EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119203 (Gene tree)
Gene ID: 51692
Gene Symbol: CPSF3
Alias: CPSF-73|CPSF73|YSH1
Full Name: cleavage and polyadenylation specific factor 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 49,574 bases
Position: chr2:9,423,537-9,473,110
Accession: 2326
RBP type: canonical RBP
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000418957	CPSF73-100_C	PF11718.8	9.3e-54	1	1
ENSP00000238112	CPSF73-100_C	PF11718.8	1.1e-53	1	1
ENSP00000418957	Beta-Casp	PF10996.8	1.7e-33	1	1
ENSP00000238112	Beta-Casp	PF10996.8	1.9e-33	1	1
ENSP00000238112	Lactamase_B	PF00753.27	4.3e-18	1	1
ENSP00000418957	Lactamase_B	PF00753.27	9.5e-15	1	1
ENSP00000419744	Lactamase_B	PF00753.27	9.1e-11	1	1
ENSP00000418957	RMMBL	PF07521.12	4.5e-21	1	1
ENSP00000238112	RMMBL	PF07521.12	5e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17128255	Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.	Nature	2006 Dec 14	Mandel CR	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475482	CPSF3-203	871	-	ENSP00000419744	136 (aa)	-	C9JZH6
ENST00000489403	CPSF3-204	688	-	-	- (aa)	-	-
ENST00000460593	CPSF3-202	3157	-	ENSP00000418957	647 (aa)	-	G5E9W3
ENST00000238112	CPSF3-201	2345	-	ENSP00000238112	684 (aa)	-	Q9UKF6
ENST00000489629	CPSF3-205	547	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000119203's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119203's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000119203	CPSF3	98	37.857	ENSG00000127054	INTS11	99	41.667

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119203	CPSF3	100	100.000	ENSAPOG00000012241	CPSF3	90	96.982	Acanthochromis_polyacanthus
ENSG00000119203	CPSF3	100	98.529	ENSAPOG00000022087	cpsf3	98	85.420	Acanthochromis_polyacanthus
ENSG00000119203	CPSF3	100	100.000	ENSAMEG00000008493	CPSF3	100	99.415	Ailuropoda_melanoleuca
ENSG00000119203	CPSF3	97	86.508	ENSACIG00000023663	CPSF3	99	86.508	Amphilophus_citrinellus
ENSG00000119203	CPSF3	97	82.803	ENSACIG00000009846	cpsf3	99	82.803	Amphilophus_citrinellus
ENSG00000119203	CPSF3	100	100.000	ENSAOCG00000010077	CPSF3	98	87.941	Amphiprion_ocellaris
ENSG00000119203	CPSF3	100	98.529	ENSAOCG00000022056	cpsf3	94	91.156	Amphiprion_ocellaris
ENSG00000119203	CPSF3	100	98.529	ENSAPEG00000019526	cpsf3	97	86.728	Amphiprion_percula
ENSG00000119203	CPSF3	100	100.000	ENSAPEG00000021167	CPSF3	98	87.941	Amphiprion_percula
ENSG00000119203	CPSF3	100	100.000	ENSATEG00000014525	CPSF3	98	83.235	Anabas_testudineus
ENSG00000119203	CPSF3	100	98.529	ENSATEG00000003959	cpsf3	98	85.420	Anabas_testudineus
ENSG00000119203	CPSF3	100	100.000	ENSAPLG00000006941	CPSF3	98	95.238	Anas_platyrhynchos
ENSG00000119203	CPSF3	98	93.071	ENSACAG00000001759	CPSF3	99	93.071	Anolis_carolinensis
ENSG00000119203	CPSF3	100	100.000	ENSANAG00000031254	CPSF3	100	93.129	Aotus_nancymaae
ENSG00000119203	CPSF3	100	98.529	ENSACLG00000014484	cpsf3	99	85.714	Astatotilapia_calliptera
ENSG00000119203	CPSF3	97	86.349	ENSACLG00000018846	CPSF3	99	86.349	Astatotilapia_calliptera
ENSG00000119203	CPSF3	100	100.000	ENSAMXG00000004786	cpsf3	98	88.235	Astyanax_mexicanus
ENSG00000119203	CPSF3	100	100.000	ENSBTAG00000019735	CPSF3	100	99.561	Bos_taurus
ENSG00000119203	CPSF3	100	69.565	WBGene00013460	cpsf-3	89	59.213	Caenorhabditis_elegans
ENSG00000119203	CPSF3	100	100.000	ENSCJAG00000006276	CPSF3	100	99.415	Callithrix_jacchus
ENSG00000119203	CPSF3	100	100.000	ENSCAFG00000003375	CPSF3	95	99.415	Canis_familiaris
ENSG00000119203	CPSF3	100	100.000	ENSCAFG00020026799	CPSF3	100	99.838	Canis_lupus_dingo
ENSG00000119203	CPSF3	57	97.403	ENSCHIG00000009354	-	99	98.230	Capra_hircus
ENSG00000119203	CPSF3	100	100.000	ENSCHIG00000013973	CPSF3	100	99.561	Capra_hircus
ENSG00000119203	CPSF3	100	100.000	ENSTSYG00000002967	CPSF3	100	99.708	Carlito_syrichta
ENSG00000119203	CPSF3	100	100.000	ENSCAPG00000013851	CPSF3	100	97.901	Cavia_aperea
ENSG00000119203	CPSF3	100	100.000	ENSCPOG00000011299	CPSF3	100	97.953	Cavia_porcellus
ENSG00000119203	CPSF3	100	100.000	ENSCCAG00000036730	CPSF3	100	99.561	Cebus_capucinus
ENSG00000119203	CPSF3	100	100.000	ENSCATG00000014770	CPSF3	99	99.828	Cercocebus_atys
ENSG00000119203	CPSF3	100	100.000	ENSCLAG00000002727	CPSF3	100	97.515	Chinchilla_lanigera
ENSG00000119203	CPSF3	100	100.000	ENSCSAG00000007125	CPSF3	100	91.959	Chlorocebus_sabaeus
ENSG00000119203	CPSF3	86	100.000	ENSCHOG00000000180	CPSF3	85	72.105	Choloepus_hoffmanni
ENSG00000119203	CPSF3	100	100.000	ENSCPBG00000014074	CPSF3	99	95.455	Chrysemys_picta_bellii
ENSG00000119203	CPSF3	100	78.676	ENSCING00000007214	-	98	68.129	Ciona_intestinalis
ENSG00000119203	CPSF3	100	100.000	ENSCANG00000034435	CPSF3	100	86.550	Colobus_angolensis_palliatus
ENSG00000119203	CPSF3	100	100.000	ENSCGRG00001013134	Cpsf3	100	98.830	Cricetulus_griseus_chok1gshd
ENSG00000119203	CPSF3	100	100.000	ENSCGRG00000018319	Cpsf3	100	98.830	Cricetulus_griseus_crigri
ENSG00000119203	CPSF3	100	99.265	ENSCSEG00000002021	CPSF3	99	86.553	Cynoglossus_semilaevis
ENSG00000119203	CPSF3	100	99.265	ENSCVAG00000015067	CPSF3	98	88.235	Cyprinodon_variegatus
ENSG00000119203	CPSF3	60	92.683	ENSCVAG00000022058	-	86	94.783	Cyprinodon_variegatus
ENSG00000119203	CPSF3	100	100.000	ENSDARG00000027649	cpsf3	98	88.971	Danio_rerio
ENSG00000119203	CPSF3	100	97.794	ENSDNOG00000008940	CPSF3	95	97.664	Dasypus_novemcinctus
ENSG00000119203	CPSF3	100	100.000	ENSDORG00000014263	Cpsf3	100	99.078	Dipodomys_ordii
ENSG00000119203	CPSF3	100	80.147	FBgn0261065	Cpsf73	98	67.305	Drosophila_melanogaster
ENSG00000119203	CPSF3	89	100.000	ENSETEG00000003893	CPSF3	100	85.561	Echinops_telfairi
ENSG00000119203	CPSF3	100	92.647	ENSEBUG00000009018	cpsf3	98	78.797	Eptatretus_burgeri
ENSG00000119203	CPSF3	100	100.000	ENSEASG00005003970	CPSF3	100	99.415	Equus_asinus_asinus
ENSG00000119203	CPSF3	100	100.000	ENSECAG00000019911	CPSF3	100	99.415	Equus_caballus
ENSG00000119203	CPSF3	100	83.918	ENSEEUG00000015422	CPSF3	100	83.918	Erinaceus_europaeus
ENSG00000119203	CPSF3	100	100.000	ENSELUG00000013775	cpsf3	98	88.088	Esox_lucius
ENSG00000119203	CPSF3	100	100.000	ENSFCAG00000007852	CPSF3	100	99.561	Felis_catus
ENSG00000119203	CPSF3	100	100.000	ENSFALG00000006572	CPSF3	100	95.518	Ficedula_albicollis
ENSG00000119203	CPSF3	100	100.000	ENSFDAG00000006317	CPSF3	99	97.361	Fukomys_damarensis
ENSG00000119203	CPSF3	63	68.780	ENSFHEG00000012186	CPSF3	99	68.780	Fundulus_heteroclitus
ENSG00000119203	CPSF3	100	98.529	ENSFHEG00000014774	cpsf3	98	85.125	Fundulus_heteroclitus
ENSG00000119203	CPSF3	60	93.902	ENSFHEG00000012215	-	60	94.828	Fundulus_heteroclitus
ENSG00000119203	CPSF3	100	99.265	ENSGMOG00000003157	cpsf3	98	86.618	Gadus_morhua
ENSG00000119203	CPSF3	100	100.000	ENSGALG00000016424	CPSF3	99	95.154	Gallus_gallus
ENSG00000119203	CPSF3	97	82.830	ENSGAFG00000019449	cpsf3	99	82.830	Gambusia_affinis
ENSG00000119203	CPSF3	100	99.265	ENSGAFG00000008016	CPSF3	98	88.071	Gambusia_affinis
ENSG00000119203	CPSF3	72	93.362	ENSGAGG00000025583	CPSF3	93	93.362	Gopherus_agassizii
ENSG00000119203	CPSF3	100	100.000	ENSGGOG00000001757	CPSF3	100	99.843	Gorilla_gorilla
ENSG00000119203	CPSF3	63	81.481	ENSHBUG00000014332	CPSF3	99	81.481	Haplochromis_burtoni
ENSG00000119203	CPSF3	100	98.529	ENSHBUG00000001188	cpsf3	99	85.609	Haplochromis_burtoni
ENSG00000119203	CPSF3	100	100.000	ENSHGLG00000000666	CPSF3	99	96.930	Heterocephalus_glaber_female
ENSG00000119203	CPSF3	100	100.000	ENSHGLG00100007765	CPSF3	99	96.930	Heterocephalus_glaber_male
ENSG00000119203	CPSF3	100	100.000	ENSHCOG00000015957	CPSF3	97	86.324	Hippocampus_comes
ENSG00000119203	CPSF3	100	98.529	ENSHCOG00000007251	cpsf3	99	84.897	Hippocampus_comes
ENSG00000119203	CPSF3	100	99.265	ENSIPUG00000023488	cpsf3	98	87.059	Ictalurus_punctatus
ENSG00000119203	CPSF3	100	100.000	ENSSTOG00000004476	CPSF3	100	98.830	Ictidomys_tridecemlineatus
ENSG00000119203	CPSF3	100	100.000	ENSJJAG00000023415	Cpsf3	100	97.807	Jaculus_jaculus
ENSG00000119203	CPSF3	100	97.794	ENSKMAG00000002806	cpsf3	98	84.831	Kryptolebias_marmoratus
ENSG00000119203	CPSF3	100	99.265	ENSKMAG00000007317	CPSF3	98	87.647	Kryptolebias_marmoratus
ENSG00000119203	CPSF3	100	98.529	ENSLBEG00000020569	cpsf3	94	78.971	Labrus_bergylta
ENSG00000119203	CPSF3	100	100.000	ENSLBEG00000013492	CPSF3	98	89.043	Labrus_bergylta
ENSG00000119203	CPSF3	58	79.625	ENSLBEG00000015018	-	99	79.625	Labrus_bergylta
ENSG00000119203	CPSF3	100	100.000	ENSLACG00000008308	CPSF3	98	83.947	Latimeria_chalumnae
ENSG00000119203	CPSF3	100	100.000	ENSLOCG00000016823	cpsf3	98	89.280	Lepisosteus_oculatus
ENSG00000119203	CPSF3	100	99.265	ENSLAFG00000009467	CPSF3	100	97.647	Loxodonta_africana
ENSG00000119203	CPSF3	100	100.000	ENSMFAG00000001339	CPSF3	100	99.708	Macaca_fascicularis
ENSG00000119203	CPSF3	100	100.000	ENSMMUG00000018038	CPSF3	100	99.691	Macaca_mulatta
ENSG00000119203	CPSF3	100	100.000	ENSMNEG00000039447	CPSF3	100	86.988	Macaca_nemestrina
ENSG00000119203	CPSF3	100	100.000	ENSMLEG00000026825	CPSF3	100	99.854	Mandrillus_leucophaeus
ENSG00000119203	CPSF3	97	85.285	ENSMAMG00000008835	CPSF3	99	85.285	Mastacembelus_armatus
ENSG00000119203	CPSF3	100	99.265	ENSMAMG00000003076	cpsf3	98	85.714	Mastacembelus_armatus
ENSG00000119203	CPSF3	100	98.529	ENSMZEG00005014358	cpsf3	99	85.609	Maylandia_zebra
ENSG00000119203	CPSF3	100	100.000	ENSMZEG00005006258	CPSF3	98	88.529	Maylandia_zebra
ENSG00000119203	CPSF3	100	100.000	ENSMGAG00000013995	CPSF3	100	95.202	Meleagris_gallopavo
ENSG00000119203	CPSF3	58	97.074	ENSMAUG00000000166	Cpsf3	100	97.074	Mesocricetus_auratus
ENSG00000119203	CPSF3	100	100.000	ENSMICG00000002363	CPSF3	100	94.006	Microcebus_murinus
ENSG00000119203	CPSF3	100	100.000	ENSMOCG00000020067	Cpsf3	100	94.152	Microtus_ochrogaster
ENSG00000119203	CPSF3	100	99.265	ENSMMOG00000018212	CPSF3	98	82.326	Mola_mola
ENSG00000119203	CPSF3	75	85.294	ENSMMOG00000011923	CPSF3	84	77.857	Mola_mola
ENSG00000119203	CPSF3	100	100.000	ENSMODG00000014703	CPSF3	100	96.093	Monodelphis_domestica
ENSG00000119203	CPSF3	91	90.698	ENSMALG00000011474	CPSF3	99	83.438	Monopterus_albus
ENSG00000119203	CPSF3	100	98.529	ENSMALG00000016416	cpsf3	99	86.050	Monopterus_albus
ENSG00000119203	CPSF3	100	100.000	MGP_CAROLIEiJ_G0017640	Cpsf3	100	98.538	Mus_caroli
ENSG00000119203	CPSF3	100	100.000	ENSMUSG00000054309	Cpsf3	100	98.538	Mus_musculus
ENSG00000119203	CPSF3	100	100.000	MGP_PahariEiJ_G0029397	Cpsf3	100	98.392	Mus_pahari
ENSG00000119203	CPSF3	100	100.000	MGP_SPRETEiJ_G0018481	Cpsf3	100	98.538	Mus_spretus
ENSG00000119203	CPSF3	100	100.000	ENSMPUG00000013213	CPSF3	100	98.977	Mustela_putorius_furo
ENSG00000119203	CPSF3	100	100.000	ENSMLUG00000010636	CPSF3	100	98.394	Myotis_lucifugus
ENSG00000119203	CPSF3	100	100.000	ENSNGAG00000019836	Cpsf3	100	98.684	Nannospalax_galili
ENSG00000119203	CPSF3	97	86.349	ENSNBRG00000010525	CPSF3	99	86.349	Neolamprologus_brichardi
ENSG00000119203	CPSF3	100	98.529	ENSNBRG00000004770	cpsf3	99	85.169	Neolamprologus_brichardi
ENSG00000119203	CPSF3	100	100.000	ENSNLEG00000013359	CPSF3	100	99.708	Nomascus_leucogenys
ENSG00000119203	CPSF3	99	66.718	ENSMEUG00000013117	-	100	65.497	Notamacropus_eugenii
ENSG00000119203	CPSF3	100	100.000	ENSOPRG00000008902	CPSF3	100	89.620	Ochotona_princeps
ENSG00000119203	CPSF3	100	100.000	ENSODEG00000003129	CPSF3	100	97.076	Octodon_degus
ENSG00000119203	CPSF3	100	98.529	ENSONIG00000018812	cpsf3	99	85.756	Oreochromis_niloticus
ENSG00000119203	CPSF3	87	96.454	ENSOANG00000008577	CPSF3	100	96.454	Ornithorhynchus_anatinus
ENSG00000119203	CPSF3	100	100.000	ENSOCUG00000003728	CPSF3	100	98.977	Oryctolagus_cuniculus
ENSG00000119203	CPSF3	100	97.059	ENSORLG00000018854	cpsf3	99	83.554	Oryzias_latipes
ENSG00000119203	CPSF3	100	97.059	ENSORLG00020013331	cpsf3	99	83.554	Oryzias_latipes_hni
ENSG00000119203	CPSF3	100	97.059	ENSORLG00015011017	cpsf3	99	83.554	Oryzias_latipes_hsok
ENSG00000119203	CPSF3	100	96.324	ENSOMEG00000010647	cpsf3	94	83.700	Oryzias_melastigma
ENSG00000119203	CPSF3	100	89.620	ENSOGAG00000001680	CPSF3	100	89.620	Otolemur_garnettii
ENSG00000119203	CPSF3	100	100.000	ENSOARG00000015073	CPSF3	100	99.561	Ovis_aries
ENSG00000119203	CPSF3	100	100.000	ENSPPAG00000042457	CPSF3	100	99.854	Pan_paniscus
ENSG00000119203	CPSF3	100	100.000	ENSPPRG00000016790	CPSF3	100	99.269	Panthera_pardus
ENSG00000119203	CPSF3	100	100.000	ENSPTIG00000003920	CPSF3	100	99.213	Panthera_tigris_altaica
ENSG00000119203	CPSF3	100	100.000	ENSPTRG00000011638	CPSF3	100	99.854	Pan_troglodytes
ENSG00000119203	CPSF3	100	100.000	ENSPANG00000016798	CPSF3	100	99.561	Papio_anubis
ENSG00000119203	CPSF3	100	100.000	ENSPKIG00000023646	cpsf3	99	89.302	Paramormyrops_kingsleyae
ENSG00000119203	CPSF3	100	100.000	ENSPSIG00000016144	CPSF3	100	93.704	Pelodiscus_sinensis
ENSG00000119203	CPSF3	63	79.259	ENSPMGG00000015311	CPSF3	99	79.259	Periophthalmus_magnuspinnatus
ENSG00000119203	CPSF3	57	98.701	ENSPMGG00000015314	-	83	98.182	Periophthalmus_magnuspinnatus
ENSG00000119203	CPSF3	86	90.756	ENSPMGG00000006141	-	99	85.340	Periophthalmus_magnuspinnatus
ENSG00000119203	CPSF3	100	100.000	ENSPEMG00000017668	Cpsf3	100	98.538	Peromyscus_maniculatus_bairdii
ENSG00000119203	CPSF3	100	94.853	ENSPMAG00000004841	cpsf3	99	90.317	Petromyzon_marinus
ENSG00000119203	CPSF3	100	100.000	ENSPCIG00000009823	CPSF3	98	97.699	Phascolarctos_cinereus
ENSG00000119203	CPSF3	100	98.529	ENSPFOG00000015922	cpsf3	99	84.751	Poecilia_formosa
ENSG00000119203	CPSF3	100	99.265	ENSPFOG00000010418	-	98	87.776	Poecilia_formosa
ENSG00000119203	CPSF3	57	98.701	ENSPLAG00000021271	-	76	100.000	Poecilia_latipinna
ENSG00000119203	CPSF3	62	80.693	ENSPLAG00000021300	-	99	80.693	Poecilia_latipinna
ENSG00000119203	CPSF3	100	98.529	ENSPLAG00000000882	cpsf3	99	84.751	Poecilia_latipinna
ENSG00000119203	CPSF3	100	98.529	ENSPMEG00000018309	cpsf3	99	84.897	Poecilia_mexicana
ENSG00000119203	CPSF3	57	98.701	ENSPMEG00000021545	-	76	100.000	Poecilia_mexicana
ENSG00000119203	CPSF3	98	82.075	ENSPREG00000014875	cpsf3	99	82.671	Poecilia_reticulata
ENSG00000119203	CPSF3	100	99.265	ENSPREG00000004482	CPSF3	98	82.474	Poecilia_reticulata
ENSG00000119203	CPSF3	100	100.000	ENSPPYG00000012666	CPSF3	100	95.322	Pongo_abelii
ENSG00000119203	CPSF3	99	99.259	ENSPCAG00000015042	CPSF3	100	63.748	Procavia_capensis
ENSG00000119203	CPSF3	100	100.000	ENSPCOG00000023016	CPSF3	98	92.199	Propithecus_coquereli
ENSG00000119203	CPSF3	100	100.000	ENSPVAG00000005324	CPSF3	99	99.413	Pteropus_vampyrus
ENSG00000119203	CPSF3	87	92.500	ENSPNYG00000021047	CPSF3	91	91.529	Pundamilia_nyererei
ENSG00000119203	CPSF3	100	98.529	ENSPNYG00000004405	cpsf3	99	85.609	Pundamilia_nyererei
ENSG00000119203	CPSF3	100	100.000	ENSPNAG00000023060	cpsf3	98	87.647	Pygocentrus_nattereri
ENSG00000119203	CPSF3	100	100.000	ENSRNOG00000052418	Cpsf3	99	98.534	Rattus_norvegicus
ENSG00000119203	CPSF3	100	99.265	ENSRBIG00000041615	CPSF3	99	95.209	Rhinopithecus_bieti
ENSG00000119203	CPSF3	100	100.000	ENSRROG00000033792	CPSF3	100	99.854	Rhinopithecus_roxellana
ENSG00000119203	CPSF3	100	54.861	YLR277C	YSH1	95	40.671	Saccharomyces_cerevisiae
ENSG00000119203	CPSF3	100	100.000	ENSSBOG00000027263	CPSF3	100	93.478	Saimiri_boliviensis_boliviensis
ENSG00000119203	CPSF3	100	100.000	ENSSHAG00000007024	CPSF3	100	97.807	Sarcophilus_harrisii
ENSG00000119203	CPSF3	100	100.000	ENSSFOG00015002108	cpsf3	99	89.574	Scleropages_formosus
ENSG00000119203	CPSF3	100	100.000	ENSSMAG00000020534	CPSF3	95	87.654	Scophthalmus_maximus
ENSG00000119203	CPSF3	100	100.000	ENSSDUG00000018498	CPSF3	98	88.088	Seriola_dumerili
ENSG00000119203	CPSF3	100	98.529	ENSSDUG00000002828	cpsf3	96	85.609	Seriola_dumerili
ENSG00000119203	CPSF3	100	100.000	ENSSLDG00000005234	CPSF3	98	88.088	Seriola_lalandi_dorsalis
ENSG00000119203	CPSF3	100	98.529	ENSSLDG00000008469	cpsf3	91	90.847	Seriola_lalandi_dorsalis
ENSG00000119203	CPSF3	100	81.433	ENSSARG00000005186	CPSF3	100	81.433	Sorex_araneus
ENSG00000119203	CPSF3	100	99.265	ENSSPUG00000015525	CPSF3	97	92.399	Sphenodon_punctatus
ENSG00000119203	CPSF3	100	98.529	ENSSPAG00000018579	cpsf3	98	85.567	Stegastes_partitus
ENSG00000119203	CPSF3	100	100.000	ENSSPAG00000002906	CPSF3	98	87.794	Stegastes_partitus
ENSG00000119203	CPSF3	100	100.000	ENSSSCG00000020799	CPSF3	99	99.414	Sus_scrofa
ENSG00000119203	CPSF3	100	100.000	ENSTGUG00000013016	CPSF3	99	95.595	Taeniopygia_guttata
ENSG00000119203	CPSF3	62	72.727	ENSTRUG00000013905	CPSF3	99	72.727	Takifugu_rubripes
ENSG00000119203	CPSF3	100	99.265	ENSTRUG00000007030	cpsf3	97	84.853	Takifugu_rubripes
ENSG00000119203	CPSF3	57	98.701	ENSTRUG00000021819	-	85	97.273	Takifugu_rubripes
ENSG00000119203	CPSF3	100	85.294	ENSTBEG00000002707	CPSF3	85	93.699	Tupaia_belangeri
ENSG00000119203	CPSF3	100	100.000	ENSTTRG00000000861	CPSF3	88	98.387	Tursiops_truncatus
ENSG00000119203	CPSF3	100	100.000	ENSUAMG00000007535	CPSF3	98	96.334	Ursus_americanus
ENSG00000119203	CPSF3	100	100.000	ENSUMAG00000003676	CPSF3	100	99.382	Ursus_maritimus
ENSG00000119203	CPSF3	100	100.000	ENSVPAG00000008041	CPSF3	100	95.741	Vicugna_pacos
ENSG00000119203	CPSF3	100	100.000	ENSVVUG00000002194	CPSF3	100	99.415	Vulpes_vulpes
ENSG00000119203	CPSF3	100	100.000	ENSXETG00000008263	cpsf3	98	90.162	Xenopus_tropicalis
ENSG00000119203	CPSF3	57	98.701	ENSXCOG00000003932	-	77	99.091	Xiphophorus_couchianus
ENSG00000119203	CPSF3	57	79.245	ENSXCOG00000000957	-	87	79.245	Xiphophorus_couchianus
ENSG00000119203	CPSF3	100	98.529	ENSXCOG00000019695	cpsf3	99	85.044	Xiphophorus_couchianus
ENSG00000119203	CPSF3	100	99.265	ENSXMAG00000027291	CPSF3	98	87.923	Xiphophorus_maculatus
ENSG00000119203	CPSF3	100	98.529	ENSXMAG00000009784	cpsf3	99	84.751	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	-	ISS	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004521	endoribonuclease activity	-	ISS	Function
GO:0005515	protein binding	18288197.18688255.21102410.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	18305108.21102410.	IDA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006379	mRNA cleavage	8929409.	TAS	Process
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	21873635.	IBA	Process
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	18688255.	IDA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008409	5'-3' exonuclease activity	21873635.	IBA	Function
GO:0008409	5'-3' exonuclease activity	-	ISS	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19136632	The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.	Proc Natl Acad Sci U S A	2009 Jan 20	Rozenblatt-Rosen O	doi: 10.1073/pnas.0812023106

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	9440545	Missense_Mutation	novel	S272L	0.31
BLCA	chr2	9433948	Splice_Site	novel	X201_splice	0.31
BLCA	chr2	9430848	Silent	novel	Y103Y	0.45
BLCA	chr2	9428802	Missense_Mutation	novel	L30I	0.52
BLCA	chr2	9440539	Missense_Mutation	novel	Y270C	0.32
BLCA	chr2	9432541	Silent	rs761040737	T124T	0.15
BLCA	chr2	9441885	Missense_Mutation	novel	G335A	0.27
BLCA	chr2	9436225	Silent	rs554338304	G208G	0.29
BLCA	chr2	9443638	Missense_Mutation	NA	R407C	0.34	CPSF73-100_C
BLCA	chr2	9441827	Missense_Mutation	NA	H316Y	0.48
BLCA	chr2	9440645	Missense_Mutation	novel	F305L	0.23
BRCA	chr2	9430828	Missense_Mutation	NA	H97D	0.18
BRCA	chr2	9471389	Missense_Mutation	novel	L635I	0.08
BRCA	chr2	9472931	Missense_Mutation	NA	E657Q	0.37
BRCA	chr2	9467720	Missense_Mutation	NA	K600N	0.36
BRCA	chr2	9430878	Splice_Region	novel	V113V	0.08
BRCA	chr2	9430004	In_Frame_Del	NA	L68del	0.12
BRCA	chr2	9456949	Missense_Mutation	NA	L540F	0.16
BRCA	chr2	9456983	Frame_Shift_Del	NA	*N553Ifs4**	0.3
CESC	chr2	9473042	3'UTR	novel		0.2
CESC	chr2	9433878	Missense_Mutation	rs759928669	Y176C	0.35
CESC	chr2	9428788	Missense_Mutation	novel	R25I	0.23
CESC	chr2	9428815	Missense_Mutation	NA	G34E	0.3
CESC	chr2	9440543	Silent	novel	A271A	0.31
CESC	chr2	9448222	Missense_Mutation	novel	E423K	0.17	CPSF73-100_C
COAD	chr2	9471394	Silent	rs762972969	S636S	0.35
COAD	chr2	9429925	Splice_Region	rs139906430	L39L	0.28
COAD	chr2	9432682	Silent	rs773798533	G171G	0.44
COAD	chr2	9432579	Missense_Mutation	NA	T137I	0.24
COAD	chr2	9455752	Missense_Mutation	NA	L533W	0.11
COAD	chr2	9430760	Missense_Mutation	novel	L74S	0.27
ESCA	chr2	9433909	Nonsense_Mutation	novel	*H187Lfs9**	0.36
ESCA	chr2	9443517	Missense_Mutation	novel	H366Q	0.2
GBM	chr2	9459564	Missense_Mutation	novel	D578Y	0.52
GBM	chr2	9440500	Missense_Mutation	novel	W257L	0.07
GBM	chr2	9423806	Silent	novel	Q11Q	0.22
GBM	chr2	9472961	Nonsense_Mutation	novel	E667*	0.27
HNSC	chr2	9440618	Silent	novel	Q296Q	0.17
HNSC	chr2	9436251	Missense_Mutation	novel	E217G	0.27
HNSC	chr2	9441932	Missense_Mutation	novel	G351S	0.3
KIRC	chr2	9440601	Missense_Mutation	NA	D291N	0.27
KIRC	chr2	9448312	Missense_Mutation	NA	A453T	0.28
KIRP	chr2	9423804	Missense_Mutation	novel	Q11E	0.41
KIRP	chr2	9430860	In_Frame_Del	novel	S108_D109del	0.34
LGG	chr2	9433898	Missense_Mutation	novel	Q183K	0.4
LGG	chr2	9467775	Nonsense_Mutation	novel	Q619*	0.07
LGG	chr2	9430873	Missense_Mutation	novel	K112E	0.46
LIHC	chr2	9433902	Missense_Mutation	NA	E184G	0.3
LIHC	chr2	9472994	Missense_Mutation	novel	E678K	0.41
LUAD	chr2	9430872	Silent	NA	V111V	0.33
LUAD	chr2	9448236	Missense_Mutation	novel	L427F	0.07	CPSF73-100_C
LUAD	chr2	9432664	Silent	novel	F165F	0.12
LUAD	chr2	9448300	Missense_Mutation	rs757160812	R449W	0.21
LUSC	chr2	9443523	Missense_Mutation	novel	M368I	0.29
LUSC	chr2	9441934	Silent	NA	G351G	0.12
LUSC	chr2	9455715	Missense_Mutation	novel	G521C	0.05
LUSC	chr2	9455716	Missense_Mutation	novel	G521V	0.06
LUSC	chr2	9432562	Silent	novel	S131S	0.26
LUSC	chr2	9430794	Missense_Mutation	novel	Q85H	0.08
LUSC	chr2	9448253	Missense_Mutation	NA	R433Q	0.28	CPSF73-100_C
LUSC	chr2	9443646	Missense_Mutation	novel	L409F	0.14	CPSF73-100_C
OV	chr2	9441892	Silent	novel	S337S	0.06
OV	chr2	9428763	Splice_Site	novel	X18_splice	0.04
OV	chr2	9436293	Missense_Mutation	novel	N231I	0.05
OV	chr2	9471412	Missense_Mutation	NA	K642N	0.43
PRAD	chr2	9455720	Silent	NA	P522P	0.11
READ	chr2	9448300	Missense_Mutation	rs757160812	R449W	0.41
READ	chr2	9452965	Missense_Mutation	novel	G483V	0.31
READ	chr2	9441953	Missense_Mutation	novel	C358G	0.2
SARC	chr2	9423920	Intron	novel		0.23
SARC	chr2	9456951	Missense_Mutation	novel	E541G	0.09
SARC	chr2	9467790	Intron	novel		0.26
SKCM	chr2	9467734	Missense_Mutation	NA	L605S	0.38
SKCM	chr2	9436338	Missense_Mutation	NA	A246D	0.1
SKCM	chr2	9429941	Missense_Mutation	novel	P45S	0.38
SKCM	chr2	9443575	Missense_Mutation	novel	M386L	0.29	CPSF73-100_C
SKCM	chr2	9455719	Missense_Mutation	NA	P522L	0.28
SKCM	chr2	9430755	Silent	NA	F72F	0.35
SKCM	chr2	9432602	Missense_Mutation	novel	E145K	0.17
SKCM	chr2	9423756	5'UTR	rs192112595		0.23
STAD	chr2	9440610	Missense_Mutation	NA	R294C	0.15
STAD	chr2	9471394	Silent	rs762972969	S636S	0.12
STAD	chr2	9441864	Missense_Mutation	NA	S328Y	0.16
THCA	chr2	9473047	3'UTR	novel		0.11
THCA	chr2	9430864	Missense_Mutation	NA	D109N	0.34
UCEC	chr2	9473087	3'UTR	rs757870752		0.27
UCEC	chr2	9456982	Frame_Shift_Ins	novel	*N553Kfs21**	0.35
UCEC	chr2	9473082	3'UTR	novel		0.38
UCEC	chr2	9457018	Silent	novel	V563V	0.39
UCEC	chr2	9430775	Missense_Mutation	novel	A79D	0.41
UCEC	chr2	9441945	Missense_Mutation	novel	A355V	0.31
UCEC	chr2	9436289	Missense_Mutation	novel	V230I	0.11
UCEC	chr2	9472949	Missense_Mutation	novel	E663K	0.31
UCEC	chr2	9441909	Missense_Mutation	NA	S343I	0.14
UCEC	chr2	9473003	Missense_Mutation	novel	T681S	0.04
UCEC	chr2	9440514	Nonsense_Mutation	NA	E262*	0.13
UCEC	chr2	9471384	Missense_Mutation	NA	S633Y	0.25
UCEC	chr2	9430872	Silent	NA	V111V	0.12
UCEC	chr2	9441845	Missense_Mutation	NA	P322S	0.42
UCEC	chr2	9452980	Missense_Mutation	novel	R488I	0.34
UCEC	chr2	9429963	Missense_Mutation	novel	A52D	0.29
UCEC	chr2	9453011	Silent	rs141972024	C498C	0.44
UCEC	chr2	9436286	Missense_Mutation	rs779316073	I229V	0.37
UCEC	chr2	9473087	3'UTR	novel		0.26
UCEC	chr2	9436263	Missense_Mutation	novel	R221I	0.45
UCEC	chr2	9432683	Missense_Mutation	rs763418256	V172M	0.44
UCEC	chr2	9452922	Missense_Mutation	novel	F469V	0.33
UCEC	chr2	9471361	Silent	novel	D625D	0.33
UCEC	chr2	9433904	Missense_Mutation	novel	D185Y	0.51
UCEC	chr2	9453012	Missense_Mutation	rs765101532	D499N	0.55
UCEC	chr2	9423825	Splice_Site	novel	X17_splice	0.12
UCEC	chr2	9471395	Missense_Mutation	rs199631426	V637I	0.25
UCEC	chr2	9440583	Missense_Mutation	novel	Y285H	0.33
UCEC	chr2	9448252	Nonsense_Mutation	rs199913516	R433*	0.4	CPSF73-100_C
UCEC	chr2	9433919	Missense_Mutation	novel	A190T	0.15
UCEC	chr2	9440548	Missense_Mutation	novel	S273Y	0.36
UCEC	chr2	9440548	Missense_Mutation	novel	S273Y	0.42
UCEC	chr2	9429925	Splice_Region	rs139906430	L39L	0.41
UCEC	chr2	9455701	Missense_Mutation	novel	A516V	0.09
UCEC	chr2	9471393	Missense_Mutation	novel	S636N	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3064	0.033813
CESC	AMP	0.2339	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0659	0.20634
OV	DEL	0.1451	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.039	0.18809

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0075	Kaplan-Meier Survival Analysis
KIRC	0.0038	Kaplan-Meier Survival Analysis
MESO	0.0041	Kaplan-Meier Survival Analysis
ACC	0.016	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
PCPG	0.046	Kaplan-Meier Survival Analysis
BLCA	0.028	Kaplan-Meier Survival Analysis
UCEC	0.0079	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.042	Kaplan-Meier Survival Analysis
UVM	0.024	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis