EuRBPDB

Description

Ensembl ID: ENSG00000120265 (Gene tree)
Gene ID: 5110
Gene Symbol: PCMT1
Alias: N
Full Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 61,979 bases
Position: chr6:149,749,443-149,811,421
Accession: 8728
RBP type: non-canonical RBP
Summary: This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494411	PCMT1-209	600	-	ENSP00000417112	72 (aa)	-	F8WAX2
ENST00000649295	PCMT1-213	1733	XM_024446451	ENSP00000497235	285 (aa)	XP_024302219	UPI0000D4C8CC
ENST00000495487	PCMT1-210	548	-	ENSP00000418881	96 (aa)	-	C9J0F2
ENST00000649032	PCMT1-212	861	-	ENSP00000497225	286 (aa)	-	UPI0001B7942B
ENST00000367384	PCMT1-203	1938	XM_011535868	ENSP00000356354	228 (aa)	XP_011534170	H7BY58
ENST00000367378	PCMT1-201	1293	-	ENSP00000356348	227 (aa)	-	A0A0A0MRJ6
ENST00000464889	PCMT1-205	1984	-	ENSP00000420813	227 (aa)	-	A0A0A0MRJ6
ENST00000367380	PCMT1-202	1628	-	ENSP00000356350	250 (aa)	-	P22061
ENST00000480010	PCMT1-206	377	-	-	- (aa)	-	-
ENST00000484601	PCMT1-207	1095	-	ENSP00000417448	66 (aa)	-	F8WAV5
ENST00000544496	PCMT1-211	1628	-	ENSP00000438247	250 (aa)	-	F6S8N6
ENST00000486585	PCMT1-208	801	-	ENSP00000418461	38 (aa)	-	H7C4X2
ENST00000460828	PCMT1-204	582	-	ENSP00000420804	62 (aa)	-	F8WDT3

Gene Model

Protein-Protein Interaction (PPI)

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	21873635.	IBA	Function
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	8074695.	TAS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006479	protein methylation	3355545.	TAS	Process
GO:0030091	protein repair	8074695.	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:1903561	extracellular vesicle	24769233.	HDA	Component