EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000118058 (Gene tree)
Gene ID: 4297
Gene Symbol: KMT2A
Alias: TRX1|HRX|ALL-1|HTRX1|CXXC7|MLL1A|MLL
Full Name: lysine methyltransferase 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 90,369 bases
Position: chr11:118,436,464-118,526,832
Accession: 7132
RBP type: non-canonical RBP
Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20460131	Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.	J Mol Biol	2010 Jul 9	Hom RA	doi: 10.1016/j.jmb.2010.04.067
24521543	Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.	Elife	2014 Feb 12	Yang YW	doi: 10.7554/eLife.02046.
26974154	RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.	J Clin Invest	2016 Apr 1	Palanichamy JK	doi: 10.1172/JCI80046
27856324	MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27acetylation.	Exp Hematol	2017 Mar	Godfrey L	doi: 10.1016/j.exphem.2016.11.003

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000648029	KMT2A-217	342	-	-	- (aa)	-	-
ENST00000527869	KMT2A-206	481	-	ENSP00000432652	160 (aa)	-	H7C5V8
ENST00000649666	KMT2A-221	520	-	ENSP00000497918	50 (aa)	-	-
ENST00000389506	KMT2A-201	13678	XM_011542831	ENSP00000374157	3969 (aa)	XP_011541133	Q03164
ENST00000649410	KMT2A-220	158	-	-	- (aa)	-	-
ENST00000649878	KMT2A-224	2321	-	ENSP00000497891	69 (aa)	-	-
ENST00000534085	KMT2A-212	1992	-	-	- (aa)	-	-
ENST00000531904	KMT2A-209	4320	-	ENSP00000432391	1439 (aa)	-	E9PR05
ENST00000648910	KMT2A-219	1410	-	-	- (aa)	-	-
ENST00000420751	KMT2A-203	237	-	-	- (aa)	-	-
ENST00000525408	KMT2A-204	857	-	-	- (aa)	-	-
ENST00000533790	KMT2A-211	908	-	ENSP00000436700	302 (aa)	-	H7C5W4
ENST00000648565	KMT2A-218	1851	-	-	- (aa)	-	-
ENST00000534678	KMT2A-214	1793	-	-	- (aa)	-	-
ENST00000532204	KMT2A-210	499	-	ENSP00000434618	87 (aa)	-	H0YEU4
ENST00000649690	KMT2A-222	521	-	ENSP00000497372	173 (aa)	-	-
ENST00000649699	KMT2A-223	11796	-	ENSP00000496927	3931 (aa)	-	UPI00014F7ADB
ENST00000528278	KMT2A-207	8635	-	-	- (aa)	-	-
ENST00000527839	KMT2A-205	4823	-	-	- (aa)	-	-
ENST00000529852	KMT2A-208	2572	-	ENSP00000436564	87 (aa)	-	H0YEU4
ENST00000534358	KMT2A-213	16628	XM_006718839	ENSP00000436786	3972 (aa)	XP_006718902	Q03164
ENST00000647638	KMT2A-215	1982	-	-	- (aa)	-	-
ENST00000647944	KMT2A-216	713	-	ENSP00000498134	237 (aa)	-	-
ENST00000392873	KMT2A-202	866	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000118058's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG
hsa04934	Cushing syndrome	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118058	Cholesterol	9.3836511376271E-5	17903299
ENSG00000118058	Blood Pressure	1.5201852E-005	-
ENSG00000118058	Depressive Disorder	1E-6	27089181
ENSG00000118058	Attention Deficit Disorder with Hyperactivity	5E-6	23453885
ENSG00000118058	Bipolar Disorder	5E-6	23453885
ENSG00000118058	Child Development Disorders, Pervasive	5E-6	23453885
ENSG00000118058	Depressive Disorder	5E-6	23453885
ENSG00000118058	Schizophrenia	5E-6	23453885

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118058	rs2017122	11	118444134	T	Depression	27089181	[NR] z score increase	4.811745	EFO_0003761\|EFO_0007006
ENSG00000118058	rs1064939	11	118525616	?	Body mass index	30595370			EFO_0004340
ENSG00000118058	rs74422681	11	118442155	?	Red blood cell count	30595370			EFO_0004305
ENSG00000118058	rs9332781	11	118475884	G	Neuroticism	30643256	[0.011-0.023] unit increase	0.016883075	EFO_0007660
ENSG00000118058	rs9332801	11	118484927	C	Depressive symptoms	30643256	[0.0072-0.0149] unit increase	0.011005157	EFO_0007006
ENSG00000118058	rs9332801	11	118484927	C	Well-being spectrum (multivariate analysis)	30643256	[0.0072-0.0146] unit increase	0.010940774	EFO_0007869
ENSG00000118058	rs9332801	11	118484927	C	Positive affect	30643256	[0.0085-0.0178] unit increase	0.013162976	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118058's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	ISS	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0003680	AT DNA binding	1423624.	NAS	Function
GO:0003700	DNA-binding transcription factor activity	10821850.	NAS	Function
GO:0005515	protein binding	11313484.15199122.15960975.18840606.19187761.19556245.20541251.20541477.20581860.20818375.20969867.21113167.21220120.22327296.22722839.23870121.25751424.26886794.27705803.	IPI	Function
GO:0005634	nucleus	11313484.15640349.22046413.	IDA	Component
GO:0005634	nucleus	1423624.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	10821850.	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0008270	zinc ion binding	16990798.19187761.	IDA	Function
GO:0032411	positive regulation of transporter activity	20861184.	IMP	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0035097	histone methyltransferase complex	19556245.	IDA	Component
GO:0035162	embryonic hemopoiesis	15618964.	TAS	Process
GO:0042800	histone methyltransferase activity (H3-K4 specific)	22012064.	EXP	Function
GO:0042800	histone methyltransferase activity (H3-K4 specific)	19187761.19556245.	IDA	Function
GO:0042800	histone methyltransferase activity (H3-K4 specific)	15960975.	IMP	Function
GO:0042802	identical protein binding	10656681.11313484.	IPI	Function
GO:0042803	protein homodimerization activity	11313484.	IDA	Function
GO:0043984	histone H4-K16 acetylation	15960975.	IMP	Process
GO:0044212	transcription regulatory region DNA binding	20484083.	IDA	Function
GO:0045322	unmethylated CpG binding	16990798.20010842.	IDA	Function
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	15960975.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20861184.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20010842.	IMP	Process
GO:0051568	histone H3-K4 methylation	19556245.	IDA	Process
GO:0051568	histone H3-K4 methylation	15960975.	IMP	Process
GO:0051571	positive regulation of histone H3-K4 methylation	-	ISS	Process
GO:0065003	protein-containing complex assembly	15199122.	IDA	Process
GO:0070577	lysine-acetylated histone binding	19187761.	IDA	Function
GO:0071339	MLL1 complex	15960975.	IDA	Component
GO:0071440	regulation of histone H3-K14 acetylation	-	ISS	Process
GO:0080182	histone H3-K4 trimethylation	20861184.	IDA	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1905642	negative regulation of DNA methylation	20010842.	IMP	Process
GO:2000615	regulation of histone H3-K9 acetylation	-	ISS	Process
GO:2001040	positive regulation of cellular response to drug	20861184.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28182322	Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.	Mol Oncol	2017 Apr	Weirich S	doi: 10.1002/1878-0261.12041
18566324	DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.	Blood	2008 Sep 1	Whitman SP	doi: 10.1182/blood-2008-01-128595
19835597	Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.	Mol Cancer	2009 Oct 16	Rhrs S	doi: 10.1186/1476-4598-8-86.
21706045	Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression.	Oncogene	2012 Jan 26	Dou L	doi: 10.1038/onc.2011.248
23132946	MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.	Proc Natl Acad Sci U S A	2012 Nov 20	Jiang X	doi: 10.1073/pnas.1217519109
15640349	Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.	Proc Natl Acad Sci U S A	2005 Jan 18	Milne TA	-
16604156	Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.	PLoS Genet	2006 Apr	Scacheri PC	-
22926525	Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo.	Oncogene	2013 Jul 11	Ansari KI	doi: 10.1038/onc.2012.352
21757704	Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.	J Biol Chem	2011 Sep 9	Murai MJ	doi: 10.1074/jbc.M111.258186
27888797	Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.	Oncotarget	2017 Jan 3	Svoboda LK	doi: 10.18632/oncotarget.13444.
28500307	ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.	Sci Rep	2017 May 12	Wang Y	doi: 10.1038/s41598-017-01913-y.
26625313	Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing.	Oncotarget	2016 Jan 19	Wu S	doi: 10.18632/oncotarget.6380.
22046413	Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.	PLoS One	2011	Dey P	doi: 10.1371/journal.pone.0026926
28131992	The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.	J Natl Cancer Inst	2017 Jan 28	Lu C	doi: 10.1093/jnci/djw283
28905448	Myeloid Zinc Finger 1 and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 in Cancer Cells.	Stem Cells	2017 Dec	Verma NK	doi: 10.1002/stem.2705

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	118473788	Missense_Mutation	novel	D877H	0.35
ACC	chr11	118498037	Missense_Mutation	novel	K1919N	0.2
ACC	chr11	118504129	Missense_Mutation	novel	R2743T	0.4
BLCA	chr11	118503212	Missense_Mutation	novel	F2437L	0.18
BLCA	chr11	118505688	Missense_Mutation	novel	P3263A	0.17
BLCA	chr11	118506188	Silent	novel	L3429L	0.2
BLCA	chr11	118506637	Nonsense_Mutation	novel	S3579*	0.09
BLCA	chr11	118503182	Silent	novel	Q2427Q	0.15
BLCA	chr11	118504194	Missense_Mutation	NA	E2765Q	0.08
BLCA	chr11	118472065	Silent	novel	R302R	0.33
BLCA	chr11	118472162	Nonsense_Mutation	novel	E335*	0.16
BLCA	chr11	118472537	Missense_Mutation	novel	E460K	0.28
BLCA	chr11	118493180	Missense_Mutation	novel	D1707N	0.14
BLCA	chr11	118503417	Missense_Mutation	NA	E2506Q	0.12
BLCA	chr11	118505731	Missense_Mutation	novel	S3277L	0.22
BLCA	chr11	118505611	Missense_Mutation	novel	S3237C	0.27
BLCA	chr11	118503665	Nonsense_Mutation	novel	Y2588*	0.54
BLCA	chr11	118473822	Missense_Mutation	rs782096521	S888L	0.58
BLCA	chr11	118473572	Nonsense_Mutation	novel	Q805*	0.45
BLCA	chr11	118503417	Missense_Mutation	NA	E2506K	0.28
BLCA	chr11	118503875	Missense_Mutation	rs142807735	K2658N	0.22
BLCA	chr11	118504416	Missense_Mutation	NA	D2839N	0.28
BLCA	chr11	118488696	Frame_Shift_Del	novel	*N1473Ifs113**	0.47
BLCA	chr11	118474276	Missense_Mutation	novel	K1039N	0.15
BLCA	chr11	118506531	Nonsense_Mutation	novel	Q3544*	0.21
BLCA	chr11	118503017	Missense_Mutation	novel	L2372F	0.08
BLCA	chr11	118503331	Missense_Mutation	rs782040269	R2477Q	0.13
BLCA	chr11	118511993	Nonsense_Mutation	novel	S3702*	0.15
BLCA	chr11	118505507	Silent	novel	S3202S	0.28
BLCA	chr11	118491196	Missense_Mutation	NA	G1566E	0.15
BLCA	chr11	118471676	Nonsense_Mutation	NA	R173*	0.36
BLCA	chr11	118522040	Frame_Shift_Del	novel	*V3927Hfs6**	0.45
BLCA	chr11	118503922	Nonsense_Mutation	novel	S2674*	0.41
BLCA	chr11	118473599	Nonsense_Mutation	novel	Q814*	0.48
BLCA	chr11	118498417	Silent	NA	L1947L	0.36
BLCA	chr11	118504419	Missense_Mutation	novel	D2840N	0.29
BLCA	chr11	118519734	Nonsense_Mutation	novel	E3752*	0.13
BLCA	chr11	118502965	Missense_Mutation	novel	S2355F	0.12
BLCA	chr11	118501738	Missense_Mutation	novel	P2126L	0.22
BLCA	chr11	118503242	Frame_Shift_Del	novel	E2448*	0.39
BLCA	chr11	118519793	Splice_Site	novel	X3771_splice	0.17
BLCA	chr11	118507537	Missense_Mutation	novel	G3585E	0.31
BLCA	chr11	118505739	Nonsense_Mutation	NA	R3280*	0.4
BLCA	chr11	118503497	Missense_Mutation	novel	E2532D	0.12
BLCA	chr11	118478083	Nonsense_Mutation	NA	R1151*	0.09
BLCA	chr11	118501005	Nonsense_Mutation	novel	W2056*	0.16
BLCA	chr11	118503582	Frame_Shift_Ins	novel	*E2563Lfs2**	0.35
BLCA	chr11	118484973	Missense_Mutation	NA	E1444Q	0.36
BLCA	chr11	118471831	Frame_Shift_Ins	novel	*P225Afs28**	0.08
BLCA	chr11	118471832	Frame_Shift_Ins	novel	*P225Hfs31**	0.07
BLCA	chr11	118473796	Silent	NA	E879E	0.3
BLCA	chr11	118502945	Silent	rs780538462	I2348I	0.19
BLCA	chr11	118481870	Nonsense_Mutation	novel	R1264*	0.29
BLCA	chr11	118472082	Missense_Mutation	novel	S308L	0.16
BLCA	chr11	118478118	Missense_Mutation	novel	Q1162H	0.18
BLCA	chr11	118472378	Nonsense_Mutation	NA	R407*	0.27
BLCA	chr11	118468820	Nonsense_Mutation	novel	R160*	0.12
BLCA	chr11	118478125	Missense_Mutation	NA	E1165K	0.37
BLCA	chr11	118473568	Silent	novel	L803L	0.53
BLCA	chr11	118502656	Nonsense_Mutation	novel	S2252*	0.13
BLCA	chr11	118504848	Missense_Mutation	novel	P2983S	0.55
BLCA	chr11	118506193	Missense_Mutation	novel	S3431C	0.58
BLCA	chr11	118504304	Silent	novel	L2801L	0.18
BLCA	chr11	118482093	Splice_Site	novel	X1338_splice	0.44
BLCA	chr11	118497956	Nonsense_Mutation	NA	Y1892*	0.3
BLCA	chr11	118473342	Missense_Mutation	novel	S728F	0.65
BRCA	chr11	118495860	Missense_Mutation	NA	T1839A	0.38
BRCA	chr11	118471922	Missense_Mutation	novel	K255E	0.18
BRCA	chr11	118501031	Missense_Mutation	novel	C2065Y	0.08
BRCA	chr11	118505035	Missense_Mutation	NA	K3045T	0.13
BRCA	chr11	118474164	Missense_Mutation	NA	S1002C	0.5
BRCA	chr11	118473857	Nonsense_Mutation	NA	Q900*	0.16
BRCA	chr11	118472484	Missense_Mutation	NA	R442Q	0.32
BRCA	chr11	118484297	Missense_Mutation	novel	I1401F	0.26
BRCA	chr11	118500986	Splice_Site	NA	X2050_splice	0.39
BRCA	chr11	118502701	Frame_Shift_Del	NA	*R2268Gfs6**	0.5
BRCA	chr11	118484197	Silent	rs781789464	P1367P	0.24
BRCA	chr11	118496302	Frame_Shift_Del	NA	*P1865Qfs3**	0.68
BRCA	chr11	118520850	Frame_Shift_Del	NA	*K3825Rfs31**	0.23
BRCA	chr11	118434931	5'Flank	novel		0.66
BRCA	chr11	118505069	Silent	NA	P3056P	0.49
BRCA	chr11	118480187	Nonsense_Mutation	NA	Q1195*	0.47
BRCA	chr11	118493172	Frame_Shift_Del	novel	*P1705Efs15**	0.44
BRCA	chr11	118507610	Splice_Site	novel	X3609_splice	0.13
BRCA	chr11	118504935	Missense_Mutation	novel	V3012I	0.08
BRCA	chr11	118522130	Silent	NA	P3956P	0.81
BRCA	chr11	118524997	3'Flank	novel		0.21
BRCA	chr11	118472997	Missense_Mutation	rs782339326	R613Q	0.07
BRCA	chr11	118502401	Missense_Mutation	novel	S2167N	0.09
BRCA	chr11	118481886	Frame_Shift_Del	novel	*K1270Efs2**	0.1
BRCA	chr11	118484197	Silent	novel	P1367P	0.1
BRCA	chr11	118506031	Missense_Mutation	NA	S3377L	0.27
BRCA	chr11	118473113	Nonsense_Mutation	NA	R652*	0.24
BRCA	chr11	118519702	Missense_Mutation	NA	R3741Q	0.17
BRCA	chr11	118505756	Silent	NA	I3285I	0.27
BRCA	chr11	118504507	Missense_Mutation	NA	S2869L	0.35
BRCA	chr11	118478187	Silent	novel	K1185K	0.08
BRCA	chr11	118488671	Nonsense_Mutation	NA	E1464*	0.83
BRCA	chr11	118473121	Silent	novel	P654P	0.06
CESC	chr11	118505968	Missense_Mutation	rs149340870	A3356V	0.21
CESC	chr11	118472185	Silent	NA	K342K	0.38
CESC	chr11	118506218	Silent	NA	A3439A	0.32
CESC	chr11	118504798	Missense_Mutation	novel	S2966C	0.2
CESC	chr11	118505499	Missense_Mutation	NA	E3200Q	0.55
CESC	chr11	118520000	Missense_Mutation	NA	R3786C	0.43
CESC	chr11	118522536	3'UTR	novel		0.44
CESC	chr11	118434867	5'Flank	novel		0.4
CESC	chr11	118439058	Intron	novel		0.12
CESC	chr11	118478087	Missense_Mutation	NA	S1152L	0.3
CESC	chr11	118482453	Silent	novel	A1348A	0.25
CESC	chr11	118484869	Missense_Mutation	novel	C1409Y	0.18
CESC	chr11	118501703	Silent	novel	A2114A	0.3
CESC	chr11	118505749	Missense_Mutation	novel	P3283H	0.3
CESC	chr11	118522787	3'UTR	rs782460416		0.18
CESC	chr11	118506589	Missense_Mutation	NA	S3563I	0.37
CESC	chr11	118524531	3'Flank	novel		0.31
CESC	chr11	118472050	Silent	novel	V297V	0.43
CESC	chr11	118491755	Missense_Mutation	NA	E1608K	0.89
CESC	chr11	118523769	3'UTR	novel		0.21
CESC	chr11	118499900	Missense_Mutation	NA	P2046S	0.53
CESC	chr11	118504868	Missense_Mutation	rs781817780	M2989I	0.4
CESC	chr11	118519745	Frame_Shift_Ins	NA	*N3759Efs9**	0.43
CHOL	chr11	118494361	Missense_Mutation	novel	K1748I	0.6
CHOL	chr11	118524372	3'Flank	novel		0.5
CHOL	chr11	118524711	3'Flank	novel		0.67
COAD	chr11	118472601	Missense_Mutation	NA	S481N	0.37
COAD	chr11	118472760	Missense_Mutation	NA	S534L	0.35
COAD	chr11	118476828	Missense_Mutation	rs782157422	E1060D	0.33
COAD	chr11	118498503	Missense_Mutation	rs782785673	R1976Q	0.33
COAD	chr11	118502945	Silent	rs780538462	I2348I	0.38
COAD	chr11	118503890	Silent	rs782199290	G2663G	0.44
COAD	chr11	118506243	Missense_Mutation	rs139366882	E3448K	0.39
COAD	chr11	118506628	Missense_Mutation	NA	S3576F	0.38
COAD	chr11	118472521	Silent	NA	P454P	0.14
COAD	chr11	118511990	Missense_Mutation	NA	R3701Q	0.2
COAD	chr11	118494727	Frame_Shift_Del	novel	*K1773Sfs47**	0.26
COAD	chr11	118472217	Missense_Mutation	NA	R353Q	0.08
COAD	chr11	118503053	Missense_Mutation	novel	D2384E	0.34
COAD	chr11	118472334	Missense_Mutation	novel	A392V	0.37
COAD	chr11	118522162	Missense_Mutation	novel	F3967Y	0.27
COAD	chr11	118502951	Silent	novel	S2350S	0.35
COAD	chr11	118505764	Missense_Mutation	NA	R3288I	0.25
COAD	chr11	118505968	Missense_Mutation	rs149340870	A3356V	0.24
COAD	chr11	118520837	Missense_Mutation	NA	R3819H	0.31
COAD	chr11	118506101	Silent	rs9332843	P3400P	0.48
COAD	chr11	118496333	Missense_Mutation	rs782094920	A1874V	0.43
COAD	chr11	118481879	Missense_Mutation	rs376303494	V1267I	0.2
COAD	chr11	118484870	Silent	novel	C1409C	0.08
COAD	chr11	118478092	Missense_Mutation	NA	R1154W	0.44
COAD	chr11	118494704	Missense_Mutation	NA	R1764H	0.38
COAD	chr11	118498386	Frame_Shift_Del	NA	*K1938Sfs43**	0.42
COAD	chr11	118521360	Silent	rs200576371	A3859A	0.52
COAD	chr11	118521970	Missense_Mutation	NA	R3903H	0.26
COAD	chr11	118490231	Missense_Mutation	NA	A1560T	0.17
COAD	chr11	118488681	Missense_Mutation	NA	L1467P	0.43
COAD	chr11	118498016	Silent	NA	E1912E	0.42
COAD	chr11	118505488	Frame_Shift_Del	NA	*L3197Wfs15**	0.31
COAD	chr11	118503345	Missense_Mutation	NA	V2482I	0.31
COAD	chr11	118506167	Silent	rs782505642	A3422A	0.15
COAD	chr11	118522142	Silent	rs201724179	G3960G	0.36
COAD	chr11	118476838	Nonsense_Mutation	NA	R1064*	0.17
COAD	chr11	118472814	Frame_Shift_Del	NA	*Q554Sfs13**	0.43
COAD	chr11	118521970	Missense_Mutation	NA	R3903H	0.33
COAD	chr11	118472402	Missense_Mutation	novel	S415G	0.1
COAD	chr11	118505355	Missense_Mutation	novel	G3152R	0.05
COAD	chr11	118436830	Silent	novel	L106L	0.41
COAD	chr11	118522056	Missense_Mutation	NA	R3932C	0.19
COAD	chr11	118505156	Missense_Mutation	NA	M3085I	0.25
COAD	chr11	118473198	Missense_Mutation	NA	S680L	0.34
COAD	chr11	118473392	Nonsense_Mutation	rs727503777	R745*	0.35
COAD	chr11	118490147	Missense_Mutation	rs781990391	R1532C	0.39
COAD	chr11	118505202	Missense_Mutation	NA	K3101Q	0.34
COAD	chr11	118504719	Missense_Mutation	NA	T2940A	0.3
COAD	chr11	118502562	Missense_Mutation	NA	R2221G	0.27
COAD	chr11	118502463	Nonsense_Mutation	NA	R2188*	0.39
COAD	chr11	118504042	Missense_Mutation	novel	I2714S	0.27
COAD	chr11	118482028	Frame_Shift_Del	NA	*E1318Kfs38**	0.28
COAD	chr11	118505200	Frame_Shift_Del	NA	*I3102Sfs3**	0.32
COAD	chr11	118472308	Frame_Shift_Ins	novel	*Q384Ffs6**	0.04
COAD	chr11	118481943	Frame_Shift_Ins	novel	*P1289Ffs68**	0.17
COAD	chr11	118491900	In_Frame_Ins	novel	T1656_T1657insSH	0.08
COAD	chr11	118507600	Missense_Mutation	NA	Q3606R	0.21
COAD	chr11	118501072	Missense_Mutation	NA	V2079I	0.5
COAD	chr11	118436804	Missense_Mutation	novel	S98P	0.44
COAD	chr11	118503987	Nonsense_Mutation	rs587783680	R2696*	0.39
COAD	chr11	118473743	Nonsense_Mutation	NA	R862*	0.4
COAD	chr11	118472302	Silent	novel	K381K	0.33
COAD	chr11	118473471	Frame_Shift_Del	NA	*P773Rfs8**	0.21
DLBC	chr11	118501804	Missense_Mutation	rs781897465	P2148L	0.33
DLBC	chr11	118501046	Missense_Mutation	novel	K2070R	0.21
ESCA	chr11	118472675	Missense_Mutation	novel	T506A	0.21
ESCA	chr11	118504240	Missense_Mutation	novel	M2780T	0.42
ESCA	chr11	118510075	Missense_Mutation	novel	I3673M	0.12
ESCA	chr11	118481870	Nonsense_Mutation	novel	R1264*	0.9
ESCA	chr11	118504675	Missense_Mutation	novel	L2925Q	0.53
ESCA	chr11	118522057	Missense_Mutation	NA	R3932H	0.5
ESCA	chr11	118504348	Missense_Mutation	NA	S2816C	0.09
ESCA	chr11	118472301	Frame_Shift_Ins	novel	*A383Gfs6**	0.42
ESCA	chr11	118478093	Missense_Mutation	NA	R1154Q	0.4
ESCA	chr11	118495788	Missense_Mutation	NA	E1815K	0.37
GBM	chr11	118521309	Silent	novel	G3842G	0.16
GBM	chr11	118506526	Missense_Mutation	novel	R3542L	0.18
GBM	chr11	118501050	Silent	novel	I2071I	0.03
GBM	chr11	118506258	Missense_Mutation	novel	Q3453E	0.13
GBM	chr11	118506356	Silent	novel	Q3485Q	0.09
GBM	chr11	118502920	Missense_Mutation	novel	S2340Y	0.07
GBM	chr11	118505731	Nonsense_Mutation	novel	S3277*	0.04
GBM	chr11	118472785	Silent	novel	T542T	0.16
GBM	chr11	118473199	Silent	novel	S680S	0.45
GBM	chr11	118481996	Missense_Mutation	novel	P1306T	0.26
GBM	chr11	118503757	Missense_Mutation	novel	R2619H	0.28
GBM	chr11	118506392	Silent	novel	Q3497Q	0.19
GBM	chr11	118519985	Missense_Mutation	novel	L3781M	0.48
GBM	chr11	118473022	Frame_Shift_Ins	novel	*L622Vfs5**	0.07
GBM	chr11	118503828	Nonsense_Mutation	novel	E2643*	0.08
GBM	chr11	118502792	Silent	NA	V2297V	0.44
GBM	chr11	118505810	Silent	NA	P3303P	0.37
GBM	chr11	118519644	Frame_Shift_Del	novel	*I3722Ffs37**	0.29
GBM	chr11	118471963	Silent	novel	T268T	0.05
GBM	chr11	118472742	Frame_Shift_Ins	novel	*S528Rfs40**	0.06
GBM	chr11	118472020	Silent	novel	T287T	0.13
GBM	chr11	118501034	Missense_Mutation	novel	V2066E	0.17
GBM	chr11	118471921	Missense_Mutation	novel	K254N	0.06
GBM	chr11	118503147	Missense_Mutation	rs782181274	E2416K	0.52
GBM	chr11	118504546	Missense_Mutation	novel	G2882V	0.17
GBM	chr11	118504934	Silent	NA	S3011S	0.22
GBM	chr11	118503063	Missense_Mutation	novel	S2388P	0.06
GBM	chr11	118519694	Missense_Mutation	novel	K3738N	0.08
GBM	chr11	118506414	Missense_Mutation	novel	V3505L	0.04
GBM	chr11	118505983	Missense_Mutation	novel	H3361P	0.1
GBM	chr11	118473288	Missense_Mutation	novel	R710K	0.07
GBM	chr11	118506144	Missense_Mutation	novel	P3415T	0.29
GBM	chr11	118504160	Silent	novel	L2753L	0.15
GBM	chr11	118507572	Nonsense_Mutation	novel	E3597*	0.14
HNSC	chr11	118506179	Silent	novel	I3426I	0.06
HNSC	chr11	118491830	Nonsense_Mutation	NA	R1633*	0.3
HNSC	chr11	118473917	Missense_Mutation	novel	D920H	0.07
HNSC	chr11	118519662	Missense_Mutation	rs781822608	V3728L	0.1
HNSC	chr11	118471762	Silent	novel	K201K	0.3
HNSC	chr11	118522074	Missense_Mutation	novel	E3938K	0.16
HNSC	chr11	118505160	Missense_Mutation	novel	P3087S	0.1
HNSC	chr11	118498047	Frame_Shift_Ins	novel	*M1923Ifs12**	0.24
HNSC	chr11	118504634	Silent	NA	V2911V	0.25
HNSC	chr11	118499835	Missense_Mutation	novel	G2024V	0.31
HNSC	chr11	118502646	Missense_Mutation	novel	P2249S	0.18
HNSC	chr11	118481870	Nonsense_Mutation	novel	R1264*	0.07
HNSC	chr11	118491254	Missense_Mutation	novel	M1585I	0.23
HNSC	chr11	118491241	Missense_Mutation	novel	Y1581C	0.43
HNSC	chr11	118498429	In_Frame_Del	novel	S1952_F1956del	0.14
HNSC	chr11	118522209	3'UTR	novel		0.56
HNSC	chr11	118468811	Missense_Mutation	novel	V157I	0.36
HNSC	chr11	118476821	Nonsense_Mutation	novel	S1058*	0.25
HNSC	chr11	118505756	Silent	NA	I3285I	0.48
HNSC	chr11	118499907	Missense_Mutation	novel	G2048V	0.25
HNSC	chr11	118519667	Silent	novel	F3729F	0.36
HNSC	chr11	118505310	Missense_Mutation	novel	P3137A	0.05
HNSC	chr11	118506647	Splice_Site	novel	X3582_splice	0.07
HNSC	chr11	118436866	Silent	novel	V118V	0.17
HNSC	chr11	118493226	Missense_Mutation	novel	S1722C	0.11
HNSC	chr11	118472748	Missense_Mutation	novel	R530K	0.14
HNSC	chr11	118503223	Missense_Mutation	novel	H2441R	0.33
HNSC	chr11	118501021	Missense_Mutation	novel	R2062C	0.13
KIRC	chr11	118478180	Frame_Shift_Ins	novel	*I1184Yfs28**	0.26
KIRC	chr11	118504336	Missense_Mutation	NA	T2812K	0.22
KIRC	chr11	118519741	Missense_Mutation	rs564690648	N3754S	0.31
KIRC	chr11	118499902	Silent	NA	P2046P	0.3
KIRC	chr11	118481998	Silent	rs781862991	P1306P	0.49
KIRC	chr11	118504563	Nonsense_Mutation	NA	E2888*	0.21
KIRP	chr11	118481830	Missense_Mutation	novel	E1250D	0.48
KIRP	chr11	118495768	Missense_Mutation	rs782730461	R1808Q	0.45
KIRP	chr11	118519985	Missense_Mutation	novel	L3781V	0.57
KIRP	chr11	118521285	Splice_Region	novel		0.32
KIRP	chr11	118506437	Silent	rs782373846	P3512P	0.37
KIRP	chr11	118506304	Frame_Shift_Del	novel	*Q3469Sfs19**	0.38
KIRP	chr11	118503217	Missense_Mutation	NA	E2439A	0.4
LAML	chr11	118504209	Frame_Shift_Del	novel	*S2770Vfs17**	0.05
LAML	chr11	118505645	Silent	novel	V3248V	0.13
LAML	chr11	118521915	Missense_Mutation	novel	F3885V	0.07
LAML	chr11	118502719	Missense_Mutation	novel	V2273G	0.04
LAML	chr11	118505570	Missense_Mutation	novel	I3223M	0.07
LAML	chr11	118494291	Missense_Mutation	novel	E1725K	0.1
LAML	chr11	118504386	Silent	NA	L2829L	0.16
LAML	chr11	118519651	Missense_Mutation	novel	H3724R	0.05
LGG	chr11	118503625	Missense_Mutation	NA	P2575L	0.16
LGG	chr11	118473586	Silent	NA	S809S	0.04
LGG	chr11	118509995	Missense_Mutation	NA	M3647V	0.07
LGG	chr11	118472269	Silent	novel	T370T	0.06
LGG	chr11	118481822	Missense_Mutation	novel	A1248T	0.07
LGG	chr11	118481968	Silent	novel	K1296K	0.5
LGG	chr11	118503672	Missense_Mutation	novel	L2591I	0.24
LGG	chr11	118505548	Missense_Mutation	novel	S3216Y	0.55
LGG	chr11	118522056	Missense_Mutation	NA	R3932C	0.4
LIHC	chr11	118506606	Missense_Mutation	novel	I3569V	0.44
LIHC	chr11	118504074	Missense_Mutation	NA	E2725K	0.2
LIHC	chr11	118498415	Missense_Mutation	novel	L1947V	0.1
LIHC	chr11	118506136	Missense_Mutation	novel	S3412L	0.23
LIHC	chr11	118488647	Missense_Mutation	novel	H1456Y	0.21
LIHC	chr11	118436535	Frame_Shift_Del	novel	*R8Pfs20**	0.3
LIHC	chr11	118505739	Nonsense_Mutation	NA	R3280*	0.45
LIHC	chr11	118502792	Silent	NA	V2297V	0.27
LIHC	chr11	118472295	Frame_Shift_Ins	novel	*A383Gfs6**	0.48
LIHC	chr11	118476837	Silent	novel	V1063V	0.05
LIHC	chr11	118491843	Frame_Shift_Del	novel	*E1639Sfs6**	0.17
LIHC	chr11	118476949	Nonsense_Mutation	novel	R1101*	0.35
LIHC	chr11	118471731	Nonsense_Mutation	NA	S191*	0.41
LUAD	chr11	118505849	Silent	rs745636858	T3316T	0.55
LUAD	chr11	118472544	Nonsense_Mutation	novel	S462*	0.06
LUAD	chr11	118481713	Splice_Site	novel	X1212_splice	0.27
LUAD	chr11	118505439	Missense_Mutation	novel	P3180T	0.17
LUAD	chr11	118504762	Missense_Mutation	novel	D2954G	0.39
LUAD	chr11	118506279	Missense_Mutation	NA	A3460P	0.19
LUAD	chr11	118519697	Missense_Mutation	NA	H3739Q	0.59
LUAD	chr11	118505425	Missense_Mutation	novel	P3175L	0.56
LUAD	chr11	118506122	Silent	novel	P3407P	0.08
LUAD	chr11	118504323	Missense_Mutation	novel	R2808C	0.05
LUAD	chr11	118491785	Missense_Mutation	NA	A1618S	0.08
LUAD	chr11	118488646	Silent	novel	F1455F	0.07
LUAD	chr11	118503868	Missense_Mutation	novel	R2656P	0.29
LUAD	chr11	118521409	Missense_Mutation	NA	D3876N	0.09
LUAD	chr11	118468800	Missense_Mutation	NA	S153L	0.26
LUAD	chr11	118481919	Missense_Mutation	novel	G1280V	0.26
LUAD	chr11	118436805	Missense_Mutation	NA	S98L	0.26
LUAD	chr11	118519674	Missense_Mutation	NA	E3732Q	0.36
LUAD	chr11	118519970	Missense_Mutation	NA	D3776H	0.29
LUAD	chr11	118473917	Missense_Mutation	NA	D920Y	0.08
LUAD	chr11	118499313	Missense_Mutation	novel	E1988G	0.11
LUAD	chr11	118472558	Missense_Mutation	novel	Q467E	0.08
LUAD	chr11	118504410	Missense_Mutation	novel	N2837Y	0.1
LUAD	chr11	118493109	Missense_Mutation	NA	R1683P	0.23
LUAD	chr11	118503628	Missense_Mutation	rs147223140	N2576S	0.12
LUAD	chr11	118473540	Missense_Mutation	novel	P794L	0.16
LUAD	chr11	118491303	Missense_Mutation	NA	L1602I	0.15
LUAD	chr11	118472108	Missense_Mutation	novel	G317C	0.41
LUAD	chr11	118510042	Frame_Shift_Ins	novel	*P3665Tfs8**	0.37
LUAD	chr11	118472456	Missense_Mutation	novel	D433Y	0.14
LUAD	chr11	118504053	Missense_Mutation	novel	D2718Y	0.18
LUAD	chr11	118499370	Missense_Mutation	rs782409744	R2007K	0.09
LUAD	chr11	118503395	Silent	NA	P2498P	0.12
LUAD	chr11	118505174	Silent	novel	L3091L	0.88
LUAD	chr11	118473693	Missense_Mutation	novel	T845I	0.28
LUAD	chr11	118495759	Missense_Mutation	novel	W1805L	0.38
LUAD	chr11	118493179	Frame_Shift_Del	novel	*D1707Ifs2**	0.35
LUAD	chr11	118473183	Missense_Mutation	novel	S675L	0.49
LUAD	chr11	118473483	Missense_Mutation	novel	S775F	0.41
LUAD	chr11	118499842	Missense_Mutation	novel	M2026I	0.07
LUSC	chr11	118474053	Missense_Mutation	novel	G965E	0.8
LUSC	chr11	118472436	Missense_Mutation	novel	R426L	0.16
LUSC	chr11	118476825	Silent	novel	S1059S	0.28
LUSC	chr11	118504025	Silent	NA	Q2708Q	0.2
LUSC	chr11	118478080	Missense_Mutation	novel	R1150C	0.23
LUSC	chr11	118503675	Missense_Mutation	novel	P2592S	0.42
LUSC	chr11	118506407	Silent	novel	S3502S	0.3
LUSC	chr11	118520001	Missense_Mutation	novel	R3786H	0.39
LUSC	chr11	118490204	Missense_Mutation	novel	H1551D	0.14
LUSC	chr11	118482086	Nonsense_Mutation	NA	E1336*	0.42
LUSC	chr11	118506085	Missense_Mutation	novel	Q3395L	0.15
LUSC	chr11	118477973	Missense_Mutation	novel	S1114L	0.3
LUSC	chr11	118505763	Silent	novel	R3288R	0.09
LUSC	chr11	118503915	Missense_Mutation	novel	S2672G	0.31
LUSC	chr11	118498381	Silent	novel	F1935F	0.27
LUSC	chr11	118476821	Missense_Mutation	novel	S1058L	0.13
LUSC	chr11	118504419	Missense_Mutation	novel	D2840Y	0.08
LUSC	chr11	118498025	Missense_Mutation	NA	D1915E	0.3
LUSC	chr11	118519731	Missense_Mutation	novel	E3751K	0.16
LUSC	chr11	118496321	Missense_Mutation	novel	N1870S	0.42
LUSC	chr11	118506140	Silent	rs782104581	Q3413Q	0.24
LUSC	chr11	118506642	Missense_Mutation	novel	T3581S	0.49
LUSC	chr11	118519647	Missense_Mutation	NA	L3723V	0.14
LUSC	chr11	118473843	Missense_Mutation	rs200600434	K895R	0.09
LUSC	chr11	118503739	Missense_Mutation	NA	K2613R	0.31
LUSC	chr11	118495719	Missense_Mutation	novel	A1792P	0.25
LUSC	chr11	118495720	Missense_Mutation	novel	A1792V	0.25
LUSC	chr11	118505463	Missense_Mutation	novel	V3188F	0.09
LUSC	chr11	118505288	Silent	NA	L3129L	0.04
LUSC	chr11	118436781	Missense_Mutation	novel	S90L	0.12
LUSC	chr11	118504176	Missense_Mutation	rs782694778	E2759K	0.27
LUSC	chr11	118468775	Missense_Mutation	novel	D145Y	0.26
LUSC	chr11	118472059	Silent	novel	V300V	0.38
MESO	chr11	118436793	Missense_Mutation	rs782775993	S94L	0.06
MESO	chr11	118522095	Missense_Mutation	novel	K3945Q	0.04
MESO	chr11	118436749	Silent	novel	A79A	0.37
MESO	chr11	118481863	Silent	novel	P1261P	0.2
MESO	chr11	118506641	Silent	novel	G3580G	0.14
OV	chr11	118503504	Missense_Mutation	novel	S2535A	0.08
OV	chr11	118506318	Missense_Mutation	novel	D3473N	0.06
OV	chr11	118501056	Silent	novel	E2073E	0.06
OV	chr11	118502889	Missense_Mutation	NA	K2330E	0.45
OV	chr11	118490134	Silent	novel	C1527C	0.08
OV	chr11	118505891	Silent	novel	S3330S	0.08
OV	chr11	118520000	Missense_Mutation	NA	R3786C	0.04
OV	chr11	118474286	Missense_Mutation	NA	L1043V	0.39
OV	chr11	118501092	Missense_Mutation	novel	S2085R	0.03
OV	chr11	118504026	Missense_Mutation	novel	C2709S	0.06
OV	chr11	118473531	Frame_Shift_Ins	novel	*L792Sfs31**	0.03
OV	chr11	118506068	Missense_Mutation	novel	S3389R	0.05
OV	chr11	118491241	Missense_Mutation	novel	Y1581C	0.29
OV	chr11	118488672	Missense_Mutation	NA	E1464G	0.12
OV	chr11	118488719	Missense_Mutation	NA	K1480E	0.78
OV	chr11	118505507	Missense_Mutation	NA	S3202R	0.23
OV	chr11	118499308	Silent	novel	V1986V	0.2
OV	chr11	118505697	Missense_Mutation	novel	P3266T	0.06
OV	chr11	118505860	Missense_Mutation	NA	S3320N	0.48
OV	chr11	118501020	Silent	novel	A2061A	0.05
OV	chr11	118471963	Silent	novel	T268T	0.08
OV	chr11	118503312	Frame_Shift_Del	novel	*P2471Lfs35**	0.08
OV	chr11	118503246	Missense_Mutation	novel	P2449S	0.04
OV	chr11	118480238	Missense_Mutation	NA	A1212P	0.18
OV	chr11	118473349	Silent	novel	G730G	0.06
OV	chr11	118471685	Missense_Mutation	NA	R176S	0.18
OV	chr11	118491195	Splice_Site	novel	X1566_splice	0.92
OV	chr11	118505726	Silent	novel	N3275N	0.05
OV	chr11	118495831	Missense_Mutation	novel	P1829H	0.41
OV	chr11	118522210	3'UTR	rs782349572		0.69
OV	chr11	118493129	Missense_Mutation	NA	D1690H	0.14
OV	chr11	118504136	Silent	novel	G2745G	0.05
OV	chr11	118503231	Missense_Mutation	novel	K2444Q	0.03
OV	chr11	118499840	Missense_Mutation	rs782378796	M2026V	0.04
PAAD	chr11	118505068	Missense_Mutation	rs782800112	P3056L	0.04
PAAD	chr11	118484311	Silent	novel	F1405F	0.22
PAAD	chr11	118502784	Missense_Mutation	novel	D2295N	0.18
PAAD	chr11	118503617	Silent	rs782809939	Q2572Q	0.19
PAAD	chr11	118504578	Missense_Mutation	novel	L2893I	0.22
PAAD	chr11	118472484	Missense_Mutation	NA	R442Q	0.2
PCPG	chr11	118505972	Silent	novel	S3357S	0.32
PRAD	chr11	118503633	Frame_Shift_Del	novel	*T2578Pfs21**	0.23
PRAD	chr11	118473256	Silent	NA	A699A	0.22
PRAD	chr11	118473360	Frame_Shift_Ins	novel	*R736Kfs7**	0.21
PRAD	chr11	118501022	Missense_Mutation	NA	R2062H	0.05
PRAD	chr11	118472666	Missense_Mutation	NA	R503W	0.17
PRAD	chr11	118495821	Missense_Mutation	novel	A1826S	0.46
PRAD	chr11	118497974	Nonsense_Mutation	novel	W1898*	0.12
PRAD	chr11	118506276	Missense_Mutation	NA	L3459F	0.46
PRAD	chr11	118519701	Nonsense_Mutation	novel	R3741*	0.1
PRAD	chr11	118472321	Frame_Shift_Ins	novel	*E390Rfs34**	0.16
READ	chr11	118472788	Silent	rs782236871	T543T	0.32
READ	chr11	118505954	Silent	novel	T3351T	0.06
READ	chr11	118506324	Missense_Mutation	novel	A3475P	0.09
READ	chr11	118473175	Silent	rs368516174	T672T	0.6
READ	chr11	118521371	Missense_Mutation	novel	I3863S	0.15
READ	chr11	118505787	Missense_Mutation	NA	F3296L	0.32
READ	chr11	118472500	Silent	rs542752721	P447P	0.1
READ	chr11	118473366	Missense_Mutation	NA	R736M	0.35
READ	chr11	118488695	Nonsense_Mutation	novel	E1472*	0.4
READ	chr11	118502639	Silent	novel	V2246V	0.42
READ	chr11	118505185	Missense_Mutation	novel	P3095Q	0.41
READ	chr11	118506028	Missense_Mutation	NA	G3376D	0.41
SARC	chr11	118505104	Missense_Mutation	novel	P3068L	0.28
SARC	chr11	118478083	Nonsense_Mutation	NA	R1151*	0.14
SARC	chr11	118481988	Frame_Shift_Del	novel	*L1303Pfs51**	0.64
SARC	chr11	118434699	5'Flank	novel		0.1
SARC	chr11	118506167	Silent	rs782505642	A3422A	0.95
SKCM	chr11	118502575	Missense_Mutation	NA	S2225F	0.48
SKCM	chr11	118472309	Nonsense_Mutation	NA	Q384*	0.61
SKCM	chr11	118482467	Missense_Mutation	novel	I1353S	0.12
SKCM	chr11	118505697	Missense_Mutation	novel	P3266S	0.66
SKCM	chr11	118482469	Missense_Mutation	NA	P1354S	0.53
SKCM	chr11	118502629	Missense_Mutation	rs139450035	V2243A	0.58
SKCM	chr11	118504642	Missense_Mutation	NA	S2914F	0.72
SKCM	chr11	118495881	Missense_Mutation	novel	P1846S	0.05
SKCM	chr11	118472378	Nonsense_Mutation	NA	R407*	0.46
SKCM	chr11	118473392	Nonsense_Mutation	rs727503777	R745*	0.94
SKCM	chr11	118478083	Nonsense_Mutation	NA	R1151*	0.5
SKCM	chr11	118472887	Silent	NA	S576S	0.3
SKCM	chr11	118490147	Missense_Mutation	rs781990391	R1532C	0.19
SKCM	chr11	118501803	Missense_Mutation	NA	P2148S	0.27
SKCM	chr11	118503613	Missense_Mutation	NA	A2571V	0.21
SKCM	chr11	118504438	Missense_Mutation	NA	P2846H	0.23
SKCM	chr11	118504684	Missense_Mutation	NA	P2928L	0.27
SKCM	chr11	118473057	Missense_Mutation	NA	S633F	0.23
SKCM	chr11	118494734	Missense_Mutation	NA	S1774F	0.11
SKCM	chr11	118491285	Missense_Mutation	NA	H1596Y	0.27
SKCM	chr11	118502886	Missense_Mutation	NA	P2329S	0.36
SKCM	chr11	118473118	Silent	novel	P653P	0.39
SKCM	chr11	118473073	Silent	rs782768829	A638A	0.42
SKCM	chr11	118505081	Silent	novel	S3060S	0.34
SKCM	chr11	118473782	Missense_Mutation	NA	E875K	0.63
SKCM	chr11	118503166	Missense_Mutation	NA	S2422F	0.17
SKCM	chr11	118506381	Missense_Mutation	novel	G3494R	0.65
SKCM	chr11	118506382	Missense_Mutation	novel	G3494E	0.65
SKCM	chr11	118473205	Silent	rs782271167	L682L	0.5
SKCM	chr11	118488677	Missense_Mutation	NA	P1466S	0.48
SKCM	chr11	118473668	Missense_Mutation	NA	P837S	0.44
SKCM	chr11	118491290	Silent	NA	S1597S	0.37
SKCM	chr11	118502950	Missense_Mutation	NA	S2350F	0.58
SKCM	chr11	118494712	Missense_Mutation	NA	P1767S	0.28
SKCM	chr11	118473972	Missense_Mutation	NA	S938L	0.19
SKCM	chr11	118472394	Missense_Mutation	novel	P412L	0.26
SKCM	chr11	118519738	Missense_Mutation	NA	A3753V	0.29
SKCM	chr11	118502525	Silent	NA	R2208R	0.28
SKCM	chr11	118477973	Missense_Mutation	novel	S1114L	0.6
SKCM	chr11	118473743	Nonsense_Mutation	NA	R862*	0.5
SKCM	chr11	118495731	Missense_Mutation	NA	P1796S	0.57
SKCM	chr11	118504349	Silent	rs142499035	S2816S	0.27
SKCM	chr11	118519984	Silent	NA	F3780F	0.58
SKCM	chr11	118503838	Missense_Mutation	NA	P2646L	0.09
SKCM	chr11	118503012	Missense_Mutation	NA	H2371Y	0.17
SKCM	chr11	118503618	Missense_Mutation	NA	P2573S	0.59
SKCM	chr11	118503575	Silent	NA	P2558P	0.46
SKCM	chr11	118503392	Silent	NA	V2497V	0.34
SKCM	chr11	118505260	Missense_Mutation	NA	S3120L	0.09
SKCM	chr11	118498049	Missense_Mutation	rs200127166	M1923I	0.49
SKCM	chr11	118498050	Missense_Mutation	novel	A1924T	0.49
SKCM	chr11	118505350	Missense_Mutation	NA	S3150N	0.91
SKCM	chr11	118473743	Nonsense_Mutation	NA	R862*	0.35
SKCM	chr11	118504702	Nonsense_Mutation	NA	L2934*	0.29
SKCM	chr11	118504720	Missense_Mutation	NA	T2940I	0.76
SKCM	chr11	118474147	Frame_Shift_Del	novel	*S997Pfs5**	0.21
SKCM	chr11	118473564	Missense_Mutation	NA	S802F	0.21
SKCM	chr11	118505526	Missense_Mutation	NA	T3209A	0.74
SKCM	chr11	118494713	Missense_Mutation	novel	P1767L	0.42
SKCM	chr11	118471998	Missense_Mutation	NA	P280L	0.22
SKCM	chr11	118494735	Silent	NA	S1774S	0.36
SKCM	chr11	118472113	Silent	novel	L318L	0.2
SKCM	chr11	118505746	Frame_Shift_Del	novel	*P3283Nfs30**	0.22
SKCM	chr11	118503375	Missense_Mutation	novel	L2492F	0.52
SKCM	chr11	118484860	Splice_Site	NA	X1407_splice	0.46
SKCM	chr11	118491896	Missense_Mutation	rs373435126	R1655W	0.52
SKCM	chr11	118519647	Missense_Mutation	novel	L3723F	0.19
SKCM	chr11	118493185	Silent	rs556592051	L1708L	0.53
SKCM	chr11	118501731	Nonsense_Mutation	NA	R2124*	0.33
SKCM	chr11	118488677	Missense_Mutation	NA	P1466S	0.52
SKCM	chr11	118502463	Nonsense_Mutation	NA	R2188*	0.55
SKCM	chr11	118505185	Missense_Mutation	NA	P3095L	0.66
SKCM	chr11	118502575	Missense_Mutation	NA	S2225F	0.51
SKCM	chr11	118474146	Missense_Mutation	NA	S996F	0.98
SKCM	chr11	118503818	Silent	novel	S2639S	0.19
STAD	chr11	118519626	Missense_Mutation	NA	G3716S	0.26
STAD	chr11	118482022	Silent	novel	P1314P	0.22
STAD	chr11	118476890	Missense_Mutation	rs756562807	R1081Q	0.07
STAD	chr11	118503881	Silent	NA	S2660S	0.27
STAD	chr11	118501100	Missense_Mutation	NA	E2088G	0.08
STAD	chr11	118494704	Missense_Mutation	NA	R1764H	0.26
STAD	chr11	118505200	Frame_Shift_Del	NA	*I3102Sfs3**	0.15
STAD	chr11	118473274	Silent	novel	S705S	0.12
STAD	chr11	118472295	Missense_Mutation	NA	A379V	0.22
STAD	chr11	118495884	Missense_Mutation	novel	P1847S	0.31
STAD	chr11	118488636	Missense_Mutation	NA	C1452F	0.31
STAD	chr11	118505211	Silent	NA	L3104L	0.18
STAD	chr11	118509143	Missense_Mutation	NA	A3612T	0.1
STAD	chr11	118493108	Missense_Mutation	rs377724112	R1683C	0.35
STAD	chr11	118521307	Missense_Mutation	NA	G3842S	0.36
STAD	chr11	118473815	Missense_Mutation	NA	R886W	0.41
STAD	chr11	118503974	Silent	NA	S2691S	0.31
STAD	chr11	118481788	Silent	rs375849517	N1236N	0.22
STAD	chr11	118482042	Missense_Mutation	NA	K1321T	0.46
STAD	chr11	118473470	Frame_Shift_Ins	rs782297546	*S774Vfs12**	0.41
STAD	chr11	118474087	Silent	novel	L976L	0.3
STAD	chr11	118490230	Silent	NA	C1559C	0.37
STAD	chr11	118484183	Missense_Mutation	NA	E1363K	0.32
STAD	chr11	118488654	Missense_Mutation	NA	F1458S	0.08
STAD	chr11	118502896	Frame_Shift_Del	novel	*P2333Hfs11**	0.07
STAD	chr11	118506121	Missense_Mutation	NA	P3407L	0.04
STAD	chr11	118472418	Missense_Mutation	NA	R420Q	0.15
STAD	chr11	118505968	Missense_Mutation	rs149340870	A3356V	0.34
STAD	chr11	118493061	Missense_Mutation	NA	A1667V	0.21
STAD	chr11	118481726	Frame_Shift_Del	novel	*E1217Rfs18**	0.21
STAD	chr11	118473471	Frame_Shift_Del	NA	*P773Rfs8**	0.19
STAD	chr11	118504345	Missense_Mutation	NA	P2815L	0.27
STAD	chr11	118491843	Frame_Shift_Del	novel	*E1639Sfs6**	0.32
STAD	chr11	118473139	Silent	rs782676585	D660D	0.25
STAD	chr11	118509180	Missense_Mutation	NA	A3624V	0.18
STAD	chr11	118472913	Missense_Mutation	NA	L585R	0.07
STAD	chr11	118473744	Missense_Mutation	NA	R862Q	0.28
STAD	chr11	118473004	Silent	rs782608459	P615P	0.08
STAD	chr11	118506100	Missense_Mutation	NA	P3400L	0.37
STAD	chr11	118521969	Missense_Mutation	NA	R3903C	0.38
STAD	chr11	118476832	Missense_Mutation	NA	S1062P	0.08
STAD	chr11	118501072	Missense_Mutation	NA	V2079I	0.22
STAD	chr11	118504618	Missense_Mutation	NA	P2906H	0.3
STAD	chr11	118472667	Missense_Mutation	rs782313746	R503Q	0.09
STAD	chr11	118436528	Missense_Mutation	NA	R6W	0.12
STAD	chr11	118505942	Silent	NA	Q3347Q	0.13
STAD	chr11	118520850	Frame_Shift_Del	NA	*K3825Rfs31**	0.24
STAD	chr11	118473113	Nonsense_Mutation	NA	R652*	0.16
STAD	chr11	118491277	Missense_Mutation	rs782281385	R1593H	0.11
STAD	chr11	118473471	Frame_Shift_Del	NA	*P773Rfs8**	0.33
STAD	chr11	118511985	Silent	novel	E3699E	0.26
STAD	chr11	118488727	Silent	NA	C1482C	0.17
STAD	chr11	118503867	Nonsense_Mutation	NA	R2656*	0.18
STAD	chr11	118505106	Missense_Mutation	NA	P3069S	0.2
STAD	chr11	118503009	Missense_Mutation	rs782655113	L2370I	0.18
STAD	chr11	118502538	Missense_Mutation	rs527501404	M2213V	0.18
THCA	chr11	118504054	Missense_Mutation	NA	D2718V	0.08
THCA	chr11	118509172	Missense_Mutation	NA	Q3621H	0.13
THCA	chr11	118496344	Frame_Shift_Ins	novel	*T1878Ifs32**	0.05
THCA	chr11	118504236	Missense_Mutation	NA	K2779E	0.23
THCA	chr11	118505083	Missense_Mutation	rs782494435	N3061S	0.22
THCA	chr11	118482080	Frame_Shift_Del	novel	*P1334Hfs22**	0.16
THCA	chr11	118491891	Missense_Mutation	NA	N1653T	0.08
THCA	chr11	118504401	Frame_Shift_Ins	novel	*D2834Gfs26**	0.05
THCA	chr11	118506444	Missense_Mutation	novel	S3515A	0.44
THCA	chr11	118506445	Missense_Mutation	novel	S3515F	0.43
UCEC	chr11	118491843	Frame_Shift_Del	novel	*E1639Sfs6**	0.28
UCEC	chr11	118476957	Missense_Mutation	NA	K1103N	0.25
UCEC	chr11	118478083	Nonsense_Mutation	NA	R1151*	0.14
UCEC	chr11	118491861	Missense_Mutation	NA	S1643Y	0.31
UCEC	chr11	118494365	Silent	novel	K1749K	0.19
UCEC	chr11	118510022	Missense_Mutation	NA	R3656W	0.42
UCEC	chr11	118468786	Missense_Mutation	novel	F148L	0.43
UCEC	chr11	118503748	Missense_Mutation	novel	Y2616C	0.14
UCEC	chr11	118504280	Silent	NA	G2793G	0.4
UCEC	chr11	118511968	Missense_Mutation	novel	T3694A	0.13
UCEC	chr11	118522860	3'UTR	novel		0.24
UCEC	chr11	118506456	Missense_Mutation	novel	P3519S	0.32
UCEC	chr11	118488652	Missense_Mutation	NA	K1457N	0.35
UCEC	chr11	118521918	Nonsense_Mutation	NA	R3886*	0.42
UCEC	chr11	118434693	5'Flank	novel		0.43
UCEC	chr11	118497955	Missense_Mutation	rs143373748	Y1892C	0.27
UCEC	chr11	118499881	Silent	novel	D2039D	0.56
UCEC	chr11	118524393	3'Flank	novel		0.42
UCEC	chr11	118507590	Missense_Mutation	novel	E3603K	0.46
UCEC	chr11	118505450	Silent	rs782530588	G3183G	0.27
UCEC	chr11	118510058	Nonsense_Mutation	novel	G3668*	0.3
UCEC	chr11	118520865	Silent	novel	K3828K	0.25
UCEC	chr11	118504213	Missense_Mutation	NA	S2771Y	0.11
UCEC	chr11	118502903	Missense_Mutation	novel	Q2334H	0.49
UCEC	chr11	118473028	Silent	novel	K623K	0.31
UCEC	chr11	118473743	Nonsense_Mutation	NA	R862*	0.38
UCEC	chr11	118505591	Missense_Mutation	novel	K3230N	0.37
UCEC	chr11	118434999	5'Flank	novel		0.27
UCEC	chr11	118471948	Silent	rs200698383	T263T	0.24
UCEC	chr11	118478177	Missense_Mutation	novel	R1182H	0.44
UCEC	chr11	118480222	Silent	novel	L1206L	0.09
UCEC	chr11	118501061	Missense_Mutation	NA	R2075H	0.19
UCEC	chr11	118519649	Silent	novel	L3723L	0.12
UCEC	chr11	118520836	Missense_Mutation	novel	R3819C	0.32
UCEC	chr11	118522550	3'UTR	novel		0.27
UCEC	chr11	118524970	3'Flank	novel		0.36
UCEC	chr11	118473267	Missense_Mutation	novel	T703I	0.28
UCEC	chr11	118504324	Missense_Mutation	rs782705469	R2808H	0.53
UCEC	chr11	118509143	Missense_Mutation	NA	A3612T	0.46
UCEC	chr11	118523033	3'UTR	novel		0.44
UCEC	chr11	118525073	3'Flank	novel		0.57
UCEC	chr11	118473966	Missense_Mutation	novel	S936Y	0.05
UCEC	chr11	118472438	Missense_Mutation	rs142138730	R427W	0.11
UCEC	chr11	118491925	Silent	NA	R1664R	0.21
UCEC	chr11	118501115	Missense_Mutation	NA	R2093M	0.31
UCEC	chr11	118502975	Silent	rs192173056	S2358S	0.2
UCEC	chr11	118474074	Missense_Mutation	rs782663858	T972N	0.38
UCEC	chr11	118472492	Missense_Mutation	novel	S445P	0.5
UCEC	chr11	118473198	Missense_Mutation	NA	S680L	0.5
UCEC	chr11	118503036	Nonsense_Mutation	rs387907275	R2379*	0.22
UCEC	chr11	118504280	Silent	NA	G2793G	0.13
UCEC	chr11	118471870	Silent	NA	H237H	0.3
UCEC	chr11	118476967	Missense_Mutation	novel	S1107T	0.28
UCEC	chr11	118478033	Missense_Mutation	novel	P1134H	0.18
UCEC	chr11	118505931	Missense_Mutation	rs781850448	V3344I	0.09
UCEC	chr11	118472186	Nonsense_Mutation	novel	E343*	0.33
UCEC	chr11	118493083	Silent	rs140439290	P1674P	0.43
UCEC	chr11	118504255	Missense_Mutation	NA	S2785Y	0.43
UCEC	chr11	118521386	Missense_Mutation	NA	T3868N	0.45
UCEC	chr11	118472379	Missense_Mutation	novel	R407Q	0.31
UCEC	chr11	118496302	Frame_Shift_Del	NA	*P1865Qfs3**	0.15
UCEC	chr11	118484909	Silent	novel	I1422I	0.06
UCEC	chr11	118503440	Silent	novel	Q2513Q	0.44
UCEC	chr11	118505650	Missense_Mutation	novel	S3250Y	0.14
UCEC	chr11	118434666	5'Flank	novel		0.37
UCEC	chr11	118484262	Missense_Mutation	novel	S1389Y	0.38
UCEC	chr11	118502598	Missense_Mutation	novel	A2233T	0.07
UCEC	chr11	118505570	Silent	novel	I3223I	0.27
UCEC	chr11	118521919	Missense_Mutation	NA	R3886Q	0.45
UCEC	chr11	118523493	3'UTR	novel		0.39
UCEC	chr11	118435025	5'Flank	novel		0.28
UCEC	chr11	118493214	Missense_Mutation	novel	G1718E	0.32
UCEC	chr11	118503384	Missense_Mutation	novel	P2495S	0.37
UCEC	chr11	118505506	Missense_Mutation	novel	S3202N	0.4
UCEC	chr11	118523635	3'UTR	novel		0.35
UCEC	chr11	118472760	Missense_Mutation	NA	S534L	0.32
UCEC	chr11	118472107	Silent	novel	S316S	0.48
UCEC	chr11	118473255	Missense_Mutation	novel	A699V	0.42
UCEC	chr11	118476883	Missense_Mutation	novel	L1079I	0.42
UCEC	chr11	118494703	Missense_Mutation	novel	R1764C	0.62
UCEC	chr11	118503235	Frame_Shift_Ins	novel	*L2447Ffs10**	0.42
UCEC	chr11	118505893	Missense_Mutation	novel	V3331A	0.43
UCEC	chr11	118522860	3'UTR	novel		0.3
UCEC	chr11	118434957	5'Flank	novel		0.51
UCEC	chr11	118510049	Missense_Mutation	novel	P3665T	0.35
UCEC	chr11	118505040	Missense_Mutation	NA	V3047M	0.2
UCEC	chr11	118473198	Missense_Mutation	NA	S680L	0.64
UCEC	chr11	118482032	Nonsense_Mutation	novel	E1318*	0.29
UCEC	chr11	118491757	Missense_Mutation	novel	E1608D	0.31
UCEC	chr11	118494337	Nonsense_Mutation	novel	S1740*	0.53
UCEC	chr11	118505650	Missense_Mutation	novel	S3250Y	0.43
UCEC	chr11	118504019	Missense_Mutation	novel	E2706D	0.32
UCEC	chr11	118474237	Silent	novel	L1026L	0.28
UCEC	chr11	118478066	Missense_Mutation	novel	P1145Q	0.55
UCEC	chr11	118481731	Frame_Shift_Ins	novel	*S1220Vfs2**	0.39
UCEC	chr11	118503500	Silent	novel	S2533S	0.25
UCEC	chr11	118503612	Missense_Mutation	novel	A2571T	0.33
UCEC	chr11	118504339	Missense_Mutation	novel	S2813N	0.36
UCEC	chr11	118505332	Missense_Mutation	novel	S3144Y	0.35
UCEC	chr11	118519627	Missense_Mutation	novel	G3716D	0.44
UCEC	chr11	118523576	3'UTR	novel		0.3
UCEC	chr11	118439107	Intron	novel		0.37
UCEC	chr11	118472788	Silent	rs782236871	T543T	0.51
UCEC	chr11	118484891	Silent	novel	E1416E	0.56
UCEC	chr11	118501139	Missense_Mutation	novel	S2101Y	0.64
UCEC	chr11	118501797	Nonsense_Mutation	novel	R2146*	0.43
UCEC	chr11	118504327	Missense_Mutation	novel	R2809I	0.63
UCEC	chr11	118505344	Missense_Mutation	novel	S3148Y	0.5
UCEC	chr11	118472982	Missense_Mutation	novel	R608Q	0.48
UCEC	chr11	118474239	Frame_Shift_Ins	novel	*A1030Gfs9**	0.48
UCEC	chr11	118473471	Frame_Shift_Del	NA	*P773Rfs8**	0.36
UCEC	chr11	118434839	5'Flank	novel		0.08
UCEC	chr11	118524698	3'Flank	novel		0.56
UCEC	chr11	118472378	Nonsense_Mutation	NA	R407*	0.27
UCEC	chr11	118478087	Missense_Mutation	NA	S1152L	0.29
UCEC	chr11	118522719	3'UTR	novel		0.46
UCEC	chr11	118525138	3'Flank	novel		0.17
UCEC	chr11	118472527	Silent	novel	C456C	0.4
UCEC	chr11	118473380	Missense_Mutation	NA	F741L	0.2
UCEC	chr11	118504053	Missense_Mutation	novel	D2718Y	0.24
UCEC	chr11	118504144	Missense_Mutation	novel	N2748S	0.32
UCEC	chr11	118523208	3'UTR	novel		0.3
UCEC	chr11	118524863	3'Flank	novel		0.4
UCEC	chr11	118472378	Nonsense_Mutation	NA	R407*	0.19
UCEC	chr11	118473832	Missense_Mutation	novel	E891D	0.33
UCEC	chr11	118498391	Missense_Mutation	novel	P1939S	0.17
UCEC	chr11	118499878	Silent	rs546635239	S2038S	0.31
UCEC	chr11	118505432	Silent	novel	I3177I	0.22
UCEC	chr11	118523592	3'UTR	novel		0.2
UCEC	chr11	118472788	Silent	rs782236871	T543T	0.42
UCEC	chr11	118491812	Missense_Mutation	rs376776245	R1627W	0.43
UCEC	chr11	118504012	Missense_Mutation	novel	R2704Q	0.46
UCEC	chr11	118523163	3'UTR	rs185757845		0.31
UCEC	chr11	118524308	3'Flank	novel		0.36
UCEC	chr11	118472217	Missense_Mutation	NA	R353Q	0.53
UCEC	chr11	118499373	Missense_Mutation	novel	R2008M	0.29
UCEC	chr11	118505620	Missense_Mutation	novel	P3240H	0.21
UCEC	chr11	118522143	Missense_Mutation	rs781866935	A3961T	0.32
UCEC	chr11	118524134	3'Flank	novel		0.38
UCEC	chr11	118434572	5'Flank	novel		0.4
UCEC	chr11	118434727	5'Flank	novel		0.41
UCEC	chr11	118439111	Intron	novel		0.35
UCEC	chr11	118506290	Silent	novel	T3463T	0.29
UCEC	chr11	118523618	3'UTR	novel		0.26
UCEC	chr11	118472058	Missense_Mutation	novel	V300A	0.24
UCEC	chr11	118472866	Silent	novel	P569P	0.39
UCEC	chr11	118495719	Missense_Mutation	novel	A1792T	0.39
UCEC	chr11	118503275	Silent	novel	G2458G	0.39
UCEC	chr11	118504913	Silent	novel	I3004I	0.52
UCEC	chr11	118505219	Silent	novel	S3106S	0.5
UCEC	chr11	118519702	Missense_Mutation	NA	R3741Q	0.24
UCEC	chr11	118524007	3'Flank	novel		0.63
UCEC	chr11	118519763	Silent	rs371289157	H3761H	0.51
UCEC	chr11	118522143	Missense_Mutation	rs781866935	A3961S	0.14
UCEC	chr11	118506247	Missense_Mutation	NA	H3449P	0.14
UCEC	chr11	118488720	Missense_Mutation	novel	K1480T	0.58
UCEC	chr11	118491861	Missense_Mutation	NA	S1643Y	0.5
UCEC	chr11	118523746	3'UTR	novel		0.3
UCEC	chr11	118472542	Silent	novel	K461K	0.06
UCEC	chr11	118481846	Missense_Mutation	NA	K1256Q	0.28
UCEC	chr11	118504737	Missense_Mutation	NA	P2946S	0.3
UCEC	chr11	118505563	Missense_Mutation	novel	R3221I	0.06
UCEC	chr11	118519690	Missense_Mutation	NA	A3737V	0.28
UCEC	chr11	118501061	Missense_Mutation	NA	R2075H	0.28
UCEC	chr11	118472628	Missense_Mutation	novel	S490F	0.25
UCEC	chr11	118473581	Missense_Mutation	novel	E808K	0.19
UCEC	chr11	118498381	Missense_Mutation	novel	F1935L	0.31
UCEC	chr11	118473028	Missense_Mutation	novel	K623N	0.26
UCEC	chr11	118490190	Missense_Mutation	novel	D1546G	0.28
UCEC	chr11	118501139	Missense_Mutation	novel	S2101Y	0.23
UCEC	chr11	118503765	Missense_Mutation	NA	R2622C	0.05
UCEC	chr11	118510115	Missense_Mutation	novel	E3687Q	0.38
UCEC	chr11	118472341	Silent	NA	L394L	0.15
UCEC	chr11	118503730	Missense_Mutation	NA	G2610D	0.3
UCEC	chr11	118521362	Missense_Mutation	novel	G3860D	0.04
UCEC	chr11	118522268	3'UTR	novel		0.07
UCEC	chr11	118482028	Frame_Shift_Ins	novel	*K1317Ffs14**	0.09
UCEC	chr11	118473496	Silent	rs781894404	S779S	0.08
UCEC	chr11	118468774	Splice_Site	novel	X145_splice	0.36
UCEC	chr11	118474016	Missense_Mutation	novel	T953A	0.26
UCEC	chr11	118490185	Silent	novel	G1544G	0.29
UCEC	chr11	118524117	3'Flank	novel		0.43
UCEC	chr11	118505546	Silent	novel	S3215S	0.13
UCEC	chr11	118504220	Silent	novel	G2773G	0.17
UCEC	chr11	118505447	Silent	novel	S3182S	0.51
UCEC	chr11	118519656	Missense_Mutation	novel	A3726T	0.49
UCEC	chr11	118505734	Missense_Mutation	novel	S3278Y	0.5
UCEC	chr11	118507598	Silent	NA	G3605G	0.12
UCEC	chr11	118471919	Missense_Mutation	NA	K254Q	0.56
UCEC	chr11	118503970	Missense_Mutation	NA	S2690Y	0.47
UCEC	chr11	118502463	Nonsense_Mutation	NA	R2188*	0.37
UCEC	chr11	118505200	Frame_Shift_Del	NA	*I3102Sfs3**	0.4
UCEC	chr11	118488713	Missense_Mutation	NA	R1478C	0.19
UCEC	chr11	118504903	Missense_Mutation	novel	A3001G	0.12
UCEC	chr11	118504905	Frame_Shift_Ins	novel	*D3002Vfs15**	0.11
UCEC	chr11	118522319	3'UTR	novel		0.22
UCEC	chr11	118473999	Missense_Mutation	novel	S947Y	0.05
UCEC	chr11	118481731	Missense_Mutation	novel	E1217D	0.08
UCEC	chr11	118503379	Missense_Mutation	NA	S2493F	0.28
UCEC	chr11	118471674	Missense_Mutation	novel	P172L	0.14
UCEC	chr11	118495839	Missense_Mutation	novel	P1832S	0.19
UCEC	chr11	118503171	Missense_Mutation	novel	D2424Y	0.2
UCEC	chr11	118505129	Missense_Mutation	novel	E3076D	0.2
UCEC	chr11	118505869	Missense_Mutation	novel	T3323I	0.2
UCEC	chr11	118506400	Frame_Shift_Ins	novel	*L3501Ffs35**	0.25
UCEC	chr11	118473102	Missense_Mutation	novel	F648S	0.44
UCEC	chr11	118482070	Missense_Mutation	novel	K1330N	0.3
UCEC	chr11	118494311	Silent	novel	V1731V	0.43
UCEC	chr11	118503756	Missense_Mutation	NA	R2619C	0.47
UCEC	chr11	118484267	Nonsense_Mutation	novel	Q1391*	0.5
UCEC	chr11	118494375	Missense_Mutation	novel	M1753V	0.17
UCEC	chr11	118501136	Missense_Mutation	novel	T2100I	0.5
UCEC	chr11	118471897	Missense_Mutation	NA	K246N	0.28
UCEC	chr11	118473544	Silent	novel	T795T	0.05
UCEC	chr11	118476838	Nonsense_Mutation	NA	R1064*	0.24
UCEC	chr11	118509998	Missense_Mutation	novel	L3648I	0.04
UCEC	chr11	118473471	Frame_Shift_Del	NA	*P773Rfs8**	0.64
UCEC	chr11	118472854	Silent	novel	L565L	0.53
UCEC	chr11	118473198	Missense_Mutation	NA	S680L	0.35
UCEC	chr11	118525109	3'Flank	rs782673496		0.53
UCEC	chr11	118473743	Nonsense_Mutation	NA	R862*	0.27
UCEC	chr11	118503447	Missense_Mutation	rs782129680	R2516W	0.41
UCEC	chr11	118522644	3'UTR	novel		0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2843	0.00015732
CESC	DEL	0.5085	1.0762e-32
CHOL	DEL	0.2778	0.048655
ESCA	AMP	0.0978	0.018342
KIRP	DEL	0.1007	2.839e-05
LAML	AMP	0.0942	1.145e-08
LIHC	DEL	0.2027	0.00030497
LUAD	DEL	0.1609	4.2393e-06
PRAD	DEL	0.0732	0.00026046
READ	DEL	0.1879	0.054114
SARC	DEL	0.4397	1.8105e-09
STAD	DEL	0.1519	8.3734e-05
TGCT	DEL	0.7667	0.21504
UCS	DEL	0.375	0.086462
UVM	DEL	0.075	0.023516

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00061	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
SKCM	0.043	Kaplan-Meier Survival Analysis
KIRP	0.0092	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
KICH	0.046	Kaplan-Meier Survival Analysis
LIHC	0.029	Kaplan-Meier Survival Analysis
LGG	0.00081	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742