EuRBPDB

Description

Ensembl ID: ENSG00000117597 (Gene tree)
Gene ID: 27042
Gene Symbol: UTP25
Alias: MGC29875|DEF|C1orf107|DIEXF
Full Name: UTP25 small subunit processor component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,599 bases
Position: chr1:209,827,967-209,857,565
Accession: 28440
RBP type: non-canonical RBP
Summary: (UTP25 Small Subunit Processor Component) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000457820	UTP25-201	2895	-	ENSP00000407345	248 (aa)	-	H7C2R4
ENST00000491415	UTP25-202	8446	XM_006711275	ENSP00000419005	756 (aa)	XP_006711338	Q68CQ4

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000117597	Platelet Function Tests	8.1086000E-005	-
ENSG00000117597	Child Development Disorders, Pervasive	4.5909000E-005	-
ENSG00000117597	Eyebrows	2E-11	27182965
ENSG00000117597	Cleft Lip	9E-19	28232668
ENSG00000117597	Cleft Palate	9E-19	28232668

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000117597	rs7546104	1	209854620	?	Reaction time	29844566	[0.0048-0.0116] unit increase	0.0082005	EFO_0008393
ENSG00000117597	rs3766612	1	209846668	?	Systolic blood pressure	30595370			EFO_0006335

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000117597	UTP25	100	86.606	ENSMUSG00000016181	Diexf	100	86.736	Mus_musculus
ENSG00000117597	UTP25	82	40.887	YIL091C		93	32.799	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	23357851.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	23357851.	IDA	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0019843	rRNA binding	21873635.	IBA	Function
GO:0030163	protein catabolic process	23357851.	IMP	Process
GO:0031648	protein destabilization	23357851.	IMP	Process
GO:0032040	small-subunit processome	21873635.	IBA	Component
GO:0034511	U3 snoRNA binding	21873635.	IBA	Function
GO:0040019	positive regulation of embryonic development	-	ISS	Process