EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000118495 (Gene tree)
Gene ID: 5325
Gene Symbol: PLAGL1
Alias: ZAC|LOT1
Full Name: PLAG1 like zinc finger 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 124,300 bases
Position: chr6:143,940,300-144,064,599
Accession: 9046
RBP type: canonical RBP
Summary: This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000346810	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000346810	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000353734	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000353734	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000356543	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000356543	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000400060	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000400060	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000400929	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000400929	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000486355	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000486355	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000496979	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000496979	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000497363	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000497363	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000497492	zf-C2H2	PF00096.26	7.3e-16	1	2
ENSP00000497492	zf-C2H2	PF00096.26	7.3e-16	2	2
ENSP00000496874	zf-C2H2	PF00096.26	5.5e-15	1	2
ENSP00000496874	zf-C2H2	PF00096.26	5.5e-15	2	2
ENSP00000486763	zf-C2H2	PF00096.26	3.3e-09	1	1
ENSP00000356544	zf-C2H2	PF00096.26	1.2e-08	1	1
ENSP00000392418	zf-C2H2	PF00096.26	1.2e-08	1	1
ENSP00000395960	zf-C2H2	PF00096.26	1.2e-08	1	1
ENSP00000496815	zf-C2H2	PF00096.26	1.2e-08	1	1
ENSP00000487447	zf-C2H2	PF00096.26	8.5e-07	1	1
ENSP00000486752	zf-C2H2	PF00096.26	1.4e-06	1	1
ENSP00000486632	zf-C2H2	PF00096.26	1.5e-06	1	1
ENSP00000485907	zf-C2H2	PF00096.26	1.5e-06	1	1
ENSP00000486632	zf-met	PF12874.7	0.00055	1	1
ENSP00000487447	zf-met	PF12874.7	0.00069	1	1
ENSP00000486752	zf-met	PF12874.7	0.00082	1	1
ENSP00000485907	zf-met	PF12874.7	0.00082	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15888726	ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.	Nucleic Acids Res	2005 May 11	Arima T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000631184	PLAGL1-222	491	-	-	- (aa)	-	-
ENST00000649307	PLAGL1-226	3229	-	ENSP00000496979	463 (aa)	-	UPI000006F274
ENST00000417959	PLAGL1-207	1645	-	ENSP00000395960	411 (aa)	-	Q9UM63
ENST00000493898	PLAGL1-210	505	-	-	- (aa)	-	-
ENST00000627449	PLAGL1-216	588	-	ENSP00000485907	73 (aa)	-	A0A0D9SEQ4
ENST00000626294	PLAGL1-213	593	-	ENSP00000487447	80 (aa)	-	A0A0D9SGF7
ENST00000392307	PLAGL1-205	6296	-	ENSP00000376124	252 (aa)	-	Q68DN7
ENST00000444202	PLAGL1-209	3197	-	ENSP00000400929	463 (aa)	-	Q9UM63
ENST00000650125	PLAGL1-227	2910	-	ENSP00000497363	463 (aa)	-	UPI000006F274
ENST00000354765	PLAGL1-201	3663	-	ENSP00000346810	463 (aa)	-	Q9UM63
ENST00000628069	PLAGL1-217	559	-	-	- (aa)	-	-
ENST00000625622	PLAGL1-211	3216	-	ENSP00000486355	463 (aa)	-	Q9UM63
ENST00000647880	PLAGL1-223	2138	-	ENSP00000496815	411 (aa)	-	UPI0000062345
ENST00000626462	PLAGL1-215	587	-	ENSP00000486752	74 (aa)	-	A0A0D9SFM8
ENST00000629890	PLAGL1-221	584	-	-	- (aa)	-	-
ENST00000626373	PLAGL1-214	333	-	ENSP00000486711	12 (aa)	-	A1YLA2
ENST00000367572	PLAGL1-204	2496	-	ENSP00000356544	411 (aa)	-	Q9UM63
ENST00000416623	PLAGL1-206	3237	-	ENSP00000400060	463 (aa)	-	Q9UM63
ENST00000649211	PLAGL1-225	3479	-	ENSP00000497492	463 (aa)	-	UPI000006F274
ENST00000437412	PLAGL1-208	2640	-	ENSP00000392418	411 (aa)	-	Q9UM63
ENST00000360537	PLAGL1-202	4430	-	ENSP00000353734	463 (aa)	-	Q9UM63
ENST00000626022	PLAGL1-212	559	-	-	- (aa)	-	-
ENST00000628630	PLAGL1-218	556	-	-	- (aa)	-	-
ENST00000628651	PLAGL1-219	563	-	ENSP00000486632	102 (aa)	-	A0A0D9SFI7
ENST00000367571	PLAGL1-203	2800	-	ENSP00000356543	463 (aa)	-	Q9UM63
ENST00000629195	PLAGL1-220	723	-	ENSP00000486763	64 (aa)	-	A1YLA1
ENST00000647988	PLAGL1-224	2383	-	ENSP00000496874	173 (aa)	-	-

Gene Model

Click here to download ENSG00000118495's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118495	Bronchodilator Agents	2E-6	26634245
ENSG00000118495	Lung Volume Measurements	2E-6	26634245
ENSG00000118495	Bronchodilator Agents	1E-6	26634245
ENSG00000118495	Lung Volume Measurements	1E-6	26634245
ENSG00000118495	Bronchodilator Agents	2E-6	26634245
ENSG00000118495	Lung Volume Measurements	2E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118495	rs17073303	6	144034900	?	Peanut allergy (maternal genetic effects)	29489655			EFO_0007017\|EFO_0005939
ENSG00000118495	rs192748541	6	144052556	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.434	GO_0097366\|EFO_0004713
ENSG00000118495	rs150612539	6	143952786	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.441	GO_0097366\|EFO_0004713
ENSG00000118495	rs150029151	6	144025056	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.432	GO_0097366\|EFO_0004713
ENSG00000118495	rs6928827	6	143994082	A	Anti-saccade response	29064472			EFO_0006874
ENSG00000118495	rs2064495	6	143948864	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118495's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	9671765.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	9671765.	IDA	Function
GO:0003677	DNA binding	15888726.	IDA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006915	apoptotic process	9671765.	TAS	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0007050	cell cycle arrest	9184226.	TAS	Process
GO:0016604	nuclear body	21873635.	IBA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	9671765.15888726.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12473647	LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.	J Biol Chem	2003 Feb 21	Abdollahi A	-
15581945	Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer.	Gynecol Oncol	2004 Dec	Cvetkovic D	-
26134521	Altered expression of the PLAGL1 (ZAC1/LOT1) gene in colorectal cancer: Correlations to the clinicopathological parameters.	Int J Oncol	2015 Sep	Kowalczyk AE	doi: 10.3892/ijo.2015.3067
28260048	Octreotide inhibits the proliferation of gastric cancer cells through P300-HAT activity and the interaction of ZAC and P300.	Oncol Rep	2017 Apr	Wang L	doi: 10.3892/or.2017.5451

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr6	143948048	Missense_Mutation	rs201696236	R30Q	0.86	zf-C2H2
BLCA	chr6	143941401	3'UTR	rs560190372		0.57
BLCA	chr6	143942002	Missense_Mutation	rs765875826	A272T	0.39
BRCA	chr6	143948199	5'UTR	novel		0.48
CESC	chr6	143948103	Missense_Mutation	NA	T12A	0.34	zf-C2H2
CESC	chr6	143942419	Missense_Mutation	novel	E133K	0.29
CESC	chr6	143941625	Silent	novel	T397T	0.49
CESC	chr6	143942342	Silent	novel	C158C	0.09
COAD	chr6	143942598	Missense_Mutation	rs753924230	R73Q	0.2
COAD	chr6	143942490	Missense_Mutation	novel	H109R	0.08
COAD	chr6	143941494	Missense_Mutation	novel	P441H	0.43
COAD	chr6	143942476	Missense_Mutation	novel	A114S	0.04
COAD	chr6	143942232	Missense_Mutation	novel	R195H	0.62
COAD	chr6	143941401	3'UTR	rs560190372		0.5
COAD	chr6	143948175	5'UTR	novel		0.32
COAD	chr6	143942216	Silent	novel	T200T	0.02
ESCA	chr6	143941892	Silent	novel	T308T	0.44
GBM	chr6	143942326	Missense_Mutation	novel	C164S	0.06
GBM	chr6	143942525	Silent	novel	G97G	0.07
GBM	chr6	143948120	Missense_Mutation	novel	C6Y	0.03
GBM	chr6	143942158	Missense_Mutation	novel	D220Y	0.12
HNSC	chr6	143942373	Missense_Mutation	rs748313279	P148L	0.21
HNSC	chr6	143942034	Missense_Mutation	novel	H261R	0.13
HNSC	chr6	143942177	Silent	novel	K213K	0.29
HNSC	chr6	143941351	3'UTR	novel		0.21
HNSC	chr6	143942642	Silent	novel	P58P	0.07
HNSC	chr6	143941804	Missense_Mutation	novel	E338K	0.48
LAML	chr6	143941867	Missense_Mutation	novel	P317T	0.05
LUAD	chr6	143941953	Missense_Mutation	rs749708141	S288L	0.13
LUAD	chr6	143942392	Missense_Mutation	novel	H142N	0.22
LUAD	chr6	143942054	Missense_Mutation	NA	S254R	0.3
LUSC	chr6	143942558	Silent	novel	P86P	0.21
LUSC	chr6	143942252	Missense_Mutation	novel	F188L	0.24
OV	chr6	143941377	3'UTR	novel		0.07
READ	chr6	143941372	3'UTR	novel		0.49
READ	chr6	143942067	Missense_Mutation	novel	N250S	0.42
READ	chr6	143948128	Silent	rs539999694	T3T	0.25
SKCM	chr6	143942176	Missense_Mutation	NA	E214K	0.28
SKCM	chr6	143941704	Missense_Mutation	novel	N371S	0.82
SKCM	chr6	143941810	Silent	novel	L336L	0.43
SKCM	chr6	143942612	Silent	NA	E68E	0.36
SKCM	chr6	143941591	Missense_Mutation	novel	E409K	0.39
SKCM	chr6	143941592	Silent	novel	G408G	0.33
SKCM	chr6	143948273	5'UTR	rs571326035		0.87
SKCM	chr6	143941727	Silent	NA	K363K	0.45
SKCM	chr6	143942052	Missense_Mutation	NA	S255N	0.09
SKCM	chr6	143941703	Silent	novel	N371N	0.63
SKCM	chr6	143942308	Missense_Mutation	novel	D170N	0.33
SKCM	chr6	143941401	3'UTR	rs560190372		0.24
SKCM	chr6	143948119	Silent	novel	C6C	0.38
SKCM	chr6	143948236	5'UTR	novel		0.36
SKCM	chr6	143941438	Missense_Mutation	NA	H460Y	0.4
SKCM	chr6	143942309	Silent	rs765832081	K169K	0.41
SKCM	chr6	143942172	Missense_Mutation	NA	S215N	0.3
SKCM	chr6	143941370	3'UTR	novel		0.49
SKCM	chr6	143948003	Missense_Mutation	NA	S45F	0.66
SKCM	chr6	143941489	Missense_Mutation	NA	P443S	0.08
SKCM	chr6	143941662	Missense_Mutation	NA	G385D	0.25
SKCM	chr6	143942652	Missense_Mutation	novel	T55I	0.82
SKCM	chr6	143948161	5'UTR	novel		0.47
SKCM	chr6	143941461	Missense_Mutation	NA	S452F	0.1
SKCM	chr6	143948164	5'UTR	novel		0.15
SKCM	chr6	143948265	5'UTR	novel		0.5
SKCM	chr6	143941978	Missense_Mutation	NA	E280K	0.66
SKCM	chr6	143948158	5'UTR	novel		0.38
SKCM	chr6	143941940	Silent	rs750070946	G292G	0.38
SKCM	chr6	143942522	Silent	novel	K98K	0.35
STAD	chr6	143948102	Missense_Mutation	NA	T12M	0.24	zf-C2H2
STAD	chr6	143941931	Silent	rs17847330	P295P	0.34
STAD	chr6	143941493	Frame_Shift_Del	NA	*I442Sfs24**	0.3
STAD	chr6	143941415	3'UTR	novel		0.29
UCEC	chr6	143942073	Missense_Mutation	NA	A248V	0.04
UCEC	chr6	143941953	Missense_Mutation	rs749708141	S288L	0.48
UCEC	chr6	143948129	Missense_Mutation	rs529372879	T3M	0.38
UCEC	chr6	143942437	Silent	novel	L127L	0.37
UCEC	chr6	143942662	Missense_Mutation	NA	H52Y	0.23
UCEC	chr6	143942071	Missense_Mutation	novel	Q249K	0.18
UCEC	chr6	143942107	Missense_Mutation	novel	A237S	0.47
UCEC	chr6	143941546	Nonsense_Mutation	novel	E424*	0.43
UCEC	chr6	143942324	Nonsense_Mutation	novel	C164*	0.33
UCEC	chr6	143942290	Missense_Mutation	novel	V176M	0.3
UCEC	chr6	143942506	Silent	novel	L104L	0.45
UCEC	chr6	143940997	3'UTR	novel		0.12
UCEC	chr6	143941401	3'UTR	rs560190372		0.45
UCEC	chr6	143941461	Missense_Mutation	novel	S452Y	0.41
UCEC	chr6	143941917	Missense_Mutation	novel	N300S	0.21
UCEC	chr6	143941258	3'UTR	novel		0.28
UCEC	chr6	143940875	3'UTR	novel		0.32
UCEC	chr6	143941283	3'UTR	novel		0.36
UCEC	chr6	143942201	Missense_Mutation	novel	K205N	0.08
UCEC	chr6	143941345	3'UTR	novel		0.5
UCEC	chr6	143940584	3'UTR	novel		0.4
UCEC	chr6	143942450	Silent	novel	C122C	0.36
UCEC	chr6	143941644	Frame_Shift_Del	novel	*P391Lfs25**	0.24
UCEC	chr6	143940762	3'UTR	novel		0.28
UCEC	chr6	143942096	Silent	novel	P240P	0.39
UCEC	chr6	143942029	Missense_Mutation	novel	L263I	0.21
UCEC	chr6	143941582	Missense_Mutation	novel	P412S	0.29
UCEC	chr6	143942606	Silent	rs144954752	T70T	0.12
UCEC	chr6	143941345	3'UTR	novel		0.24
UCEC	chr6	143942478	Missense_Mutation	novel	H113R	0.54
UCEC	chr6	143941212	3'UTR	novel		0.37
UCEC	chr6	143948032	Silent	novel	V35V	0.3
UCEC	chr6	143948078	Missense_Mutation	rs769533076	T20M	0.39	zf-C2H2
UCEC	chr6	143942598	Missense_Mutation	rs753924230	R73Q	0.21
UCEC	chr6	143941897	Missense_Mutation	NA	S307A	0.27
UCEC	chr6	143941270	3'UTR	novel		0.33
UCEC	chr6	143942232	Missense_Mutation	novel	R195H	0.25
UCEC	chr6	143942130	Missense_Mutation	rs751187671	S229L	0.18
UCEC	chr6	143942423	Silent	novel	S131S	0.35
UCEC	chr6	143941724	Silent	NA	E364E	0.21
UCEC	chr6	143942420	Silent	rs142899386	T132T	0.32
UCEC	chr6	143941421	3'UTR	novel		0.33
UCEC	chr6	143942593	Missense_Mutation	novel	D75Y	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.2357	1.056e-05
KIRC	DEL	0.2443	7.439e-11
LGG	DEL	0.1481	0.0054594
MESO	DEL	0.4253	0.05642
PAAD	DEL	0.3587	0.11274
SKCM	DEL	0.5477	1.5442e-06
THYM	DEL	0.1301	0.10691
UVM	DEL	0.2875	0.0054289

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0077	Kaplan-Meier Survival Analysis
STAD	0.0059	Kaplan-Meier Survival Analysis
MESO	0.0015	Kaplan-Meier Survival Analysis
ACC	0.00046	Kaplan-Meier Survival Analysis
UCS	0.029	Kaplan-Meier Survival Analysis
SKCM	0.028	Kaplan-Meier Survival Analysis
KIRP	0.031	Kaplan-Meier Survival Analysis
PAAD	0.0054	Kaplan-Meier Survival Analysis
BLCA	0.03	Kaplan-Meier Survival Analysis
CESC	0.018	Kaplan-Meier Survival Analysis
LAML	0.011	Kaplan-Meier Survival Analysis
UCEC	0.0049	Kaplan-Meier Survival Analysis
GBM	0.036	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
THCA	0.0091	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742