EuRBPDB

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  • Basic Information
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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000117877 (Gene tree)
Gene ID
10849
Gene Symbol
CD3EAP
Alias
ASE-1|CAST|PAF49
Full Name
CD3e molecule associated protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,558 bases
Position
chr19:45,406,209-45,410,766
Accession
24219
RBP type
canonical RBP
Summary
(CD3e Molecule Associated Protein) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000310966RNA_polI_A34PF08208.111.6e-3711
ENSP00000465099RNA_polI_A34PF08208.111.6e-3711
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16809778RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.Mol Cell Biol2006 JulPanov KI-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000590794CD3EAP-203489-ENSP0000046650367 (aa)-K7EMH2
ENST00000309424CD3EAP-2013286-ENSP00000310966510 (aa)-O15446
ENST00000592852CD3EAP-2041061-ENSP0000046777139 (aa)-K7EQC8
ENST00000589804CD3EAP-2021830-ENSP00000465099512 (aa)-O15446
Gene Model
Click here to download ENSG00000117877's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000117877's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000117877CD3EAP9567.568ENSAMEG00000012438CD3EAP9861.996Ailuropoda_melanoleuca
ENSG00000117877CD3EAP10097.436ENSANAG00000022477CD3EAP10086.019Aotus_nancymaae
ENSG00000117877CD3EAP9965.537ENSBTAG00000023601CD3EAP9865.779Bos_taurus
ENSG00000117877CD3EAP10097.436ENSCJAG00000012689CD3EAP10083.752Callithrix_jacchus
ENSG00000117877CD3EAP9957.519ENSCAFG00000004455CD3EAP9357.707Canis_familiaris
ENSG00000117877CD3EAP9959.398ENSCAFG00020011342CD3EAP9359.586Canis_lupus_dingo
ENSG00000117877CD3EAP9965.537ENSCHIG00000022038CD3EAP9765.970Capra_hircus
ENSG00000117877CD3EAP9967.647ENSTSYG00000036564CD3EAP9866.994Carlito_syrichta
ENSG00000117877CD3EAP9760.853ENSCPOG00000033293CD3EAP9860.687Cavia_porcellus
ENSG00000117877CD3EAP10083.685ENSCCAG00000024253CD3EAP10083.685Cebus_capucinus
ENSG00000117877CD3EAP9991.016ENSCATG00000030677CD3EAP9991.142Cercocebus_atys
ENSG00000117877CD3EAP9758.189ENSCLAG00000004691CD3EAP8757.736Chinchilla_lanigera
ENSG00000117877CD3EAP9990.820ENSCSAG00000003181CD3EAP9990.945Chlorocebus_sabaeus
ENSG00000117877CD3EAP9990.039ENSCANG00000024271CD3EAP9990.157Colobus_angolensis_palliatus
ENSG00000117877CD3EAP8555.430ENSCGRG00001023584Cd3eap9752.743Cricetulus_griseus_chok1gshd
ENSG00000117877CD3EAP9962.949ENSDNOG00000041816CD3EAP9862.998Dasypus_novemcinctus
ENSG00000117877CD3EAP5759.871ENSDORG00000027052-8756.704Dipodomys_ordii
ENSG00000117877CD3EAP9866.348ENSEASG00005014188CD3EAP9767.433Equus_asinus_asinus
ENSG00000117877CD3EAP9866.348ENSECAG00000032490CD3EAP9767.433Equus_caballus
ENSG00000117877CD3EAP7058.824ENSEEUG00000012763-8661.661Erinaceus_europaeus
ENSG00000117877CD3EAP9958.974ENSFCAG00000043166CD3EAP9958.974Felis_catus
ENSG00000117877CD3EAP8257.412ENSFDAG00000012196-8660.172Fukomys_damarensis
ENSG00000117877CD3EAP100100.000ENSGGOG00000015872-10097.070Gorilla_gorilla
ENSG00000117877CD3EAP100100.000ENSGGOG00000041192-10097.070Gorilla_gorilla
ENSG00000117877CD3EAP10060.952ENSHGLG00000002795CD3EAP8860.952Heterocephalus_glaber_female
ENSG00000117877CD3EAP10060.952ENSHGLG00100006839CD3EAP8860.952Heterocephalus_glaber_male
ENSG00000117877CD3EAP9758.600ENSSTOG00000002799CD3EAP9657.510Ictidomys_tridecemlineatus
ENSG00000117877CD3EAP8353.647ENSJJAG00000013173Cd3eap8755.833Jaculus_jaculus
ENSG00000117877CD3EAP9559.459ENSLAFG00000001827CD3EAP8469.359Loxodonta_africana
ENSG00000117877CD3EAP9990.039ENSMFAG00000006908CD3EAP9990.157Macaca_fascicularis
ENSG00000117877CD3EAP9990.039ENSMNEG00000028086CD3EAP9990.157Macaca_nemestrina
ENSG00000117877CD3EAP9990.856ENSMLEG00000043530CD3EAP9990.980Mandrillus_leucophaeus
ENSG00000117877CD3EAP6660.116ENSMAUG00000007876Cd3eap8658.960Mesocricetus_auratus
ENSG00000117877CD3EAP9967.954ENSMICG00000031258CD3EAP9867.057Microcebus_murinus
ENSG00000117877CD3EAP6659.347ENSMOCG00000013766Cd3eap8259.880Microtus_ochrogaster
ENSG00000117877CD3EAP8133.864ENSMODG00000021547-8139.286Monodelphis_domestica
ENSG00000117877CD3EAP8253.882MGP_CAROLIEiJ_G0029285Cd3eap8157.692Mus_caroli
ENSG00000117877CD3EAP8454.756ENSMUSG00000047649Cd3eap8358.382Mus_musculus
ENSG00000117877CD3EAP8454.608MGP_SPRETEiJ_G0030369Cd3eap9754.654Mus_spretus
ENSG00000117877CD3EAP9961.260ENSMPUG00000005965CD3EAP9961.641Mustela_putorius_furo
ENSG00000117877CD3EAP9575.676ENSMLUG00000012319CD3EAP9764.567Myotis_lucifugus
ENSG00000117877CD3EAP7766.667ENSNGAG00000015313Cd3eap8861.236Nannospalax_galili
ENSG00000117877CD3EAP100100.000ENSNLEG00000035363CD3EAP10094.902Nomascus_leucogenys
ENSG00000117877CD3EAP8359.719ENSODEG00000007587-9960.190Octodon_degus
ENSG00000117877CD3EAP9767.659ENSOGAG00000013782CD3EAP9966.602Otolemur_garnettii
ENSG00000117877CD3EAP9965.160ENSOARG00000009943CD3EAP9865.589Ovis_aries
ENSG00000117877CD3EAP100100.000ENSPPAG00000004958CD3EAP10098.828Pan_paniscus
ENSG00000117877CD3EAP9959.055ENSPPRG00000001954CD3EAP9959.449Panthera_pardus
ENSG00000117877CD3EAP7468.966ENSPTIG00000014078-9758.652Panthera_tigris_altaica
ENSG00000117877CD3EAP100100.000ENSPTRG00000011151CD3EAP10099.022Pan_troglodytes
ENSG00000117877CD3EAP9991.634ENSPANG00000014599CD3EAP9991.765Papio_anubis
ENSG00000117877CD3EAP9763.158ENSPEMG00000018578Cd3eap8263.050Peromyscus_maniculatus_bairdii
ENSG00000117877CD3EAP5440.214ENSPCIG00000022939-6348.000Phascolarctos_cinereus
ENSG00000117877CD3EAP100100.000ENSPPYG00000010119CD3EAP9995.635Pongo_abelii
ENSG00000117877CD3EAP9765.789ENSPCAG00000012953-9966.129Procavia_capensis
ENSG00000117877CD3EAP10068.511ENSPCOG00000028780CD3EAP9868.605Propithecus_coquereli
ENSG00000117877CD3EAP9966.139ENSPVAG00000001330CD3EAP9767.002Pteropus_vampyrus
ENSG00000117877CD3EAP9453.608ENSRNOG00000016825Cd3eap10052.429Rattus_norvegicus
ENSG00000117877CD3EAP9990.625ENSRBIG00000040738CD3EAP9990.748Rhinopithecus_bieti
ENSG00000117877CD3EAP9990.802ENSRROG00000043410CD3EAP9990.927Rhinopithecus_roxellana
ENSG00000117877CD3EAP10080.851ENSSBOG00000032782CD3EAP10081.044Saimiri_boliviensis_boliviensis
ENSG00000117877CD3EAP6853.258ENSSARG00000008700-9056.678Sorex_araneus
ENSG00000117877CD3EAP9570.270ENSSSCG00000020754CD3EAP9863.105Sus_scrofa
ENSG00000117877CD3EAP9964.368ENSTTRG00000008311CD3EAP9765.815Tursiops_truncatus
ENSG00000117877CD3EAP9962.311ENSUAMG00000020204CD3EAP9862.380Ursus_americanus
ENSG00000117877CD3EAP9962.311ENSUMAG00000023587CD3EAP9862.188Ursus_maritimus
ENSG00000117877CD3EAP9957.491ENSVVUG00000004115CD3EAP9358.083Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000120RNA polymerase I transcription factor complex9426281.TASComponent
GO:0001650fibrillar center-IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0003899DNA-directed 5'-3' RNA polymerase activity-IEAFunction
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005694chromosome-IEAComponent
GO:0005730nucleolus9426281.TASComponent
GO:0005739mitochondrion-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006361transcription initiation from RNA polymerase I promoter-TASProcess
GO:0006362transcription elongation from RNA polymerase I promoter-TASProcess
GO:0006363termination of RNA polymerase I transcription-TASProcess
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway10373416.TASProcess
GO:0009303rRNA transcription9426281.TASProcess
GO:0045815positive regulation of gene expression, epigenetic-TASProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18289367A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study.BMC Cancer2008 Feb 20Hansen RDdoi: 10.1186/1471-2407-8-54.
23624123Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women.Gene2013 Jul 25Yin Jdoi: 10.1016/j.gene.2013.04.017
25917613NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population.Gene2015 Aug 1Yin Jdoi: 10.1016/j.gene.2015.04.059
26563375Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population.Tumour Biol2016 AprYin Jdoi: 10.1007/s13277-015-4373-3
19396015Association of a single nucleotide polymorphic variation in the human chromosome 19q13.3 with drug responses in the NCI60 cell lines.Anticancer Drugs2009 MarNissen KKdoi: 10.1097/CAD.0b013e3283229ae3.
22335888A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.Lung Cancer2012 JunYin Jdoi: 10.1016/j.lungcan.2012.01.001
2887078319p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese.Chem Biol Interact2017 Nov 1Hou Wdoi: 10.1016/j.cbi.2017.08.018
29620255Different splicing isoforms of ERCC1 affect the expression of its overlapping genes CD3EAP and PPP1R13L, and indicate a potential application in non-small cell lung cancer treatment.Int J Oncol2018 JunZhang Gdoi: 10.3892/ijo.2018.4347
30128886GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.Curr Med Sci2018 AugYin JYdoi: 10.1007/s11596-018-1938-6

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1945407109Missense_Mutationrs756102625S13F0.1
BLCAchr1945408456Missense_MutationnovelS163L0.7RNA_polI_A34
BLCAchr1945409243SilentnovelK425K0.09
BLCAchr1945408952Missense_MutationnovelK328N0.29
BLCAchr1945409246SilentnovelK426K0.39
BLCAchr1945409255Missense_MutationNAE429D0.69
BRCAchr19454065725'UTRnovel0.44
BRCAchr1945408745Missense_MutationnovelK259N0.12
BRCAchr1945409076Missense_MutationNAE370K0.16
BRCAchr1945408159Missense_MutationnovelS64F0.16RNA_polI_A34
CESCchr1945408692SilentnovelL242L0.22
CESCchr1945408795Missense_MutationnovelT276S0.25
CESCchr1945409012Missense_MutationNAE348D0.38
CESCchr1945409240Frame_Shift_DelnovelK425Rfs*100.27
CESCchr1945409242Frame_Shift_DelnovelK426Efs*100.27
CESCchr19454098023'UTRnovel0.37
CESCchr1945409445Missense_Mutationrs372336084E493K0.45
COADchr1945408984Missense_Mutationrs778451525M339T0.31
COADchr1945408173Missense_Mutationrs778171085V69I0.1RNA_polI_A34
COADchr1945408455Missense_MutationNAS163T0.27RNA_polI_A34
COADchr1945408582Missense_MutationNAS205L0.5RNA_polI_A34
COADchr19454065625'UTRnovel0.44
COADchr1945408999Missense_Mutationrs146750944T344M0.27
COADchr19454065425'UTRnovel0.29
ESCAchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.39RNA_polI_A34
GBMchr1945408916Frame_Shift_DelnovelE316Dfs*240.28
GBMchr1945408599Missense_Mutationrs751999730R211W0.16RNA_polI_A34
HNSCchr1945407131SilentnovelA20A0.26
HNSCchr1945409055Missense_MutationnovelT363A0.31
HNSCchr1945407134SilentnovelK21K0.24
KIRCchr1945409426Frame_Shift_InsnovelN487Afs*320.08
KIRCchr1945409428Missense_MutationnovelN487S0.08
KIRPchr1945408268Frame_Shift_DelnovelA101Qfs*150.47RNA_polI_A34
LGGchr1945409083Missense_Mutationrs112438131A372V0.39
LUADchr1945408140Missense_MutationNAG58R0.26RNA_polI_A34
LUADchr1945409246Missense_MutationNAK426N0.33
LUADchr1945408721Missense_MutationnovelK251N0.06RNA_polI_A34
LUSCchr1945408976SilentnovelQ336Q0.17
LUSCchr1945408997SilentnovelG343G0.06
LUSCchr1945409340Missense_MutationnovelG458R0.28
LUSCchr1945408358SilentnovelL130L0.2
OVchr1945408195Missense_MutationnovelK76M0.11RNA_polI_A34
OVchr1945408507Missense_MutationnovelQ180R0.26RNA_polI_A34
OVchr1945409445Missense_MutationnovelE493Q0.26
OVchr1945409417SilentnovelG483G0.19
OVchr1945408953Frame_Shift_DelnovelR330Kfs*80.05
OVchr1945407168Missense_MutationNAE33K0.46
OVchr1945408716Missense_MutationnovelT250S0.07RNA_polI_A34
PRADchr1945408709Silentrs749731534P247P0.38
READchr1945408512Frame_Shift_DelNAT182Qfs*100.17RNA_polI_A34
READchr1945408142SilentnovelG58G0.16
SARCchr1945407186Missense_MutationnovelD39N0.14
SARCchr1945409039SilentnovelL357L0.1
SARCchr1945408799Silentrs370766397E277E0.37
SKCMchr1945408920SilentNAL318L0.14
STADchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.36RNA_polI_A34
STADchr1945408265Silentrs140241488T99T0.25
STADchr1945407113Frame_Shift_InsnovelN17Qfs*1030.09
STADchr1945408465Frame_Shift_DelnovelN168Tfs*140.22RNA_polI_A34
STADchr1945408940Frame_Shift_InsnovelT327Yfs*810.07
STADchr1945409379Missense_MutationNAR471W0.18
STADchr1945409258SilentnovelR430R0.3
STADchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.2RNA_polI_A34
STADchr1945408885Missense_MutationnovelT306K0.08
STADchr1945407235Missense_MutationnovelC55F0.06RNA_polI_A34
STADchr1945408212Missense_MutationnovelV82F0.27RNA_polI_A34
STADchr1945408761Missense_MutationnovelE265Q0.26
STADchr1945408890Missense_MutationnovelE308Q0.32
STADchr1945409329Missense_MutationNAR454M0.28
STADchr1945408879Missense_MutationNAG304V0.14
STADchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.16RNA_polI_A34
STADchr1945408359Nonsense_MutationNAQ131*0.13RNA_polI_A34
STADchr1945409249Frame_Shift_DelnovelK428Efs*50.04
STADchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.13RNA_polI_A34
UCECchr1945408855Missense_Mutationrs143986145T296M0.38
UCECchr1945409276SilentnovelE436E0.42
UCECchr1945408393Missense_MutationnovelP142H0.19RNA_polI_A34
UCECchr1945409378Missense_MutationnovelS470R0.49
UCECchr1945408924Missense_MutationNAE319G0.16
UCECchr1945408616SilentnovelK216K0.32
UCECchr1945407129Missense_MutationnovelA20T0.29
UCECchr1945408583Silentrs77680493S205S0.35
UCECchr1945409452Missense_MutationnovelP495L0.42
UCECchr19454066655'UTRnovel0.26
UCECchr1945407164SilentnovelS31S0.48
UCECchr19454065295'UTRnovel0.6
UCECchr19454098693'UTRnovel0.37
UCECchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.33RNA_polI_A34
UCECchr1945408244Silentrs200375319A92A0.43
UCECchr1945408197Missense_MutationnovelR77W0.5RNA_polI_A34
UCECchr1945408143Missense_Mutationrs549329477R59W0.39RNA_polI_A34
UCECchr1945409063Silentrs755479894A365A0.37
UCECchr1945409420Silentrs199556175P484P0.42
UCECchr1945408614Frame_Shift_Delrs753626854N218Ifs*40.37RNA_polI_A34
UCECchr1945408616SilentnovelK216K0.37
UCECchr19454097913'UTRnovel0.16
UCECchr1945409460Missense_Mutationrs777786624R498W0.48
UCECchr1945408396Missense_MutationnovelP143H0.23RNA_polI_A34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.07120.027508
KIRPDEL0.04170.054726
READDEL0.06670.23023
TGCTDEL0.28670.0046229
UCSDEL0.19640.12448

Survival Analysis
CancerP-value Q-value
KIRC0.00069

Kaplan-Meier Survival Analysis

SARC0.00026

Kaplan-Meier Survival Analysis

MESO0.00016

Kaplan-Meier Survival Analysis

HNSC0.03

Kaplan-Meier Survival Analysis

SKCM0.0023

Kaplan-Meier Survival Analysis

KIRP0.0019

Kaplan-Meier Survival Analysis

UCEC0.00046

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.00083

Kaplan-Meier Survival Analysis

THCA0.031

Kaplan-Meier Survival Analysis

LUAD0.00045

Kaplan-Meier Survival Analysis

UVM0.012

Kaplan-Meier Survival Analysis


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