	0.07
BRCA	chr1	155950413	Silent	NA	R925R	0.25
BRCA	chr1	155947921	3'UTR	novel		0.2
BRCA	chr1	155961763	Missense_Mutation	NA	P456S	0.41
CESC	chr1	155965685	Missense_Mutation	rs374781823	R139H	0.14
CESC	chr1	155962947	Missense_Mutation	NA	L321V	0.17
CESC	chr1	155964995	Silent	NA	V239V	0.15
CESC	chr1	155947235	3'UTR	novel		0.44
CESC	chr1	155961718	Missense_Mutation	NA	R471C	0.21
CESC	chr1	155962208	Silent	novel	P372P	0.58
CESC	chr1	155963128	Silent	NA	L260L	0.23
CESC	chr1	155951143	Missense_Mutation	NA	P797S	0.67
CESC	chr1	155962145	Silent	NA	K393K	0.27
CESC	chr1	155947435	3'UTR	novel		0.33
CESC	chr1	155957770	Missense_Mutation	novel	T553I	0.43
CESC	chr1	155963062	Silent	rs761662798	C282C	0.23
CESC	chr1	155962701	Silent	rs75834511	A331A	0.29
CESC	chr1	155948006	Missense_Mutation	NA	R966T	0.22
CESC	chr1	155962966	Silent	rs368444093	V314V	0.1
CESC	chr1	155947418	3'UTR	novel		0.33
CESC	chr1	155950861	Missense_Mutation	rs767282425	D891N	0.33
CESC	chr1	155969221	Nonsense_Mutation	novel	S48*	0.46
CHOL	chr1	155947139	3'UTR	novel		0.23
CHOL	chr1	155983106	5'Flank	novel		0.42
COAD	chr1	155947924	3'UTR	novel		0.4
COAD	chr1	155965335	Missense_Mutation	novel	R183Q	0.3
COAD	chr1	155950878	Missense_Mutation	rs377007664	R885H	0.21
COAD	chr1	155954919	Missense_Mutation	novel	Y589F	0.26
COAD	chr1	155978377	Silent	NA	E17E	0.11
COAD	chr1	155965072	Missense_Mutation	novel	A214T	0.3
COAD	chr1	155950464	Missense_Mutation	novel	R908C	0.26
COAD	chr1	155951019	Missense_Mutation	NA	R838Q	0.26
COAD	chr1	155957847	Silent	novel	I527I	0.27
COAD	chr1	155962185	Missense_Mutation	NA	V380A	0.36
COAD	chr1	155952147	Silent	rs762316330	S691S	0.33
COAD	chr1	155957761	Missense_Mutation	NA	R556Q	0.29
COAD	chr1	155951497	Missense_Mutation	novel	L749I	0.24
COAD	chr1	155951232	Missense_Mutation	novel	F767S	0.24
COAD	chr1	155951258	Silent	NA	Q758Q	0.53
DLBC	chr1	155947974	Missense_Mutation	novel	R977C	0.42
DLBC	chr1	155958368	Silent	novel	V499V	0.25
DLBC	chr1	155950380	Missense_Mutation	rs751186042	R936W	0.22
ESCA	chr1	155947226	3'UTR	novel		0.14
ESCA	chr1	155946924	3'UTR	novel		0.57
ESCA	chr1	155950962	Missense_Mutation	rs533748068	R857Q	0.33
ESCA	chr1	155952654	Missense_Mutation	novel	R653Q	0.38
ESCA	chr1	155966845	Missense_Mutation	novel	A84V	0.26
ESCA	chr1	155951066	Silent	novel	R822R	0.33
GBM	chr1	155957719	Missense_Mutation	novel	V570E	0.17
GBM	chr1	155963082	Missense_Mutation	novel	V276F	0.11
GBM	chr1	155965761	Splice_Site	novel	X114_splice	0.45
HNSC	chr1	155954917	Silent	novel	L590L	0.32
HNSC	chr1	155961775	Missense_Mutation	novel	R452W	0.25
HNSC	chr1	155954938	Missense_Mutation	novel	E583Q	0.16
HNSC	chr1	155952644	Missense_Mutation	novel	Q656H	0.19
HNSC	chr1	155950868	Silent	rs753546449	P888P	0.47
KICH	chr1	155962702	Missense_Mutation	rs763347486	A331V	0.46
KICH	chr1	155951748	Missense_Mutation	rs768686704	P734L	0.39
KIRC	chr1	155969222	Missense_Mutation	novel	S48T	0.42
KIRP	chr1	155978440	5'UTR	novel		0.29
LAML	chr1	155952161	Missense_Mutation	novel	L687M	0.67
LGG	chr1	155965742	Missense_Mutation	novel	P120L	0.32
LGG	chr1	155951014	Missense_Mutation	rs371193783	R840W	0.53
LGG	chr1	155962612	Missense_Mutation	NA	R361H	0.42
LGG	chr1	155962976	Missense_Mutation	rs755710866	R311Q	0.31
LGG	chr1	155961796	Missense_Mutation	NA	I445V	0.48
LIHC	chr1	155965742	Missense_Mutation	novel	P120R	0.07
LIHC	chr1	155962669	Missense_Mutation	NA	C342Y	0.09
LIHC	chr1	155961678	Missense_Mutation	NA	A484E	0.14
LIHC	chr1	155978430	5'UTR	novel		0.14
LIHC	chr1	155947937	3'UTR	novel		0.21
LIHC	chr1	155952718	Missense_Mutation	NA	A632T	0.19
LIHC	chr1	155961858	Missense_Mutation	NA	E424V	0.11
LUAD	chr1	155965756	Silent	NA	T115T	0.39
LUAD	chr1	155950996	Missense_Mutation	novel	R846W	0.54
LUAD	chr1	155962985	Missense_Mutation	NA	G308V	0.13
LUAD	chr1	155962182	Missense_Mutation	NA	Q381L	0.12
LUAD	chr1	155951529	Missense_Mutation	rs138090439	A738V	0.11
LUAD	chr1	155963184	Splice_Site	NA	X242_splice	0.11
LUAD	chr1	155952694	Missense_Mutation	novel	L640V	0.38
LUAD	chr1	155965630	Splice_Site	novel	X157_splice	0.05
LUAD	chr1	155965380	Missense_Mutation	NA	R168L	0.28
LUAD	chr1	155950284	Intron	novel		0.19
LUAD	chr1	155950270	Intron	novel		0.31
LUSC	chr1	155961896	Missense_Mutation	NA	E411D	0.39
LUSC	chr1	155962703	Missense_Mutation	novel	A331S	0.15
LUSC	chr1	155952207	Frame_Shift_Del	novel	*P672Qfs7**	0.19
LUSC	chr1	155957822	Missense_Mutation	NA	K536E	0.17
LUSC	chr1	155963111	Missense_Mutation	novel	L266R	0.27
LUSC	chr1	155950327	Missense_Mutation	NA	S953R	0.43
LUSC	chr1	155952698	Missense_Mutation	NA	R638S	0.17
LUSC	chr1	155951534	Splice_Site	NA	X737_splice	0.52
LUSC	chr1	155951480	Splice_Region	novel		0.09
LUSC	chr1	155966466	Missense_Mutation	NA	A97V	0.19
MESO	chr1	155950902	Missense_Mutation	rs749600621	R877H	0.37
OV	chr1	155961691	Missense_Mutation	novel	L480I	0.08
OV	chr1	155962130	Silent	NA	I398I	0.2
OV	chr1	155962126	Missense_Mutation	rs776511128	R400C	0.59
OV	chr1	155969281	Missense_Mutation	novel	M28R	0.04
OV	chr1	155951965	Missense_Mutation	NA	N709S	0.21
OV	chr1	155961714	Missense_Mutation	novel	K472R	0.11
OV	chr1	155961889	Frame_Shift_Ins	novel	*D414Lfs135**	0.04
OV	chr1	155961891	Nonsense_Mutation	novel	*R412_Q413insLS**	0.03
PRAD	chr1	155961763	Missense_Mutation	NA	P456S	0.2
PRAD	chr1	155951019	Missense_Mutation	NA	R838Q	0.35
PRAD	chr1	155961719	Missense_Mutation	novel	R470S	0.42
PRAD	chr1	155961894	Missense_Mutation	novel	R412H	0.3
PRAD	chr1	155965381	Missense_Mutation	rs770552827	R168C	0.43
READ	chr1	155951773	Nonsense_Mutation	NA	R726*	0.36
READ	chr1	155947937	3'UTR	novel		0.47
READ	chr1	155952814	Nonsense_Mutation	novel	K600*	0.11
READ	chr1	155952815	Missense_Mutation	novel	Q599H	0.11
SARC	chr1	155961718	Missense_Mutation	NA	R471C	0.28
SKCM	chr1	155952664	Missense_Mutation	rs768385602	R650C	0.21
SKCM	chr1	155965725	Missense_Mutation	NA	P126S	0.42
SKCM	chr1	155952677	Silent	NA	S645S	0.35
SKCM	chr1	155965362	Missense_Mutation	NA	S174F	0.27
SKCM	chr1	155961764	Silent	NA	T455T	0.27
SKCM	chr1	155966435	Silent	novel	S107S	0.22
SKCM	chr1	155952130	Missense_Mutation	novel	P697L	0.36
SKCM	chr1	155952131	Missense_Mutation	rs767426471	P697A	0.35
SKCM	chr1	155965367	Silent	rs149517516	S172S	0.21
SKCM	chr1	155951185	Missense_Mutation	rs762005951	R783W	0.18
SKCM	chr1	155950388	Missense_Mutation	NA	P933L	0.23
SKCM	chr1	155965699	Silent	rs267598071	L134L	0.13
SKCM	chr1	155962626	Silent	rs370489054	Y356Y	0.48
SKCM	chr1	155961799	Missense_Mutation	NA	E444K	0.19
SKCM	chr1	155962110	Missense_Mutation	NA	S405F	0.17
SKCM	chr1	155965703	Missense_Mutation	NA	S133F	0.24
SKCM	chr1	155963124	Missense_Mutation	rs144287482	R262C	0.25
SKCM	chr1	155965332	Missense_Mutation	NA	T184I	0.31
SKCM	chr1	155950963	Nonsense_Mutation	NA	R857*	0.65
SKCM	chr1	155952787	Missense_Mutation	NA	R609G	0.16
SKCM	chr1	155950974	Missense_Mutation	novel	A853V	0.47
SKCM	chr1	155950325	Missense_Mutation	NA	R954H	0.41
SKCM	chr1	155961788	Missense_Mutation	NA	N447K	0.27
SKCM	chr1	155950326	Missense_Mutation	NA	R954C	0.26
SKCM	chr1	155950431	Missense_Mutation	novel	H919Y	0.14
SKCM	chr1	155950432	Silent	novel	V918V	0.16
SKCM	chr1	155966425	Frame_Shift_Del	novel	*R111Efs36**	0.45
SKCM	chr1	155963135	Missense_Mutation	novel	T258I	0.36
STAD	chr1	155962988	Missense_Mutation	NA	P307H	0.18
STAD	chr1	155957716	Missense_Mutation	rs544890242	R571H	0.17
STAD	chr1	155961808	Missense_Mutation	NA	R441C	0.17
STAD	chr1	155969251	Missense_Mutation	rs758919022	N38S	0.13
STAD	chr1	155950380	Missense_Mutation	rs751186042	R936W	0.18
STAD	chr1	155965708	Silent	NA	R131R	0.18
STAD	chr1	155954914	Missense_Mutation	NA	R591W	0.19
STAD	chr1	155950868	Frame_Shift_Del	novel	*A889Qfs7**	0.07
STAD	chr1	155961895	Missense_Mutation	rs781587819	R412C	0.32
STAD	chr1	155951118	Missense_Mutation	NA	A805V	0.18
STAD	chr1	155963057	Missense_Mutation	NA	D284G	0.09
STAD	chr1	155961718	Missense_Mutation	NA	R471C	0.27
STAD	chr1	155950833	Frame_Shift_Del	NA	*P900Hfs83**	0.07
STAD	chr1	155969260	Missense_Mutation	NA	R35H	0.2
TGCT	chr1	155978466	5'UTR	novel		0.21
THCA	chr1	155961838	Missense_Mutation	novel	E431K	0.05
THYM	chr1	155950871	Silent	rs765072859	L887L	0.09
UCEC	chr1	155966456	Silent	novel	K100K	0.15
UCEC	chr1	155950302	Nonsense_Mutation	novel	R962*	0.33
UCEC	chr1	155947581	3'UTR	novel		0.21
UCEC	chr1	155957863	Missense_Mutation	rs756219943	S522L	0.18
UCEC	chr1	155947519	3'UTR	novel		0.1
UCEC	chr1	155962958	Missense_Mutation	rs550963600	R317H	0.36
UCEC	chr1	155961758	Silent	novel	V457V	0.2
UCEC	chr1	155957793	Silent	novel	P545P	0.19
UCEC	chr1	155969260	Missense_Mutation	novel	R35L	0.32
UCEC	chr1	155947615	3'UTR	novel		0.31
UCEC	chr1	155954910	Missense_Mutation	novel	R592Q	0.47
UCEC	chr1	155965730	Missense_Mutation	novel	I124T	0.43
UCEC	chr1	155952136	Missense_Mutation	rs140822619	T695M	0.43
UCEC	chr1	155962617	Silent	novel	D359D	0.06
UCEC	chr1	155951074	Missense_Mutation	novel	R820C	0.33
UCEC	chr1	155965751	Missense_Mutation	rs753323497	R117Q	0.28
UCEC	chr1	155965685	Missense_Mutation	rs374781823	R139H	0.36
UCEC	chr1	155950439	Missense_Mutation	NA	R916H	0.42
UCEC	chr1	155957846	Missense_Mutation	rs765138663	V528I	0.13
UCEC	chr1	155961778	Missense_Mutation	novel	P451T	0.12
UCEC	chr1	155962157	Missense_Mutation	novel	Q389H	0.33
UCEC	chr1	155965019	Silent	novel	K231K	0.22
UCEC	chr1	155962991	Missense_Mutation	novel	C306Y	0.11
UCEC	chr1	155962626	Silent	rs370489054	Y356Y	0.39
UCEC	chr1	155965001	Silent	novel	Q237Q	0.37
UCEC	chr1	155963119	Silent	novel	T263T	0.36
UCEC	chr1	155961679	Missense_Mutation	novel	A484T	0.4
UCEC	chr1	155963123	Missense_Mutation	novel	R262H	0.35
UCEC	chr1	155954930	Missense_Mutation	novel	E585D	0.29
UCEC	chr1	155952135	Silent	rs776959763	T695T	0.25
UCEC	chr1	155963132	Missense_Mutation	rs148865279	R259H	0.11
UCEC	chr1	155965107	Missense_Mutation	NA	M202T	0.1
UCEC	chr1	155966470	Missense_Mutation	novel	A96T	0.29
UCEC	chr1	155952792	Missense_Mutation	novel	L607P	0.23
UCEC	chr1	155947853	3'UTR	novel		0.14
UCEC	chr1	155965000	Missense_Mutation	rs761622296	D238N	0.27
UCEC	chr1	155962125	Missense_Mutation	novel	R400H	0.41
UCEC	chr1	155962195	Missense_Mutation	novel	R377W	0.33
UCEC	chr1	155952808	Missense_Mutation	novel	R602W	0.29
UCEC	chr1	155961701	Silent	novel	D476D	0.23
UCEC	chr1	155948016	Splice_Site	novel	X963_splice	0.35
UCEC	chr1	155958329	Silent	novel	F512F	0.34
UCEC	chr1	155950905	Missense_Mutation	novel	A876V	0.16
UCEC	chr1	155947686	3'UTR	novel		0.48
UCEC	chr1	155969173	Missense_Mutation	NA	E64G	0.24
UCEC	chr1	155965023	Missense_Mutation	novel	K230T	0.1
UCEC	chr1	155951966	Missense_Mutation	novel	N709D	0.54
UCEC	chr1	155966850	Silent	novel	T82T	0.43
UCEC	chr1	155952147	Silent	rs762316330	S691S	0.21
UCEC	chr1	155962612	Missense_Mutation	NA	R361H	0.18
UCEC	chr1	155950948	Missense_Mutation	rs759637676	A862T	0.39
UCEC	chr1	155961678	Missense_Mutation	rs576936245	A484V	0.25
UCEC	chr1	155963120	Missense_Mutation	rs199822429	T263M	0.11
UCEC	chr1	155962205	Silent	rs539613231	A373A	0.38
UCEC	chr1	155966468	Silent	rs372878297	A96A	0.16
UCEC	chr1	155954944	Frame_Shift_Del	novel	L581*	0.09
UCEC	chr1	155950315	Silent	rs201575550	P957P	0.17
UCEC	chr1	155952660	Missense_Mutation	novel	G651D	0.32
UCEC	chr1	155961786	Missense_Mutation	novel	R448H	0.21
UCEC	chr1	155963061	Missense_Mutation	rs753689780	V283M	0.29
UCEC	chr1	155947041	3'UTR	novel		0.54
UCEC	chr1	155966851	Missense_Mutation	novel	T82I	0.26
UCEC	chr1	155952823	Silent	novel	L597L	0.41
UCEC	chr1	155962139	Silent	rs373544686	P395P	0.3
UCEC	chr1	155962612	Missense_Mutation	NA	R361H	0.64
UCS	chr1	155950885	Missense_Mutation	novel	R883W	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3967	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2283	0.085665
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4905	9.6912e-06
TGCT	AMP	0.34	0.088103
UCEC	AMP	0.449	1.3482e-23
UCS	AMP	0.6786	3.9555e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0017	Kaplan-Meier Survival Analysis
MESO	0.02	Kaplan-Meier Survival Analysis
ACC	0.0028	Kaplan-Meier Survival Analysis
LUSC	0.037	Kaplan-Meier Survival Analysis
BRCA	0.023	Kaplan-Meier Survival Analysis
ESCA	0.05	Kaplan-Meier Survival Analysis
COAD	0.019	Kaplan-Meier Survival Analysis
CESC	0.0095	Kaplan-Meier Survival Analysis
KICH	0.025	Kaplan-Meier Survival Analysis
UCEC	0.00079	Kaplan-Meier Survival Analysis
LIHC	0.00058	Kaplan-Meier Survival Analysis
THCA	0.016	Kaplan-Meier Survival Analysis
LUAD	0.0065	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742