EuRBPDB

Description

Ensembl ID: ENSG00000118873 (Gene tree)
Gene ID: 25782
Gene Symbol: RAB3GAP2
Alias: RAB3-GAP150|KIAA0839|DKFZP434D245|SPG69
Full Name: RAB3 GTPase activating non-catalytic protein subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 124,234 bases
Position: chr1:220,148,268-220,272,501
Accession: 17168
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19605474	ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.	J Virol	2009 Oct	Clerzius G	doi: 10.1128/JVI.02457-08

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474966	RAB3GAP2-205	848	-	-	- (aa)	-	-
ENST00000237724	RAB3GAP2-201	821	-	-	- (aa)	-	-
ENST00000491005	RAB3GAP2-209	897	-	-	- (aa)	-	-
ENST00000462353	RAB3GAP2-203	1906	-	-	- (aa)	-	-
ENST00000358951	RAB3GAP2-202	7257	-	ENSP00000351832	1393 (aa)	-	Q9H2M9
ENST00000478976	RAB3GAP2-207	575	-	-	- (aa)	-	-
ENST00000491305	RAB3GAP2-210	843	-	-	- (aa)	-	-
ENST00000484658	RAB3GAP2-208	515	-	ENSP00000418560	172 (aa)	-	H7C4Y9
ENST00000474178	RAB3GAP2-204	539	-	ENSP00000420156	82 (aa)	-	F8WDJ2
ENST00000475769	RAB3GAP2-206	375	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000118873	Body Mass Index	3.80491780301001E-7	17903300
ENSG00000118873	Body Mass Index	4.30661088431723E-8	17903300
ENSG00000118873	Body Mass Index	7.21121237005637E-6	17903300
ENSG00000118873	Body Weight	4.04055823800276E-7	17903300
ENSG00000118873	Body Weight	3.06781747639379E-6	17903300
ENSG00000118873	Abdominal Fat	1.02917442013383E-6	17903300
ENSG00000118873	Abdominal Fat	1.49691438397067E-6	17903300
ENSG00000118873	Cholesterol, HDL	2.85349725326667E-10	17903299
ENSG00000118873	Cholesterol, HDL	6.69425428079053E-8	17903299
ENSG00000118873	C-Reactive Protein	8.37147685636342E-8	17903293

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000118873	rs116518462	1	220184504	G	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.011-0.022] unit increase	0.0163656	EFO_0006527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005096	GTPase activator activity	-	IEA	Function
GO:0005515	protein binding	22337587.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006886	intracellular protein transport	9733780.	TAS	Process
GO:0008047	enzyme activator activity	9733780.	TAS	Function
GO:0017112	Rab guanyl-nucleotide exchange factor activity	21873635.	IBA	Function
GO:0017112	Rab guanyl-nucleotide exchange factor activity	24891604.	IMP	Function
GO:0017137	Rab GTPase binding	24891604.	IPI	Function
GO:0030234	enzyme regulator activity	-	ISS	Function
GO:0032991	protein-containing complex	24891604.	IDA	Component
GO:0043087	regulation of GTPase activity	21873635.	IBA	Process
GO:0043087	regulation of GTPase activity	-	ISS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0046982	protein heterodimerization activity	-	ISS	Function
GO:0097051	establishment of protein localization to endoplasmic reticulum membrane	24891604.	IMP	Process
GO:1903061	positive regulation of protein lipidation	25495476.	IMP	Process
GO:1903373	positive regulation of endoplasmic reticulum tubular network organization	24891604.	IMP	Process
GO:2000786	positive regulation of autophagosome assembly	25495476.	IMP	Process