EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116747 (Gene tree)
Gene ID
6738
Gene Symbol
RO60
Alias
Ro60|SSA2|TROVE2
Full Name
Ro60, Y RNA binding protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
32,356 bases
Position
chr1:193,059,422-193,091,777
Accession
11313
RBP type
canonical RBP
Summary
(Ro60, Y RNA Binding Protein) is a Protein Coding gene. Diseases associated with RO60 include Sjogren Syndrome and Lupus Erythematosus. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000356413TROVEPF05731.114e-6011
ENSP00000356414TROVEPF05731.114.3e-6011
ENSP00000356415TROVEPF05731.114.6e-6011
ENSP00000356411TROVEPF05731.114.7e-6011
ENSP00000356416TROVEPF05731.114.7e-6011
ENSP00000383752TROVEPF05731.114.7e-6011
ENSP00000424612TROVEPF05731.113.8e-2211
ENSP00000472298TROVEPF05731.111.8e-1511
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15928345RNA chaperone activity of protein components of human Ro RNPs.RNA2005 JulBelisova A-
29152879Y RNA derived small RNAs in Sjgren's syndrome: Candidate biomarkers?Int J Rheum Dis2017 NovKabeerdoss Jdoi: 10.1111/1756-185X.13229
16890888The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.Autoimmun Rev2006 JulWolin SL-
24036917Non-coding Y RNAs as tethers and gates: Insights from bacteria.RNA Biol2013 OctWolin SLdoi: 10.4161/rna.26166
26382853The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.Science2015 Oct 23Hung Tdoi: 10.1126/science.aac7442
29593104Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus.Sci Transl Med2018 Mar 28Greiling TMdoi: 10.1126/scitranslmed.aan2306.
31084369Ro60 and Y RNAs: structure, functions, and roles in autoimmunity.Crit Rev Biochem Mol Biol2019 AprBoccitto Mdoi: 10.1080/10409238.2019.1608902
8973618RNA-labelled Ro and La ribonucleoprotein complexes reassembled in vitro; characterization by gel shift analysis.Clin Exp Immunol1996 DecGranger D-
8608450The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.RNA1996 MarSimons FH-
10785401Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins.Eur J Biochem2000 MayFabini G-
11350038Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs.RNA2001 MayRutjes SA-
11279198The heterogeneous nuclear ribonucleoproteins I and K interact with a subset of the ro ribonucleoprotein-associated Y RNAs in vitro and in vivo.J Biol Chem2001 Jun 8Fabini G-
10524322Identification of ribonucleoprotein (RNP)-specific protein interactions using a yeast RNP interaction trap assay (RITA).Biotechniques1999 OctBouffard P-
1383550Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions.J Mol Biol1992 Sep 20Slobbe RL-
10668799Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.RNA2000 JanBouffard P-
15817567Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs.Nucleic Acids Res2005 Apr 7Perreault J-
16943439Functional requirement of noncoding Y RNAs for human chromosomal DNA replication.Mol Cell Biol2006 SepChristov CP-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000400968TROVE2-2062143XM_006711495ENSP00000383752538 (aa)XP_006711558P10155
ENST00000367445TROVE2-2041898-ENSP00000356415534 (aa)-P10155
ENST00000506303TROVE2-211613-ENSP0000042529641 (aa)-D6RDN1
ENST00000367446TROVE2-2053081XM_006711496ENSP00000356416538 (aa)XP_006711559P10155
ENST00000367441TROVE2-2011791XM_024449332ENSP00000356411538 (aa)XP_024305100P10155
ENST00000367443TROVE2-2021909-ENSP00000356413518 (aa)-P10155
ENST00000367444TROVE2-2031857-ENSP00000356414525 (aa)-P10155
ENST00000512587TROVE2-212581-ENSP00000424612193 (aa)-H0Y9N5
ENST00000460715TROVE2-2091474--- (aa)--
ENST00000415442TROVE2-207377-ENSP0000040117666 (aa)-D6RE09
ENST00000469214TROVE2-210592--- (aa)--
ENST00000432079TROVE2-2087848XM_011509922ENSP00000472298263 (aa)XP_011508224G5E9R9
Gene Model
Click here to download ENSG00000116747's gene model file
Pathways
Pathway IDPathway NameSource
hsa05322Systemic lupus erythematosusKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000116747Platelet Function Tests8.9800000E-007-
ENSG00000116747Platelet Function Tests1.2595500E-005-
ENSG00000116747Platelet Function Tests6.8000000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116747's network
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116747RO6010054.404ENSAPOG00000015903trove29755.684Acanthochromis_polyacanthus
ENSG00000116747RO6010096.578ENSAMEG00000015881TROVE210096.468Ailuropoda_melanoleuca
ENSG00000116747RO6010050.777ENSACIG00000010149trove29949.071Amphilophus_citrinellus
ENSG00000116747RO6010039.002ENSACIG00000002080-10039.002Amphilophus_citrinellus
ENSG00000116747RO6010054.922ENSAOCG00000000143trove29755.491Amphiprion_ocellaris
ENSG00000116747RO6010054.404ENSAPEG00000003310trove29755.299Amphiprion_percula
ENSG00000116747RO6010053.368ENSATEG00000021195trove210053.789Anabas_testudineus
ENSG00000116747RO6010082.342ENSAPLG00000003121TROVE210082.342Anas_platyrhynchos
ENSG00000116747RO6010080.483ENSACAG00000008263TROVE210080.483Anolis_carolinensis
ENSG00000116747RO60100100.000ENSANAG00000027305TROVE210099.257Aotus_nancymaae
ENSG00000116747RO6010050.777ENSACLG00000012217trove29647.593Astatotilapia_calliptera
ENSG00000116747RO6010055.682ENSAMXG00000002118trove210055.064Astyanax_mexicanus
ENSG00000116747RO6010095.725ENSBTAG00000013812TROVE26395.725Bos_taurus
ENSG00000116747RO609841.313WBGene00004405rop-19136.457Caenorhabditis_elegans
ENSG00000116747RO60100100.000ENSCJAG00000008566TROVE210098.699Callithrix_jacchus
ENSG00000116747RO6010097.398ENSCAFG00000010552TROVE29797.398Canis_familiaris
ENSG00000116747RO609997.363ENSCAFG00020004457TROVE210097.363Canis_lupus_dingo
ENSG00000116747RO6010095.353ENSCHIG00000018260TROVE210095.353Capra_hircus
ENSG00000116747RO6010095.911ENSTSYG00000004227TROVE210095.911Carlito_syrichta
ENSG00000116747RO6010090.244ENSCAPG00000009733TROVE210072.491Cavia_aperea
ENSG00000116747RO6010090.698ENSCPOG00000000669TROVE210090.335Cavia_porcellus
ENSG00000116747RO6010097.674ENSCCAG00000027978TROVE29998.370Cebus_capucinus
ENSG00000116747RO60100100.000ENSCATG00000027732TROVE210099.442Cercocebus_atys
ENSG00000116747RO6010095.167ENSCLAG00000016391TROVE210095.167Chinchilla_lanigera
ENSG00000116747RO60100100.000ENSCSAG00000013402TROVE210099.814Chlorocebus_sabaeus
ENSG00000116747RO6010093.916ENSCHOG00000009571TROVE28697.409Choloepus_hoffmanni
ENSG00000116747RO6010085.502ENSCPBG00000010558TROVE210085.502Chrysemys_picta_bellii
ENSG00000116747RO607230.026ENSCING00000013754-9430.026Ciona_intestinalis
ENSG00000116747RO609836.641ENSCSAVG00000008738-9934.076Ciona_savignyi
ENSG00000116747RO607131.429ENSCSAVG00000008732-6231.429Ciona_savignyi
ENSG00000116747RO6010099.628ENSCANG00000041293TROVE210099.628Colobus_angolensis_palliatus
ENSG00000116747RO6010091.822ENSCGRG00001016925Trove210091.822Cricetulus_griseus_chok1gshd
ENSG00000116747RO6010091.822ENSCGRG00000003396Trove210091.822Cricetulus_griseus_crigri
ENSG00000116747RO6010054.404ENSCSEG00000009989trove210053.148Cynoglossus_semilaevis
ENSG00000116747RO6010053.368ENSCVAG00000008160trove29652.907Cyprinodon_variegatus
ENSG00000116747RO609954.409ENSDARG00000089225trove29954.409Danio_rerio
ENSG00000116747RO6010093.866ENSDNOG00000002157TROVE210093.866Dasypus_novemcinctus
ENSG00000116747RO6010094.981ENSDORG00000006152Trove210094.981Dipodomys_ordii
ENSG00000116747RO6010088.213ENSETEG00000018261TROVE210090.116Echinops_telfairi
ENSG00000116747RO6010095.167ENSEASG00005003388TROVE210095.167Equus_asinus_asinus
ENSG00000116747RO6010095.817ENSECAG00000018653TROVE210095.539Equus_caballus
ENSG00000116747RO6010091.280ENSEEUG00000014190TROVE210091.280Erinaceus_europaeus
ENSG00000116747RO609954.409ENSELUG00000004473trove29954.409Esox_lucius
ENSG00000116747RO6010096.840ENSFCAG00000010161TROVE210096.840Felis_catus
ENSG00000116747RO6010078.810ENSFALG00000002913TROVE210078.810Ficedula_albicollis
ENSG00000116747RO6010095.349ENSFDAG00000015923TROVE210095.167Fukomys_damarensis
ENSG00000116747RO6010053.368ENSFHEG00000016128trove29653.682Fundulus_heteroclitus
ENSG00000116747RO609950.000ENSGMOG00000010318-9751.835Gadus_morhua
ENSG00000116747RO6010080.855ENSGALG00000002504TROVE210080.855Gallus_gallus
ENSG00000116747RO6010053.886ENSGAFG00000011806trove29653.295Gambusia_affinis
ENSG00000116747RO6010084.387ENSGAGG00000017742TROVE210084.387Gopherus_agassizii
ENSG00000116747RO60100100.000ENSGGOG00000034815TROVE2100100.000Gorilla_gorilla
ENSG00000116747RO6010050.777ENSHBUG00000014208trove29849.140Haplochromis_burtoni
ENSG00000116747RO6010095.725ENSHGLG00000003152TROVE210095.725Heterocephalus_glaber_female
ENSG00000116747RO6010095.725ENSHGLG00100010586TROVE210095.725Heterocephalus_glaber_male
ENSG00000116747RO6010050.777ENSHCOG00000004153trove29950.464Hippocampus_comes
ENSG00000116747RO6010048.106ENSIPUG00000011780trove29949.529Ictalurus_punctatus
ENSG00000116747RO6010090.698ENSSTOG00000012307TROVE210086.803Ictidomys_tridecemlineatus
ENSG00000116747RO6010094.424ENSJJAG00000019489Trove210094.424Jaculus_jaculus
ENSG00000116747RO6010053.886ENSKMAG00000004951trove29752.987Kryptolebias_marmoratus
ENSG00000116747RO6010055.959ENSLBEG00000009672trove29855.388Labrus_bergylta
ENSG00000116747RO6010075.836ENSLACG00000007822TROVE29975.836Latimeria_chalumnae
ENSG00000116747RO609972.067ENSLOCG00000007384trove29972.067Lepisosteus_oculatus
ENSG00000116747RO6010097.674ENSLAFG00000014808TROVE210095.353Loxodonta_africana
ENSG00000116747RO60100100.000ENSMFAG00000016020TROVE210099.628Macaca_fascicularis
ENSG00000116747RO6010099.240ENSMMUG00000022643TROVE210099.437Macaca_mulatta
ENSG00000116747RO60100100.000ENSMNEG00000039348TROVE210099.814Macaca_nemestrina
ENSG00000116747RO60100100.000ENSMLEG00000040042TROVE210099.442Mandrillus_leucophaeus
ENSG00000116747RO609952.083ENSMAMG00000002004trove210051.941Mastacembelus_armatus
ENSG00000116747RO6010050.777ENSMZEG00005008107trove29647.778Maylandia_zebra
ENSG00000116747RO6010081.369ENSMGAG00000005429TROVE210080.855Meleagris_gallopavo
ENSG00000116747RO6010091.078ENSMAUG00000008125Trove210091.078Mesocricetus_auratus
ENSG00000116747RO6010097.674ENSMICG00000011506TROVE210097.398Microcebus_murinus
ENSG00000116747RO6010089.405ENSMOCG00000021175Trove210089.405Microtus_ochrogaster
ENSG00000116747RO6010053.886ENSMMOG00000017049trove210053.604Mola_mola
ENSG00000116747RO6010090.698ENSMODG00000012203TROVE210087.732Monodelphis_domestica
ENSG00000116747RO6010054.404ENSMALG00000007367trove210053.974Monopterus_albus
ENSG00000116747RO6010091.822MGP_CAROLIEiJ_G0014676Trove210091.822Mus_caroli
ENSG00000116747RO6010089.777ENSMUSG00000018199Trove210089.777Mus_musculus
ENSG00000116747RO6010091.636MGP_PahariEiJ_G0027912Trove29191.636Mus_pahari
ENSG00000116747RO6010090.892MGP_SPRETEiJ_G0015483Trove210090.892Mus_spretus
ENSG00000116747RO6010096.097ENSMPUG00000004631TROVE210096.097Mustela_putorius_furo
ENSG00000116747RO6010093.536ENSMLUG00000001442TROVE29994.030Myotis_lucifugus
ENSG00000116747RO6010092.565ENSNGAG00000015898Trove210092.565Nannospalax_galili
ENSG00000116747RO6010052.332ENSNBRG00000005311trove29649.713Neolamprologus_brichardi
ENSG00000116747RO6010099.257ENSNLEG00000018048TROVE210099.257Nomascus_leucogenys
ENSG00000116747RO608988.889ENSMEUG00000005618-72100.000Notamacropus_eugenii
ENSG00000116747RO6010065.779ENSOPRG00000017247TROVE210075.312Ochotona_princeps
ENSG00000116747RO6010094.981ENSODEG00000010468TROVE210094.981Octodon_degus
ENSG00000116747RO6010052.332ENSONIG00000018579trove29848.704Oreochromis_niloticus
ENSG00000116747RO6010090.114ENSOANG00000002961TROVE29986.406Ornithorhynchus_anatinus
ENSG00000116747RO6010094.052ENSOCUG00000012814TROVE210094.052Oryctolagus_cuniculus
ENSG00000116747RO6010049.242ENSORLG00000010951trove29951.698Oryzias_latipes
ENSG00000116747RO6010049.242ENSORLG00020009759trove29951.887Oryzias_latipes_hni
ENSG00000116747RO6010049.242ENSORLG00015004497trove29951.887Oryzias_latipes_hsok
ENSG00000116747RO6010050.515ENSOMEG00000010440trove29751.515Oryzias_melastigma
ENSG00000116747RO6010095.506ENSOGAG00000032047TROVE210095.506Otolemur_garnettii
ENSG00000116747RO6010095.539ENSOARG00000009462TROVE29695.539Ovis_aries
ENSG00000116747RO60100100.000ENSPPAG00000043846TROVE210099.814Pan_paniscus
ENSG00000116747RO6010097.378ENSPPRG00000017233TROVE210097.378Panthera_pardus
ENSG00000116747RO6010096.816ENSPTIG00000015535TROVE210096.816Panthera_tigris_altaica
ENSG00000116747RO60100100.000ENSPTRG00000001794TROVE210099.814Pan_troglodytes
ENSG00000116747RO60100100.000ENSPANG00000000341TROVE210099.257Papio_anubis
ENSG00000116747RO609955.729ENSPKIG00000018217trove29859.064Paramormyrops_kingsleyae
ENSG00000116747RO6010083.086ENSPSIG00000009877TROVE210083.086Pelodiscus_sinensis
ENSG00000116747RO6010044.737ENSPMGG00000009282-10044.737Periophthalmus_magnuspinnatus
ENSG00000116747RO6010091.635ENSPEMG00000001419Trove210091.264Peromyscus_maniculatus_bairdii
ENSG00000116747RO6010087.546ENSPCIG00000028632TROVE210087.546Phascolarctos_cinereus
ENSG00000116747RO6010052.850ENSPFOG00000006974trove29652.519Poecilia_formosa
ENSG00000116747RO6010053.368ENSPLAG00000009027trove29652.907Poecilia_latipinna
ENSG00000116747RO6010052.850ENSPMEG00000015081trove29552.713Poecilia_mexicana
ENSG00000116747RO6010053.886ENSPREG00000005674trove29652.907Poecilia_reticulata
ENSG00000116747RO60100100.000ENSPPYG00000000397TROVE210099.814Pongo_abelii
ENSG00000116747RO6010095.349ENSPCAG00000003959TROVE210094.796Procavia_capensis
ENSG00000116747RO6010097.674ENSPCOG00000015951-10097.378Propithecus_coquereli
ENSG00000116747RO6010089.734ENSPCOG00000015454-10089.734Propithecus_coquereli
ENSG00000116747RO609892.857ENSPVAG00000001182TROVE210092.197Pteropus_vampyrus
ENSG00000116747RO6010050.777ENSPNYG00000020148trove29647.778Pundamilia_nyererei
ENSG00000116747RO6010054.982ENSPNAG00000024223trove29955.140Pygocentrus_nattereri
ENSG00000116747RO6010089.591ENSRNOG00000003434Trove210089.591Rattus_norvegicus
ENSG00000116747RO60100100.000ENSRBIG00000030073TROVE210099.814Rhinopithecus_bieti
ENSG00000116747RO60100100.000ENSRROG00000034428TROVE210099.814Rhinopithecus_roxellana
ENSG00000116747RO60100100.000ENSSBOG00000024070TROVE210098.885Saimiri_boliviensis_boliviensis
ENSG00000116747RO6010087.546ENSSHAG00000013205TROVE210087.546Sarcophilus_harrisii
ENSG00000116747RO609963.128ENSSFOG00015011990trove29963.128Scleropages_formosus
ENSG00000116747RO6010054.404ENSSMAG00000009058trove29753.497Scophthalmus_maximus
ENSG00000116747RO6010055.440ENSSDUG00000009083trove210053.875Seriola_dumerili
ENSG00000116747RO6010055.440ENSSLDG00000019857trove210053.875Seriola_lalandi_dorsalis
ENSG00000116747RO6010093.123ENSSARG00000009347TROVE210093.123Sorex_araneus
ENSG00000116747RO6010084.015ENSSPUG00000014304TROVE210084.015Sphenodon_punctatus
ENSG00000116747RO6010055.440ENSSPAG00000003171trove29655.684Stegastes_partitus
ENSG00000116747RO6010093.536ENSSSCG00000032055TROVE210092.937Sus_scrofa
ENSG00000116747RO6010079.468ENSTGUG00000004126TROVE210082.296Taeniopygia_guttata
ENSG00000116747RO6010052.850ENSTRUG00000009656trove210052.037Takifugu_rubripes
ENSG00000116747RO6010053.704ENSTNIG00000007802trove210053.704Tetraodon_nigroviridis
ENSG00000116747RO6010095.652ENSTBEG00000006806TROVE28395.238Tupaia_belangeri
ENSG00000116747RO6010095.057ENSTTRG00000009291TROVE210095.717Tursiops_truncatus
ENSG00000116747RO6010097.212ENSUAMG00000013365TROVE210097.212Ursus_americanus
ENSG00000116747RO6010097.026ENSUMAG00000020464TROVE210097.026Ursus_maritimus
ENSG00000116747RO6010086.047ENSVPAG00000010303TROVE28598.000Vicugna_pacos
ENSG00000116747RO6010097.490ENSVVUG00000013405TROVE27297.490Vulpes_vulpes
ENSG00000116747RO6010078.067ENSXETG00000017224trove210078.067Xenopus_tropicalis
ENSG00000116747RO6010053.886ENSXCOG00000007527trove29548.837Xiphophorus_couchianus
ENSG00000116747RO6010053.886ENSXMAG00000004825trove29653.101Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002520immune system development-IEAProcess
GO:0003723RNA binding21873635.IBAFunction
GO:0003723RNA binding26382853.IDAFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006383transcription by RNA polymerase III3200833.TASProcess
GO:0007224smoothened signaling pathway-IEAProcess
GO:0009411response to UV-IEAProcess
GO:0010468regulation of gene expression26382853.IDAProcess
GO:0030620U2 snRNA binding-IEAFunction
GO:0035457cellular response to interferon-alpha26382853.IDAProcess
GO:0046872metal ion binding-IEAFunction
GO:0060271cilium assembly-IEAProcess
GO:1990904ribonucleoprotein complex21873635.IBAComponent
GO:1990904ribonucleoprotein complex17289661.IDAComponent

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