EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119720 (Gene tree)
Gene ID: 55051
Gene Symbol: NRDE2
Alias: FLJ14051|C14orf102
Full Name: NRDE-2, necessary for RNA interference, domain containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 64,282 bases
Position: chr14:90,267,856-90,332,137
Accession: 20186
RBP type: canonical RBP
Summary: NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000346335	NRDE-2	PF08424.10	2.4e-104	1	1
ENSP00000452071	NRDE-2	PF08424.10	2.6e-52	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31227740	Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans.	Sci Rep	2019 Jun 21	Fields BD	doi: 10.1038/s41598-019-45052-y.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000628832	NRDE2-210	132	-	ENSP00000486385	43 (aa)	-	G3V338
ENST00000612614	NRDE2-209	3538	-	-	- (aa)	-	-
ENST00000554464	NRDE2-203	612	-	ENSP00000452071	204 (aa)	-	H0YJT0
ENST00000354366	NRDE2-201	14208	XM_011536886	ENSP00000346335	1164 (aa)	XP_011535188	Q9H7Z3
ENST00000557064	NRDE2-206	577	-	-	- (aa)	-	-
ENST00000556189	NRDE2-205	2937	-	ENSP00000452107	227 (aa)	-	H0YJT6
ENST00000555903	NRDE2-204	1384	-	-	- (aa)	-	-
ENST00000557106	NRDE2-207	580	-	-	- (aa)	-	-
ENST00000553409	NRDE2-202	3434	-	ENSP00000451025	43 (aa)	-	G3V338
ENST00000557732	NRDE2-208	623	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000119720's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000119720	Asthma	1.18852E-05	11022011
ENSG00000119720	Longevity	1E-6	20834067
ENSG00000119720	Longevity	2E-9	25918517
ENSG00000119720	Gastrointestinal Microbiome	2E-8	27723756
ENSG00000119720	Microbiota	2E-8	27723756

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000119720	rs11626933	14	90287967	G	Gut microbiota (bacterial taxa)	27723756	unit decrease	0.24	EFO_0007874\|EFO_0007883
ENSG00000119720	rs2282032	14	90292547	?	Longevity	20834067			EFO_0004300
ENSG00000119720	rs4904670	14	90303866	?	Lifespan	25918517	unit decrease	5.026	EFO_0004300

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119720's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119720	NRDE2	100	67.805	ENSAPOG00000009202	nrde2	99	45.888	Acanthochromis_polyacanthus
ENSG00000119720	NRDE2	100	86.275	ENSAMEG00000001807	NRDE2	99	82.857	Ailuropoda_melanoleuca
ENSG00000119720	NRDE2	100	69.118	ENSACIG00000014783	nrde2	97	48.384	Amphilophus_citrinellus
ENSG00000119720	NRDE2	100	68.780	ENSAOCG00000015576	nrde2	98	45.861	Amphiprion_ocellaris
ENSG00000119720	NRDE2	100	68.780	ENSAPEG00000001711	nrde2	99	46.045	Amphiprion_percula
ENSG00000119720	NRDE2	100	66.829	ENSATEG00000010247	nrde2	99	46.446	Anabas_testudineus
ENSG00000119720	NRDE2	100	73.659	ENSAPLG00000015870	NRDE2	99	62.009	Anas_platyrhynchos
ENSG00000119720	NRDE2	100	62.439	ENSACAG00000014571	NRDE2	99	57.630	Anolis_carolinensis
ENSG00000119720	NRDE2	99	91.976	ENSANAG00000025313	NRDE2	99	91.976	Aotus_nancymaae
ENSG00000119720	NRDE2	100	65.196	ENSACLG00000025154	nrde2	99	45.041	Astatotilapia_calliptera
ENSG00000119720	NRDE2	100	63.902	ENSAMXG00000034642	nrde2	94	41.816	Astyanax_mexicanus
ENSG00000119720	NRDE2	100	84.314	ENSBTAG00000005427	NRDE2	99	81.154	Bos_taurus
ENSG00000119720	NRDE2	99	94.550	ENSCJAG00000017711	NRDE2	99	94.550	Callithrix_jacchus
ENSG00000119720	NRDE2	99	80.273	ENSCAFG00000017515	NRDE2	99	80.223	Canis_familiaris
ENSG00000119720	NRDE2	100	85.784	ENSCAFG00020016346	NRDE2	99	83.261	Canis_lupus_dingo
ENSG00000119720	NRDE2	100	83.333	ENSCHIG00000005876	NRDE2	99	79.307	Capra_hircus
ENSG00000119720	NRDE2	100	87.255	ENSTSYG00000000161	NRDE2	99	80.833	Carlito_syrichta
ENSG00000119720	NRDE2	100	89.706	ENSCAPG00000012039	NRDE2	99	85.211	Cavia_aperea
ENSG00000119720	NRDE2	100	90.196	ENSCPOG00000002428	NRDE2	99	85.256	Cavia_porcellus
ENSG00000119720	NRDE2	100	93.627	ENSCCAG00000024917	NRDE2	99	93.685	Cebus_capucinus
ENSG00000119720	NRDE2	100	91.176	ENSCLAG00000015185	NRDE2	99	85.714	Chinchilla_lanigera
ENSG00000119720	NRDE2	100	97.595	ENSCSAG00000011451	NRDE2	100	97.595	Chlorocebus_sabaeus
ENSG00000119720	NRDE2	75	82.507	ENSCHOG00000006165	NRDE2	74	82.577	Choloepus_hoffmanni
ENSG00000119720	NRDE2	100	77.451	ENSCPBG00000008537	NRDE2	97	66.982	Chrysemys_picta_bellii
ENSG00000119720	NRDE2	100	96.821	ENSCANG00000029067	NRDE2	100	96.821	Colobus_angolensis_palliatus
ENSG00000119720	NRDE2	100	84.507	ENSCGRG00001015658	Nrde2	99	81.153	Cricetulus_griseus_chok1gshd
ENSG00000119720	NRDE2	100	88.235	ENSCGRG00000005062	Nrde2	99	81.520	Cricetulus_griseus_crigri
ENSG00000119720	NRDE2	100	67.157	ENSCSEG00000000089	nrde2	99	45.628	Cynoglossus_semilaevis
ENSG00000119720	NRDE2	100	66.176	ENSCVAG00000023105	nrde2	99	46.115	Cyprinodon_variegatus
ENSG00000119720	NRDE2	100	66.667	ENSDARG00000074726	nrde2	99	49.187	Danio_rerio
ENSG00000119720	NRDE2	100	89.706	ENSDNOG00000024057	NRDE2	99	84.848	Dasypus_novemcinctus
ENSG00000119720	NRDE2	100	91.667	ENSDORG00000003197	Nrde2	99	84.816	Dipodomys_ordii
ENSG00000119720	NRDE2	75	86.452	ENSETEG00000000198	NRDE2	74	71.261	Echinops_telfairi
ENSG00000119720	NRDE2	100	60.287	ENSEBUG00000014552	nrde2	99	39.585	Eptatretus_burgeri
ENSG00000119720	NRDE2	100	89.216	ENSEASG00005020675	NRDE2	99	86.904	Equus_asinus_asinus
ENSG00000119720	NRDE2	100	89.706	ENSECAG00000003862	NRDE2	100	86.376	Equus_caballus
ENSG00000119720	NRDE2	86	81.726	ENSEEUG00000004026	-	73	90.909	Erinaceus_europaeus
ENSG00000119720	NRDE2	100	66.667	ENSELUG00000005973	nrde2	99	49.241	Esox_lucius
ENSG00000119720	NRDE2	100	86.765	ENSFCAG00000011312	NRDE2	99	84.128	Felis_catus
ENSG00000119720	NRDE2	100	77.451	ENSFALG00000012260	NRDE2	99	62.543	Ficedula_albicollis
ENSG00000119720	NRDE2	100	87.745	ENSFDAG00000021350	NRDE2	99	85.269	Fukomys_damarensis
ENSG00000119720	NRDE2	100	67.157	ENSFHEG00000021385	nrde2	99	46.269	Fundulus_heteroclitus
ENSG00000119720	NRDE2	100	63.415	ENSGMOG00000015815	nrde2	90	53.734	Gadus_morhua
ENSG00000119720	NRDE2	100	75.610	ENSGALG00000010677	NRDE2	99	62.125	Gallus_gallus
ENSG00000119720	NRDE2	100	67.647	ENSGAFG00000019546	nrde2	97	50.725	Gambusia_affinis
ENSG00000119720	NRDE2	100	66.667	ENSGACG00000012619	nrde2	99	47.475	Gasterosteus_aculeatus
ENSG00000119720	NRDE2	100	76.471	ENSGAGG00000003252	NRDE2	99	66.150	Gopherus_agassizii
ENSG00000119720	NRDE2	100	99.313	ENSGGOG00000008835	NRDE2	100	99.313	Gorilla_gorilla
ENSG00000119720	NRDE2	100	64.706	ENSHBUG00000016736	nrde2	99	45.124	Haplochromis_burtoni
ENSG00000119720	NRDE2	100	90.196	ENSHGLG00000006731	NRDE2	99	86.395	Heterocephalus_glaber_female
ENSG00000119720	NRDE2	100	90.196	ENSHGLG00100017736	NRDE2	98	86.584	Heterocephalus_glaber_male
ENSG00000119720	NRDE2	100	51.961	ENSHCOG00000009559	nrde2	95	43.458	Hippocampus_comes
ENSG00000119720	NRDE2	100	65.196	ENSIPUG00000016129	nrde2	99	45.021	Ictalurus_punctatus
ENSG00000119720	NRDE2	100	91.176	ENSSTOG00000001678	NRDE2	99	85.690	Ictidomys_tridecemlineatus
ENSG00000119720	NRDE2	100	90.686	ENSJJAG00000000907	Nrde2	99	83.665	Jaculus_jaculus
ENSG00000119720	NRDE2	100	66.667	ENSKMAG00000008647	nrde2	99	46.336	Kryptolebias_marmoratus
ENSG00000119720	NRDE2	100	67.647	ENSLBEG00000021428	nrde2	96	48.015	Labrus_bergylta
ENSG00000119720	NRDE2	100	66.667	ENSLACG00000013921	NRDE2	99	61.765	Latimeria_chalumnae
ENSG00000119720	NRDE2	100	68.293	ENSLOCG00000009037	nrde2	99	54.156	Lepisosteus_oculatus
ENSG00000119720	NRDE2	100	90.196	ENSLAFG00000004966	NRDE2	99	82.601	Loxodonta_africana
ENSG00000119720	NRDE2	100	99.510	ENSMMUG00000010442	NRDE2	100	99.510	Macaca_mulatta
ENSG00000119720	NRDE2	100	65.854	ENSMAMG00000013452	nrde2	99	45.029	Mastacembelus_armatus
ENSG00000119720	NRDE2	100	65.196	ENSMZEG00005008319	nrde2	99	44.959	Maylandia_zebra
ENSG00000119720	NRDE2	100	75.610	ENSMGAG00000013052	NRDE2	99	64.862	Meleagris_gallopavo
ENSG00000119720	NRDE2	100	88.235	ENSMAUG00000018578	Nrde2	99	81.779	Mesocricetus_auratus
ENSG00000119720	NRDE2	100	92.647	ENSMICG00000016741	NRDE2	99	90.286	Microcebus_murinus
ENSG00000119720	NRDE2	100	88.235	ENSMOCG00000014472	Nrde2	99	78.381	Microtus_ochrogaster
ENSG00000119720	NRDE2	100	69.608	ENSMMOG00000004703	nrde2	93	48.339	Mola_mola
ENSG00000119720	NRDE2	100	84.314	ENSMODG00000002711	NRDE2	100	72.687	Monodelphis_domestica
ENSG00000119720	NRDE2	100	62.745	ENSMALG00000021869	nrde2	94	46.247	Monopterus_albus
ENSG00000119720	NRDE2	100	87.255	MGP_CAROLIEiJ_G0018020	Nrde2	99	80.673	Mus_caroli
ENSG00000119720	NRDE2	100	87.745	ENSMUSG00000021179	Nrde2	99	79.862	Mus_musculus
ENSG00000119720	NRDE2	100	87.745	MGP_PahariEiJ_G0029778	Nrde2	99	80.500	Mus_pahari
ENSG00000119720	NRDE2	100	86.275	MGP_SPRETEiJ_G0018865	Nrde2	98	82.011	Mus_spretus
ENSG00000119720	NRDE2	100	85.784	ENSMPUG00000008135	NRDE2	99	80.000	Mustela_putorius_furo
ENSG00000119720	NRDE2	100	91.176	ENSMLUG00000007484	NRDE2	99	85.628	Myotis_lucifugus
ENSG00000119720	NRDE2	100	87.745	ENSNGAG00000002993	Nrde2	99	82.815	Nannospalax_galili
ENSG00000119720	NRDE2	100	65.686	ENSNBRG00000010184	nrde2	98	47.893	Neolamprologus_brichardi
ENSG00000119720	NRDE2	99	96.048	ENSNLEG00000017032	NRDE2	100	98.486	Nomascus_leucogenys
ENSG00000119720	NRDE2	100	49.020	ENSMEUG00000011097	NRDE2	77	66.667	Notamacropus_eugenii
ENSG00000119720	NRDE2	100	69.118	ENSOPRG00000001375	-	61	84.848	Ochotona_princeps
ENSG00000119720	NRDE2	100	86.275	ENSODEG00000012422	NRDE2	99	84.541	Octodon_degus
ENSG00000119720	NRDE2	100	66.829	ENSONIG00000019512	nrde2	99	45.599	Oreochromis_niloticus
ENSG00000119720	NRDE2	66	77.612	ENSOANG00000021759	-	95	75.339	Ornithorhynchus_anatinus
ENSG00000119720	NRDE2	100	88.725	ENSOCUG00000010083	NRDE2	99	83.377	Oryctolagus_cuniculus
ENSG00000119720	NRDE2	100	66.667	ENSORLG00000017730	nrde2	95	47.802	Oryzias_latipes
ENSG00000119720	NRDE2	100	68.137	ENSORLG00020015965	nrde2	99	45.665	Oryzias_latipes_hni
ENSG00000119720	NRDE2	100	68.137	ENSORLG00015012437	nrde2	99	45.919	Oryzias_latipes_hsok
ENSG00000119720	NRDE2	100	70.588	ENSOMEG00000010890	nrde2	99	46.612	Oryzias_melastigma
ENSG00000119720	NRDE2	100	89.806	ENSOGAG00000006624	NRDE2	99	89.957	Otolemur_garnettii
ENSG00000119720	NRDE2	100	80.882	ENSOARG00000003475	NRDE2	100	77.768	Ovis_aries
ENSG00000119720	NRDE2	98	98.775	ENSPPAG00000034133	NRDE2	100	99.464	Pan_paniscus
ENSG00000119720	NRDE2	100	86.275	ENSPPRG00000006422	NRDE2	99	84.215	Panthera_pardus
ENSG00000119720	NRDE2	100	86.275	ENSPTIG00000009989	NRDE2	99	83.955	Panthera_tigris_altaica
ENSG00000119720	NRDE2	100	99.570	ENSPTRG00000023399	NRDE2	100	99.570	Pan_troglodytes
ENSG00000119720	NRDE2	100	68.293	ENSPKIG00000009331	nrde2	99	47.225	Paramormyrops_kingsleyae
ENSG00000119720	NRDE2	100	75.000	ENSPSIG00000005588	NRDE2	99	65.289	Pelodiscus_sinensis
ENSG00000119720	NRDE2	100	62.745	ENSPMGG00000024089	nrde2	93	45.900	Periophthalmus_magnuspinnatus
ENSG00000119720	NRDE2	100	86.275	ENSPEMG00000023707	Nrde2	99	81.411	Peromyscus_maniculatus_bairdii
ENSG00000119720	NRDE2	100	58.824	ENSPMAG00000003270	-	99	43.134	Petromyzon_marinus
ENSG00000119720	NRDE2	100	82.843	ENSPCIG00000018567	NRDE2	99	75.490	Phascolarctos_cinereus
ENSG00000119720	NRDE2	100	66.184	ENSPFOG00000013217	nrde2	99	45.591	Poecilia_formosa
ENSG00000119720	NRDE2	100	66.184	ENSPLAG00000022350	nrde2	99	46.084	Poecilia_latipinna
ENSG00000119720	NRDE2	100	66.184	ENSPMEG00000000778	nrde2	99	46.331	Poecilia_mexicana
ENSG00000119720	NRDE2	100	66.184	ENSPREG00000009066	nrde2	99	46.496	Poecilia_reticulata
ENSG00000119720	NRDE2	100	93.627	ENSPPYG00000006245	NRDE2	100	95.399	Pongo_abelii
ENSG00000119720	NRDE2	100	86.275	ENSPCAG00000016399	NRDE2	81	96.226	Procavia_capensis
ENSG00000119720	NRDE2	100	91.667	ENSPCOG00000024684	NRDE2	100	89.809	Propithecus_coquereli
ENSG00000119720	NRDE2	100	88.235	ENSPVAG00000010023	NRDE2	100	82.844	Pteropus_vampyrus
ENSG00000119720	NRDE2	100	64.706	ENSPNYG00000022833	nrde2	96	48.356	Pundamilia_nyererei
ENSG00000119720	NRDE2	100	66.667	ENSPNAG00000015807	nrde2	97	47.584	Pygocentrus_nattereri
ENSG00000119720	NRDE2	100	86.765	ENSRNOG00000004004	Nrde2	100	79.943	Rattus_norvegicus
ENSG00000119720	NRDE2	99	94.965	ENSSBOG00000024346	NRDE2	99	94.965	Saimiri_boliviensis_boliviensis
ENSG00000119720	NRDE2	100	83.824	ENSSHAG00000016736	NRDE2	96	73.489	Sarcophilus_harrisii
ENSG00000119720	NRDE2	100	69.756	ENSSFOG00015011794	nrde2	99	49.066	Scleropages_formosus
ENSG00000119720	NRDE2	100	64.878	ENSSMAG00000011671	nrde2	98	44.873	Scophthalmus_maximus
ENSG00000119720	NRDE2	100	66.829	ENSSDUG00000017948	nrde2	99	45.984	Seriola_dumerili
ENSG00000119720	NRDE2	100	67.647	ENSSLDG00000023798	nrde2	98	49.835	Seriola_lalandi_dorsalis
ENSG00000119720	NRDE2	100	75.490	ENSSPUG00000006348	NRDE2	99	66.220	Sphenodon_punctatus
ENSG00000119720	NRDE2	100	67.647	ENSSPAG00000000539	nrde2	99	47.489	Stegastes_partitus
ENSG00000119720	NRDE2	100	90.244	ENSSSCG00000002434	NRDE2	99	87.435	Sus_scrofa
ENSG00000119720	NRDE2	100	76.471	ENSTGUG00000012462	-	99	63.725	Taeniopygia_guttata
ENSG00000119720	NRDE2	100	62.255	ENSTRUG00000002798	nrde2	96	49.175	Takifugu_rubripes
ENSG00000119720	NRDE2	94	81.655	ENSTBEG00000011834	NRDE2	94	81.622	Tupaia_belangeri
ENSG00000119720	NRDE2	100	89.216	ENSTTRG00000013583	NRDE2	99	86.904	Tursiops_truncatus
ENSG00000119720	NRDE2	100	85.784	ENSUAMG00000004159	NRDE2	99	81.272	Ursus_americanus
ENSG00000119720	NRDE2	100	85.784	ENSUMAG00000006393	NRDE2	97	83.547	Ursus_maritimus
ENSG00000119720	NRDE2	100	84.804	ENSVVUG00000018202	NRDE2	99	82.620	Vulpes_vulpes
ENSG00000119720	NRDE2	99	65.196	ENSXETG00000015708	nrde2	99	54.421	Xenopus_tropicalis
ENSG00000119720	NRDE2	100	67.157	ENSXCOG00000013298	nrde2	96	47.512	Xiphophorus_couchianus
ENSG00000119720	NRDE2	100	66.184	ENSXMAG00000009320	nrde2	99	46.040	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005575	cellular_component	-	ND	Component
GO:0008150	biological_process	-	ND	Process
GO:0016246	RNA interference	21873635.	IBA	Process
GO:0031048	chromatin silencing by small RNA	21873635.	IBA	Process