EuRBPDB

Description

Ensembl ID: ENSG00000118363 (Gene tree)
Gene ID: 9789
Gene Symbol: SPCS2
Alias: KIAA0102
Full Name: signal peptidase complex subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 29,785 bases
Position: chr11:74,949,247-74,979,031
Accession: 28962
RBP type: non-canonical RBP
Summary: (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Protein export and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17987630	Quantitative proteome analysis of cisplatin-induced apoptotic Jurkat T cells by stable isotope labeling with amino acids in cell culture, SDS-PAGE, and LC-MALDI-TOF/TOF MS.	Electrophoresis	2007 Dec	Schmidt F	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527225	SPCS2-204	321	-	-	- (aa)	-	-
ENST00000532972	SPCS2-208	839	-	ENSP00000436759	257 (aa)	-	E9PI68
ENST00000526883	SPCS2-203	498	-	ENSP00000434706	166 (aa)	-	H0YE04
ENST00000530257	SPCS2-207	612	-	ENSP00000433439	157 (aa)	-	E9PL01
ENST00000527290	SPCS2-205	265	-	-	- (aa)	-	-
ENST00000528265	SPCS2-206	577	-	-	- (aa)	-	-
ENST00000526361	SPCS2-202	772	-	ENSP00000434248	87 (aa)	-	E9PRB9
ENST00000610881	SPCS2-209	2711	-	ENSP00000478550	227 (aa)	-	A0A087WUC6
ENST00000263672	SPCS2-201	2708	-	ENSP00000263672	226 (aa)	-	Q15005

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000118363	SPCS2	79	41.667	FBgn0030306	Spase25	93	40.212	Drosophila_melanogaster
ENSG00000118363	SPCS2	100	95.789	ENSMUSG00000035227	Spcs2	100	99.187	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005787	signal peptidase complex	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006465	signal peptide processing	21873635.	IBA	Process
GO:0008233	peptidase activity	21873635.	IBA	Function
GO:0016021	integral component of membrane	-	IEA	Component
GO:0045047	protein targeting to ER	21873635.	IBA	Process