EuRBPDB

Description

RBDs

PRI

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000118197 (Gene tree)
Gene ID: 83479
Gene Symbol: DDX59
Alias: DKFZP564B1023|ZNHIT5
Full Name: DEAD-box helicase 59
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 46,103 bases
Position: chr1:200,623,896-200,669,998
Accession: 25360
RBP type: canonical RBP
Summary: (DEAD-Box Helicase 59) is a Protein Coding gene. Diseases associated with DDX59 include Orofaciodigital Syndrome V and Orofaciodigital Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DDX42.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000330460	DEAD	PF00270.29	2.8e-43	1	1
ENSP00000394367	DEAD	PF00270.29	3e-43	1	1

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000429498	DDX59-203	725	-	ENSP00000408662	197 (aa)	-	H0Y6Y1
ENST00000331314	DDX59-201	2289	XM_017002432	ENSP00000330460	619 (aa)	XP_016857921	Q5T1V6
ENST00000436897	DDX59-205	635	-	ENSP00000391312	160 (aa)	-	Q5T1V5
ENST00000447706	DDX59-206	2900	-	ENSP00000394367	580 (aa)	-	Q5T1V6
ENST00000453944	DDX59-208	643	-	ENSP00000398152	75 (aa)	-	B7ZBU4
ENST00000413408	DDX59-202	945	-	ENSP00000394304	205 (aa)	-	Q5T1W1
ENST00000452560	DDX59-207	580	-	ENSP00000416331	94 (aa)	-	H0Y7Z8
ENST00000433235	DDX59-204	889	-	ENSP00000409954	224 (aa)	-	B7ZBU3

Gene Model

Click here to download ENSG00000118197's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118197	Electrocardiography	5E-6	19389651

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118197's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000118197	DDX59	91	30.882	ENSG00000161960	EIF4A1	99	33.742
ENSG00000118197	DDX59	99	32.400	ENSG00000174243	DDX23	52	35.566
ENSG00000118197	DDX59	98	30.667	ENSG00000198231	DDX42	64	33.261
ENSG00000118197	DDX59	61	31.759	ENSG00000110367	DDX6	78	31.759
ENSG00000118197	DDX59	57	35.030	ENSG00000123064	DDX54	92	44.103
ENSG00000118197	DDX59	96	34.234	ENSG00000183258	DDX41	79	37.956
ENSG00000118197	DDX59	64	35.000	ENSG00000156976	EIF4A2	90	30.481
ENSG00000118197	DDX59	95	33.796	ENSG00000278053	DDX52	99	33.333
ENSG00000118197	DDX59	98	32.883	ENSG00000080007	DDX43	60	35.427
ENSG00000118197	DDX59	92	33.333	ENSG00000141543	EIF4A3	86	33.520
ENSG00000118197	DDX59	82	30.102	ENSG00000182810	DDX28	70	31.899
ENSG00000118197	DDX59	79	30.387	ENSG00000198563	DDX39B	93	30.387
ENSG00000118197	DDX59	59	30.966	ENSG00000105671	DDX49	69	42.857
ENSG00000118197	DDX59	100	36.842	ENSG00000108654	DDX5	93	46.512
ENSG00000118197	DDX59	98	32.127	ENSG00000100201	DDX17	57	34.450
ENSG00000118197	DDX59	100	30.667	ENSG00000213782	DDX47	81	36.000
ENSG00000118197	DDX59	70	34.848	ENSG00000124228	DDX27	88	34.426
ENSG00000118197	DDX59	58	32.081	ENSG00000088205	DDX18	53	32.773
ENSG00000118197	DDX59	86	37.500	ENSG00000152670	DDX4	72	35.446
ENSG00000118197	DDX59	97	36.486	ENSG00000184735	DDX53	59	33.766
ENSG00000118197	DDX59	61	31.387	ENSG00000109832	DDX25	90	30.000
ENSG00000118197	DDX59	56	31.871	ENSG00000111364	DDX55	87	36.310
ENSG00000118197	DDX59	99	34.802	ENSG00000215301	DDX3X	87	34.615
ENSG00000118197	DDX59	78	30.120	ENSG00000123136	DDX39A	93	33.708
ENSG00000118197	DDX59	99	35.683	ENSG00000067048	DDX3Y	66	34.247

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000118197	DDX59	100	74.107	ENSAPOG00000014282	ddx59	99	58.951	Acanthochromis_polyacanthus
ENSG00000118197	DDX59	100	94.643	ENSAMEG00000012596	DDX59	100	89.839	Ailuropoda_melanoleuca
ENSG00000118197	DDX59	100	72.768	ENSACIG00000009666	ddx59	94	65.455	Amphilophus_citrinellus
ENSG00000118197	DDX59	100	74.107	ENSAOCG00000013277	ddx59	99	59.434	Amphiprion_ocellaris
ENSG00000118197	DDX59	100	74.107	ENSAPEG00000003447	ddx59	96	59.652	Amphiprion_percula
ENSG00000118197	DDX59	100	72.321	ENSATEG00000013973	ddx59	99	59.906	Anabas_testudineus
ENSG00000118197	DDX59	100	81.250	ENSAPLG00000012921	DDX59	100	71.086	Anas_platyrhynchos
ENSG00000118197	DDX59	100	79.464	ENSACAG00000006225	DDX59	99	70.635	Anolis_carolinensis
ENSG00000118197	DDX59	100	98.667	ENSANAG00000025559	DDX59	100	96.290	Aotus_nancymaae
ENSG00000118197	DDX59	100	75.000	ENSAMXG00000035102	ddx59	85	63.258	Astyanax_mexicanus
ENSG00000118197	DDX59	100	86.607	ENSBTAG00000020563	DDX59	100	77.097	Bos_taurus
ENSG00000118197	DDX59	100	98.667	ENSCJAG00000005183	DDX59	100	96.290	Callithrix_jacchus
ENSG00000118197	DDX59	100	95.982	ENSCAFG00000011120	DDX59	99	89.320	Canis_familiaris
ENSG00000118197	DDX59	100	95.982	ENSCAFG00020018385	DDX59	100	89.839	Canis_lupus_dingo
ENSG00000118197	DDX59	100	84.821	ENSCHIG00000014558	DDX59	100	75.968	Capra_hircus
ENSG00000118197	DDX59	100	97.333	ENSTSYG00000013832	DDX59	100	91.613	Carlito_syrichta
ENSG00000118197	DDX59	99	81.858	ENSCAPG00000017836	-	100	92.021	Cavia_aperea
ENSG00000118197	DDX59	98	90.674	ENSCPOG00000008420	DDX59	100	84.355	Cavia_porcellus
ENSG00000118197	DDX59	100	97.768	ENSCCAG00000026682	DDX59	100	94.677	Cebus_capucinus
ENSG00000118197	DDX59	100	98.661	ENSCATG00000039084	DDX59	100	96.935	Cercocebus_atys
ENSG00000118197	DDX59	100	95.536	ENSCLAG00000011057	DDX59	100	88.387	Chinchilla_lanigera
ENSG00000118197	DDX59	100	99.107	ENSCSAG00000013799	DDX59	100	97.581	Chlorocebus_sabaeus
ENSG00000118197	DDX59	100	83.482	ENSCPBG00000028288	DDX59	100	74.841	Chrysemys_picta_bellii
ENSG00000118197	DDX59	100	98.661	ENSCANG00000029749	DDX59	100	96.774	Colobus_angolensis_palliatus
ENSG00000118197	DDX59	100	90.179	ENSCGRG00001012693	Ddx59	100	85.000	Cricetulus_griseus_chok1gshd
ENSG00000118197	DDX59	100	90.179	ENSCGRG00000013029	Ddx59	100	85.000	Cricetulus_griseus_crigri
ENSG00000118197	DDX59	100	74.107	ENSCSEG00000015765	ddx59	99	59.748	Cynoglossus_semilaevis
ENSG00000118197	DDX59	100	73.661	ENSCVAG00000012835	ddx59	99	59.464	Cyprinodon_variegatus
ENSG00000118197	DDX59	100	73.214	ENSDARG00000022177	ddx59	100	65.243	Danio_rerio
ENSG00000118197	DDX59	100	96.429	ENSDNOG00000017948	DDX59	100	90.323	Dasypus_novemcinctus
ENSG00000118197	DDX59	100	90.625	ENSDORG00000007702	Ddx59	100	81.583	Dipodomys_ordii
ENSG00000118197	DDX59	100	91.518	ENSETEG00000016680	DDX59	100	81.965	Echinops_telfairi
ENSG00000118197	DDX59	100	54.468	ENSEBUG00000007713	ddx59	83	51.073	Eptatretus_burgeri
ENSG00000118197	DDX59	100	93.304	ENSEASG00005003122	DDX59	99	90.132	Equus_asinus_asinus
ENSG00000118197	DDX59	100	93.304	ENSECAG00000006958	DDX59	100	84.814	Equus_caballus
ENSG00000118197	DDX59	100	93.304	ENSEEUG00000013507	DDX59	100	80.377	Erinaceus_europaeus
ENSG00000118197	DDX59	100	72.768	ENSELUG00000005585	ddx59	100	57.839	Esox_lucius
ENSG00000118197	DDX59	100	95.982	ENSFCAG00000027373	DDX59	96	90.864	Felis_catus
ENSG00000118197	DDX59	100	82.589	ENSFALG00000002703	DDX59	100	71.200	Ficedula_albicollis
ENSG00000118197	DDX59	100	94.196	ENSFDAG00000010141	DDX59	100	86.129	Fukomys_damarensis
ENSG00000118197	DDX59	100	74.554	ENSFHEG00000018289	ddx59	99	52.782	Fundulus_heteroclitus
ENSG00000118197	DDX59	100	70.089	ENSGMOG00000001063	ddx59	99	56.857	Gadus_morhua
ENSG00000118197	DDX59	100	82.589	ENSGALG00000002164	DDX59	100	72.887	Gallus_gallus
ENSG00000118197	DDX59	100	75.000	ENSGAFG00000013552	ddx59	99	59.084	Gambusia_affinis
ENSG00000118197	DDX59	100	73.661	ENSGACG00000008863	ddx59	99	60.510	Gasterosteus_aculeatus
ENSG00000118197	DDX59	100	83.929	ENSGAGG00000021228	DDX59	100	74.245	Gopherus_agassizii
ENSG00000118197	DDX59	100	100.000	ENSGGOG00000014615	DDX59	100	99.515	Gorilla_gorilla
ENSG00000118197	DDX59	100	72.768	ENSHBUG00000007049	ddx59	99	58.777	Haplochromis_burtoni
ENSG00000118197	DDX59	100	95.536	ENSHGLG00000016068	DDX59	100	87.903	Heterocephalus_glaber_female
ENSG00000118197	DDX59	100	95.536	ENSHGLG00100019169	DDX59	100	87.903	Heterocephalus_glaber_male
ENSG00000118197	DDX59	100	72.321	ENSHCOG00000009983	ddx59	99	58.360	Hippocampus_comes
ENSG00000118197	DDX59	100	74.107	ENSIPUG00000008100	Ddx59	100	59.404	Ictalurus_punctatus
ENSG00000118197	DDX59	100	96.000	ENSSTOG00000027030	DDX59	100	85.668	Ictidomys_tridecemlineatus
ENSG00000118197	DDX59	100	89.333	ENSJJAG00000023695	Ddx59	100	81.774	Jaculus_jaculus
ENSG00000118197	DDX59	100	74.107	ENSKMAG00000007764	ddx59	99	59.652	Kryptolebias_marmoratus
ENSG00000118197	DDX59	100	68.000	ENSLBEG00000022261	ddx59	99	59.107	Labrus_bergylta
ENSG00000118197	DDX59	100	78.667	ENSLACG00000010101	DDX59	99	64.163	Latimeria_chalumnae
ENSG00000118197	DDX59	100	76.339	ENSLOCG00000007710	ddx59	100	61.206	Lepisosteus_oculatus
ENSG00000118197	DDX59	100	89.333	ENSLAFG00000030362	DDX59	100	81.718	Loxodonta_africana
ENSG00000118197	DDX59	100	99.107	ENSMFAG00000035416	DDX59	100	97.419	Macaca_fascicularis
ENSG00000118197	DDX59	100	99.107	ENSMMUG00000004268	DDX59	100	97.258	Macaca_mulatta
ENSG00000118197	DDX59	100	93.065	ENSMNEG00000040640	DDX59	100	93.065	Macaca_nemestrina
ENSG00000118197	DDX59	100	98.661	ENSMLEG00000042339	DDX59	100	97.097	Mandrillus_leucophaeus
ENSG00000118197	DDX59	100	72.321	ENSMAMG00000002727	ddx59	99	58.255	Mastacembelus_armatus
ENSG00000118197	DDX59	100	82.143	ENSMGAG00000005954	DDX59	99	70.740	Meleagris_gallopavo
ENSG00000118197	DDX59	100	91.518	ENSMAUG00000015701	Ddx59	100	84.516	Mesocricetus_auratus
ENSG00000118197	DDX59	100	97.333	ENSMICG00000012110	DDX59	100	91.774	Microcebus_murinus
ENSG00000118197	DDX59	100	90.179	ENSMOCG00000016551	Ddx59	100	83.871	Microtus_ochrogaster
ENSG00000118197	DDX59	100	73.661	ENSMMOG00000008374	ddx59	99	57.903	Mola_mola
ENSG00000118197	DDX59	100	84.821	ENSMODG00000012873	DDX59	100	77.010	Monodelphis_domestica
ENSG00000118197	DDX59	100	72.768	ENSMALG00000014185	ddx59	99	60.095	Monopterus_albus
ENSG00000118197	DDX59	100	90.625	MGP_CAROLIEiJ_G0014656	Ddx59	100	83.845	Mus_caroli
ENSG00000118197	DDX59	100	91.071	ENSMUSG00000026404	Ddx59	100	83.683	Mus_musculus
ENSG00000118197	DDX59	100	90.625	MGP_PahariEiJ_G0027892	Ddx59	100	83.226	Mus_pahari
ENSG00000118197	DDX59	100	91.071	MGP_SPRETEiJ_G0015463	Ddx59	100	84.168	Mus_spretus
ENSG00000118197	DDX59	100	95.089	ENSMPUG00000010489	DDX59	100	89.015	Mustela_putorius_furo
ENSG00000118197	DDX59	100	83.482	ENSMLUG00000016730	DDX59	100	73.885	Myotis_lucifugus
ENSG00000118197	DDX59	100	91.964	ENSNGAG00000021782	Ddx59	100	87.581	Nannospalax_galili
ENSG00000118197	DDX59	100	72.768	ENSNBRG00000002029	ddx59	99	59.486	Neolamprologus_brichardi
ENSG00000118197	DDX59	100	100.000	ENSNLEG00000018069	DDX59	100	98.546	Nomascus_leucogenys
ENSG00000118197	DDX59	100	78.571	ENSMEUG00000005420	DDX59	100	70.257	Notamacropus_eugenii
ENSG00000118197	DDX59	100	94.643	ENSODEG00000009771	DDX59	100	86.774	Octodon_degus
ENSG00000118197	DDX59	100	72.768	ENSONIG00000012538	ddx59	90	65.556	Oreochromis_niloticus
ENSG00000118197	DDX59	100	80.000	ENSOANG00000007164	DDX59	99	73.146	Ornithorhynchus_anatinus
ENSG00000118197	DDX59	100	86.607	ENSOCUG00000016514	DDX59	100	76.613	Oryctolagus_cuniculus
ENSG00000118197	DDX59	100	72.768	ENSORLG00000006897	ddx59	99	58.230	Oryzias_latipes
ENSG00000118197	DDX59	100	72.768	ENSORLG00020000553	ddx59	99	58.658	Oryzias_latipes_hni
ENSG00000118197	DDX59	100	72.768	ENSORLG00015014207	ddx59	99	58.125	Oryzias_latipes_hsok
ENSG00000118197	DDX59	100	71.875	ENSOMEG00000020321	ddx59	99	65.029	Oryzias_melastigma
ENSG00000118197	DDX59	100	97.333	ENSOGAG00000008925	DDX59	100	88.978	Otolemur_garnettii
ENSG00000118197	DDX59	100	86.161	ENSOARG00000016307	DDX59	100	75.806	Ovis_aries
ENSG00000118197	DDX59	99	100.000	ENSPPAG00000031649	DDX59	100	98.966	Pan_paniscus
ENSG00000118197	DDX59	100	95.536	ENSPPRG00000016091	DDX59	100	90.806	Panthera_pardus
ENSG00000118197	DDX59	100	95.536	ENSPTIG00000007021	DDX59	100	90.968	Panthera_tigris_altaica
ENSG00000118197	DDX59	100	99.554	ENSPTRG00000001821	DDX59	100	99.031	Pan_troglodytes
ENSG00000118197	DDX59	100	98.214	ENSPANG00000017384	DDX59	100	96.935	Papio_anubis
ENSG00000118197	DDX59	100	72.321	ENSPKIG00000004361	ddx59	99	59.190	Paramormyrops_kingsleyae
ENSG00000118197	DDX59	100	84.821	ENSPSIG00000016333	DDX59	100	73.502	Pelodiscus_sinensis
ENSG00000118197	DDX59	100	73.214	ENSPMGG00000010951	ddx59	99	57.962	Periophthalmus_magnuspinnatus
ENSG00000118197	DDX59	100	89.732	ENSPEMG00000010715	Ddx59	100	84.355	Peromyscus_maniculatus_bairdii
ENSG00000118197	DDX59	99	60.526	ENSPMAG00000003852	ddx59	99	54.494	Petromyzon_marinus
ENSG00000118197	DDX59	100	85.333	ENSPCIG00000030390	DDX59	100	79.255	Phascolarctos_cinereus
ENSG00000118197	DDX59	100	74.554	ENSPFOG00000024216	ddx59	99	59.685	Poecilia_formosa
ENSG00000118197	DDX59	100	74.554	ENSPLAG00000004104	ddx59	99	59.685	Poecilia_latipinna
ENSG00000118197	DDX59	100	74.554	ENSPMEG00000018965	ddx59	99	59.937	Poecilia_mexicana
ENSG00000118197	DDX59	100	74.554	ENSPREG00000007774	ddx59	99	59.621	Poecilia_reticulata
ENSG00000118197	DDX59	100	97.500	ENSPPYG00000025828	-	99	97.759	Pongo_abelii
ENSG00000118197	DDX59	100	89.732	ENSPCAG00000014921	DDX59	100	85.000	Procavia_capensis
ENSG00000118197	DDX59	100	97.333	ENSPCOG00000012737	DDX59	100	97.701	Propithecus_coquereli
ENSG00000118197	DDX59	100	78.667	ENSPVAG00000002569	DDX59	100	68.548	Pteropus_vampyrus
ENSG00000118197	DDX59	100	72.768	ENSPNYG00000019810	ddx59	99	58.713	Pundamilia_nyererei
ENSG00000118197	DDX59	100	74.554	ENSPNAG00000002963	ddx59	96	58.359	Pygocentrus_nattereri
ENSG00000118197	DDX59	100	88.839	ENSRNOG00000042451	Ddx59	100	83.871	Rattus_norvegicus
ENSG00000118197	DDX59	100	98.661	ENSRBIG00000043232	DDX59	100	97.742	Rhinopithecus_bieti
ENSG00000118197	DDX59	100	98.661	ENSRROG00000042119	DDX59	100	97.742	Rhinopithecus_roxellana
ENSG00000118197	DDX59	100	100.000	ENSSBOG00000035527	DDX59	100	94.194	Saimiri_boliviensis_boliviensis
ENSG00000118197	DDX59	100	84.375	ENSSHAG00000014781	DDX59	100	77.047	Sarcophilus_harrisii
ENSG00000118197	DDX59	100	75.446	ENSSFOG00015003999	ddx59	97	62.521	Scleropages_formosus
ENSG00000118197	DDX59	100	73.661	ENSSMAG00000021230	ddx59	99	60.703	Scophthalmus_maximus
ENSG00000118197	DDX59	100	70.667	ENSSLDG00000011566	-	95	70.813	Seriola_lalandi_dorsalis
ENSG00000118197	DDX59	100	73.661	ENSSPAG00000002321	ddx59	100	58.806	Stegastes_partitus
ENSG00000118197	DDX59	100	89.732	ENSSSCG00000024444	DDX59	100	79.806	Sus_scrofa
ENSG00000118197	DDX59	100	81.696	ENSTGUG00000004456	DDX59	100	70.720	Taeniopygia_guttata
ENSG00000118197	DDX59	100	73.661	ENSTRUG00000010162	ddx59	99	59.524	Takifugu_rubripes
ENSG00000118197	DDX59	100	72.321	ENSTNIG00000010081	ddx59	99	59.709	Tetraodon_nigroviridis
ENSG00000118197	DDX59	79	88.136	ENSTBEG00000008272	DDX59	100	81.761	Tupaia_belangeri
ENSG00000118197	DDX59	100	85.333	ENSTTRG00000008129	DDX59	100	73.548	Tursiops_truncatus
ENSG00000118197	DDX59	100	94.643	ENSUAMG00000015430	DDX59	100	89.677	Ursus_americanus
ENSG00000118197	DDX59	100	94.643	ENSUMAG00000025376	DDX59	100	89.839	Ursus_maritimus
ENSG00000118197	DDX59	98	62.694	ENSVPAG00000011310	-	68	79.412	Vicugna_pacos
ENSG00000118197	DDX59	100	96.429	ENSVVUG00000001095	DDX59	100	88.585	Vulpes_vulpes
ENSG00000118197	DDX59	100	76.786	ENSXETG00000000311	ddx59	100	61.440	Xenopus_tropicalis
ENSG00000118197	DDX59	100	73.661	ENSXCOG00000003621	ddx59	99	60.484	Xiphophorus_couchianus
ENSG00000118197	DDX59	100	74.554	ENSXMAG00000006040	ddx59	99	59.561	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function