EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119922 (Gene tree)
Gene ID: 3433
Gene Symbol: IFIT2
Alias: IFI-54|ISG-54K|cig42|GARG-39|IFI54|G10P2
Full Name: interferon induced protein with tetratricopeptide repeats 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 25,583 bases
Position: chr10:89,283,694-89,309,276
Accession: 5409
RBP type: non-canonical RBP
Summary: (Interferon Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Type II interferon signaling (IFNG). An important paralog of this gene is IFIT3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22825553	Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.	Cell Res	2012 Sep	Yang Z	doi: 10.1038/cr.2012.111
28637751	Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.	J Virol	2017 Aug 10	Davis BM	doi: 10.1128/JVI.00889-17
11533154	Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus.	J Virol	2001 Oct	Preston CM	-
15194680	Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.	J Biol Chem	2004 Sep 24	Sakamoto S	-
29554348	IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.	Nucleic Acids Res	2018 Jun 1	Fleith RC	doi: 10.1093/nar/gky191.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000638108	IFIT2-203	3703	-	ENSP00000490935	472 (aa)	-	P09913
ENST00000611722	IFIT2-202	3038	-	ENSP00000484770	483 (aa)	-	A0A087X279
ENST00000371826	IFIT2-201	3489	-	ENSP00000360891	472 (aa)	-	P09913

Gene Model

Click here to download ENSG00000119922's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000119922	Proteins	3.7480000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000119922	rs4934470	10	89307681	C	Blood protein levels	29875488	[0.15-0.27] unit increase	0.21	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119922's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119922	IFIT2	97	46.237	ENSG00000152778	IFIT5	96	46.237	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	19416887.21190939.21642987.	IPI	Function
GO:0005737	cytoplasm	21190939.	IDA	Component
GO:0005783	endoplasmic reticulum	21190939.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008637	apoptotic mitochondrial changes	21190939.	TAS	Process
GO:0009615	response to virus	19416887.	IDA	Process
GO:0009615	response to virus	21642987.	IMP	Process
GO:0032091	negative regulation of protein binding	19416887.	IDA	Process
GO:0035457	cellular response to interferon-alpha	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	21190939.	IDA	Process
GO:0051607	defense response to virus	21873635.	IBA	Process
GO:0060337	type I interferon signaling pathway	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25174799	MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.	BMC Cancer	2014 Aug 29	Feng X	doi: 10.1186/1471-2407-14-633.
21190939	The interferon stimulated gene 54 promotes apoptosis.	J Biol Chem	2011 Mar 4	Stawowczyk M	doi: 10.1074/jbc.M110.207068
28367102	Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis.	Int J Biol Sci	2017 Feb 25	Chen L	doi: 10.7150/ijbs.17236

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	89301966	5'UTR	novel		0.29
BLCA	chr10	89302126	Translation_Start_Site	NA	M1?	0.26
BLCA	chr10	89306614	Missense_Mutation	NA	H220Y	0.12
BLCA	chr10	89307097	Nonsense_Mutation	NA	Q381*	0.65
BLCA	chr10	89302056	5'UTR	novel		0.54
BLCA	chr10	89306935	Missense_Mutation	rs763699307	D327N	0.1
BLCA	chr10	89306065	Frame_Shift_Del	novel	*V38Yfs23**	0.66
BRCA	chr10	89306245	Frame_Shift_Ins	novel	*N99Kfs27**	0.3
BRCA	chr10	89306550	Silent	NA	L198L	0.25
BRCA	chr10	89307310	Missense_Mutation	novel	D452H	0.44
BRCA	chr10	89306513	Nonsense_Mutation	novel	D186_N187ins*	0.17
BRCA	chr10	89306542	Missense_Mutation	NA	D196N	0.3
CESC	chr10	89307169	Missense_Mutation	NA	S405A	0.59
CESC	chr10	89306686	Missense_Mutation	NA	P244S	0.31
CESC	chr10	89302106	5'UTR	novel		0.21
COAD	chr10	89307220	Nonsense_Mutation	rs773031617	R422*	0.2
COAD	chr10	89307206	Missense_Mutation	novel	K417T	0.29
COAD	chr10	89306707	Missense_Mutation	rs537050168	R251C	0.28
COAD	chr10	89306767	Nonsense_Mutation	rs770640915	K271*	0.45
COAD	chr10	89306857	Missense_Mutation	novel	L301V	0.17
COAD	chr10	89306153	Frame_Shift_Del	novel	*N67Tfs14**	0.28
COAD	chr10	89306767	Frame_Shift_Del	NA	*K272Rfs3**	0.12
COAD	chr10	89306155	Missense_Mutation	NA	N67H	0.23
COAD	chr10	89306767	Frame_Shift_Del	NA	*K272Rfs3**	0.28
GBM	chr10	89307164	Missense_Mutation	NA	Q403L	0.43
GBM	chr10	89306311	Missense_Mutation	novel	K119Q	0.15
GBM	chr10	89307042	Silent	novel	S362S	0.43
GBM	chr10	89306781	Missense_Mutation	novel	E275D	0.07
GBM	chr10	89306832	Silent	novel	R292R	0.11
HNSC	chr10	89307202	Missense_Mutation	novel	Q416K	0.24
HNSC	chr10	89302076	5'UTR	novel		0.2
HNSC	chr10	89306694	Silent	novel	V246V	0.27
KIRC	chr10	89306000	Missense_Mutation	NA	Q15P	0.16
KIRC	chr10	89306911	Missense_Mutation	NA	A319S	0.22
KIRP	chr10	89305996	Missense_Mutation	rs777976445	R14W	0.39
LAML	chr10	89306128	Missense_Mutation	novel	A58P	0.08
LGG	chr10	89306505	Nonsense_Mutation	novel	Y183*	0.3
LGG	chr10	89306593	Missense_Mutation	NA	V213I	0.34
LGG	chr10	89306893	Missense_Mutation	rs774089331	L313M	0.38
LIHC	chr10	89306684	Missense_Mutation	NA	A243V	0.09
LIHC	chr10	89306722	Missense_Mutation	novel	F256I	0.11
LUAD	chr10	89307384	3'UTR	novel		0.34
LUAD	chr10	89302075	5'UTR	novel		0.33
LUAD	chr10	89306623	Missense_Mutation	rs370009481	R223C	0.14
LUAD	chr10	89306155	Missense_Mutation	NA	N67H	0.16
LUSC	chr10	89306708	Missense_Mutation	NA	R251H	0.09
LUSC	chr10	89306248	Missense_Mutation	NA	G98R	0.17
MESO	chr10	89306293	Missense_Mutation	rs769134303	V113I	0.44
OV	chr10	89306548	Missense_Mutation	NA	L198V	0.43
OV	chr10	89306148	Missense_Mutation	novel	K64N	0.05
PRAD	chr10	89307181	Missense_Mutation	novel	E409K	0.33
PRAD	chr10	89306782	Missense_Mutation	novel	Y276N	0.18
PRAD	chr10	89306686	Missense_Mutation	NA	P244S	0.39
PRAD	chr10	89307013	Missense_Mutation	novel	A353T	0.09
READ	chr10	89306772	Missense_Mutation	novel	K272N	0.1
READ	chr10	89302126	Translation_Start_Site	NA	M1?	0.41
READ	chr10	89306466	Missense_Mutation	NA	K170N	0.41
READ	chr10	89307141	Missense_Mutation	novel	F395L	0.38
SKCM	chr10	89306328	Nonsense_Mutation	novel	C124*	0.07
SKCM	chr10	89306439	Missense_Mutation	NA	F161L	0.1
SKCM	chr10	89306366	Missense_Mutation	NA	E137G	0.32
SKCM	chr10	89306778	Missense_Mutation	NA	L274F	0.1
SKCM	chr10	89302123	5'UTR	novel		0.77
SKCM	chr10	89306546	Missense_Mutation	NA	P197L	0.36
SKCM	chr10	89306350	Missense_Mutation	rs759821795	R132G	0.2
SKCM	chr10	89306685	Silent	rs190103711	A243A	0.26
SKCM	chr10	89306686	Missense_Mutation	NA	P244S	0.27
STAD	chr10	89306426	Missense_Mutation	rs773713688	A157V	0.2
STAD	chr10	89307146	Missense_Mutation	NA	E397A	0.18
STAD	chr10	89306501	Missense_Mutation	NA	S182I	0.12
STAD	chr10	89306707	Missense_Mutation	rs537050168	R251C	0.35
STAD	chr10	89306657	Missense_Mutation	NA	K234R	0.15
STAD	chr10	89306293	Missense_Mutation	rs769134303	V113I	0.23
STAD	chr10	89306946	Silent	NA	N330N	0.06
STAD	chr10	89306989	Missense_Mutation	NA	A345T	0.34
STAD	chr10	89307074	Missense_Mutation	novel	L373P	0.35
THCA	chr10	89307394	3'UTR	novel		0.12
UCEC	chr10	89306604	Silent	novel	A216A	0.43
UCEC	chr10	89307018	Missense_Mutation	novel	E354D	0.14
UCEC	chr10	89306480	Frame_Shift_Ins	novel	*S176Ifs22**	0.12
UCEC	chr10	89307224	Missense_Mutation	novel	L423H	0.26
UCEC	chr10	89307397	3'UTR	novel		0.3
UCEC	chr10	89306383	Missense_Mutation	novel	G143R	0.37
UCEC	chr10	89307220	Nonsense_Mutation	rs773031617	R422*	0.52
UCEC	chr10	89307292	Missense_Mutation	rs148978582	M446V	0.19
UCEC	chr10	89306466	Missense_Mutation	NA	K170N	0.48
UCEC	chr10	89307138	Missense_Mutation	NA	H394Q	0.34
UCEC	chr10	89306679	Silent	rs765899784	E241E	0.34
UCEC	chr10	89306096	Missense_Mutation	rs373422979	R47H	0.11
UCEC	chr10	89306426	Missense_Mutation	rs773713688	A157V	0.52
UCEC	chr10	89306025	Missense_Mutation	novel	N23K	0.28
UCEC	chr10	89307212	Missense_Mutation	novel	A419V	0.47
UCEC	chr10	89307340	Missense_Mutation	novel	L462I	0.48
UCEC	chr10	89306673	Silent	novel	A239A	0.42
UCEC	chr10	89307128	In_Frame_Ins	novel	A391_I392insSSTN	0.08
UCEC	chr10	89306743	Missense_Mutation	novel	P263S	0.1
UCEC	chr10	89306959	Missense_Mutation	rs368019671	R335C	0.23
UCEC	chr10	89306335	Missense_Mutation	novel	F127L	0.32
UCEC	chr10	89306536	Missense_Mutation	rs144300435	A194T	0.42
UCEC	chr10	89306977	Missense_Mutation	novel	A341P	0.36
UCEC	chr10	89306056	Missense_Mutation	novel	F34V	0.41
UCEC	chr10	89306753	Missense_Mutation	rs370750247	A266V	0.24
UCEC	chr10	89307220	Nonsense_Mutation	rs773031617	R422*	0.27
UCEC	chr10	89306426	Missense_Mutation	rs773713688	A157V	0.34
UCEC	chr10	89306896	Missense_Mutation	novel	E314K	0.33
UCEC	chr10	89307114	Silent	novel	K386K	0.3
UCEC	chr10	89306699	Frame_Shift_Ins	novel	*V249Ffs15**	0.18
UCEC	chr10	89305974	Missense_Mutation	NA	K6N	0.45
UCEC	chr10	89307173	Missense_Mutation	NA	R406M	0.1
UCEC	chr10	89306441	In_Frame_Ins	novel	E162_K163insFT	0.15
UCEC	chr10	89306387	Missense_Mutation	novel	W144L	0.21
UCEC	chr10	89306761	Missense_Mutation	novel	L269M	0.21
UCEC	chr10	89306838	Missense_Mutation	novel	K294N	0.46
UCEC	chr10	89306912	Missense_Mutation	novel	A319V	0.37
UCEC	chr10	89306911	Missense_Mutation	rs775027680	A319T	0.36
UCS	chr10	89306053	Missense_Mutation	novel	D33Y	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
CHOL	DEL	0.1667	0.048655
DLBC	DEL	0.125	0.00048456
ESCA	DEL	0.2609	0.00081373
MESO	DEL	0.2529	0.00015289
PAAD	DEL	0.125	0.169
READ	DEL	0.2545	0.014135
THCA	DEL	0.022	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0096	Kaplan-Meier Survival Analysis
STAD	0.026	Kaplan-Meier Survival Analysis
SARC	0.0097	Kaplan-Meier Survival Analysis
MESO	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
TGCT	0.031	Kaplan-Meier Survival Analysis
PAAD	0.00041	Kaplan-Meier Survival Analysis
LAML	0.0081	Kaplan-Meier Survival Analysis
GBM	0.034	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis
THCA	0.013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742