EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116898 (Gene tree)
Gene ID: 64960
Gene Symbol: MRPS15
Alias: FLJ11564
Full Name: mitochondrial ribosomal protein S15
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 8,722 bases
Position: chr1:36,455,718-36,464,439
Accession: 14504
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362208	Ribosomal_S15	PF00312.22	3.8e-20	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373116	MRPS15-201	1006	-	ENSP00000362208	257 (aa)	-	P82914
ENST00000462067	MRPS15-202	1612	-	-	- (aa)	-	-
ENST00000477040	MRPS15-203	533	-	-	- (aa)	-	-
ENST00000488606	MRPS15-204	2127	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000116898's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116898's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116898	MRPS15	65	53.293	ENSAPOG00000024393	mrps15	60	53.595	Acanthochromis_polyacanthus
ENSG00000116898	MRPS15	100	66.667	ENSAMEG00000001463	-	100	64.729	Ailuropoda_melanoleuca
ENSG00000116898	MRPS15	79	66.995	ENSAMEG00000005835	-	81	69.697	Ailuropoda_melanoleuca
ENSG00000116898	MRPS15	69	50.000	ENSACIG00000017933	mrps15	80	50.292	Amphilophus_citrinellus
ENSG00000116898	MRPS15	65	52.695	ENSAOCG00000014871	mrps15	61	53.125	Amphiprion_ocellaris
ENSG00000116898	MRPS15	65	52.695	ENSAPEG00000005965	mrps15	61	53.125	Amphiprion_percula
ENSG00000116898	MRPS15	65	54.491	ENSATEG00000009826	mrps15	61	55.000	Anabas_testudineus
ENSG00000116898	MRPS15	86	45.833	ENSAPLG00000008180	MRPS15	89	46.083	Anas_platyrhynchos
ENSG00000116898	MRPS15	68	55.556	ENSACAG00000001061	MRPS15	78	53.672	Anolis_carolinensis
ENSG00000116898	MRPS15	100	83.268	ENSANAG00000024978	MRPS15	100	83.268	Aotus_nancymaae
ENSG00000116898	MRPS15	65	54.491	ENSACLG00000027820	mrps15	61	55.000	Astatotilapia_calliptera
ENSG00000116898	MRPS15	70	50.811	ENSAMXG00000001781	mrps15	86	45.413	Astyanax_mexicanus
ENSG00000116898	MRPS15	100	70.656	ENSBTAG00000024097	MRPS15	100	70.656	Bos_taurus
ENSG00000116898	MRPS15	100	82.946	ENSCJAG00000001852	MRPS15	100	82.946	Callithrix_jacchus
ENSG00000116898	MRPS15	73	75.401	ENSCAFG00000030390	MRPS15	99	73.118	Canis_familiaris
ENSG00000116898	MRPS15	100	65.891	ENSCAFG00020008912	MRPS15	100	63.953	Canis_lupus_dingo
ENSG00000116898	MRPS15	100	72.587	ENSCHIG00000016923	-	100	72.587	Capra_hircus
ENSG00000116898	MRPS15	100	76.265	ENSTSYG00000008948	-	100	76.265	Carlito_syrichta
ENSG00000116898	MRPS15	99	70.312	ENSCPOG00000010877	MRPS15	85	74.771	Cavia_porcellus
ENSG00000116898	MRPS15	100	87.160	ENSCATG00000044771	-	100	87.160	Cercocebus_atys
ENSG00000116898	MRPS15	99	67.692	ENSCLAG00000015562	MRPS15	84	74.312	Chinchilla_lanigera
ENSG00000116898	MRPS15	100	87.938	ENSCSAG00000001103	MRPS15	100	87.938	Chlorocebus_sabaeus
ENSG00000116898	MRPS15	61	78.205	ENSCHOG00000012439	-	99	78.710	Choloepus_hoffmanni
ENSG00000116898	MRPS15	68	51.397	ENSCPBG00000018508	MRPS15	81	55.102	Chrysemys_picta_bellii
ENSG00000116898	MRPS15	100	87.938	ENSCANG00000031766	MRPS15	100	87.938	Colobus_angolensis_palliatus
ENSG00000116898	MRPS15	99	62.791	ENSCGRG00001019050	Mrps15	100	62.016	Cricetulus_griseus_chok1gshd
ENSG00000116898	MRPS15	99	62.791	ENSCGRG00000005380	Mrps15	100	62.016	Cricetulus_griseus_crigri
ENSG00000116898	MRPS15	65	52.096	ENSCSEG00000019008	mrps15	64	52.500	Cynoglossus_semilaevis
ENSG00000116898	MRPS15	61	53.205	ENSCVAG00000017500	mrps15	60	52.941	Cyprinodon_variegatus
ENSG00000116898	MRPS15	94	40.562	ENSDARG00000109289	mrps15	83	42.009	Danio_rerio
ENSG00000116898	MRPS15	100	71.984	ENSDNOG00000046736	MRPS15	100	69.261	Dasypus_novemcinctus
ENSG00000116898	MRPS15	70	61.429	ENSDORG00000007581	-	80	62.963	Dipodomys_ordii
ENSG00000116898	MRPS15	62	39.759	ENSEBUG00000002513	mrps15	73	39.759	Eptatretus_burgeri
ENSG00000116898	MRPS15	100	71.042	ENSEASG00005012199	MRPS15	100	67.181	Equus_asinus_asinus
ENSG00000116898	MRPS15	100	74.131	ENSECAG00000000933	MRPS15	100	70.270	Equus_caballus
ENSG00000116898	MRPS15	67	71.098	ENSEEUG00000008922	-	100	70.520	Erinaceus_europaeus
ENSG00000116898	MRPS15	61	63.924	ENSEEUG00000009264	-	61	62.025	Erinaceus_europaeus
ENSG00000116898	MRPS15	79	49.010	ENSELUG00000017968	mrps15	69	49.231	Esox_lucius
ENSG00000116898	MRPS15	100	70.270	ENSFCAG00000005265	MRPS15	100	70.270	Felis_catus
ENSG00000116898	MRPS15	83	46.396	ENSFALG00000000866	MRPS15	80	50.562	Ficedula_albicollis
ENSG00000116898	MRPS15	99	67.578	ENSFDAG00000008245	MRPS15	99	67.578	Fukomys_damarensis
ENSG00000116898	MRPS15	60	54.839	ENSFHEG00000001013	mrps15	61	54.545	Fundulus_heteroclitus
ENSG00000116898	MRPS15	61	48.077	ENSGMOG00000007959	mrps15	92	47.712	Gadus_morhua
ENSG00000116898	MRPS15	54	43.537	ENSGALG00000044433	-	72	45.000	Gallus_gallus
ENSG00000116898	MRPS15	63	53.988	ENSGAFG00000008549	mrps15	62	53.750	Gambusia_affinis
ENSG00000116898	MRPS15	61	57.595	ENSGACG00000013792	mrps15	83	58.278	Gasterosteus_aculeatus
ENSG00000116898	MRPS15	87	45.726	ENSGAGG00000024844	MRPS15	79	47.525	Gopherus_agassizii
ENSG00000116898	MRPS15	100	97.276	ENSGGOG00000013565	MRPS15	100	97.276	Gorilla_gorilla
ENSG00000116898	MRPS15	65	54.491	ENSHBUG00000009456	mrps15	61	55.000	Haplochromis_burtoni
ENSG00000116898	MRPS15	99	70.703	ENSHGLG00000012109	MRPS15	100	70.703	Heterocephalus_glaber_female
ENSG00000116898	MRPS15	99	71.094	ENSHGLG00100001929	MRPS15	100	71.094	Heterocephalus_glaber_male
ENSG00000116898	MRPS15	61	45.283	ENSHCOG00000006158	mrps15	63	44.872	Hippocampus_comes
ENSG00000116898	MRPS15	74	52.308	ENSIPUG00000015599	mrps15	68	52.514	Ictalurus_punctatus
ENSG00000116898	MRPS15	100	71.538	ENSSTOG00000000608	MRPS15	100	71.154	Ictidomys_tridecemlineatus
ENSG00000116898	MRPS15	100	69.650	ENSJJAG00000022198	Mrps15	100	69.650	Jaculus_jaculus
ENSG00000116898	MRPS15	68	51.136	ENSKMAG00000013807	mrps15	66	52.071	Kryptolebias_marmoratus
ENSG00000116898	MRPS15	65	54.762	ENSLBEG00000009087	mrps15	63	57.143	Labrus_bergylta
ENSG00000116898	MRPS15	75	53.695	ENSLACG00000018586	MRPS15	72	54.082	Latimeria_chalumnae
ENSG00000116898	MRPS15	75	52.239	ENSLOCG00000003165	mrps15	83	55.000	Lepisosteus_oculatus
ENSG00000116898	MRPS15	99	71.875	ENSLAFG00000011450	MRPS15	100	71.875	Loxodonta_africana
ENSG00000116898	MRPS15	100	86.770	ENSMFAG00000038082	MRPS15	100	86.770	Macaca_fascicularis
ENSG00000116898	MRPS15	100	85.992	ENSMMUG00000020433	-	100	85.992	Macaca_mulatta
ENSG00000116898	MRPS15	95	71.429	ENSMMUG00000013527	-	82	83.582	Macaca_mulatta
ENSG00000116898	MRPS15	100	80.934	ENSMNEG00000042543	MRPS15	100	80.934	Macaca_nemestrina
ENSG00000116898	MRPS15	100	86.770	ENSMLEG00000040975	-	100	86.770	Mandrillus_leucophaeus
ENSG00000116898	MRPS15	65	54.819	ENSMAMG00000007572	mrps15	68	55.346	Mastacembelus_armatus
ENSG00000116898	MRPS15	65	54.491	ENSMZEG00005007070	mrps15	61	55.000	Maylandia_zebra
ENSG00000116898	MRPS15	74	48.980	ENSMGAG00000003562	MRPS15	74	49.171	Meleagris_gallopavo
ENSG00000116898	MRPS15	99	62.016	ENSMAUG00000021202	Mrps15	100	62.016	Mesocricetus_auratus
ENSG00000116898	MRPS15	95	76.543	ENSMICG00000047526	MRPS15	85	78.899	Microcebus_murinus
ENSG00000116898	MRPS15	97	63.095	ENSMOCG00000004474	Mrps15	85	65.297	Microtus_ochrogaster
ENSG00000116898	MRPS15	63	51.553	ENSMMOG00000000640	mrps15	59	52.597	Mola_mola
ENSG00000116898	MRPS15	83	58.605	ENSMODG00000017813	MRPS15	89	61.538	Monodelphis_domestica
ENSG00000116898	MRPS15	74	48.969	ENSMALG00000012101	mrps15	66	52.047	Monopterus_albus
ENSG00000116898	MRPS15	86	64.253	MGP_CAROLIEiJ_G0026465	Mrps15	85	65.000	Mus_caroli
ENSG00000116898	MRPS15	98	63.636	ENSMUSG00000028861	Mrps15	98	64.567	Mus_musculus
ENSG00000116898	MRPS15	99	62.891	MGP_PahariEiJ_G0028796	Mrps15	99	63.813	Mus_pahari
ENSG00000116898	MRPS15	86	65.158	MGP_SPRETEiJ_G0027444	Mrps15	85	65.909	Mus_spretus
ENSG00000116898	MRPS15	100	66.279	ENSMLUG00000006475	MRPS15	100	64.341	Myotis_lucifugus
ENSG00000116898	MRPS15	100	64.093	ENSNGAG00000018718	Mrps15	100	64.479	Nannospalax_galili
ENSG00000116898	MRPS15	62	54.375	ENSNBRG00000009851	mrps15	59	54.902	Neolamprologus_brichardi
ENSG00000116898	MRPS15	100	93.385	ENSNLEG00000030022	-	100	93.385	Nomascus_leucogenys
ENSG00000116898	MRPS15	100	84.047	ENSNLEG00000004684	-	100	84.047	Nomascus_leucogenys
ENSG00000116898	MRPS15	100	68.992	ENSOPRG00000001726	MRPS15	100	68.605	Ochotona_princeps
ENSG00000116898	MRPS15	74	74.737	ENSODEG00000005390	MRPS15	99	74.737	Octodon_degus
ENSG00000116898	MRPS15	63	54.601	ENSONIG00000016261	mrps15	61	54.375	Oreochromis_niloticus
ENSG00000116898	MRPS15	65	74.556	ENSOANG00000002063	-	83	75.974	Ornithorhynchus_anatinus
ENSG00000116898	MRPS15	99	74.219	ENSOCUG00000005675	MRPS15	99	74.219	Oryctolagus_cuniculus
ENSG00000116898	MRPS15	81	44.712	ENSORLG00000014487	mrps15	71	45.455	Oryzias_latipes
ENSG00000116898	MRPS15	61	51.923	ENSORLG00020019352	mrps15	68	53.020	Oryzias_latipes_hni
ENSG00000116898	MRPS15	76	46.231	ENSORLG00015004415	mrps15	75	45.918	Oryzias_latipes_hsok
ENSG00000116898	MRPS15	68	45.402	ENSOMEG00000000701	mrps15	66	45.029	Oryzias_melastigma
ENSG00000116898	MRPS15	95	76.230	ENSOGAG00000031357	-	84	78.899	Otolemur_garnettii
ENSG00000116898	MRPS15	100	76.654	ENSOGAG00000002656	-	100	76.654	Otolemur_garnettii
ENSG00000116898	MRPS15	100	72.587	ENSOARG00000019708	MRPS15	100	72.587	Ovis_aries
ENSG00000116898	MRPS15	100	98.444	ENSPPAG00000025884	MRPS15	100	98.444	Pan_paniscus
ENSG00000116898	MRPS15	100	69.884	ENSPPRG00000024277	MRPS15	100	69.884	Panthera_pardus
ENSG00000116898	MRPS15	100	70.155	ENSPTIG00000022020	MRPS15	100	70.155	Panthera_tigris_altaica
ENSG00000116898	MRPS15	100	98.054	ENSPTRG00000000541	MRPS15	100	98.054	Pan_troglodytes
ENSG00000116898	MRPS15	100	85.271	ENSPANG00000009656	-	100	84.884	Papio_anubis
ENSG00000116898	MRPS15	100	85.603	ENSPANG00000009486	-	100	85.603	Papio_anubis
ENSG00000116898	MRPS15	68	47.191	ENSPKIG00000004939	mrps15	67	47.191	Paramormyrops_kingsleyae
ENSG00000116898	MRPS15	67	53.631	ENSPSIG00000009916	MRPS15	83	55.844	Pelodiscus_sinensis
ENSG00000116898	MRPS15	88	67.257	ENSPEMG00000022897	Mrps15	87	67.123	Peromyscus_maniculatus_bairdii
ENSG00000116898	MRPS15	63	53.049	ENSPFOG00000013553	mrps15	61	52.795	Poecilia_formosa
ENSG00000116898	MRPS15	63	52.761	ENSPLAG00000000454	mrps15	62	52.500	Poecilia_latipinna
ENSG00000116898	MRPS15	63	52.761	ENSPMEG00000018914	mrps15	62	52.500	Poecilia_mexicana
ENSG00000116898	MRPS15	63	50.932	ENSPREG00000005592	mrps15	62	51.948	Poecilia_reticulata
ENSG00000116898	MRPS15	99	85.039	ENSPPYG00000001537	MRPS15	100	85.039	Pongo_abelii
ENSG00000116898	MRPS15	97	75.100	ENSPCOG00000014731	MRPS15	99	75.100	Propithecus_coquereli
ENSG00000116898	MRPS15	100	64.865	ENSPVAG00000008648	MRPS15	100	63.707	Pteropus_vampyrus
ENSG00000116898	MRPS15	65	55.689	ENSPNYG00000013431	mrps15	61	56.250	Pundamilia_nyererei
ENSG00000116898	MRPS15	88	46.281	ENSPNAG00000015400	mrps15	79	50.000	Pygocentrus_nattereri
ENSG00000116898	MRPS15	99	63.566	ENSRNOG00000008279	Mrps15	100	63.178	Rattus_norvegicus
ENSG00000116898	MRPS15	100	87.160	ENSRBIG00000038467	MRPS15	100	87.160	Rhinopithecus_bieti
ENSG00000116898	MRPS15	100	86.381	ENSRROG00000045410	MRPS15	100	86.381	Rhinopithecus_roxellana
ENSG00000116898	MRPS15	100	83.658	ENSSBOG00000034679	MRPS15	100	83.658	Saimiri_boliviensis_boliviensis
ENSG00000116898	MRPS15	80	64.115	ENSSHAG00000018120	MRPS15	84	59.740	Sarcophilus_harrisii
ENSG00000116898	MRPS15	74	47.668	ENSSFOG00015005771	mrps15	67	47.872	Scleropages_formosus
ENSG00000116898	MRPS15	67	51.462	ENSSMAG00000003899	mrps15	64	51.829	Scophthalmus_maximus
ENSG00000116898	MRPS15	68	52.273	ENSSDUG00000009946	mrps15	67	52.663	Seriola_dumerili
ENSG00000116898	MRPS15	68	52.273	ENSSLDG00000003653	mrps15	67	52.663	Seriola_lalandi_dorsalis
ENSG00000116898	MRPS15	100	58.755	ENSSARG00000012061	MRPS15	100	56.809	Sorex_araneus
ENSG00000116898	MRPS15	96	42.353	ENSSPUG00000001388	MRPS15	87	44.144	Sphenodon_punctatus
ENSG00000116898	MRPS15	68	48.295	ENSSPAG00000020369	mrps15	76	48.521	Stegastes_partitus
ENSG00000116898	MRPS15	87	73.009	ENSSSCG00000034647	MRPS15	92	73.182	Sus_scrofa
ENSG00000116898	MRPS15	67	51.163	ENSTRUG00000011129	mrps15	63	52.500	Takifugu_rubripes
ENSG00000116898	MRPS15	66	50.588	ENSTNIG00000012190	mrps15	61	52.597	Tetraodon_nigroviridis
ENSG00000116898	MRPS15	98	77.291	ENSTBEG00000000958	MRPS15	86	79.817	Tupaia_belangeri
ENSG00000116898	MRPS15	100	69.112	ENSTTRG00000002345	MRPS15	100	67.181	Tursiops_truncatus
ENSG00000116898	MRPS15	100	65.116	ENSUAMG00000020261	MRPS15	100	63.178	Ursus_americanus
ENSG00000116898	MRPS15	100	65.116	ENSUMAG00000001358	MRPS15	100	63.178	Ursus_maritimus
ENSG00000116898	MRPS15	100	62.162	ENSVPAG00000000608	MRPS15	100	62.162	Vicugna_pacos
ENSG00000116898	MRPS15	100	65.504	ENSVVUG00000023194	MRPS15	100	63.566	Vulpes_vulpes
ENSG00000116898	MRPS15	65	57.143	ENSXETG00000005257	mrps15	68	57.558	Xenopus_tropicalis
ENSG00000116898	MRPS15	65	52.096	ENSXCOG00000001481	mrps15	61	51.829	Xiphophorus_couchianus
ENSG00000116898	MRPS15	63	52.761	ENSXMAG00000028874	mrps15	61	52.500	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0003735	structural constituent of ribosome	11279123.	NAS	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	11279123.25838379.	IDA	Component
GO:0006412	translation	11279123.	NAS	Process
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process