EuRBPDB

Description

Ensembl ID: ENSG00000117519 (Gene tree)
Gene ID: 1266
Gene Symbol: CNN3
Alias: N
Full Name: calponin 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 30,330 bases
Position: chr1:94,896,949-94,927,278
Accession: 2157
RBP type: non-canonical RBP
Summary: This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474409	CNN3-205	544	-	-	- (aa)	-	-
ENST00000461018	CNN3-204	568	-	-	- (aa)	-	-
ENST00000415017	CNN3-203	792	-	ENSP00000401452	185 (aa)	-	E9PDU6
ENST00000487539	CNN3-206	739	-	-	- (aa)	-	-
ENST00000370206	CNN3-201	2165	-	ENSP00000359225	329 (aa)	-	Q15417
ENST00000545882	CNN3-207	1902	XM_017000245	ENSP00000440081	288 (aa)	XP_016855734	Q15417
ENST00000394202	CNN3-202	1974	-	ENSP00000377752	283 (aa)	-	Q15417

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000117519	Phospholipids	2E-14	23362303

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000117519	rs860873	1	94921652	A	Stearic acid (18:0) levels	23362303	unit increase	0.1472	EFO_0005110

Protein-Protein Interaction (PPI)

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000117519	CNN3	100	98.378	ENSMUSG00000053931	Cnn3	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005913	cell-cell adherens junction	25468996.	HDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0008017	microtubule binding	-	IEA	Function
GO:0014069	postsynaptic density	-	IEA	Component
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0031032	actomyosin structure organization	-	IEA	Process
GO:0032780	negative regulation of ATPase activity	-	IEA	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043197	dendritic spine	-	IEA	Component
GO:0098609	cell-cell adhesion	-	IEA	Process
GO:0098641	cadherin binding involved in cell-cell adhesion	25468996.	HDA	Function