EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000120438 (Gene tree)
Gene ID: 6950
Gene Symbol: TCP1
Alias: D6S230E|CCT1|Ccta
Full Name: t-complex 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,252 bases
Position: chr6:159,778,498-159,789,749
Accession: 11655
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11054821	Analysis of 114 kb of DNA sequence from fission yeast chromosome 2 immediately centromere-distal to his5.	Yeast	2000 Nov	Xiang Z	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539948	TCP1-212	706	-	ENSP00000439671	136 (aa)	-	F5H136
ENST00000538530	TCP1-210	918	-	ENSP00000440617	65 (aa)	-	F5GYL4
ENST00000543517	TCP1-213	561	-	ENSP00000444423	100 (aa)	-	F5GZI8
ENST00000467544	TCP1-204	658	-	-	- (aa)	-	-
ENST00000546023	TCP1-217	1135	-	-	- (aa)	-	-
ENST00000546204	TCP1-218	566	-	-	- (aa)	-	-
ENST00000536607	TCP1-206	572	-	-	- (aa)	-	-
ENST00000539756	TCP1-211	780	-	ENSP00000441345	221 (aa)	-	F5GZ03
ENST00000538128	TCP1-209	557	-	ENSP00000442185	59 (aa)	-	F5H7Y1
ENST00000545764	TCP1-216	709	-	-	- (aa)	-	-
ENST00000420894	TCP1-203	1671	-	ENSP00000390159	433 (aa)	-	E7ERF2
ENST00000536807	TCP1-207	873	-	-	- (aa)	-	-
ENST00000536394	TCP1-205	535	-	ENSP00000442856	91 (aa)	-	F5H726
ENST00000321394	TCP1-201	2499	-	ENSP00000317334	556 (aa)	-	P17987
ENST00000544255	TCP1-215	1403	-	ENSP00000439447	332 (aa)	-	F5H282
ENST00000392168	TCP1-202	1878	-	ENSP00000376008	401 (aa)	-	E7EQR6
ENST00000537390	TCP1-208	691	-	ENSP00000437840	111 (aa)	-	F5H676
ENST00000543532	TCP1-214	561	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000120438's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120438's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120438	TCP1	99	85.556	WBGene00000377	cct-1	99	68.819	Caenorhabditis_elegans
ENSG00000120438	TCP1	100	91.209	FBgn0003676	CCT1	99	73.333	Drosophila_melanogaster
ENSG00000120438	TCP1	100	99.099	ENSMUSG00000068039	Tcp1	100	96.403	Mus_musculus
ENSG00000120438	TCP1	100	75.824	YDR212W	TCP1	97	63.486	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000242	pericentriolar material	-	IEA	Component
GO:0001669	acrosomal vesicle	-	IEA	Component
GO:0002199	zona pellucida receptor complex	-	IEA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	14532270.16085932.16097032.21098288.24846140.25416956.25467444.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005720	nuclear heterochromatin	-	IEA	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005813	centrosome	20080638.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.25467444.	IDA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007021	tubulin complex assembly	11532003.	NAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	21753002.	IPI	Function
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0044053	translocation of peptides or proteins into host cell cytoplasm	-	IEA	Process
GO:0044297	cell body	-	IEA	Component
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0051973	positive regulation of telomerase activity	25467444.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0090666	scaRNA localization to Cajal body	25467444.	IMP	Process
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	IMP	Process
GO:2000109	regulation of macrophage apoptotic process	-	IEA	Process