EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000118246 (Gene tree)
Gene ID: 22868
Gene Symbol: FASTKD2
Alias: KIAA0971
Full Name: FAST kinase domains 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,833 bases
Position: chr2:206,765,357-206,796,189
Accession: 29160
RBP type: canonical RBP
Summary: This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000236980	RAP	PF08373.10	2.7e-11	1	1
ENSP00000384929	RAP	PF08373.10	2.7e-11	1	1
ENSP00000385990	RAP	PF08373.10	2.7e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26370583	FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.	RNA	2015 Nov	Popow J	doi: 10.1261/rna.052365.115
25683715	Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis.	Cell Rep	2015 Feb 17	Antonicka H	doi: 10.1016/j.celrep.2015.01.030

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000236980	FASTKD2-201	3188	-	ENSP00000236980	710 (aa)	-	Q9NYY8
ENST00000487777	FASTKD2-206	4999	-	-	- (aa)	-	-
ENST00000403094	FASTKD2-203	2344	-	ENSP00000384929	710 (aa)	-	Q9NYY8
ENST00000418289	FASTKD2-204	576	-	ENSP00000409927	124 (aa)	-	C9JPI6
ENST00000402774	FASTKD2-202	2586	-	ENSP00000385990	710 (aa)	-	Q9NYY8
ENST00000471788	FASTKD2-205	842	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000118246's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118246	Body Height	5E-6	20966902
ENSG00000118246	Longevity	2E-6	27015805
ENSG00000118246	Memory, Episodic	4E-9	25385369

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118246	rs145455367	2	206789597	?	Parental longevity (mother's age at death)	27015805	[0.029-0.069] unit increase	0.049273	EFO_0007796
ENSG00000118246	rs7594645	2	206781950	G	Episodic memory	25385369	unit increase	0.072	EFO_0004333
ENSG00000118246	rs2277912	2	206769512	G	Height	20966902	[0.62-1.52] cm increase	1.07	EFO_0004339

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118246's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000118246	FASTKD2	98	70.085	ENSAMEG00000002917	FASTKD2	99	70.085	Ailuropoda_melanoleuca
ENSG00000118246	FASTKD2	76	43.321	ENSAPLG00000006177	FASTKD2	99	43.321	Anas_platyrhynchos
ENSG00000118246	FASTKD2	95	41.983	ENSACAG00000009610	FASTKD2	99	41.983	Anolis_carolinensis
ENSG00000118246	FASTKD2	98	84.438	ENSANAG00000034550	FASTKD2	100	84.438	Aotus_nancymaae
ENSG00000118246	FASTKD2	98	70.529	ENSBTAG00000016193	FASTKD2	99	70.529	Bos_taurus
ENSG00000118246	FASTKD2	99	85.634	ENSCJAG00000005971	FASTKD2	100	85.634	Callithrix_jacchus
ENSG00000118246	FASTKD2	98	67.049	ENSCAFG00000013457	FASTKD2	99	67.049	Canis_familiaris
ENSG00000118246	FASTKD2	98	67.049	ENSCAFG00020027426	FASTKD2	99	67.049	Canis_lupus_dingo
ENSG00000118246	FASTKD2	98	68.956	ENSCHIG00000015121	FASTKD2	99	68.956	Capra_hircus
ENSG00000118246	FASTKD2	99	72.380	ENSTSYG00000003494	FASTKD2	99	72.380	Carlito_syrichta
ENSG00000118246	FASTKD2	97	61.516	ENSCAPG00000016090	FASTKD2	99	61.516	Cavia_aperea
ENSG00000118246	FASTKD2	97	61.373	ENSCPOG00000005624	FASTKD2	99	61.373	Cavia_porcellus
ENSG00000118246	FASTKD2	98	85.159	ENSCCAG00000025887	FASTKD2	100	85.159	Cebus_capucinus
ENSG00000118246	FASTKD2	100	91.702	ENSCATG00000038647	FASTKD2	98	91.702	Cercocebus_atys
ENSG00000118246	FASTKD2	98	67.756	ENSCLAG00000007036	FASTKD2	99	68.040	Chinchilla_lanigera
ENSG00000118246	FASTKD2	98	91.787	ENSCSAG00000010158	FASTKD2	100	91.787	Chlorocebus_sabaeus
ENSG00000118246	FASTKD2	99	66.154	ENSCHOG00000008329	FASTKD2	99	66.154	Choloepus_hoffmanni
ENSG00000118246	FASTKD2	77	46.112	ENSCPBG00000020108	FASTKD2	82	46.112	Chrysemys_picta_bellii
ENSG00000118246	FASTKD2	98	92.363	ENSCANG00000038557	FASTKD2	100	92.363	Colobus_angolensis_palliatus
ENSG00000118246	FASTKD2	97	62.931	ENSCGRG00001020432	Fastkd2	100	63.362	Cricetulus_griseus_chok1gshd
ENSG00000118246	FASTKD2	97	62.931	ENSCGRG00000008898	Fastkd2	100	63.362	Cricetulus_griseus_crigri
ENSG00000118246	FASTKD2	75	35.466	ENSDARG00000074031	fastkd2	84	35.466	Danio_rerio
ENSG00000118246	FASTKD2	99	70.350	ENSDNOG00000012653	FASTKD2	99	70.350	Dasypus_novemcinctus
ENSG00000118246	FASTKD2	97	67.622	ENSDORG00000011295	Fastkd2	100	67.954	Dipodomys_ordii
ENSG00000118246	FASTKD2	99	57.622	ENSETEG00000003094	FASTKD2	99	57.762	Echinops_telfairi
ENSG00000118246	FASTKD2	98	71.674	ENSEASG00005002958	FASTKD2	99	74.876	Equus_asinus_asinus
ENSG00000118246	FASTKD2	98	71.102	ENSECAG00000008822	FASTKD2	99	71.714	Equus_caballus
ENSG00000118246	FASTKD2	63	58.000	ENSEEUG00000015265	-	99	58.000	Erinaceus_europaeus
ENSG00000118246	FASTKD2	98	69.714	ENSFCAG00000015373	FASTKD2	99	70.429	Felis_catus
ENSG00000118246	FASTKD2	77	45.173	ENSFALG00000003964	FASTKD2	97	45.173	Ficedula_albicollis
ENSG00000118246	FASTKD2	97	67.192	ENSFDAG00000003815	FASTKD2	99	67.192	Fukomys_damarensis
ENSG00000118246	FASTKD2	77	43.920	ENSGALG00000008529	FASTKD2	81	43.920	Gallus_gallus
ENSG00000118246	FASTKD2	97	42.717	ENSGAGG00000012072	FASTKD2	99	42.717	Gopherus_agassizii
ENSG00000118246	FASTKD2	100	99.014	ENSGGOG00000002062	FASTKD2	100	99.014	Gorilla_gorilla
ENSG00000118246	FASTKD2	96	69.388	ENSHGLG00000004761	FASTKD2	99	69.388	Heterocephalus_glaber_female
ENSG00000118246	FASTKD2	96	69.388	ENSHGLG00100014148	FASTKD2	99	69.388	Heterocephalus_glaber_male
ENSG00000118246	FASTKD2	98	70.386	ENSSTOG00000022821	FASTKD2	99	70.529	Ictidomys_tridecemlineatus
ENSG00000118246	FASTKD2	97	69.010	ENSJJAG00000000986	Fastkd2	100	69.584	Jaculus_jaculus
ENSG00000118246	FASTKD2	76	43.993	ENSLACG00000005248	FASTKD2	97	43.993	Latimeria_chalumnae
ENSG00000118246	FASTKD2	75	43.148	ENSLOCG00000010389	-	78	43.148	Lepisosteus_oculatus
ENSG00000118246	FASTKD2	95	71.408	ENSLAFG00000005198	FASTKD2	98	71.408	Loxodonta_africana
ENSG00000118246	FASTKD2	98	91.354	ENSMFAG00000033471	FASTKD2	100	91.354	Macaca_fascicularis
ENSG00000118246	FASTKD2	98	90.922	ENSMMUG00000017735	FASTKD2	100	90.922	Macaca_mulatta
ENSG00000118246	FASTKD2	98	91.499	ENSMNEG00000043091	FASTKD2	100	91.499	Macaca_nemestrina
ENSG00000118246	FASTKD2	99	91.549	ENSMLEG00000030777	FASTKD2	99	91.549	Mandrillus_leucophaeus
ENSG00000118246	FASTKD2	77	43.243	ENSMGAG00000008516	FASTKD2	95	43.243	Meleagris_gallopavo
ENSG00000118246	FASTKD2	97	64.604	ENSMAUG00000009136	Fastkd2	100	64.748	Mesocricetus_auratus
ENSG00000118246	FASTKD2	99	69.371	ENSMICG00000026515	FASTKD2	99	69.371	Microcebus_murinus
ENSG00000118246	FASTKD2	97	61.925	ENSMOCG00000019859	Fastkd2	100	61.925	Microtus_ochrogaster
ENSG00000118246	FASTKD2	96	51.926	ENSMODG00000015997	FASTKD2	98	51.926	Monodelphis_domestica
ENSG00000118246	FASTKD2	97	64.511	MGP_CAROLIEiJ_G0014204	Fastkd2	100	64.511	Mus_caroli
ENSG00000118246	FASTKD2	97	65.517	ENSMUSG00000025962	Fastkd2	100	65.517	Mus_musculus
ENSG00000118246	FASTKD2	97	63.584	MGP_PahariEiJ_G0027442	Fastkd2	99	63.584	Mus_pahari
ENSG00000118246	FASTKD2	97	65.517	MGP_SPRETEiJ_G0015011	Fastkd2	100	65.517	Mus_spretus
ENSG00000118246	FASTKD2	98	68.723	ENSMPUG00000000477	FASTKD2	99	68.723	Mustela_putorius_furo
ENSG00000118246	FASTKD2	99	69.620	ENSMLUG00000009411	FASTKD2	99	69.620	Myotis_lucifugus
ENSG00000118246	FASTKD2	96	66.667	ENSNGAG00000001279	Fastkd2	99	67.246	Nannospalax_galili
ENSG00000118246	FASTKD2	99	95.346	ENSNLEG00000007116	FASTKD2	100	95.346	Nomascus_leucogenys
ENSG00000118246	FASTKD2	97	66.476	ENSODEG00000009880	FASTKD2	100	66.476	Octodon_degus
ENSG00000118246	FASTKD2	53	50.000	ENSOANG00000020472	-	99	50.000	Ornithorhynchus_anatinus
ENSG00000118246	FASTKD2	93	71.493	ENSOCUG00000012211	-	100	71.493	Oryctolagus_cuniculus
ENSG00000118246	FASTKD2	98	68.625	ENSOCUG00000010515	-	100	68.625	Oryctolagus_cuniculus
ENSG00000118246	FASTKD2	99	74.022	ENSOGAG00000017008	FASTKD2	99	74.022	Otolemur_garnettii
ENSG00000118246	FASTKD2	98	69.242	ENSOARG00000018793	FASTKD2	99	69.242	Ovis_aries
ENSG00000118246	FASTKD2	98	99.281	ENSPPAG00000021300	FASTKD2	100	99.281	Pan_paniscus
ENSG00000118246	FASTKD2	98	69.099	ENSPPRG00000006075	FASTKD2	99	69.814	Panthera_pardus
ENSG00000118246	FASTKD2	98	69.242	ENSPTIG00000011891	FASTKD2	99	69.957	Panthera_tigris_altaica
ENSG00000118246	FASTKD2	100	99.296	ENSPTRG00000012848	FASTKD2	100	99.296	Pan_troglodytes
ENSG00000118246	FASTKD2	98	92.075	ENSPANG00000012835	FASTKD2	100	92.075	Papio_anubis
ENSG00000118246	FASTKD2	97	42.678	ENSPSIG00000017841	FASTKD2	99	42.678	Pelodiscus_sinensis
ENSG00000118246	FASTKD2	97	64.943	ENSPEMG00000010593	Fastkd2	100	64.943	Peromyscus_maniculatus_bairdii
ENSG00000118246	FASTKD2	97	51.773	ENSPCIG00000018777	FASTKD2	99	51.773	Phascolarctos_cinereus
ENSG00000118246	FASTKD2	98	93.795	ENSPPYG00000013112	FASTKD2	100	93.795	Pongo_abelii
ENSG00000118246	FASTKD2	98	69.774	ENSPCAG00000006780	FASTKD2	99	69.774	Procavia_capensis
ENSG00000118246	FASTKD2	99	72.511	ENSPVAG00000006535	FASTKD2	99	73.072	Pteropus_vampyrus
ENSG00000118246	FASTKD2	76	40.550	ENSPNAG00000009780	fastkd2	81	40.550	Pygocentrus_nattereri
ENSG00000118246	FASTKD2	96	64.296	ENSRNOG00000023923	Fastkd2	99	64.296	Rattus_norvegicus
ENSG00000118246	FASTKD2	99	91.983	ENSRBIG00000039778	FASTKD2	100	91.983	Rhinopithecus_bieti
ENSG00000118246	FASTKD2	98	92.075	ENSRROG00000036558	FASTKD2	100	92.075	Rhinopithecus_roxellana
ENSG00000118246	FASTKD2	98	84.870	ENSSBOG00000029513	FASTKD2	100	84.870	Saimiri_boliviensis_boliviensis
ENSG00000118246	FASTKD2	97	50.498	ENSSHAG00000016740	-	99	50.498	Sarcophilus_harrisii
ENSG00000118246	FASTKD2	76	37.158	ENSSFOG00015006306	fastkd2	80	37.158	Scleropages_formosus
ENSG00000118246	FASTKD2	99	67.324	ENSSARG00000010699	FASTKD2	99	67.324	Sorex_araneus
ENSG00000118246	FASTKD2	54	43.702	ENSSPUG00000001879	-	99	43.702	Sphenodon_punctatus
ENSG00000118246	FASTKD2	98	69.814	ENSSSCG00000016134	FASTKD2	99	69.814	Sus_scrofa
ENSG00000118246	FASTKD2	74	46.212	ENSTGUG00000010004	FASTKD2	99	46.212	Taeniopygia_guttata
ENSG00000118246	FASTKD2	99	67.041	ENSTBEG00000016505	FASTKD2	99	67.602	Tupaia_belangeri
ENSG00000118246	FASTKD2	99	74.126	ENSTTRG00000009846	FASTKD2	99	74.126	Tursiops_truncatus
ENSG00000118246	FASTKD2	98	68.867	ENSUAMG00000015474	FASTKD2	99	68.867	Ursus_americanus
ENSG00000118246	FASTKD2	98	68.867	ENSUMAG00000022590	FASTKD2	99	68.867	Ursus_maritimus
ENSG00000118246	FASTKD2	75	73.970	ENSVPAG00000007491	FASTKD2	99	73.970	Vicugna_pacos
ENSG00000118246	FASTKD2	98	67.622	ENSVVUG00000011933	FASTKD2	99	67.622	Vulpes_vulpes
ENSG00000118246	FASTKD2	75	40.370	ENSXETG00000031283	FASTKD2	97	40.370	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004672	protein kinase activity	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005739	mitochondrion	20869947.	IDA	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0019843	rRNA binding	25683715.	IDA	Function
GO:0035770	ribonucleoprotein granule	25683715.	IDA	Component
GO:0042645	mitochondrial nucleoid	25683715.	IDA	Component
GO:0045171	intercellular bridge	-	IDA	Component
GO:0045333	cellular respiration	20869947.	ISS	Process
GO:0070131	positive regulation of mitochondrial translation	27667664.	IMP	Process
GO:1902775	mitochondrial large ribosomal subunit assembly	25683715.	IMP	Process