EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119707 (Gene tree)
Gene ID: 58517
Gene Symbol: RBM25
Alias: S164|fSAP94|NET52|Snu71|RNPC7
Full Name: RNA binding motif protein 25
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 65,463 bases
Position: chr14:73,058,436-73,123,898
Accession: 23244
RBP type: canonical RBP
Summary: (RNA Binding Motif Protein 25) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000434333	RRM_1	PF00076.22	5e-09	1	1
ENSP00000436225	RRM_1	PF00076.22	6.3e-09	1	1
ENSP00000436868	RRM_1	PF00076.22	6.6e-09	1	1
ENSP00000261973	RRM_1	PF00076.22	2.7e-08	1	1
ENSP00000431150	RRM_1	PF00076.22	2.7e-08	1	1
ENSP00000261973	PWI	PF01480.17	2.2e-13	1	1
ENSP00000431150	PWI	PF01480.17	2.2e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23190262	Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region.	Biochem J	2013 Feb 15	Gong D	doi: 10.1042/BJ20121382.
26074452	Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.	Aquat Toxicol	2015 Aug	Tse AC	doi: 10.1016/j.aquatox.2015.06.002
28655759	RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.	J Biol Chem	2017 Aug 11	Carlson SM	doi: 10.1074/jbc.M117.784371
31039132	HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif.	Aging (Albany NY)	2019 Apr 29	Wu Y	doi: 10.18632/aging.101927.
17560998	Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.	FEBS Lett	2007 Jun 26	Fortes P	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527449	RBM25-206	3469	-	-	- (aa)	-	-
ENST00000525161	RBM25-202	541	-	ENSP00000434004	127 (aa)	-	E9PSE8
ENST00000532683	RBM25-212	6848	-	-	- (aa)	-	-
ENST00000531500	RBM25-209	1039	-	ENSP00000434333	243 (aa)	-	E9PQU5
ENST00000261973	RBM25-201	6910	XM_011537044	ENSP00000261973	843 (aa)	XP_011535346	P49756
ENST00000526754	RBM25-204	1567	-	ENSP00000436225	294 (aa)	-	P49756
ENST00000527432	RBM25-205	3375	-	ENSP00000431150	843 (aa)	-	P49756
ENST00000525321	RBM25-203	2470	-	ENSP00000436868	300 (aa)	-	P49756
ENST00000530978	RBM25-208	441	-	-	- (aa)	-	-
ENST00000532483	RBM25-211	1052	-	-	- (aa)	-	-
ENST00000532192	RBM25-210	898	-	ENSP00000434950	73 (aa)	-	H0YE46
ENST00000528081	RBM25-207	3008	-	ENSP00000434444	164 (aa)	-	P49756

Gene Model

Click here to download ENSG00000119707's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000119707	rs2806048	14	73062386	A	Cognitive performance	30038396	[0.013-0.025] unit decrease	0.019	EFO_0008354
ENSG00000119707	rs11392696	14	73112414	G	Pulse pressure	30578418	[0.15-0.26] mmHg decrease	0.2049	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119707's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119707	RBM25	100	69.531	ENSAPOG00000017757	rbm25a	54	76.794	Acanthochromis_polyacanthus
ENSG00000119707	RBM25	100	100.000	ENSAMEG00000016270	RBM25	100	99.881	Ailuropoda_melanoleuca
ENSG00000119707	RBM25	100	65.354	ENSACIG00000014178	rbm25b	53	68.027	Amphilophus_citrinellus
ENSG00000119707	RBM25	100	69.531	ENSAOCG00000013695	rbm25a	52	77.831	Amphiprion_ocellaris
ENSG00000119707	RBM25	100	69.531	ENSAPEG00000007514	rbm25a	53	77.831	Amphiprion_percula
ENSG00000119707	RBM25	98	66.667	ENSATEG00000017312	rbm25b	55	77.966	Anabas_testudineus
ENSG00000119707	RBM25	79	95.312	ENSAPLG00000006643	RBM25	100	92.385	Anas_platyrhynchos
ENSG00000119707	RBM25	100	99.763	ENSANAG00000028295	RBM25	100	99.763	Aotus_nancymaae
ENSG00000119707	RBM25	100	80.469	ENSAMXG00000024525	rbm25b	85	75.433	Astyanax_mexicanus
ENSG00000119707	RBM25	100	100.000	ENSBTAG00000017177	RBM25	100	99.881	Bos_taurus
ENSG00000119707	RBM25	100	100.000	ENSCJAG00000014441	-	100	100.000	Callithrix_jacchus
ENSG00000119707	RBM25	84	100.000	ENSCAFG00000016809	-	98	99.515	Canis_familiaris
ENSG00000119707	RBM25	100	100.000	ENSTSYG00000003024	RBM25	100	100.000	Carlito_syrichta
ENSG00000119707	RBM25	93	97.059	ENSCAPG00000005239	RBM25	95	98.837	Cavia_aperea
ENSG00000119707	RBM25	100	100.000	ENSCPOG00000002479	RBM25	100	99.763	Cavia_porcellus
ENSG00000119707	RBM25	100	100.000	ENSCATG00000039651	RBM25	100	100.000	Cercocebus_atys
ENSG00000119707	RBM25	100	100.000	ENSCLAG00000003977	RBM25	100	99.644	Chinchilla_lanigera
ENSG00000119707	RBM25	100	100.000	ENSCSAG00000012801	RBM25	100	99.881	Chlorocebus_sabaeus
ENSG00000119707	RBM25	93	98.529	ENSCHOG00000008903	RBM25	63	99.412	Choloepus_hoffmanni
ENSG00000119707	RBM25	93	98.529	ENSCPBG00000011025	RBM25	57	87.872	Chrysemys_picta_bellii
ENSG00000119707	RBM25	100	100.000	ENSCANG00000043874	RBM25	100	99.660	Colobus_angolensis_palliatus
ENSG00000119707	RBM25	100	99.213	ENSCGRG00001020817	Rbm25	100	92.527	Cricetulus_griseus_chok1gshd
ENSG00000119707	RBM25	100	99.288	ENSCGRG00000017595	Rbm25	100	99.288	Cricetulus_griseus_crigri
ENSG00000119707	RBM25	100	68.504	ENSCVAG00000003478	rbm25b	54	68.552	Cyprinodon_variegatus
ENSG00000119707	RBM25	100	58.015	ENSDARG00000039266	rbm25a	98	94.872	Danio_rerio
ENSG00000119707	RBM25	100	100.000	ENSDNOG00000004959	RBM25	100	99.763	Dasypus_novemcinctus
ENSG00000119707	RBM25	100	97.153	ENSDORG00000013247	Rbm25	100	97.153	Dipodomys_ordii
ENSG00000119707	RBM25	100	95.848	ENSETEG00000015941	RBM25	100	95.848	Echinops_telfairi
ENSG00000119707	RBM25	100	100.000	ENSEEUG00000007350	RBM25	100	91.017	Erinaceus_europaeus
ENSG00000119707	RBM25	100	100.000	ENSFCAG00000011716	RBM25	100	100.000	Felis_catus
ENSG00000119707	RBM25	100	96.094	ENSFALG00000005445	RBM25	56	94.043	Ficedula_albicollis
ENSG00000119707	RBM25	100	100.000	ENSFDAG00000006542	RBM25	100	99.763	Fukomys_damarensis
ENSG00000119707	RBM25	100	73.171	ENSFHEG00000005318	rbm25a	50	70.433	Fundulus_heteroclitus
ENSG00000119707	RBM25	76	74.265	ENSGMOG00000014070	rbm25a	85	72.684	Gadus_morhua
ENSG00000119707	RBM25	95	63.011	ENSGMOG00000014097	rbm25b	89	68.127	Gadus_morhua
ENSG00000119707	RBM25	100	95.312	ENSGALG00000047486	-	100	90.652	Gallus_gallus
ENSG00000119707	RBM25	100	73.438	ENSGAFG00000018036	rbm25a	52	77.273	Gambusia_affinis
ENSG00000119707	RBM25	100	67.523	ENSGAFG00000001092	rbm25b	50	72.639	Gambusia_affinis
ENSG00000119707	RBM25	93	98.529	ENSGAGG00000024524	RBM25	58	92.340	Gopherus_agassizii
ENSG00000119707	RBM25	100	100.000	ENSGGOG00000002415	RBM25	100	100.000	Gorilla_gorilla
ENSG00000119707	RBM25	100	67.188	ENSHBUG00000016908	rbm25a	51	78.554	Haplochromis_burtoni
ENSG00000119707	RBM25	100	100.000	ENSHGLG00000014745	RBM25	100	99.407	Heterocephalus_glaber_female
ENSG00000119707	RBM25	100	100.000	ENSHGLG00100018236	-	100	100.000	Heterocephalus_glaber_male
ENSG00000119707	RBM25	100	65.354	ENSHCOG00000000142	rbm25b	52	75.980	Hippocampus_comes
ENSG00000119707	RBM25	98	63.668	ENSIPUG00000021051	rbm25b	52	77.590	Ictalurus_punctatus
ENSG00000119707	RBM25	100	100.000	ENSSTOG00000011117	RBM25	100	99.881	Ictidomys_tridecemlineatus
ENSG00000119707	RBM25	100	67.188	ENSKMAG00000016242	rbm25a	54	76.867	Kryptolebias_marmoratus
ENSG00000119707	RBM25	100	65.354	ENSKMAG00000018826	rbm25b	52	74.334	Kryptolebias_marmoratus
ENSG00000119707	RBM25	100	86.719	ENSLACG00000011845	RBM25	50	91.133	Latimeria_chalumnae
ENSG00000119707	RBM25	100	82.812	ENSLOCG00000014196	rbm25b	51	84.541	Lepisosteus_oculatus
ENSG00000119707	RBM25	100	100.000	ENSMFAG00000040040	RBM25	100	100.000	Macaca_fascicularis
ENSG00000119707	RBM25	100	100.000	ENSMMUG00000002332	RBM25	100	99.881	Macaca_mulatta
ENSG00000119707	RBM25	100	97.509	ENSMNEG00000032922	RBM25	100	97.509	Macaca_nemestrina
ENSG00000119707	RBM25	100	100.000	ENSMLEG00000035157	RBM25	100	100.000	Mandrillus_leucophaeus
ENSG00000119707	RBM25	100	65.164	ENSMAMG00000000165	rbm25a	51	78.030	Mastacembelus_armatus
ENSG00000119707	RBM25	100	67.188	ENSMZEG00005011183	rbm25a	54	78.554	Maylandia_zebra
ENSG00000119707	RBM25	100	99.660	ENSMICG00000034082	RBM25	100	99.660	Microcebus_murinus
ENSG00000119707	RBM25	100	97.390	ENSMOCG00000001935	Rbm25	100	97.390	Microtus_ochrogaster
ENSG00000119707	RBM25	96	67.089	ENSMMOG00000009065	rbm25a	53	77.938	Mola_mola
ENSG00000119707	RBM25	100	72.210	ENSMMOG00000015545	rbm25b	52	85.714	Mola_mola
ENSG00000119707	RBM25	100	98.458	ENSMODG00000006820	RBM25	99	98.458	Monodelphis_domestica
ENSG00000119707	RBM25	100	99.213	MGP_CAROLIEiJ_G0017921	Rbm25	100	99.170	Mus_caroli
ENSG00000119707	RBM25	100	99.213	ENSMUSG00000010608	Rbm25	100	99.170	Mus_musculus
ENSG00000119707	RBM25	100	99.213	MGP_PahariEiJ_G0029677	Rbm25	100	99.170	Mus_pahari
ENSG00000119707	RBM25	100	99.213	MGP_SPRETEiJ_G0018766	-	100	98.974	Mus_spretus
ENSG00000119707	RBM25	93	98.529	ENSMPUG00000003698	RBM25	99	99.458	Mustela_putorius_furo
ENSG00000119707	RBM25	100	100.000	ENSMLUG00000015434	-	100	93.950	Myotis_lucifugus
ENSG00000119707	RBM25	100	95.276	ENSMLUG00000024167	-	50	92.099	Myotis_lucifugus
ENSG00000119707	RBM25	100	99.288	ENSNGAG00000018465	Rbm25	100	99.288	Nannospalax_galili
ENSG00000119707	RBM25	100	100.000	ENSNLEG00000002701	RBM25	100	100.000	Nomascus_leucogenys
ENSG00000119707	RBM25	72	100.000	ENSOPRG00000016744	-	66	99.310	Ochotona_princeps
ENSG00000119707	RBM25	100	96.801	ENSOANG00000001056	RBM25	98	96.801	Ornithorhynchus_anatinus
ENSG00000119707	RBM25	100	99.407	ENSOCUG00000013737	RBM25	100	99.407	Oryctolagus_cuniculus
ENSG00000119707	RBM25	59	71.053	ENSORLG00000024690	-	100	75.194	Oryzias_latipes
ENSG00000119707	RBM25	98	65.972	ENSORLG00020016422	rbm25b	51	75.545	Oryzias_latipes_hni
ENSG00000119707	RBM25	100	72.656	ENSORLG00020002472	-	62	68.136	Oryzias_latipes_hni
ENSG00000119707	RBM25	100	94.793	ENSOGAG00000014986	RBM25	100	94.793	Otolemur_garnettii
ENSG00000119707	RBM25	100	100.000	ENSOARG00000000319	RBM25	100	99.881	Ovis_aries
ENSG00000119707	RBM25	100	100.000	ENSPPAG00000039402	RBM25	100	100.000	Pan_paniscus
ENSG00000119707	RBM25	100	100.000	ENSPPRG00000017374	RBM25	100	100.000	Panthera_pardus
ENSG00000119707	RBM25	100	100.000	ENSPTIG00000017309	RBM25	100	100.000	Panthera_tigris_altaica
ENSG00000119707	RBM25	100	100.000	ENSPTRG00000006509	RBM25	100	100.000	Pan_troglodytes
ENSG00000119707	RBM25	100	100.000	ENSPANG00000018212	RBM25	100	100.000	Papio_anubis
ENSG00000119707	RBM25	100	80.469	ENSPKIG00000003203	rbm25b	54	79.954	Paramormyrops_kingsleyae
ENSG00000119707	RBM25	100	96.564	ENSPSIG00000006058	RBM25	100	96.564	Pelodiscus_sinensis
ENSG00000119707	RBM25	95	91.304	ENSPCIG00000011166	RBM25	100	91.304	Phascolarctos_cinereus
ENSG00000119707	RBM25	100	74.219	ENSPLAG00000018338	rbm25a	52	78.365	Poecilia_latipinna
ENSG00000119707	RBM25	100	74.219	ENSPMEG00000024470	rbm25a	52	78.365	Poecilia_mexicana
ENSG00000119707	RBM25	100	68.504	ENSPMEG00000019161	rbm25b	50	72.182	Poecilia_mexicana
ENSG00000119707	RBM25	100	74.219	ENSPREG00000009228	rbm25a	53	77.885	Poecilia_reticulata
ENSG00000119707	RBM25	100	99.177	ENSPCAG00000006226	RBM25	83	99.177	Procavia_capensis
ENSG00000119707	RBM25	100	100.000	ENSPCOG00000023107	RBM25	100	99.660	Propithecus_coquereli
ENSG00000119707	RBM25	100	99.213	ENSPVAG00000003931	RBM25	100	96.441	Pteropus_vampyrus
ENSG00000119707	RBM25	84	78.851	ENSPNYG00000022596	rbm25a	52	78.554	Pundamilia_nyererei
ENSG00000119707	RBM25	100	79.688	ENSPNAG00000012024	rbm25b	53	74.771	Pygocentrus_nattereri
ENSG00000119707	RBM25	100	99.213	ENSRNOG00000002871	Rbm25l1	50	98.768	Rattus_norvegicus
ENSG00000119707	RBM25	100	100.000	ENSRBIG00000039904	RBM25	100	100.000	Rhinopithecus_bieti
ENSG00000119707	RBM25	100	100.000	ENSRROG00000035556	RBM25	100	100.000	Rhinopithecus_roxellana
ENSG00000119707	RBM25	100	98.458	ENSSHAG00000012859	RBM25	100	98.109	Sarcophilus_harrisii
ENSG00000119707	RBM25	100	100.000	ENSSARG00000002327	RBM25	100	99.644	Sorex_araneus
ENSG00000119707	RBM25	100	96.094	ENSSPUG00000000970	-	100	89.492	Sphenodon_punctatus
ENSG00000119707	RBM25	100	99.588	ENSSSCG00000039876	RBM25	100	99.805	Sus_scrofa
ENSG00000119707	RBM25	100	66.929	ENSTRUG00000017964	rbm25b	52	77.724	Takifugu_rubripes
ENSG00000119707	RBM25	97	60.000	ENSTNIG00000012222	rbm25b	66	77.590	Tetraodon_nigroviridis
ENSG00000119707	RBM25	99	71.784	ENSTBEG00000010538	-	67	98.485	Tupaia_belangeri
ENSG00000119707	RBM25	93	98.529	ENSUAMG00000007707	RBM25	100	99.683	Ursus_americanus
ENSG00000119707	RBM25	100	96.296	ENSVPAG00000009052	RBM25	100	93.238	Vicugna_pacos
ENSG00000119707	RBM25	100	100.000	ENSVVUG00000004426	RBM25	98	99.881	Vulpes_vulpes
ENSG00000119707	RBM25	95	72.569	ENSXETG00000021857	rbm25	53	87.654	Xenopus_tropicalis
ENSG00000119707	RBM25	100	73.878	ENSXCOG00000004043	RBM25	53	78.469	Xiphophorus_couchianus
ENSG00000119707	RBM25	100	68.504	ENSXCOG00000002222	rbm25b	52	72.705	Xiphophorus_couchianus
ENSG00000119707	RBM25	100	74.286	ENSXMAG00000009077	RBM25	51	74.402	Xiphophorus_maculatus
ENSG00000119707	RBM25	100	68.504	ENSXMAG00000017290	rbm25b	52	72.488	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	18663000.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	18663000.	IDA	Function
GO:0005515	protein binding	18663000.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	18663000.	IDA	Component
GO:0042981	regulation of apoptotic process	18663000.	IDA	Process