EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119335 (Gene tree)
Gene ID: 6418
Gene Symbol: SET
Alias: PHAPII|2PP2A|IPP2A2|TAF-IBETA|IGAAD|TAF-I
Full Name: SET nuclear proto-oncogene
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,977 bases
Position: chr9:128,683,424-128,696,400
Accession: 10760
RBP type: non-canonical RBP
Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372686	SET-202	1029	-	ENSP00000361771	265 (aa)	-	Q01105
ENST00000372688	SET-203	801	-	ENSP00000361773	266 (aa)	-	A0A0C4DFV9
ENST00000372692	SET-204	2850	XM_017015013	ENSP00000361777	290 (aa)	XP_016870502	Q01105
ENST00000466009	SET-207	597	-	-	- (aa)	-	-
ENST00000322030	SET-201	2915	XM_017015016	ENSP00000318012	277 (aa)	XP_016870505	Q01105
ENST00000409104	SET-205	962	-	ENSP00000387321	268 (aa)	-	Q01105
ENST00000480536	SET-210	388	-	-	- (aa)	-	-
ENST00000477806	SET-208	957	-	-	- (aa)	-	-
ENST00000485056	SET-211	483	-	-	- (aa)	-	-
ENST00000454747	SET-206	235	-	ENSP00000410806	32 (aa)	-	B2REB7
ENST00000480217	SET-209	509	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000119335's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000119335	Macular Degeneration	5.41248E-6	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119335's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119335	SET	100	97.834	ENSMUSG00000054766	Set	100	97.834	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0004864	protein phosphatase inhibitor activity	8626647.	TAS	Function
GO:0005515	protein binding	11909973.16189514.17245428.17318177.19343227.20195357.21988832.23195690.24983498.25416956.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	11555662.	IDA	Component
GO:0005634	nucleus	18374643.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	11909973.12524539.	IDA	Component
GO:0005783	endoplasmic reticulum	11555662.12524539.	IDA	Component
GO:0005811	lipid droplet	-	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006260	DNA replication	7753797.	TAS	Process
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006337	nucleosome disassembly	11555662.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0019888	protein phosphatase regulator activity	11555662.	TAS	Function
GO:0032515	negative regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0032991	protein-containing complex	11909973.	IDA	Component
GO:0035067	negative regulation of histone acetylation	11555662.	TAS	Process
GO:0042393	histone binding	11555662.	TAS	Function
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043524	negative regulation of neuron apoptotic process	18374643.	IGI	Process
GO:0045892	negative regulation of transcription, DNA-templated	19343227.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	11555662.12524539.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27517624	Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer.	Oncotarget	2017 Jun 20	Crist??bal I	doi: 10.18632/oncotarget.11174.
24621013	Proteomics identified overexpression of SET oncogene product and possible therapeutic utility of protein phosphatase 2A in alveolar soft part sarcoma.	J Proteome Res	2014 May 2	Kubota D	doi: 10.1021/pr400929h
27383536	MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein.	Cell Physiol Biochem	2016	Ying X	doi: 10.1159/000445642
16286244	The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.	Cancer Cell	2005 Nov	Neviani P	-
25388166	Deregulation of the PP2A inhibitor SET shows promising therapeutic implications and determines poor clinical outcome in patients with metastatic colorectal cancer.	Clin Cancer Res	2015 Jan 15	Crist??bal I	doi: 10.1158/1078-0432.CCR-14-0724
25234598	Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion.	Biochem Biophys Res Commun	2014 Oct 10	Li J	doi: 10.1016/j.bbrc.2014.09.013
26563471	Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.	Sci Rep	2015 Nov 13	Hu X	doi: 10.1038/srep15182.
26234767	PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer.	Tumour Biol	2015 Aug	Gonz??lez-Alonso P	doi: 10.1007/s13277-015-3849-5
22739068	SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.	Oral Oncol	2012 Nov	Leopoldino AM	doi: 10.1016/j.oraloncology.2012.05.014
15930275	PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.	Cancer Res	2005 Jun 1	Anazawa Y	-
24025258	Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment.	Cancer Biol Ther	2013 Oct 1	Mukhopadhyay A	doi: 10.4161/cbt.25943
27035430	Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells.	Mol Med Rep	2016 May	Wang Y	doi: 10.3892/mmr.2016.5049
28356029	Oncogenic Role of SET/I2PP2A for Gynecologic Cancers.	Curr Drug Targets	2017	Jiang SW	doi: 10.2174/1389450118666170328114506.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	128694707	3'UTR	NA		0.66
BLCA	chr9	128693728	Missense_Mutation	novel	D208Y	0.1
BLCA	chr9	128691855	Splice_Region	novel		0.28
BLCA	chr9	128693790	Missense_Mutation	novel	N228K	0.16
BRCA	chr9	128691169	Splice_Site	novel	X38_splice	0.32
BRCA	chr9	128692693	Silent	novel	E115E	0.04
BRCA	chr9	128695697	3'UTR	novel		0.2
BRCA	chr9	128696339	3'UTR	novel		0.13
CESC	chr9	128694841	3'UTR	novel		0.24
CESC	chr9	128691857	Splice_Site	NA	X57_splice	0.3
CESC	chr9	128694894	3'UTR	novel		0.24
CESC	chr9	128695629	3'UTR	novel		0.74
CESC	chr9	128691957	Missense_Mutation	novel	K90N	0.28
CESC	chr9	128696228	3'UTR	novel		0.28
CHOL	chr9	128695446	3'UTR	novel		0.42
CHOL	chr9	128695448	3'UTR	novel		0.39
COAD	chr9	128691916	Missense_Mutation	NA	R77C	0.41
COAD	chr9	128693678	Missense_Mutation	NA	S191N	0.41
COAD	chr9	128689611	Intron	novel		0.6
COAD	chr9	128693927	Missense_Mutation	NA	G245E	0.25
COAD	chr9	128691960	Frame_Shift_Del	NA	*P92Qfs5**	0.32
COAD	chr9	128692958	Missense_Mutation	NA	E170K	0.22
COAD	chr9	128691947	Missense_Mutation	novel	L87S	0.08
COAD	chr9	128692958	Nonsense_Mutation	NA	E170*	0.25
COAD	chr9	128693663	Missense_Mutation	rs150832256	T186M	0.48
ESCA	chr9	128695465	3'UTR	novel		0.17
ESCA	chr9	128683929	Missense_Mutation	novel	Q12E	0.27
ESCA	chr9	128695618	3'UTR	novel		0.22
ESCA	chr9	128695850	3'UTR	novel		0.17
ESCA	chr9	128693663	Missense_Mutation	rs150832256	T186M	0.44
ESCA	chr9	128695807	3'UTR	novel		0.41
ESCA	chr9	128692924	Silent	novel	L158L	0.15
ESCA	chr9	128694980	3'UTR	novel		0.15
HNSC	chr9	128693921	Missense_Mutation	novel	G243A	0.16
LGG	chr9	128694640	Splice_Site	novel	X284_splice	0.08
LUAD	chr9	128691905	Missense_Mutation	novel	Y73C	0.5
LUSC	chr9	128694010	Missense_Mutation	novel	D273Y	0.56
MESO	chr9	128691880	Missense_Mutation	novel	E65K	0.43
OV	chr9	128694650	Nonsense_Mutation	novel	G287*	0.05
PAAD	chr9	128692757	Missense_Mutation	novel	I137L	0.14
PRAD	chr9	128692757	Missense_Mutation	novel	I137V	0.25
SARC	chr9	128691880	Missense_Mutation	novel	E65K	0.51
SKCM	chr9	128693682	Silent	NA	R192R	0.07
SKCM	chr9	128692935	Frame_Shift_Ins	novel	D163*	0.21
SKCM	chr9	128692922	Silent	NA	L158L	0.39
SKCM	chr9	128692884	Missense_Mutation	NA	P145L	0.13
STAD	chr9	128693645	Missense_Mutation	NA	T180M	0.27
STAD	chr9	128692755	Missense_Mutation	NA	R136T	0.43
STAD	chr9	128692976	Missense_Mutation	novel	G176R	0.25
STAD	chr9	128693654	Missense_Mutation	rs142648600	S183L	0.3
STAD	chr9	128692700	Missense_Mutation	NA	H118Y	0.15
UCEC	chr9	128691179	Missense_Mutation	NA	Q41P	0.2
UCEC	chr9	128683894	5'UTR	novel		0.35
UCEC	chr9	128691916	Missense_Mutation	NA	R77C	0.35
UCEC	chr9	128695474	3'UTR	novel		0.21
UCEC	chr9	128692760	Missense_Mutation	novel	D138Y	0.42
UCEC	chr9	128683909	Missense_Mutation	novel	R5H	0.41
UCEC	chr9	128696384	3'UTR	rs577399588		0.51
UCEC	chr9	128694883	3'UTR	novel		0.1
UCEC	chr9	128691186	Missense_Mutation	NA	E43D	0.45
UCEC	chr9	128694696	3'UTR	novel		0.19
UCEC	chr9	128692702	Silent	novel	H118H	0.06
UCEC	chr9	128692727	Nonsense_Mutation	novel	E127*	0.2
UCEC	chr9	128691929	Missense_Mutation	novel	F81Y	0.38
UCEC	chr9	128695560	3'UTR	novel		0.24
UCEC	chr9	128695359	3'UTR	novel		0.15
UCEC	chr9	128695774	3'UTR	novel		0.14
UCEC	chr9	128696338	3'UTR	novel		0.19
UCEC	chr9	128691983	Missense_Mutation	NA	F99C	0.24
UCEC	chr9	128695025	3'UTR	novel		0.2
UCEC	chr9	128692904	Missense_Mutation	novel	L152I	0.28
UCEC	chr9	128694883	3'UTR	novel		0.42
UCEC	chr9	128696386	3'UTR	novel		0.45
UCEC	chr9	128691882	Missense_Mutation	NA	E65D	0.28
UCEC	chr9	128694883	3'UTR	novel		0.38
UCEC	chr9	128695161	3'UTR	novel		0.38
UCEC	chr9	128696350	3'UTR	novel		0.37
UCEC	chr9	128694759	3'UTR	novel		0.44
UCEC	chr9	128692958	Missense_Mutation	NA	E170K	0.33
UCEC	chr9	128696221	3'UTR	novel		0.31
UCEC	chr9	128691952	Missense_Mutation	novel	A89T	0.43
UCEC	chr9	128693706	Missense_Mutation	novel	E200D	0.32
UCEC	chr9	128695091	3'UTR	novel		0.24
UCEC	chr9	128695544	3'UTR	novel		0.21
UCEC	chr9	128683834	5'UTR	novel		0.37
UCEC	chr9	128693650	Missense_Mutation	novel	R182C	0.38
UCEC	chr9	128695045	3'UTR	novel		0.2
UCEC	chr9	128693980	Missense_Mutation	NA	E263K	0.43
UCEC	chr9	128683987	Missense_Mutation	NA	A31V	0.19
UCEC	chr9	128696386	3'UTR	novel		0.58
UCEC	chr9	128695163	3'UTR	rs762630044		0.26
UCEC	chr9	128696386	3'UTR	novel		0.21
UCEC	chr9	128695630	3'UTR	novel		0.19
UCEC	chr9	128692661	Splice_Site	novel	X105_splice	0.12
UCEC	chr9	128692958	Missense_Mutation	NA	E170K	0.16
UCEC	chr9	128696386	3'UTR	novel		0.82
UCEC	chr9	128691218	Missense_Mutation	novel	E54A	0.28
UCEC	chr9	128694941	3'UTR	novel		0.33
UCEC	chr9	128695777	3'UTR	novel		0.15
UCEC	chr9	128693657	Missense_Mutation	NA	S184I	0.26
UCEC	chr9	128692948	Silent	novel	S166S	0.24
UCEC	chr9	128695510	3'UTR	novel		0.05

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0604	0.21332
LIHC	DEL	0.2514	0.12467
PRAD	AMP	0.0813	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5714	0.089783

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0057	Kaplan-Meier Survival Analysis
KIRC	0.0029	Kaplan-Meier Survival Analysis
SARC	0.0019	Kaplan-Meier Survival Analysis
MESO	0.00017	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0042	Kaplan-Meier Survival Analysis
PAAD	0.027	Kaplan-Meier Survival Analysis
BLCA	0.049	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.044	Kaplan-Meier Survival Analysis
LUAD	0.0023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742