EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119392 (Gene tree)
Gene ID: 2733
Gene Symbol: GLE1
Alias: hGLE1|GLE1L|LCCS1
Full Name: GLE1 RNA export mediator
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 37,610 bases
Position: chr9:128,504,692-128,542,301
Accession: 4315
RBP type: canonical RBP
Summary: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361856	GLE1	PF07817.13	1.2e-87	1	1
ENSP00000308622	GLE1	PF07817.13	1.4e-87	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28980860	behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.	Autophagy	2017	Uversky VN	doi: 10.1080/15548627.2017.1384889
21576265	The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.	Genes Dev	2011 May 15	Hodge CA	doi: 10.1101/gad.2041611.
21441902	A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.	Nature	2011 Apr 14	Montpetit B	doi: 10.1038/nature09862
28784717	Gle1 Regulates RNA Binding of the DEAD-Box Helicase Ded1 in Its Complex Role in Translation Initiation.	Mol Cell Biol	2017 Oct 13	Aryanpur PP	doi: 10.1128/MCB.00139-17
29899397	Structural and functional analysis of mRNA export regulation by the nuclear pore complex.	Nat Commun	2018 Jun 13	Lin DH	doi: 10.1038/s41467-018-04459-3.
21576266	The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1.	Genes Dev	2011 May 15	Noble KN	doi: 10.1101/gad.2040611.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000309971	GLE1-201	3321	XM_006717059	ENSP00000308622	698 (aa)	XP_006717122	Q53GS7
ENST00000372770	GLE1-202	2218	-	ENSP00000361856	659 (aa)	-	Q53GS7
ENST00000494417	GLE1-203	778	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000119392's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119392's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119392	GLE1	100	51.648	ENSAPOG00000020086	gle1	100	52.420	Acanthochromis_polyacanthus
ENSG00000119392	GLE1	100	87.393	ENSAMEG00000015537	GLE1	100	87.393	Ailuropoda_melanoleuca
ENSG00000119392	GLE1	100	53.419	ENSACIG00000009154	gle1	100	53.704	Amphilophus_citrinellus
ENSG00000119392	GLE1	100	53.112	ENSAOCG00000000782	gle1	100	53.250	Amphiprion_ocellaris
ENSG00000119392	GLE1	100	53.112	ENSAPEG00000020337	gle1	100	53.250	Amphiprion_percula
ENSG00000119392	GLE1	83	58.000	ENSATEG00000009075	gle1	95	53.443	Anabas_testudineus
ENSG00000119392	GLE1	99	65.751	ENSAPLG00000016355	GLE1	99	65.751	Anas_platyrhynchos
ENSG00000119392	GLE1	100	56.822	ENSACAG00000008564	GLE1	100	56.955	Anolis_carolinensis
ENSG00000119392	GLE1	90	96.933	ENSANAG00000031688	GLE1	100	96.933	Aotus_nancymaae
ENSG00000119392	GLE1	100	52.647	ENSACLG00000000598	gle1	100	52.647	Astatotilapia_calliptera
ENSG00000119392	GLE1	100	54.972	ENSAMXG00000012542	gle1	100	54.972	Astyanax_mexicanus
ENSG00000119392	GLE1	100	86.963	ENSBTAG00000030566	GLE1	100	86.963	Bos_taurus
ENSG00000119392	GLE1	100	95.415	ENSCJAG00000020060	GLE1	100	95.415	Callithrix_jacchus
ENSG00000119392	GLE1	100	87.106	ENSCAFG00000020050	GLE1	100	87.106	Canis_familiaris
ENSG00000119392	GLE1	100	87.393	ENSCAFG00020019679	GLE1	100	87.393	Canis_lupus_dingo
ENSG00000119392	GLE1	100	83.238	ENSCHIG00000025665	GLE1	100	83.238	Capra_hircus
ENSG00000119392	GLE1	89	93.168	ENSTSYG00000000174	GLE1	100	93.168	Carlito_syrichta
ENSG00000119392	GLE1	95	78.797	ENSCAPG00000011927	GLE1	100	78.797	Cavia_aperea
ENSG00000119392	GLE1	100	78.805	ENSCPOG00000004235	GLE1	100	78.805	Cavia_porcellus
ENSG00000119392	GLE1	100	89.828	ENSCCAG00000034829	GLE1	97	96.029	Cebus_capucinus
ENSG00000119392	GLE1	100	97.135	ENSCATG00000038445	GLE1	100	97.135	Cercocebus_atys
ENSG00000119392	GLE1	100	79.972	ENSCLAG00000001047	GLE1	100	79.545	Chinchilla_lanigera
ENSG00000119392	GLE1	100	97.421	ENSCSAG00000014225	GLE1	100	97.421	Chlorocebus_sabaeus
ENSG00000119392	GLE1	89	83.801	ENSCHOG00000007600	GLE1	89	83.801	Choloepus_hoffmanni
ENSG00000119392	GLE1	100	67.429	ENSCPBG00000024524	GLE1	100	68.519	Chrysemys_picta_bellii
ENSG00000119392	GLE1	100	94.126	ENSCANG00000040881	GLE1	100	96.970	Colobus_angolensis_palliatus
ENSG00000119392	GLE1	99	64.429	ENSCGRG00001023196	-	99	64.387	Cricetulus_griseus_chok1gshd
ENSG00000119392	GLE1	100	84.473	ENSCGRG00001023522	-	100	84.900	Cricetulus_griseus_chok1gshd
ENSG00000119392	GLE1	99	64.429	ENSCGRG00000015571	-	99	64.387	Cricetulus_griseus_crigri
ENSG00000119392	GLE1	100	83.258	ENSCGRG00000017733	-	100	84.559	Cricetulus_griseus_crigri
ENSG00000119392	GLE1	100	50.554	ENSCSEG00000013971	gle1	100	51.040	Cynoglossus_semilaevis
ENSG00000119392	GLE1	100	50.480	ENSCVAG00000021883	gle1	100	50.476	Cyprinodon_variegatus
ENSG00000119392	GLE1	100	51.872	ENSDARG00000043559	gle1	100	51.734	Danio_rerio
ENSG00000119392	GLE1	100	80.966	ENSDORG00000012158	Gle1	100	80.966	Dipodomys_ordii
ENSG00000119392	GLE1	52	30.481	FBgn0033316	CG14749	53	30.952	Drosophila_melanogaster
ENSG00000119392	GLE1	84	78.788	ENSETEG00000011283	GLE1	84	78.788	Echinops_telfairi
ENSG00000119392	GLE1	100	89.828	ENSEASG00005015580	GLE1	100	89.828	Equus_asinus_asinus
ENSG00000119392	GLE1	100	90.258	ENSECAG00000010980	GLE1	100	90.258	Equus_caballus
ENSG00000119392	GLE1	70	76.923	ENSEEUG00000013690	-	70	76.923	Erinaceus_europaeus
ENSG00000119392	GLE1	100	53.189	ENSELUG00000001930	gle1	100	53.189	Esox_lucius
ENSG00000119392	GLE1	100	87.679	ENSFCAG00000005845	GLE1	100	87.679	Felis_catus
ENSG00000119392	GLE1	99	60.143	ENSFALG00000001404	GLE1	99	60.143	Ficedula_albicollis
ENSG00000119392	GLE1	100	79.513	ENSFDAG00000001258	GLE1	100	79.513	Fukomys_damarensis
ENSG00000119392	GLE1	99	60.372	ENSGALG00000004738	GLE1	95	60.515	Gallus_gallus
ENSG00000119392	GLE1	100	50.545	ENSGAFG00000006283	gle1	100	51.293	Gambusia_affinis
ENSG00000119392	GLE1	100	53.258	ENSGACG00000014779	gle1	100	53.399	Gasterosteus_aculeatus
ENSG00000119392	GLE1	100	68.265	ENSGAGG00000023030	GLE1	100	68.265	Gopherus_agassizii
ENSG00000119392	GLE1	90	98.818	ENSGGOG00000001356	GLE1	100	98.818	Gorilla_gorilla
ENSG00000119392	GLE1	100	51.724	ENSHBUG00000010794	gle1	100	52.000	Haplochromis_burtoni
ENSG00000119392	GLE1	100	80.372	ENSHGLG00000016370	GLE1	100	80.372	Heterocephalus_glaber_female
ENSG00000119392	GLE1	100	80.372	ENSHGLG00100014943	GLE1	100	80.372	Heterocephalus_glaber_male
ENSG00000119392	GLE1	100	48.544	ENSHCOG00000002096	gle1	100	48.544	Hippocampus_comes
ENSG00000119392	GLE1	100	53.631	ENSIPUG00000013197	gle1	99	53.492	Ictalurus_punctatus
ENSG00000119392	GLE1	100	88.252	ENSSTOG00000010493	GLE1	100	88.252	Ictidomys_tridecemlineatus
ENSG00000119392	GLE1	100	83.903	ENSJJAG00000021252	Gle1	100	83.903	Jaculus_jaculus
ENSG00000119392	GLE1	100	51.578	ENSKMAG00000003876	gle1	100	51.961	Kryptolebias_marmoratus
ENSG00000119392	GLE1	77	59.449	ENSLBEG00000002150	-	89	46.954	Labrus_bergylta
ENSG00000119392	GLE1	100	52.156	ENSLBEG00000016448	gle1	100	52.573	Labrus_bergylta
ENSG00000119392	GLE1	100	51.758	ENSLACG00000013535	GLE1	99	52.756	Latimeria_chalumnae
ENSG00000119392	GLE1	100	50.700	ENSLOCG00000005909	gle1	73	66.887	Lepisosteus_oculatus
ENSG00000119392	GLE1	100	87.019	ENSLAFG00000018612	GLE1	100	87.019	Loxodonta_africana
ENSG00000119392	GLE1	100	96.991	ENSMFAG00000036995	GLE1	100	96.991	Macaca_fascicularis
ENSG00000119392	GLE1	100	97.135	ENSMMUG00000005989	GLE1	100	97.135	Macaca_mulatta
ENSG00000119392	GLE1	100	97.278	ENSMNEG00000035668	GLE1	100	97.278	Macaca_nemestrina
ENSG00000119392	GLE1	100	92.143	ENSMLEG00000008252	GLE1	100	92.264	Mandrillus_leucophaeus
ENSG00000119392	GLE1	100	53.453	ENSMAMG00000017122	gle1	100	52.394	Mastacembelus_armatus
ENSG00000119392	GLE1	100	52.000	ENSMZEG00005020182	gle1	100	52.276	Maylandia_zebra
ENSG00000119392	GLE1	83	65.338	ENSMGAG00000004391	GLE1	96	65.338	Meleagris_gallopavo
ENSG00000119392	GLE1	100	84.330	ENSMAUG00000022138	Gle1	100	84.330	Mesocricetus_auratus
ENSG00000119392	GLE1	100	87.249	ENSMICG00000017640	-	100	87.249	Microcebus_murinus
ENSG00000119392	GLE1	100	87.249	ENSMICG00000036945	-	100	87.249	Microcebus_murinus
ENSG00000119392	GLE1	100	78.205	ENSMOCG00000014845	Gle1	100	78.205	Microtus_ochrogaster
ENSG00000119392	GLE1	100	52.877	ENSMMOG00000014660	gle1	100	52.770	Mola_mola
ENSG00000119392	GLE1	100	69.286	ENSMODG00000022519	-	100	69.143	Monodelphis_domestica
ENSG00000119392	GLE1	100	69.429	ENSMODG00000025009	-	100	69.286	Monodelphis_domestica
ENSG00000119392	GLE1	100	69.429	ENSMODG00000025008	-	100	69.286	Monodelphis_domestica
ENSG00000119392	GLE1	100	76.538	ENSMODG00000006130	-	100	76.395	Monodelphis_domestica
ENSG00000119392	GLE1	100	69.429	ENSMODG00000029340	-	100	69.286	Monodelphis_domestica
ENSG00000119392	GLE1	100	51.511	ENSMALG00000006083	gle1	100	51.444	Monopterus_albus
ENSG00000119392	GLE1	100	81.909	MGP_CAROLIEiJ_G0023375	Gle1	100	82.764	Mus_caroli
ENSG00000119392	GLE1	100	82.194	ENSMUSG00000019715	Gle1	100	83.048	Mus_musculus
ENSG00000119392	GLE1	100	82.336	MGP_PahariEiJ_G0024832	Gle1	100	83.191	Mus_pahari
ENSG00000119392	GLE1	100	82.194	MGP_SPRETEiJ_G0024292	Gle1	100	83.048	Mus_spretus
ENSG00000119392	GLE1	97	85.423	ENSMPUG00000013164	GLE1	91	85.423	Mustela_putorius_furo
ENSG00000119392	GLE1	100	81.027	ENSMLUG00000022756	-	100	81.027	Myotis_lucifugus
ENSG00000119392	GLE1	100	86.020	ENSMLUG00000007379	-	100	86.020	Myotis_lucifugus
ENSG00000119392	GLE1	98	78.871	ENSMLUG00000023113	-	100	78.107	Myotis_lucifugus
ENSG00000119392	GLE1	99	79.480	ENSMLUG00000029829	-	100	78.672	Myotis_lucifugus
ENSG00000119392	GLE1	100	84.091	ENSNGAG00000010816	Gle1	100	84.517	Nannospalax_galili
ENSG00000119392	GLE1	100	86.819	ENSNLEG00000026659	GLE1	100	86.819	Nomascus_leucogenys
ENSG00000119392	GLE1	99	75.725	ENSMEUG00000014314	GLE1	100	73.104	Notamacropus_eugenii
ENSG00000119392	GLE1	100	77.364	ENSOPRG00000017060	GLE1	100	77.364	Ochotona_princeps
ENSG00000119392	GLE1	100	80.372	ENSODEG00000017394	GLE1	100	79.799	Octodon_degus
ENSG00000119392	GLE1	100	52.083	ENSONIG00000013967	gle1	100	52.000	Oreochromis_niloticus
ENSG00000119392	GLE1	95	71.814	ENSOANG00000011987	GLE1	100	72.305	Ornithorhynchus_anatinus
ENSG00000119392	GLE1	100	85.673	ENSOCUG00000012314	GLE1	100	85.673	Oryctolagus_cuniculus
ENSG00000119392	GLE1	99	51.332	ENSOMEG00000020041	gle1	99	50.912	Oryzias_melastigma
ENSG00000119392	GLE1	100	89.255	ENSOGAG00000001452	GLE1	100	89.255	Otolemur_garnettii
ENSG00000119392	GLE1	100	86.819	ENSOARG00000009976	GLE1	100	86.819	Ovis_aries
ENSG00000119392	GLE1	100	98.711	ENSPPAG00000033580	GLE1	100	98.711	Pan_paniscus
ENSG00000119392	GLE1	100	87.536	ENSPPRG00000014293	GLE1	100	87.536	Panthera_pardus
ENSG00000119392	GLE1	98	87.627	ENSPTIG00000020770	GLE1	98	87.627	Panthera_tigris_altaica
ENSG00000119392	GLE1	100	96.418	ENSPTRG00000021431	GLE1	100	96.418	Pan_troglodytes
ENSG00000119392	GLE1	100	90.171	ENSPANG00000035525	GLE1	100	90.171	Papio_anubis
ENSG00000119392	GLE1	100	56.000	ENSPKIG00000023647	gle1	100	55.895	Paramormyrops_kingsleyae
ENSG00000119392	GLE1	100	67.983	ENSPSIG00000017668	GLE1	100	67.983	Pelodiscus_sinensis
ENSG00000119392	GLE1	100	48.805	ENSPMGG00000014033	gle1	100	49.648	Periophthalmus_magnuspinnatus
ENSG00000119392	GLE1	100	82.764	ENSPEMG00000021037	-	100	83.048	Peromyscus_maniculatus_bairdii
ENSG00000119392	GLE1	100	84.046	ENSPEMG00000011251	-	100	84.330	Peromyscus_maniculatus_bairdii
ENSG00000119392	GLE1	75	43.898	ENSPMAG00000003060	gle1	96	43.898	Petromyzon_marinus
ENSG00000119392	GLE1	100	76.395	ENSPCIG00000029781	GLE1	100	76.109	Phascolarctos_cinereus
ENSG00000119392	GLE1	100	51.729	ENSPFOG00000013740	gle1	96	51.223	Poecilia_formosa
ENSG00000119392	GLE1	100	51.591	ENSPLAG00000023944	gle1	96	51.648	Poecilia_latipinna
ENSG00000119392	GLE1	100	51.519	ENSPMEG00000015406	gle1	96	51.223	Poecilia_mexicana
ENSG00000119392	GLE1	100	50.439	ENSPREG00000003860	gle1	92	50.975	Poecilia_reticulata
ENSG00000119392	GLE1	100	97.994	ENSPPYG00000019656	GLE1	100	97.994	Pongo_abelii
ENSG00000119392	GLE1	63	83.784	ENSPCAG00000012697	-	86	83.784	Procavia_capensis
ENSG00000119392	GLE1	100	90.401	ENSPCOG00000017042	GLE1	100	90.401	Propithecus_coquereli
ENSG00000119392	GLE1	100	88.968	ENSPVAG00000008115	GLE1	100	88.968	Pteropus_vampyrus
ENSG00000119392	GLE1	100	52.000	ENSPNYG00000007027	gle1	100	52.276	Pundamilia_nyererei
ENSG00000119392	GLE1	100	54.521	ENSPNAG00000007573	gle1	100	54.910	Pygocentrus_nattereri
ENSG00000119392	GLE1	99	62.853	ENSRNOG00000012652	AABR07065139.1	99	63.842	Rattus_norvegicus
ENSG00000119392	GLE1	71	62.325	ENSRNOG00000053311	AABR07065139.2	99	62.325	Rattus_norvegicus
ENSG00000119392	GLE1	100	82.906	ENSRNOG00000015237	Gle1	100	83.761	Rattus_norvegicus
ENSG00000119392	GLE1	100	96.991	ENSRBIG00000036689	GLE1	100	96.991	Rhinopithecus_bieti
ENSG00000119392	GLE1	100	96.705	ENSRROG00000035562	GLE1	100	96.705	Rhinopithecus_roxellana
ENSG00000119392	GLE1	100	95.559	ENSSBOG00000020790	GLE1	100	96.271	Saimiri_boliviensis_boliviensis
ENSG00000119392	GLE1	74	74.806	ENSSHAG00000018769	GLE1	100	74.806	Sarcophilus_harrisii
ENSG00000119392	GLE1	99	50.223	ENSSFOG00015007734	gle1	98	50.520	Scleropages_formosus
ENSG00000119392	GLE1	100	48.774	ENSSMAG00000015860	gle1	97	48.767	Scophthalmus_maximus
ENSG00000119392	GLE1	100	52.368	ENSSDUG00000014016	gle1	100	51.962	Seriola_dumerili
ENSG00000119392	GLE1	100	52.368	ENSSLDG00000024801	gle1	100	51.962	Seriola_lalandi_dorsalis
ENSG00000119392	GLE1	81	84.848	ENSSARG00000001110	GLE1	84	84.848	Sorex_araneus
ENSG00000119392	GLE1	99	59.636	ENSSPUG00000015268	GLE1	99	59.636	Sphenodon_punctatus
ENSG00000119392	GLE1	100	51.862	ENSSPAG00000010259	gle1	100	52.000	Stegastes_partitus
ENSG00000119392	GLE1	100	89.112	ENSSSCG00000005652	GLE1	100	90.678	Sus_scrofa
ENSG00000119392	GLE1	83	66.321	ENSTGUG00000003910	-	98	66.321	Taeniopygia_guttata
ENSG00000119392	GLE1	99	48.252	ENSTRUG00000006713	gle1	99	48.039	Takifugu_rubripes
ENSG00000119392	GLE1	99	46.619	ENSTNIG00000016727	gle1	99	46.220	Tetraodon_nigroviridis
ENSG00000119392	GLE1	84	87.879	ENSTBEG00000017534	GLE1	84	87.879	Tupaia_belangeri
ENSG00000119392	GLE1	100	87.249	ENSTTRG00000011590	GLE1	100	87.249	Tursiops_truncatus
ENSG00000119392	GLE1	100	87.822	ENSUMAG00000021966	GLE1	100	87.822	Ursus_maritimus
ENSG00000119392	GLE1	79	80.745	ENSVPAG00000007823	-	79	80.745	Vicugna_pacos
ENSG00000119392	GLE1	100	87.393	ENSVVUG00000015799	GLE1	100	87.393	Vulpes_vulpes
ENSG00000119392	GLE1	99	48.824	ENSXETG00000006584	gle1	97	48.382	Xenopus_tropicalis
ENSG00000119392	GLE1	100	50.622	ENSXCOG00000010463	gle1	100	50.409	Xiphophorus_couchianus
ENSG00000119392	GLE1	100	52.489	ENSXMAG00000002812	gle1	100	52.113	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000822	inositol hexakisphosphate binding	21873635.	IBA	Function
GO:0005515	protein binding	18724935.24243016.	IPI	Function
GO:0005543	phospholipid binding	21873635.	IBA	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005643	nuclear pore	9618489.	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0006446	regulation of translational initiation	21873635.	IBA	Process
GO:0006449	regulation of translational termination	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016973	poly(A)+ mRNA export from nucleus	-	IEA	Process
GO:0031369	translation initiation factor binding	21873635.	IBA	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0042802	identical protein binding	24243016.	IPI	Function
GO:0044614	nuclear pore cytoplasmic filaments	21873635.	IBA	Component