EuRBPDB

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  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116641 (Gene tree)
Gene ID
85440
Gene Symbol
DOCK7
Alias
KIAA1771|ZIR2
Full Name
dedicator of cytokinesis 7
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
234,071 bases
Position
chr1:62,454,298-62,688,368
Accession
19190
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000635123DOCK7-2186297XM_017002639ENSP000004894992098 (aa)XP_016858128Q96N67
ENST00000637144DOCK7-228100--- (aa)--
ENST00000637487DOCK7-234123--- (aa)--
ENST00000635286DOCK7-220580--- (aa)--
ENST00000637839DOCK7-236126--- (aa)--
ENST00000635027DOCK7-216275--- (aa)--
ENST00000637431DOCK7-233100--- (aa)--
ENST00000634929DOCK7-215765-ENSP00000489037255 (aa)-A0A0U1RQJ5
ENST00000454575DOCK7-2046985XM_011542327ENSP000004135832129 (aa)XP_011540629Q96N67
ENST00000251157DOCK7-2017084-ENSP000002511572131 (aa)-Q96N67
ENST00000636167DOCK7-224100--- (aa)--
ENST00000635088DOCK7-217382-ENSP00000489412101 (aa)-A0A0U1RR97
ENST00000637255DOCK7-2314071-ENSP000004908881229 (aa)-A0A1B0GWE0
ENST00000340370DOCK7-2026731-ENSP000003407422109 (aa)-Q96N67
ENST00000636635DOCK7-226122--- (aa)--
ENST00000634495DOCK7-2123678--- (aa)--
ENST00000637306DOCK7-232100--- (aa)--
ENST00000404627DOCK7-2032678-ENSP00000384446632 (aa)-Q96N67
ENST00000635348DOCK7-2212221--- (aa)--
ENST00000634223DOCK7-210681-ENSP0000048898846 (aa)-A0A0U1RQG7
ENST00000614472DOCK7-2091982-ENSP00000483062245 (aa)-A0A0C4DGY6
ENST00000637735DOCK7-235100--- (aa)--
ENST00000479983DOCK7-2071566--- (aa)--
ENST00000634912DOCK7-2141315--- (aa)--
ENST00000467758DOCK7-206855--- (aa)--
ENST00000636370DOCK7-225117--- (aa)--
ENST00000634264DOCK7-2116303-ENSP000004892842100 (aa)-Q96N67
ENST00000635983DOCK7-2236506--- (aa)--
ENST00000637227DOCK7-230100--- (aa)--
ENST00000637208DOCK7-2298283-ENSP00000490079602 (aa)-A0A1B0GUE9
ENST00000489185DOCK7-2081855--- (aa)--
ENST00000636746DOCK7-227100--- (aa)--
ENST00000638042DOCK7-237100--- (aa)--
ENST00000634652DOCK7-213745-ENSP00000489450248 (aa)-A0A0U1RRC1
ENST00000635253DOCK7-2196423XM_011542326ENSP000004891242140 (aa)XP_011540628Q96N67
ENST00000635827DOCK7-2223335-ENSP00000490677443 (aa)-A0A1B0GVW2
ENST00000464312DOCK7-205519-ENSP00000489164173 (aa)-A0A0U1RQT6
Gene Model
Click here to download ENSG00000116641's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000116641Cholesterol, LDL4.07e-00519060910
ENSG00000116641Cholesterol, LDL9.517e-00519060910
ENSG00000116641Triglycerides5.7140000E-006-
ENSG00000116641Triglycerides4.7660000E-006-
ENSG00000116641Triglycerides4.8520000E-006-
ENSG00000116641Triglycerides5.3120000E-006-
ENSG00000116641Triglycerides4.0450000E-006-
ENSG00000116641Lipids8.5170000E-006-
ENSG00000116641Lipids9.9160000E-006-
ENSG00000116641Lipids9.5220000E-006-
ENSG00000116641Lipids8.4300000E-006-
ENSG00000116641Lipids8.4610000E-006-
ENSG00000116641Crohn Disease7E-826192919
ENSG00000116641Cholesterol5E-826582766
ENSG00000116641Cholesterol, LDL3E-1820686565
ENSG00000116641Triglycerides6E-3425961943
ENSG00000116641Triglycerides2E-1219060911
ENSG00000116641Fatty Acids7E-725378659
ENSG00000116641Cholesterol, LDL8E-619060911
ENSG00000116641Triglycerides6E-820864672
ENSG00000116641Crohn Disease4E-628067908
ENSG00000116641Cholesterol, LDL2E-1125961943
ENSG00000116641Triglycerides9E-4320686565
ENSG00000116641Cholesterol4E-1219060911
ENSG00000116641Triglycerides2E-920139978
ENSG00000116641Cholesterol5E-4120686565
ENSG00000116641Triglycerides2E-1018193043
ENSG00000116641Cholesterol, LDL5E-724386095
ENSG00000116641Lipids4E-919936222
ENSG00000116641Vascular Calcification8E-1522916037
ENSG00000116641Triglycerides3E-719060906
ENSG00000116641Triglycerides3E-7424097068
ENSG00000116641Cholesterol6E-1024386095
ENSG00000116641Triglycerides8E-1226582766
ENSG00000116641Lipids3E-1322286219
ENSG00000116641Pneumococcal Infections5E-627236921
ENSG00000116641Cholesterol, LDL3E-3224097068
ENSG00000116641Cholesterol4E-8024097068
ENSG00000116641Lipids1E-1419936222
ENSG00000116641Lipids1E-1219936222
ENSG00000116641Lipids7E-1019936222
ENSG00000116641Lipids3E-1019936222
ENSG00000116641Lipids2E-1119936222
ENSG00000116641Lipids1E-1319936222
ENSG00000116641Lipids3E-1727005778
ENSG00000116641Metabolism3E-1727005778
ENSG00000116641Cholesterol2E-3425961943
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000116641rs1168000162467144?Pneumococcal bacteremia27236921[NR]2.85EFO_1001925
ENSG00000116641rs10889353162652525CTriglycerides20139978[0.085-0.167] unit decrease0.126EFO_0004530
ENSG00000116641rs11207995162583880CLipid traits24386095[0.00024-0.02376] mmol/L decrease0.012EFO_0004574
ENSG00000116641rs2131925162560271GLDL cholesterol24097068[NR] unit decrease0.049EFO_0004611
ENSG00000116641rs2131925162560271GTriglycerides24097068[NR] mg/dL decrease0.066EFO_0004530
ENSG00000116641rs1168103162662410TVery long-chain saturated fatty acid levels (fatty acid 20:0)25378659[NR] Z score decrease4.968EFO_0006796
ENSG00000116641rs1168041162494579CMetabolite levels (lipid measures)27005778[0.08-0.12] unit increase0.1EFO_0004529|EFO_0005664
ENSG00000116641rs12042319162584148GTriglycerides26582766[0.014-0.026] unit increase0.02EFO_0004530
ENSG00000116641rs9988450162458777CTriglycerides25961943[0.065-0.089] s.d. increase0.077EFO_0004530
ENSG00000116641rs10889348162612551ALDL cholesterol25961943[0.031-0.055] s.d. increase0.043EFO_0004611
ENSG00000116641rs1748195162583922GCrohn's disease26192919[1.05-1.09]1.0702562EFO_0000384
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease0.033EFO_0004529
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease0.035EFO_0004529
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease1.32EFO_0004529
ENSG00000116641rs1167998162465961?Lipid metabolism phenotypes19936222[NR] unit decrease1.505EFO_0004529
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease1.323EFO_0004529
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease2.688EFO_0004529
ENSG00000116641rs10889353162652525?Lipid metabolism phenotypes19936222[NR] unit decrease2.973EFO_0004529
ENSG00000116641rs10889332162485187?Metabolite levels22916037EFO_0004723
ENSG00000116641rs636523162454337GLipid traits24386095mmol/L decrease0.021EFO_0004611
ENSG00000116641rs10889353162652525CTriglycerides19060906[0.01-0.09] s.d. decrease0.05EFO_0004530
ENSG00000116641rs35529421162499950?Triglyceride levels29403010[0.062-0.087] unit decrease novel0.07475EFO_0004530
ENSG00000116641rs61775910162527732?Total cholesterol levels29403010[0.024-0.046] unit decrease novel0.03518EFO_0004574
ENSG00000116641rs60286666162655431TCPlatelet distribution width27863252[0.037-0.052] unit increase0.04483325EFO_0007984
ENSG00000116641rs1748195162583922?Crohn's disease28067908EFO_0000384
ENSG00000116641rs2131925162560271GLDL cholesterol20686565[1.22-1.96] mg/dL decrease1.59EFO_0004611
ENSG00000116641rs2131925162560271GTriglycerides20686565[4.16-5.72] mg/dL decrease4.94EFO_0004530
ENSG00000116641rs1168013162531167GTriglycerides20864672[0.03-0.05] unit increase0.04EFO_0004530
ENSG00000116641rs1168029162503731?Lipid metabolism phenotypes22286219[0.091-0.169] unit increase0.13EFO_0004529
ENSG00000116641rs1748195162583922CTriglycerides18193043[NR] mg/dl increase7.12EFO_0004530
ENSG00000116641rs1167998162465961CTriglycerides19060911[NR] s.d. decrease0.09EFO_0004530
ENSG00000116641rs10889353162652525CLDL cholesterol19060911[NR] s.d. decrease0.06EFO_0004611
ENSG00000116641rs11485618162628536ALDL cholesterol levels28334899[0.042-0.058] unit increase (EA Beta value)0.05EFO_0004611
ENSG00000116641rs995000162641855TTriglyceride levels28334899[0.06-0.11] unit decrease0.085EFO_0004530
ENSG00000116641rs11208004162679768ATotal cholesterol levels28334899[0.069-0.083] unit decrease (EA Beta values)0.0758EFO_0004574
ENSG00000116641rs11208004162679768ATotal cholesterol levels28334899[0.029-0.07] unit decrease0.0494EFO_0004574
ENSG00000116641rs995000162641855TTriglyceride levels28334899[0.062-0.076] unit decrease (EA Beta values)0.0691EFO_0004530
ENSG00000116641rs995000162641855TTriglyceride levels28334899[0.059-0.102] unit decrease0.0808EFO_0004530
ENSG00000116641rs7547965162460700ABlood protein levels30072576[0.18-0.28] unit increase0.228EFO_0007937
ENSG00000116641rs1168128162670175GBlood protein levels30072576[0.16-0.26] unit increase0.208EFO_0007937
ENSG00000116641rs9988450162458777CLow density lipoprotein cholesterol levels29507422unit increase0.037EFO_0004611
ENSG00000116641rs9988450162458777CLow density lipoprotein cholesterol levels29507422unit increase0.039EFO_0004611
ENSG00000116641rs2131925162560271GLow density lipoprotein cholesterol levels29507422unit decrease0.037EFO_0004611
ENSG00000116641rs2131925162560271GLow density lipoprotein cholesterol levels29507422unit decrease0.039EFO_0004611
ENSG00000116641rs11207995162583880ALow density lipoprotein cholesterol levels29507422unit increase0.036EFO_0004611
ENSG00000116641rs11207995162583880ALow density lipoprotein cholesterol levels29507422unit increase0.038EFO_0004611
ENSG00000116641rs1748195162583922CLow density lipoprotein cholesterol levels29507422unit increase0.038EFO_0004611
ENSG00000116641rs1748195162583922CLow density lipoprotein cholesterol levels29507422unit increase0.039EFO_0004611
ENSG00000116641rs3850634162584927TLow density lipoprotein cholesterol levels29507422unit increase0.037EFO_0004611
ENSG00000116641rs3850634162584927TLow density lipoprotein cholesterol levels29507422unit increase0.039EFO_0004611
ENSG00000116641rs10889348162612551ALow density lipoprotein cholesterol levels29507422unit increase0.037EFO_0004611
ENSG00000116641rs10889348162612551ALow density lipoprotein cholesterol levels29507422unit increase0.039EFO_0004611
ENSG00000116641rs6587980162625187CLow density lipoprotein cholesterol levels29507422unit increase0.038EFO_0004611
ENSG00000116641rs6587980162625187CLow density lipoprotein cholesterol levels29507422unit increase0.039EFO_0004611
ENSG00000116641rs12047226162639867TLow density lipoprotein cholesterol levels29507422unit increase0.038EFO_0004611
ENSG00000116641rs12047226162639867TLow density lipoprotein cholesterol levels29507422unit increase0.04EFO_0004611
ENSG00000116641rs9988450162458777CTotal cholesterol levels29507422unit increase0.06EFO_0004574
ENSG00000116641rs9988450162458777CTotal cholesterol levels29507422unit increase0.086EFO_0004574
ENSG00000116641rs9988450162458777CTotal cholesterol levels29507422unit increase0.061EFO_0004574
ENSG00000116641rs2131925162560271GTotal cholesterol levels29507422unit decrease0.06EFO_0004574
ENSG00000116641rs2131925162560271GTotal cholesterol levels29507422unit decrease0.083EFO_0004574
ENSG00000116641rs2131925162560271GTotal cholesterol levels29507422unit decrease0.061EFO_0004574
ENSG00000116641rs11207995162583880ATotal cholesterol levels29507422unit increase0.059EFO_0004574
ENSG00000116641rs11207995162583880ATotal cholesterol levels29507422unit increase0.087EFO_0004574
ENSG00000116641rs11207995162583880ATotal cholesterol levels29507422unit increase0.061EFO_0004574
ENSG00000116641rs1748195162583922CTotal cholesterol levels29507422unit increase0.06EFO_0004574
ENSG00000116641rs1748195162583922CTotal cholesterol levels29507422unit increase0.081EFO_0004574
ENSG00000116641rs1748195162583922CTotal cholesterol levels29507422unit increase0.061EFO_0004574
ENSG00000116641rs3850634162584927TTotal cholesterol levels29507422unit increase0.06EFO_0004574
ENSG00000116641rs3850634162584927TTotal cholesterol levels29507422unit increase0.093EFO_0004574
ENSG00000116641rs3850634162584927TTotal cholesterol levels29507422unit increase0.062EFO_0004574
ENSG00000116641rs10889348162612551ATotal cholesterol levels29507422unit increase0.059EFO_0004574
ENSG00000116641rs10889348162612551ATotal cholesterol levels29507422unit increase0.096EFO_0004574
ENSG00000116641rs10889348162612551ATotal cholesterol levels29507422unit increase0.062EFO_0004574
ENSG00000116641rs6587980162625187CTotal cholesterol levels29507422unit increase0.06EFO_0004574
ENSG00000116641rs6587980162625187CTotal cholesterol levels29507422unit increase0.087EFO_0004574
ENSG00000116641rs6587980162625187CTotal cholesterol levels29507422unit increase0.062EFO_0004574
ENSG00000116641rs12047226162639867TTotal cholesterol levels29507422unit increase0.061EFO_0004574
ENSG00000116641rs12047226162639867TTotal cholesterol levels29507422unit increase0.093EFO_0004574
ENSG00000116641rs12047226162639867TTotal cholesterol levels29507422unit increase0.063EFO_0004574
ENSG00000116641rs9988450162458777CTriglycerides29507422unit increase0.062EFO_0004530
ENSG00000116641rs9988450162458777CTriglycerides29507422unit increase0.071EFO_0004530
ENSG00000116641rs9988450162458777CTriglycerides29507422unit increase0.06EFO_0004530
ENSG00000116641rs2131925162560271GTriglycerides29507422unit decrease0.061EFO_0004530
ENSG00000116641rs2131925162560271GTriglycerides29507422unit decrease0.067EFO_0004530
ENSG00000116641rs2131925162560271GTriglycerides29507422unit decrease0.06EFO_0004530
ENSG00000116641rs11207995162583880ATriglycerides29507422unit increase0.06EFO_0004530
ENSG00000116641rs11207995162583880ATriglycerides29507422unit increase0.07EFO_0004530
ENSG00000116641rs11207995162583880ATriglycerides29507422unit increase0.06EFO_0004530
ENSG00000116641rs1748195162583922CTriglycerides29507422unit increase0.062EFO_0004530
ENSG00000116641rs1748195162583922CTriglycerides29507422unit increase0.06EFO_0004530
ENSG00000116641rs3850634162584927TTriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs3850634162584927TTriglycerides29507422unit increase0.072EFO_0004530
ENSG00000116641rs3850634162584927TTriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs10889348162612551ATriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs10889348162612551ATriglycerides29507422unit increase0.072EFO_0004530
ENSG00000116641rs10889348162612551ATriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs6587980162625187CTriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs6587980162625187CTriglycerides29507422unit increase0.068EFO_0004530
ENSG00000116641rs6587980162625187CTriglycerides29507422unit increase0.06EFO_0004530
ENSG00000116641rs12047226162639867TTriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs12047226162639867TTriglycerides29507422unit increase0.071EFO_0004530
ENSG00000116641rs12047226162639867TTriglycerides29507422unit increase0.061EFO_0004530
ENSG00000116641rs4350231162456989?Cardiovascular disease30595370EFO_0000319
ENSG00000116641rs4495740162658794TTriglycerides x physical activity interaction (2df test)30670697EFO_0004530|EFO_0003940
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116641's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116641DOCK710098.190ENSMUSG00000028556Dock710098.190Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000226microtubule cytoskeleton organization16982419.IMPProcess
GO:0005085guanyl-nucleotide exchange factor activity-IEAFunction
GO:0005515protein binding27812135.29187380.IPIFunction
GO:0005925focal adhesion21423176.HDAComponent
GO:0007264small GTPase mediated signal transduction-IEAProcess
GO:0007409axonogenesis16982419.IMPProcess
GO:0008180COP9 signalosome18850735.IDAComponent
GO:0022027interkinetic nuclear migration-ISSProcess
GO:0030424axon16982419.TASComponent
GO:0030426growth cone16982419.TASComponent
GO:0031175neuron projection development16982419.IMPProcess
GO:0033138positive regulation of peptidyl-serine phosphorylation16982419.IMPProcess
GO:0043005neuron projection16982419.TASComponent
GO:0045178basal part of cell16982419.TASComponent
GO:0045200establishment of neuroblast polarity16982419.IMPProcess
GO:0048365Rac GTPase binding16982419.IDAFunction
GO:0050767regulation of neurogenesis-ISSProcess
GO:0090630activation of GTPase activity16982419.IDAProcess
GO:0120163negative regulation of cold-induced thermogenesis23553822.ISSProcess
GO:1904754positive regulation of vascular associated smooth muscle cell migration22158624.IMPProcess

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