EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000116711 (Gene tree)
Gene ID: 5321
Gene Symbol: PLA2G4A
Alias: cPLA2-alpha|PLA2G4
Full Name: phospholipase A2 group IVA
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 160,082 bases
Position: chr1:186,828,900-186,988,981
Accession: 9035
RBP type: non-canonical RBP
Summary: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31238788	PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.	Autophagy	2019 Jun 25:1-20	Sarkar C	doi: 10.1080/15548627.2019.1628538
8425544	Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.	Eur J Biochem	1993 Jan 15	Arcone R	-
17901074	Paradox of glucocorticoid-induced cytosolic phospholipase A2 group IVA messenger RNA expression involves glucocorticoid receptor binding to the promoter in human amnion fibroblasts.	Biol Reprod	2008 Jan	Guo C	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367466	PLA2G4A-201	2875	XM_005245267	ENSP00000356436	749 (aa)	XP_005245324	P47712
ENST00000466600	PLA2G4A-202	850	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000116711's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00564	Glycerophospholipid metabolism	KEGG
hsa00565	Ether lipid metabolism	KEGG
hsa00590	Arachidonic acid metabolism	KEGG
hsa00591	Linoleic acid metabolism	KEGG
hsa00592	alpha-Linolenic acid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04217	Necroptosis	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04370	VEGF signaling pathway	KEGG
hsa04611	Platelet activation	KEGG
hsa04664	Fc epsilon RI signaling pathway	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04724	Glutamatergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04913	Ovarian steroidogenesis	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa05231	Choline metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000116711	Cholesterol, LDL	3.27953964541687E-7	17903299
ENSG00000116711	Muscle, Skeletal	9.9090000E-005	-
ENSG00000116711	Muscle, Skeletal	5.2920000E-005	-
ENSG00000116711	Muscle, Skeletal	5.5770000E-005	-
ENSG00000116711	Muscle, Skeletal	3.0900000E-007	-
ENSG00000116711	Muscle, Skeletal	1.3720000E-005	-
ENSG00000116711	Muscle, Skeletal	1.1420000E-005	-
ENSG00000116711	Muscle, Skeletal	6.4220000E-005	-
ENSG00000116711	Muscle, Skeletal	3.0200000E-005	-
ENSG00000116711	Muscle, Skeletal	2.6250000E-007	-
ENSG00000116711	Muscle, Skeletal	2.8230000E-005	-
ENSG00000116711	Muscle, Skeletal	1.9410000E-005	-
ENSG00000116711	Muscle, Skeletal	4.0260000E-005	-
ENSG00000116711	Muscle, Skeletal	3.2840000E-005	-
ENSG00000116711	Muscle, Skeletal	6.8900000E-005	-
ENSG00000116711	Muscle, Skeletal	7.2330000E-005	-
ENSG00000116711	Muscle, Skeletal	1.1200000E-006	-
ENSG00000116711	Muscle, Skeletal	7.8960000E-005	-
ENSG00000116711	Muscle, Skeletal	6.5720000E-005	-
ENSG00000116711	Muscle, Skeletal	1.0890000E-006	-
ENSG00000116711	Muscle, Skeletal	5.6940000E-005	-
ENSG00000116711	Muscle, Skeletal	7.5600000E-005	-
ENSG00000116711	Muscle, Skeletal	8.2600000E-005	-
ENSG00000116711	Lipoprotein(a)	9.7740000E-005	-
ENSG00000116711	Lipoprotein(a)	5.4440000E-007	-
ENSG00000116711	Urine	3.9483822E-006	-
ENSG00000116711	Blood Pressure	8.2994520E-005	-
ENSG00000116711	Blood Pressure	3.0252510E-006	-
ENSG00000116711	Body Mass Index	9.1584512E-005	-
ENSG00000116711	Body Mass Index	8.4753884E-005	-
ENSG00000116711	Platelet Function Tests	1.8161500E-005	-
ENSG00000116711	Platelet Function Tests	2.8354695E-006	-
ENSG00000116711	Platelet Function Tests	2.7777360E-006	-
ENSG00000116711	Platelet Function Tests	2.3508931E-006	-
ENSG00000116711	Platelet Function Tests	6.0759671E-006	-
ENSG00000116711	Platelet Function Tests	5.9546754E-006	-
ENSG00000116711	Platelet Function Tests	5.1498934E-006	-
ENSG00000116711	Platelet Function Tests	2.2204460E-016	-
ENSG00000116711	Platelet Function Tests	2.2204460E-016	-
ENSG00000116711	Child Development Disorders, Pervasive	1.0935600E-005	-
ENSG00000116711	Child Development Disorders, Pervasive	1.4833000E-005	-
ENSG00000116711	Autistic Disorder	6.2900000E-006	-
ENSG00000116711	Child Development Disorders, Pervasive	1.1864000E-005	-
ENSG00000116711	Child Development Disorders, Pervasive	1.0050000E-005	-
ENSG00000116711	Child Development Disorders, Pervasive	1.8346600E-005	-
ENSG00000116711	Interleukin-6	8.6980000E-006	-
ENSG00000116711	Interleukin-6	3.9120000E-005	-
ENSG00000116711	Triiodothyronine	2.0540000E-005	-
ENSG00000116711	Iron	1.0470000E-005	-
ENSG00000116711	Vitamin A	3.7360000E-006	-
ENSG00000116711	Schizophrenia	7E-6	26198764
ENSG00000116711	Hydroxyindoleacetic Acid	7E-6	23319000
ENSG00000116711	Crohn Disease	4E-9	26192919
ENSG00000116711	Inflammatory Bowel Diseases	2E-7	26192919
ENSG00000116711	Epilepsy	9E-6	22949513

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116711	rs114333818	1	186856584	A	Schizophrenia	26198764	[NR]	1.3513513	EFO_0000692
ENSG00000116711	rs10798069	1	186906327	A	Crohn's disease	26192919		1.0729233	EFO_0000384
ENSG00000116711	rs10798069	1	186906327	C	Inflammatory bowel disease	26192919		1.0524286	EFO_0003767
ENSG00000116711	rs12720541	1	186900940	T	Generalized epilepsy	22949513	[1.10-1.35]	1.21	EFO_0000474

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116711's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004622	lysophospholipase activity	-	IEA	Function
GO:0004623	phospholipase A2 activity	21873635.	IBA	Function
GO:0004623	phospholipase A2 activity	8702602.	IDA	Function
GO:0004623	phospholipase A2 activity	8381049.	NAS	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005509	calcium ion binding	9430701.9665851.	IDA	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005544	calcium-dependent phospholipid binding	9665851.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005811	lipid droplet	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	8381049.	NAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006644	phospholipid metabolic process	-	TAS	Process
GO:0006654	phosphatidic acid biosynthetic process	-	TAS	Process
GO:0006663	platelet activating factor biosynthetic process	9430701.	NAS	Process
GO:0006690	icosanoid metabolic process	9430701.	NAS	Process
GO:0019369	arachidonic acid metabolic process	-	TAS	Process
GO:0031410	cytoplasmic vesicle	-	IEA	Component
GO:0035965	cardiolipin acyl-chain remodeling	-	TAS	Process
GO:0036148	phosphatidylglycerol acyl-chain remodeling	-	TAS	Process
GO:0036149	phosphatidylinositol acyl-chain remodeling	-	TAS	Process
GO:0036150	phosphatidylserine acyl-chain remodeling	-	TAS	Process
GO:0036151	phosphatidylcholine acyl-chain remodeling	-	TAS	Process
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	-	TAS	Process
GO:0042127	regulation of cell proliferation	-	IEA	Process
GO:0046456	icosanoid biosynthetic process	-	IEA	Process
GO:0046475	glycerophospholipid catabolic process	21873635.	IBA	Process
GO:0047498	calcium-dependent phospholipase A2 activity	21873635.	IBA	Function
GO:0050482	arachidonic acid secretion	-	IEA	Process
GO:0071236	cellular response to antibiotic	-	IEA	Process
GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	-	IEA	Function
GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20635443	Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.	Yonsei Med J	2010 Sep	Lim SC	doi: 10.3349/ymj.2010.51.5.692.
21198294	Immunohistochemical expression of cytosolic phospholipase A2α in non-small cell lung carcinoma.	Asian Pac J Cancer Prev	2010	Sundarraj S	-
28383549	cPLA2α mediates TGF-β-induced epithelial-mesenchymal transition in breast cancer through PI3k/Akt signaling.	Cell Death Dis	2017 Apr 6	Chen L	doi: 10.1038/cddis.2017.152.
29307829	Blockage of cytosolic phospholipase A2 alpha sensitizes aggressive breast cancer to doxorubicin through suppressing ERK and mTOR kinases.	Biochem Biophys Res Commun	2018 Jan 29	Li Z	doi: 10.1016/j.bbrc.2018.01.016
25365190	Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation.	Oncotarget	2014 Dec 15	Zheng Z	-
15975962	Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells.	Carcinogenesis	2005 Nov	Parhamifar L	-
23307260	Reduced group IVA phospholipase A2 expression is associated with unfavorable outcome for patients with gastric cancer.	Med Oncol	2013 Mar	Zhang X	doi: 10.1007/s12032-012-0454-y
20227521	Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells.	Biochim Biophys Acta	2010 Jul	Niknami M	doi: 10.1016/j.bbalip.2010.03.003
24721622	Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells.	J Ovarian Res	2014 Apr 11	Yu Y	doi: 10.1186/1757-2215-7-39
22274867	Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.	J Cancer Res Clin Oncol	2012 May	Sundarraj S	doi: 10.1007/s00432-012-1157-7
26416244	Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.	Oncotarget	2015 Oct 27	Yao M	doi: 10.18632/oncotarget.5277.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	186939015	Missense_Mutation	novel	S235P	0.47
ACC	chr1	186940006	Missense_Mutation	novel	L315F	0.1
ACC	chr1	186911253	Missense_Mutation	novel	C141F	0.34
BLCA	chr1	186965441	Silent	NA	L538L	0.26
BLCA	chr1	186965449	Silent	novel	V540V	0.22
BLCA	chr1	186977769	Missense_Mutation	novel	F647L	0.91
BLCA	chr1	186977679	Silent	NA	L617L	0.25
BRCA	chr1	186956195	Missense_Mutation	NA	A477G	0.16
BRCA	chr1	186939153	Missense_Mutation	novel	K281E	0.12
BRCA	chr1	186932771	Silent	NA	V189V	0.2
BRCA	chr1	186988739	3'UTR	novel		0.31
BRCA	chr1	186977665	Missense_Mutation	novel	D613H	0.05
BRCA	chr1	186965586	Missense_Mutation	NA	P586L	0.44
BRCA	chr1	186939155	Silent	novel	K281K	0.18
BRCA	chr1	186977721	Missense_Mutation	NA	E631D	0.15
BRCA	chr1	186939016	Missense_Mutation	novel	S235L	0.08
BRCA	chr1	186946721	Missense_Mutation	NA	F373C	0.22
BRCA	chr1	186965506	Silent	novel	P559P	0.11
BRCA	chr1	186911391	Splice_Site	NA	X186_splice	0.16
BRCA	chr1	186911255	Missense_Mutation	novel	P142S	0.35
BRCA	chr1	186939080	Missense_Mutation	NA	M256I	0.14
BRCA	chr1	186956210	Missense_Mutation	NA	R482T	0.34
CESC	chr1	186911265	Missense_Mutation	NA	R145Q	0.35
CESC	chr1	186946721	Missense_Mutation	NA	F373C	0.35
CESC	chr1	186956123	Missense_Mutation	novel	G453A	0.13
CESC	chr1	186932856	Silent	NA	L218L	0.5
CESC	chr1	186940033	Silent	rs760087737	C324C	0.38
CESC	chr1	186977671	Missense_Mutation	novel	E615K	0.45
CESC	chr1	186854301	5'UTR	novel		0.07
CESC	chr1	186906995	Missense_Mutation	rs373613129	E137K	0.24
COAD	chr1	186965427	Missense_Mutation	rs114563081	R533Q	0.4
COAD	chr1	186894180	Missense_Mutation	novel	E116A	0.27
COAD	chr1	186932786	Silent	novel	G194G	0.27
COAD	chr1	186956301	Silent	novel	T512T	0.1
COAD	chr1	186932799	Missense_Mutation	novel	F199I	0.25
COAD	chr1	186946937	Missense_Mutation	novel	G414S	0.28
COAD	chr1	186946916	Missense_Mutation	novel	V407I	0.28
COAD	chr1	186939100	Missense_Mutation	novel	P263H	0.12
COAD	chr1	186946660	Missense_Mutation	NA	E353K	0.33
COAD	chr1	186956164	Missense_Mutation	rs367829430	R467C	0.2
COAD	chr1	186894109	Missense_Mutation	NA	M92I	0.34
COAD	chr1	186988546	3'UTR	novel		0.46
COAD	chr1	186988637	3'UTR	novel		0.38
COAD	chr1	186946896	Missense_Mutation	novel	L400S	0.22
COAD	chr1	186932793	Frame_Shift_Del	NA	*G198Vfs11**	0.26
COAD	chr1	186911265	Missense_Mutation	NA	R145Q	0.18
COAD	chr1	186977677	Silent	NA	L617L	0.16
COAD	chr1	186979389	Missense_Mutation	NA	S679P	0.1
COAD	chr1	186946660	Missense_Mutation	NA	E353K	0.31
COAD	chr1	186956129	Missense_Mutation	NA	D455G	0.16
COAD	chr1	186988489	In_Frame_Ins	novel	L744_S745insLS	0.08
ESCA	chr1	186988728	3'UTR	novel		0.36
GBM	chr1	186893108	Nonsense_Mutation	rs755561592	W71*	0.18
GBM	chr1	186965537	Missense_Mutation	NA	L570I	0.04
GBM	chr1	186894134	Missense_Mutation	NA	T101S	0.41
GBM	chr1	186977762	Missense_Mutation	novel	I645N	0.1
GBM	chr1	186979387	Missense_Mutation	NA	F678C	0.37
GBM	chr1	186894127	Missense_Mutation	NA	M98I	0.45
GBM	chr1	186956271	Nonsense_Mutation	novel	Y502*	0.08
GBM	chr1	186979386	Frame_Shift_Del	novel	*S679Qfs24**	0.09
HNSC	chr1	186854301	5'UTR	novel		0.15
HNSC	chr1	186854370	Frame_Shift_Del	novel	*P6Lfs6**	0.47
HNSC	chr1	186870463	Missense_Mutation	novel	T21M	0.24
HNSC	chr1	186977662	Missense_Mutation	novel	F612I	0.24
HNSC	chr1	186979349	Silent	rs149831494	I665I	0.24
HNSC	chr1	186988564	3'UTR	novel		0.11
KIRC	chr1	186870440	Silent	NA	E13E	0.15
KIRP	chr1	186911271	Missense_Mutation	novel	S147N	0.21
LAML	chr1	186977747	Missense_Mutation	novel	F640C	0.05
LGG	chr1	186894152	Missense_Mutation	NA	F107V	0.31
LGG	chr1	186977701	Missense_Mutation	NA	P625A	0.25
LGG	chr1	186965445	Missense_Mutation	NA	D539G	0.14
LGG	chr1	186979327	Missense_Mutation	NA	E658G	0.05
LGG	chr1	186979441	Missense_Mutation	novel	L696P	0.07
LIHC	chr1	186911325	Missense_Mutation	NA	I165K	0.06
LIHC	chr1	186988541	3'UTR	novel		0.16
LIHC	chr1	186939149	Missense_Mutation	novel	L279F	0.06
LIHC	chr1	186988606	3'UTR	novel		0.33
LIHC	chr1	186911384	Missense_Mutation	rs374028240	R185C	0.41
LIHC	chr1	186894140	Missense_Mutation	rs28395828	G103R	0.18
LIHC	chr1	186911345	Missense_Mutation	NA	L172F	0.17
LIHC	chr1	186979376	Silent	NA	P674P	0.49
LIHC	chr1	186911264	Nonsense_Mutation	rs774762374	R145*	0.34
LIHC	chr1	186979359	Missense_Mutation	NA	D669Y	0.34
LIHC	chr1	186870515	Missense_Mutation	novel	M38I	0.27
LIHC	chr1	186870516	Missense_Mutation	rs758024598	L39I	0.27
LIHC	chr1	186946688	Missense_Mutation	novel	F362C	0.37
LUAD	chr1	186946660	Nonsense_Mutation	novel	E353*	0.12
LUAD	chr1	186893033	Silent	NA	V46V	0.15
LUAD	chr1	186965473	Silent	NA	V548V	0.2
LUAD	chr1	186965587	Silent	NA	P586P	0.4
LUAD	chr1	186939088	Missense_Mutation	novel	V259D	0.07
LUAD	chr1	186988438	Missense_Mutation	NA	S727C	0.07
LUAD	chr1	186932791	Missense_Mutation	NA	G196V	0.3
LUAD	chr1	186932851	Missense_Mutation	NA	G216V	0.2
LUAD	chr1	186939091	Missense_Mutation	novel	S260N	0.11
LUAD	chr1	186977675	Missense_Mutation	novel	G616E	0.31
LUAD	chr1	186940029	Missense_Mutation	NA	Q323P	0.11
LUAD	chr1	186854301	5'UTR	novel		0.19
LUAD	chr1	186988468	Missense_Mutation	NA	R737I	0.2
LUAD	chr1	186946881	Missense_Mutation	novel	S395I	0.59
LUAD	chr1	186956216	Missense_Mutation	novel	G484V	0.58
LUAD	chr1	186939217	Missense_Mutation	NA	T302K	0.36
LUAD	chr1	186977661	Frame_Shift_Ins	novel	D613*	0.18
LUAD	chr1	186939087	Missense_Mutation	NA	V259L	0.23
LUAD	chr1	186946729	Missense_Mutation	novel	T376S	0.29
LUAD	chr1	186946730	Missense_Mutation	novel	T376K	0.27
LUAD	chr1	186988458	Nonsense_Mutation	novel	E734*	0.36
LUAD	chr1	186940015	Missense_Mutation	NA	K318N	0.15
LUAD	chr1	186893159	Frame_Shift_Del	novel		0.17
LUAD	chr1	186977688	Missense_Mutation	novel	C620W	0.16
LUAD	chr1	186965559	Missense_Mutation	NA	S577Y	0.06
LUSC	chr1	186965495	Silent	novel	L556L	0.52
LUSC	chr1	186956182	Missense_Mutation	NA	V473L	0.42
LUSC	chr1	186911354	Missense_Mutation	NA	P175S	0.2
LUSC	chr1	186988438	Missense_Mutation	NA	S727C	0.21
LUSC	chr1	186988559	3'UTR	novel		0.09
LUSC	chr1	186977658	Silent	NA	Y610Y	0.11
LUSC	chr1	186965504	Missense_Mutation	novel	P559S	0.09
LUSC	chr1	186988379	Splice_Region	novel	V707V	0.06
LUSC	chr1	186950718	Missense_Mutation	NA	H442Q	0.11
LUSC	chr1	186965408	Splice_Site	NA	X527_splice	0.29
LUSC	chr1	186988482	Missense_Mutation	NA	E742Q	0.08
LUSC	chr1	186911302	Silent	NA	F157F	0.18
LUSC	chr1	186988417	Missense_Mutation	rs559871981	R720I	0.24
LUSC	chr1	186946679	Missense_Mutation	novel	Y359C	0.31
MESO	chr1	186932874	Missense_Mutation	rs12720588	V224I	0.23
MESO	chr1	186956315	Missense_Mutation	novel	D517V	0.12
OV	chr1	186950718	Missense_Mutation	NA	H442Q	0.14
PAAD	chr1	186946891	Silent	novel	S398S	0.11
PAAD	chr1	186988511	3'UTR	novel		0.08
PRAD	chr1	186946677	Silent	NA	K358K	0.15
PRAD	chr1	186946735	Missense_Mutation	rs772018373	V378I	0.16
PRAD	chr1	186956192	Nonsense_Mutation	novel	S476*	0.42
PRAD	chr1	186893104	Missense_Mutation	NA	V70G	0.1
PRAD	chr1	186965455	Frame_Shift_Ins	novel	*I545Dfs11**	0.38
READ	chr1	186911345	Missense_Mutation	NA	L172F	0.13
READ	chr1	186894131	Nonsense_Mutation	NA	E100*	0.08
READ	chr1	186979340	Missense_Mutation	novel	E662D	0.07
READ	chr1	186932843	Silent	rs750211032	Y213Y	0.26
READ	chr1	186950719	Missense_Mutation	rs200911298	E443K	0.49
READ	chr1	186939984	Missense_Mutation	novel	M308T	0.16
SARC	chr1	186893055	Missense_Mutation	novel	P54S	0.17
SKCM	chr1	186932802	Nonsense_Mutation	NA	R200*	0.21
SKCM	chr1	186950719	Missense_Mutation	rs200911298	E443K	0.39
SKCM	chr1	186965465	Missense_Mutation	NA	H546Y	0.08
SKCM	chr1	186939985	Missense_Mutation	novel	M308I	0.54
SKCM	chr1	186893101	Missense_Mutation	NA	P69L	0.25
SKCM	chr1	186894208	Silent	NA	N125N	0.19
SKCM	chr1	186854327	5'UTR	novel		0.14
SKCM	chr1	186939151	Nonsense_Mutation	NA	W280*	0.41
SKCM	chr1	186979410	Missense_Mutation	NA	P686S	0.38
SKCM	chr1	186956323	Missense_Mutation	NA	E520K	0.65
SKCM	chr1	186977595	Splice_Region	NA	E589E	0.3
SKCM	chr1	186911312	Silent	NA	R161R	0.42
SKCM	chr1	186932864	Missense_Mutation	NA	C220W	0.1
SKCM	chr1	186911347	Silent	NA	L172L	0.27
SKCM	chr1	186946716	Frame_Shift_Ins	rs750546323	*M374Yfs6**	0.23
SKCM	chr1	186965585	Missense_Mutation	NA	P586S	0.24
SKCM	chr1	186950710	Missense_Mutation	NA	E440K	0.34
SKCM	chr1	186965465	Missense_Mutation	NA	H546Y	0.31
SKCM	chr1	186956213	Missense_Mutation	NA	E483V	0.45
SKCM	chr1	186940010	Missense_Mutation	NA	E317K	0.55
SKCM	chr1	186911288	Nonsense_Mutation	NA	Q153*	0.52
SKCM	chr1	186956309	Missense_Mutation	NA	S515F	0.3
SKCM	chr1	186893025	Missense_Mutation	novel	P44S	0.45
SKCM	chr1	186977593	Missense_Mutation	novel	E589K	0.26
STAD	chr1	186893096	Frame_Shift_Del	novel	*N68Tfs24**	0.43
STAD	chr1	186950703	Silent	NA	S437S	0.09
STAD	chr1	186988526	3'UTR	novel		0.13
STAD	chr1	186939080	Frame_Shift_Ins	novel	*N258Kfs3**	0.33
STAD	chr1	186893146	Missense_Mutation	novel	E84A	0.16
STAD	chr1	186979414	Missense_Mutation	NA	N687S	0.42
STAD	chr1	186911265	Missense_Mutation	NA	R145Q	0.05
STAD	chr1	186950678	Missense_Mutation	NA	I429T	0.2
STAD	chr1	186946717	Frame_Shift_Del	novel	*F373Lfs17**	0.41
THCA	chr1	186939168	Nonsense_Mutation	novel	G286delinsVNKAW*	0.13
UCEC	chr1	186988468	Missense_Mutation	NA	R737I	0.2
UCEC	chr1	186893076	Silent	NA	R61R	0.27
UCEC	chr1	186977725	Missense_Mutation	NA	D633Y	0.33
UCEC	chr1	186906989	Missense_Mutation	novel	S135P	0.4
UCEC	chr1	186894184	Missense_Mutation	NA	K117N	0.23
UCEC	chr1	186988386	Nonsense_Mutation	NA	E710*	0.34
UCEC	chr1	186854294	5'UTR	novel		0.29
UCEC	chr1	186939981	Missense_Mutation	NA	R307I	0.14
UCEC	chr1	186977646	Missense_Mutation	novel	K606N	0.06
UCEC	chr1	186870503	Silent	NA	A34A	0.26
UCEC	chr1	186906983	Nonsense_Mutation	NA	E133*	0.2
UCEC	chr1	186946743	Silent	novel	K380K	0.39
UCEC	chr1	186956268	Silent	novel	S501S	0.12
UCEC	chr1	186893049	Missense_Mutation	novel	T52A	0.45
UCEC	chr1	186939082	Missense_Mutation	novel	K257R	0.05
UCEC	chr1	186946962	Splice_Site	novel	X422_splice	0.04
UCEC	chr1	186950658	Missense_Mutation	NA	E422D	0.34
UCEC	chr1	186988414	Missense_Mutation	novel	R719K	0.1
UCEC	chr1	186988485	Missense_Mutation	rs753490896	F743L	0.51
UCEC	chr1	186965499	Missense_Mutation	novel	P557Q	0.39
UCEC	chr1	186979374	Missense_Mutation	novel	P674T	0.16
UCEC	chr1	186988610	3'UTR	novel		0.36
UCEC	chr1	186988815	3'UTR	novel		0.54
UCEC	chr1	186988526	3'UTR	novel		0.07
UCEC	chr1	186988780	3'UTR	novel		0.18
UCEC	chr1	186956332	Missense_Mutation	novel	A523T	0.38
UCEC	chr1	186988677	3'UTR	novel		0.43
UCEC	chr1	186939059	Missense_Mutation	novel	E249D	0.11
UCEC	chr1	186988494	Missense_Mutation	NA	K746E	0.24
UCEC	chr1	186965525	Missense_Mutation	novel	R566G	0.35
UCEC	chr1	186939145	Missense_Mutation	novel	S278Y	0.06
UCEC	chr1	186946672	Missense_Mutation	novel	A357T	0.45
UCEC	chr1	186956165	Missense_Mutation	rs760643719	R467H	0.43
UCEC	chr1	186988816	3'UTR	novel		0.4
UCEC	chr1	186946750	Missense_Mutation	novel	E383Q	0.26
UCEC	chr1	186939168	Nonsense_Mutation	novel	G286delinsVNKAW*	0.08
UCEC	chr1	186979340	Missense_Mutation	novel	E662D	0.45
UCEC	chr1	186988817	3'UTR	rs543762204		0.25
UCEC	chr1	186977706	Silent	novel	K626K	0.18
UCEC	chr1	186979346	Missense_Mutation	novel	E664D	0.16
UCEC	chr1	186988819	3'UTR	novel		0.29
UCEC	chr1	186854302	5'UTR	novel		0.3
UCEC	chr1	186956231	Missense_Mutation	rs758642971	V489A	0.14
UCEC	chr1	186893076	Silent	NA	R61R	0.46
UCEC	chr1	186911265	Missense_Mutation	NA	R145Q	0.28
UCEC	chr1	186932874	Missense_Mutation	rs12720588	V224I	0.3
UCEC	chr1	186939213	Missense_Mutation	novel	E301K	0.38
UCEC	chr1	186946660	Missense_Mutation	NA	E353K	0.14
UCEC	chr1	186965511	Missense_Mutation	novel	I561T	0.37
UCEC	chr1	186911265	Missense_Mutation	NA	R145Q	0.41
UCEC	chr1	186988815	3'UTR	novel		0.48
UCEC	chr1	186911343	Missense_Mutation	novel	K171R	0.55
UCEC	chr1	186988819	3'UTR	novel		0.15
UCEC	chr1	186977631	Silent	NA	K601K	0.19
UCEC	chr1	186870477	Missense_Mutation	NA	R26S	0.41
UCEC	chr1	186946716	Frame_Shift_Ins	rs750546323	*M374Yfs6**	0.46
UCEC	chr1	186946721	Missense_Mutation	NA	F373C	0.59
UCEC	chr1	186979344	Nonsense_Mutation	NA	E664*	0.45
UCEC	chr1	186988686	3'UTR	novel		0.35
UCEC	chr1	186988439	Silent	rs761783969	S727S	0.13
UCEC	chr1	186911318	Nonsense_Mutation	NA	E163*	0.32
UCEC	chr1	186939220	Frame_Shift_Ins	novel	*I304Nfs3**	0.14
UCEC	chr1	186946662	Silent	novel	E353E	0.08
UCEC	chr1	186965517	Missense_Mutation	NA	R563K	0.12
UCEC	chr1	186939169	Missense_Mutation	novel	G286V	0.09
UCEC	chr1	186939170	Frame_Shift_Ins	novel	*Q287Nfs9**	0.09
UCEC	chr1	186956165	Missense_Mutation	rs760643719	R467H	0.36
UCEC	chr1	186911266	Silent	novel	R145R	0.18
UCEC	chr1	186977776	Missense_Mutation	novel	Y650H	0.08
UCEC	chr1	186965455	Frame_Shift_Ins	novel	*I545Dfs11**	0.21
UCEC	chr1	186979448	Missense_Mutation	novel	H698Q	0.04
UCEC	chr1	186988527	3'UTR	novel		0.19
UCEC	chr1	186870440	Silent	NA	E13E	0.4
UCEC	chr1	186939984	Missense_Mutation	novel	M308T	0.39
UCEC	chr1	186956165	Missense_Mutation	rs760643719	R467H	0.49
UCEC	chr1	186870441	Missense_Mutation	novel	H14Y	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.0871	0.059566
PAAD	AMP	0.2283	0.085665
READ	AMP	0.2788	0.14328
TGCT	AMP	0.3467	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
THYM	0.025	Kaplan-Meier Survival Analysis
KIRC	0.03	Kaplan-Meier Survival Analysis
MESO	0.032	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
BRCA	0.0069	Kaplan-Meier Survival Analysis
BLCA	0.029	Kaplan-Meier Survival Analysis
LAML	0.00014	Kaplan-Meier Survival Analysis
UCEC	0.0012	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.05	Kaplan-Meier Survival Analysis
LUAD	0.04	Kaplan-Meier Survival Analysis
UVM	0.023	Kaplan-Meier Survival Analysis
OV	0.0092	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742