EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119718 (Gene tree)
Gene ID: 8892
Gene Symbol: EIF2B2
Alias: EIF2B|EIF-2Bbeta
Full Name: eukaryotic translation initiation factor 2B subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,458 bases
Position: chr14:75,002,909-75,012,366
Accession: 3258
RBP type: canonical RBP
Summary: This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000266126	IF-2B	PF01008.17	5e-91	1	1
ENSP00000452582	IF-2B	PF01008.17	7.7e-24	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556668	EIF2B2-207	1011	-	-	- (aa)	-	-
ENST00000553401	EIF2B2-202	896	-	ENSP00000451681	200 (aa)	-	H0YJJ8
ENST00000266126	EIF2B2-201	4314	-	ENSP00000266126	351 (aa)	-	P49770
ENST00000553539	EIF2B2-203	1094	-	-	- (aa)	-	-
ENST00000554748	EIF2B2-204	551	-	ENSP00000452582	71 (aa)	-	H0YK01
ENST00000555522	EIF2B2-205	772	-	-	- (aa)	-	-
ENST00000556028	EIF2B2-206	831	-	ENSP00000452311	206 (aa)	-	G3V5E5

Gene Model

Click here to download ENSG00000119718's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119718's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000119718	EIF2B2	85	35.000	ENSG00000111361	EIF2B1	72	31.390

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119718	EIF2B2	92	92.308	ENSAPOG00000000548	eif2b2	100	79.213	Acanthochromis_polyacanthus
ENSG00000119718	EIF2B2	100	94.017	ENSAMEG00000018315	EIF2B2	100	94.017	Ailuropoda_melanoleuca
ENSG00000119718	EIF2B2	97	73.529	ENSACIG00000004446	eif2b2	100	68.258	Amphilophus_citrinellus
ENSG00000119718	EIF2B2	92	92.308	ENSAOCG00000006456	eif2b2	100	79.213	Amphiprion_ocellaris
ENSG00000119718	EIF2B2	92	92.308	ENSAPEG00000001351	eif2b2	100	79.213	Amphiprion_percula
ENSG00000119718	EIF2B2	97	74.510	ENSATEG00000007102	eif2b2	100	68.539	Anabas_testudineus
ENSG00000119718	EIF2B2	92	95.385	ENSAPLG00000010140	EIF2B2	100	88.889	Anas_platyrhynchos
ENSG00000119718	EIF2B2	96	91.176	ENSACAG00000016798	EIF2B2	99	83.333	Anolis_carolinensis
ENSG00000119718	EIF2B2	100	98.860	ENSANAG00000025345	EIF2B2	100	98.860	Aotus_nancymaae
ENSG00000119718	EIF2B2	92	90.769	ENSACLG00000013294	eif2b2	100	80.056	Astatotilapia_calliptera
ENSG00000119718	EIF2B2	97	73.500	ENSAMXG00000013730	eif2b2	100	67.898	Astyanax_mexicanus
ENSG00000119718	EIF2B2	100	96.581	ENSBTAG00000008664	EIF2B2	100	96.581	Bos_taurus
ENSG00000119718	EIF2B2	100	98.575	ENSCJAG00000044557	EIF2B2	100	98.575	Callithrix_jacchus
ENSG00000119718	EIF2B2	100	94.872	ENSCAFG00000016998	EIF2B2	100	94.872	Canis_familiaris
ENSG00000119718	EIF2B2	100	94.872	ENSCAFG00020002450	EIF2B2	100	94.872	Canis_lupus_dingo
ENSG00000119718	EIF2B2	100	96.581	ENSCHIG00000020696	EIF2B2	100	96.581	Capra_hircus
ENSG00000119718	EIF2B2	100	94.017	ENSTSYG00000034108	EIF2B2	100	94.017	Carlito_syrichta
ENSG00000119718	EIF2B2	92	100.000	ENSCAPG00000012049	EIF2B2	100	95.146	Cavia_aperea
ENSG00000119718	EIF2B2	100	96.296	ENSCPOG00000008155	EIF2B2	100	96.296	Cavia_porcellus
ENSG00000119718	EIF2B2	100	98.575	ENSCCAG00000034957	EIF2B2	100	98.575	Cebus_capucinus
ENSG00000119718	EIF2B2	100	99.430	ENSCATG00000044945	EIF2B2	100	99.430	Cercocebus_atys
ENSG00000119718	EIF2B2	100	94.017	ENSCLAG00000003404	EIF2B2	100	94.017	Chinchilla_lanigera
ENSG00000119718	EIF2B2	100	99.430	ENSCSAG00000012187	EIF2B2	100	99.430	Chlorocebus_sabaeus
ENSG00000119718	EIF2B2	92	98.462	ENSCHOG00000010892	EIF2B2	100	87.749	Choloepus_hoffmanni
ENSG00000119718	EIF2B2	92	95.385	ENSCPBG00000026237	EIF2B2	100	85.470	Chrysemys_picta_bellii
ENSG00000119718	EIF2B2	87	70.968	ENSCING00000004197	-	100	57.225	Ciona_intestinalis
ENSG00000119718	EIF2B2	87	70.968	ENSCSAVG00000007363	-	100	56.977	Ciona_savignyi
ENSG00000119718	EIF2B2	100	99.145	ENSCANG00000034992	EIF2B2	100	99.145	Colobus_angolensis_palliatus
ENSG00000119718	EIF2B2	100	92.308	ENSCGRG00001019280	Eif2b2	100	92.308	Cricetulus_griseus_chok1gshd
ENSG00000119718	EIF2B2	92	95.385	ENSCGRG00000004251	Eif2b2	98	93.462	Cricetulus_griseus_crigri
ENSG00000119718	EIF2B2	97	73.529	ENSCSEG00000019706	eif2b2	100	68.539	Cynoglossus_semilaevis
ENSG00000119718	EIF2B2	92	90.769	ENSCVAG00000022891	eif2b2	100	79.775	Cyprinodon_variegatus
ENSG00000119718	EIF2B2	92	90.769	ENSDARG00000041397	eif2b2	100	79.494	Danio_rerio
ENSG00000119718	EIF2B2	92	100.000	ENSDNOG00000032838	EIF2B2	87	78.348	Dasypus_novemcinctus
ENSG00000119718	EIF2B2	92	100.000	ENSDORG00000004892	Eif2b2	100	97.541	Dipodomys_ordii
ENSG00000119718	EIF2B2	90	70.312	FBgn0024996	eIF2Bbeta	95	48.503	Drosophila_melanogaster
ENSG00000119718	EIF2B2	100	93.447	ENSETEG00000010596	EIF2B2	100	93.447	Echinops_telfairi
ENSG00000119718	EIF2B2	98	62.536	ENSEBUG00000012191	eif2b2	96	62.536	Eptatretus_burgeri
ENSG00000119718	EIF2B2	100	96.296	ENSEASG00005012035	EIF2B2	100	96.296	Equus_asinus_asinus
ENSG00000119718	EIF2B2	100	96.296	ENSECAG00000000332	EIF2B2	100	96.296	Equus_caballus
ENSG00000119718	EIF2B2	92	96.923	ENSEEUG00000010813	EIF2B2	100	87.726	Erinaceus_europaeus
ENSG00000119718	EIF2B2	92	90.769	ENSELUG00000004938	eif2b2	100	81.742	Esox_lucius
ENSG00000119718	EIF2B2	100	96.011	ENSFCAG00000028235	EIF2B2	87	96.011	Felis_catus
ENSG00000119718	EIF2B2	92	95.385	ENSFALG00000006338	EIF2B2	100	87.879	Ficedula_albicollis
ENSG00000119718	EIF2B2	100	96.011	ENSFDAG00000007970	EIF2B2	100	96.011	Fukomys_damarensis
ENSG00000119718	EIF2B2	92	90.769	ENSFHEG00000001385	eif2b2	100	80.056	Fundulus_heteroclitus
ENSG00000119718	EIF2B2	92	90.769	ENSGMOG00000011032	eif2b2	100	79.494	Gadus_morhua
ENSG00000119718	EIF2B2	97	92.754	ENSGALG00000010301	EIF2B2	87	83.453	Gallus_gallus
ENSG00000119718	EIF2B2	92	90.769	ENSGAFG00000009564	eif2b2	100	80.056	Gambusia_affinis
ENSG00000119718	EIF2B2	92	92.308	ENSGACG00000010441	eif2b2	98	81.556	Gasterosteus_aculeatus
ENSG00000119718	EIF2B2	92	95.385	ENSGAGG00000020106	EIF2B2	100	85.185	Gopherus_agassizii
ENSG00000119718	EIF2B2	100	99.430	ENSGGOG00000000514	EIF2B2	100	99.430	Gorilla_gorilla
ENSG00000119718	EIF2B2	92	90.769	ENSHBUG00000012113	eif2b2	100	80.056	Haplochromis_burtoni
ENSG00000119718	EIF2B2	100	96.866	ENSHGLG00000016520	EIF2B2	100	96.866	Heterocephalus_glaber_female
ENSG00000119718	EIF2B2	100	96.866	ENSHGLG00100016163	EIF2B2	100	96.866	Heterocephalus_glaber_male
ENSG00000119718	EIF2B2	92	86.154	ENSHCOG00000007914	eif2b2	100	76.404	Hippocampus_comes
ENSG00000119718	EIF2B2	92	89.231	ENSIPUG00000016004	eif2b2	100	78.933	Ictalurus_punctatus
ENSG00000119718	EIF2B2	100	97.151	ENSSTOG00000007283	EIF2B2	100	97.151	Ictidomys_tridecemlineatus
ENSG00000119718	EIF2B2	100	95.157	ENSJJAG00000015912	Eif2b2	100	95.157	Jaculus_jaculus
ENSG00000119718	EIF2B2	92	90.769	ENSKMAG00000014088	eif2b2	97	80.460	Kryptolebias_marmoratus
ENSG00000119718	EIF2B2	92	90.769	ENSLBEG00000027621	eif2b2	100	79.775	Labrus_bergylta
ENSG00000119718	EIF2B2	92	93.846	ENSLACG00000018341	EIF2B2	100	81.197	Latimeria_chalumnae
ENSG00000119718	EIF2B2	92	92.308	ENSLOCG00000010473	eif2b2	100	79.213	Lepisosteus_oculatus
ENSG00000119718	EIF2B2	100	95.442	ENSLAFG00000016616	EIF2B2	100	95.442	Loxodonta_africana
ENSG00000119718	EIF2B2	100	99.145	ENSMFAG00000043749	EIF2B2	100	99.145	Macaca_fascicularis
ENSG00000119718	EIF2B2	100	100.000	ENSMMUG00000002910	EIF2B2	100	100.000	Macaca_mulatta
ENSG00000119718	EIF2B2	100	99.145	ENSMNEG00000034034	EIF2B2	100	99.145	Macaca_nemestrina
ENSG00000119718	EIF2B2	100	99.145	ENSMLEG00000041601	EIF2B2	100	99.145	Mandrillus_leucophaeus
ENSG00000119718	EIF2B2	92	90.769	ENSMAMG00000017801	eif2b2	100	80.056	Mastacembelus_armatus
ENSG00000119718	EIF2B2	92	90.769	ENSMZEG00005016450	eif2b2	100	80.056	Maylandia_zebra
ENSG00000119718	EIF2B2	92	95.385	ENSMGAG00000012733	EIF2B2	98	82.675	Meleagris_gallopavo
ENSG00000119718	EIF2B2	100	94.302	ENSMAUG00000015945	Eif2b2	100	94.302	Mesocricetus_auratus
ENSG00000119718	EIF2B2	100	97.436	ENSMICG00000006100	EIF2B2	100	97.436	Microcebus_murinus
ENSG00000119718	EIF2B2	100	93.162	ENSMOCG00000003698	Eif2b2	100	93.162	Microtus_ochrogaster
ENSG00000119718	EIF2B2	100	61.972	ENSMMOG00000015719	eif2b2	100	61.972	Mola_mola
ENSG00000119718	EIF2B2	100	91.453	ENSMODG00000006061	-	100	91.453	Monodelphis_domestica
ENSG00000119718	EIF2B2	92	95.385	ENSMODG00000014565	-	100	83.476	Monodelphis_domestica
ENSG00000119718	EIF2B2	99	71.429	ENSMALG00000002631	eif2b2	100	71.429	Monopterus_albus
ENSG00000119718	EIF2B2	100	94.017	MGP_CAROLIEiJ_G0017961	Eif2b2	100	94.017	Mus_caroli
ENSG00000119718	EIF2B2	100	94.017	ENSMUSG00000004788	Eif2b2	100	94.017	Mus_musculus
ENSG00000119718	EIF2B2	100	93.447	MGP_PahariEiJ_G0029720	Eif2b2	100	93.447	Mus_pahari
ENSG00000119718	EIF2B2	100	93.732	MGP_SPRETEiJ_G0018806	Eif2b2	100	93.732	Mus_spretus
ENSG00000119718	EIF2B2	92	100.000	ENSMPUG00000009241	EIF2B2	84	94.667	Mustela_putorius_furo
ENSG00000119718	EIF2B2	97	93.467	ENSMLUG00000022497	-	100	93.467	Myotis_lucifugus
ENSG00000119718	EIF2B2	100	92.877	ENSMLUG00000005942	-	100	92.877	Myotis_lucifugus
ENSG00000119718	EIF2B2	100	94.302	ENSNGAG00000012270	Eif2b2	100	94.302	Nannospalax_galili
ENSG00000119718	EIF2B2	97	73.039	ENSNBRG00000018798	eif2b2	100	68.539	Neolamprologus_brichardi
ENSG00000119718	EIF2B2	100	99.430	ENSNLEG00000016383	EIF2B2	100	99.430	Nomascus_leucogenys
ENSG00000119718	EIF2B2	92	98.462	ENSMEUG00000010119	EIF2B2	100	92.578	Notamacropus_eugenii
ENSG00000119718	EIF2B2	100	95.442	ENSOPRG00000011892	EIF2B2	100	95.442	Ochotona_princeps
ENSG00000119718	EIF2B2	100	95.157	ENSODEG00000015442	-	100	95.157	Octodon_degus
ENSG00000119718	EIF2B2	92	83.582	ENSODEG00000006647	-	94	70.255	Octodon_degus
ENSG00000119718	EIF2B2	92	90.769	ENSONIG00000015252	eif2b2	100	80.056	Oreochromis_niloticus
ENSG00000119718	EIF2B2	100	95.726	ENSOCUG00000010175	EIF2B2	91	95.726	Oryctolagus_cuniculus
ENSG00000119718	EIF2B2	92	90.769	ENSORLG00000017494	eif2b2	100	79.494	Oryzias_latipes
ENSG00000119718	EIF2B2	92	90.769	ENSORLG00020001281	eif2b2	100	79.775	Oryzias_latipes_hni
ENSG00000119718	EIF2B2	92	90.769	ENSORLG00015017894	eif2b2	100	79.775	Oryzias_latipes_hsok
ENSG00000119718	EIF2B2	92	92.308	ENSOMEG00000021791	eif2b2	100	82.143	Oryzias_melastigma
ENSG00000119718	EIF2B2	92	100.000	ENSOGAG00000008234	EIF2B2	100	91.738	Otolemur_garnettii
ENSG00000119718	EIF2B2	100	95.480	ENSOARG00000001566	EIF2B2	100	95.480	Ovis_aries
ENSG00000119718	EIF2B2	100	99.430	ENSPPAG00000031197	EIF2B2	100	99.430	Pan_paniscus
ENSG00000119718	EIF2B2	100	96.011	ENSPPRG00000000321	EIF2B2	100	96.011	Panthera_pardus
ENSG00000119718	EIF2B2	99	94.286	ENSPTIG00000015724	EIF2B2	100	94.286	Panthera_tigris_altaica
ENSG00000119718	EIF2B2	100	99.430	ENSPTRG00000006547	EIF2B2	100	99.430	Pan_troglodytes
ENSG00000119718	EIF2B2	100	98.860	ENSPANG00000006825	EIF2B2	100	98.860	Papio_anubis
ENSG00000119718	EIF2B2	92	90.769	ENSPKIG00000002826	eif2b2	100	79.775	Paramormyrops_kingsleyae
ENSG00000119718	EIF2B2	92	95.385	ENSPSIG00000017425	EIF2B2	100	89.116	Pelodiscus_sinensis
ENSG00000119718	EIF2B2	97	74.146	ENSPMGG00000017185	eif2b2	100	68.067	Periophthalmus_magnuspinnatus
ENSG00000119718	EIF2B2	100	94.872	ENSPEMG00000007004	Eif2b2	100	94.872	Peromyscus_maniculatus_bairdii
ENSG00000119718	EIF2B2	92	76.923	ENSPMAG00000002926	eif2b2	100	77.517	Petromyzon_marinus
ENSG00000119718	EIF2B2	100	91.453	ENSPCIG00000008741	EIF2B2	100	91.453	Phascolarctos_cinereus
ENSG00000119718	EIF2B2	92	90.769	ENSPFOG00000008104	eif2b2	100	80.056	Poecilia_formosa
ENSG00000119718	EIF2B2	92	90.769	ENSPLAG00000006595	eif2b2	100	80.056	Poecilia_latipinna
ENSG00000119718	EIF2B2	92	90.769	ENSPMEG00000018375	eif2b2	100	80.056	Poecilia_mexicana
ENSG00000119718	EIF2B2	92	90.769	ENSPREG00000019462	eif2b2	100	80.056	Poecilia_reticulata
ENSG00000119718	EIF2B2	100	99.430	ENSPPYG00000005996	EIF2B2	100	99.430	Pongo_abelii
ENSG00000119718	EIF2B2	100	95.726	ENSPCAG00000008502	EIF2B2	100	95.726	Procavia_capensis
ENSG00000119718	EIF2B2	100	98.291	ENSPCOG00000016320	EIF2B2	100	98.291	Propithecus_coquereli
ENSG00000119718	EIF2B2	100	96.011	ENSPVAG00000000663	EIF2B2	100	96.011	Pteropus_vampyrus
ENSG00000119718	EIF2B2	92	89.231	ENSPNYG00000008123	eif2b2	100	79.494	Pundamilia_nyererei
ENSG00000119718	EIF2B2	92	90.769	ENSPNAG00000021288	eif2b2	100	80.114	Pygocentrus_nattereri
ENSG00000119718	EIF2B2	100	93.732	ENSRNOG00000006467	Eif2b2	92	93.732	Rattus_norvegicus
ENSG00000119718	EIF2B2	100	99.715	ENSRBIG00000040243	EIF2B2	100	99.715	Rhinopithecus_bieti
ENSG00000119718	EIF2B2	100	99.715	ENSRROG00000042761	EIF2B2	100	99.715	Rhinopithecus_roxellana
ENSG00000119718	EIF2B2	90	44.615	YLR291C	-	95	32.970	Saccharomyces_cerevisiae
ENSG00000119718	EIF2B2	100	98.860	ENSSBOG00000009267	EIF2B2	100	98.860	Saimiri_boliviensis_boliviensis
ENSG00000119718	EIF2B2	92	98.462	ENSSHAG00000018075	EIF2B2	100	90.341	Sarcophilus_harrisii
ENSG00000119718	EIF2B2	92	90.769	ENSSFOG00015023976	eif2b2	100	79.494	Scleropages_formosus
ENSG00000119718	EIF2B2	92	90.769	ENSSMAG00000012038	eif2b2	100	79.775	Scophthalmus_maximus
ENSG00000119718	EIF2B2	92	90.769	ENSSDUG00000014892	eif2b2	100	80.337	Seriola_dumerili
ENSG00000119718	EIF2B2	92	90.769	ENSSLDG00000001301	eif2b2	100	79.775	Seriola_lalandi_dorsalis
ENSG00000119718	EIF2B2	100	94.872	ENSSARG00000008853	EIF2B2	100	94.872	Sorex_araneus
ENSG00000119718	EIF2B2	92	95.385	ENSSPUG00000014804	EIF2B2	100	84.330	Sphenodon_punctatus
ENSG00000119718	EIF2B2	100	63.739	ENSSPAG00000021096	eif2b2	100	63.739	Stegastes_partitus
ENSG00000119718	EIF2B2	100	95.442	ENSSSCG00000002377	EIF2B2	100	95.442	Sus_scrofa
ENSG00000119718	EIF2B2	92	95.385	ENSTGUG00000012191	EIF2B2	100	83.476	Taeniopygia_guttata
ENSG00000119718	EIF2B2	92	90.769	ENSTRUG00000010849	eif2b2	100	79.494	Takifugu_rubripes
ENSG00000119718	EIF2B2	92	89.231	ENSTNIG00000016359	eif2b2	100	78.371	Tetraodon_nigroviridis
ENSG00000119718	EIF2B2	92	100.000	ENSTBEG00000008840	EIF2B2	62	99.029	Tupaia_belangeri
ENSG00000119718	EIF2B2	92	100.000	ENSTTRG00000001921	EIF2B2	100	95.268	Tursiops_truncatus
ENSG00000119718	EIF2B2	100	94.017	ENSUAMG00000013519	EIF2B2	100	94.017	Ursus_americanus
ENSG00000119718	EIF2B2	100	94.017	ENSUMAG00000008256	EIF2B2	87	94.017	Ursus_maritimus
ENSG00000119718	EIF2B2	100	96.011	ENSVPAG00000003082	EIF2B2	100	96.011	Vicugna_pacos
ENSG00000119718	EIF2B2	92	100.000	ENSVVUG00000005229	-	88	92.739	Vulpes_vulpes
ENSG00000119718	EIF2B2	92	95.385	ENSVVUG00000022282	-	100	82.670	Vulpes_vulpes
ENSG00000119718	EIF2B2	92	92.308	ENSXETG00000013261	eif2b2	100	80.057	Xenopus_tropicalis
ENSG00000119718	EIF2B2	92	90.769	ENSXCOG00000005161	eif2b2	100	75.281	Xiphophorus_couchianus
ENSG00000119718	EIF2B2	92	90.769	ENSXMAG00000004027	eif2b2	100	80.056	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001541	ovarian follicle development	15507143.	IMP	Process
GO:0003743	translation initiation factor activity	16289705.	IDA	Function
GO:0005085	guanyl-nucleotide exchange factor activity	11323413.	IDA	Function
GO:0005085	guanyl-nucleotide exchange factor activity	15054402.	IMP	Function
GO:0005515	protein binding	15060152.21516116.25910212.	IPI	Function
GO:0005524	ATP binding	11323413.	IDA	Function
GO:0005525	GTP binding	11323413.	IDA	Function
GO:0005737	cytoplasm	11323413.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005851	eukaryotic translation initiation factor 2B complex	11323413.15060152.	IDA	Component
GO:0006413	translational initiation	16289705.	IDA	Process
GO:0006446	regulation of translational initiation	15060152.	TAS	Process
GO:0007417	central nervous system development	15776425.	IMP	Process
GO:0009408	response to heat	-	ISS	Process
GO:0009408	response to heat	12499492.	TAS	Process
GO:0009749	response to glucose	-	ISS	Process
GO:0014003	oligodendrocyte development	15217090.	IMP	Process
GO:0042552	myelination	14566705.	IMP	Process
GO:0043434	response to peptide hormone	-	ISS	Process
GO:0050852	T cell receptor signaling pathway	8626696.	IDA	Process