EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000120662 (Gene tree)
Gene ID: 9617
Gene Symbol: MTRF1
Alias: RF1|MTTRF1|MGC47721
Full Name: mitochondrial translation release factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,429 bases
Position: chr13:41,216,369-41,263,797
Accession: 7469
RBP type: canonical RBP
Summary: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000368790	RF-1	PF00472.20	6.7e-39	1	1
ENSP00000368793	RF-1	PF00472.20	6.7e-39	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27164557	Genetic Relationship between Schizophrenia and Nicotine Dependence.	Sci Rep	2016 May 10	Chen J	doi: 10.1038/srep25671.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497679	MTRF1-209	863	-	ENSP00000484414	153 (aa)	-	A0A087X1S1
ENST00000430347	MTRF1-204	557	-	ENSP00000400031	151 (aa)	-	Q8N6Z2
ENST00000473492	MTRF1-206	598	-	-	- (aa)	-	-
ENST00000452359	MTRF1-205	820	XM_017020879	ENSP00000399279	226 (aa)	XP_016876368	X6RFD4
ENST00000480434	MTRF1-207	737	-	ENSP00000482339	137 (aa)	-	A0A087WZ41
ENST00000379480	MTRF1-203	2185	XM_006719898	ENSP00000368793	445 (aa)	XP_006719961	O75570
ENST00000239852	MTRF1-201	1561	-	ENSP00000481161	151 (aa)	-	Q8N6Z2
ENST00000492827	MTRF1-208	618	-	-	- (aa)	-	-
ENST00000379477	MTRF1-202	1948	XM_011535315	ENSP00000368790	445 (aa)	XP_011533617	O75570
ENST00000498245	MTRF1-210	728	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000120662's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120662's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000120662	MTRF1	88	40.164	ENSG00000112031	MTRF1L	98	47.388

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120662	MTRF1	92	48.062	ENSAPOG00000010181	mtrf1	86	57.386	Acanthochromis_polyacanthus
ENSG00000120662	MTRF1	100	88.565	ENSAMEG00000008696	MTRF1	100	88.565	Ailuropoda_melanoleuca
ENSG00000120662	MTRF1	52	67.826	ENSACIG00000001495	mtrf1	93	67.826	Amphilophus_citrinellus
ENSG00000120662	MTRF1	87	56.122	ENSAOCG00000002832	mtrf1	88	56.122	Amphiprion_ocellaris
ENSG00000120662	MTRF1	87	55.867	ENSAPEG00000014844	mtrf1	88	55.867	Amphiprion_percula
ENSG00000120662	MTRF1	92	46.875	ENSATEG00000017403	mtrf1	84	56.941	Anabas_testudineus
ENSG00000120662	MTRF1	99	64.920	ENSAPLG00000009317	MTRF1	99	64.920	Anas_platyrhynchos
ENSG00000120662	MTRF1	89	64.484	ENSACAG00000000897	MTRF1	89	64.484	Anolis_carolinensis
ENSG00000120662	MTRF1	100	94.714	ENSANAG00000023063	-	100	87.472	Aotus_nancymaae
ENSG00000120662	MTRF1	92	97.619	ENSANAG00000025310	-	97	87.879	Aotus_nancymaae
ENSG00000120662	MTRF1	88	55.668	ENSACLG00000023945	mtrf1	87	55.668	Astatotilapia_calliptera
ENSG00000120662	MTRF1	52	67.100	ENSAMXG00000031859	mtrf1	96	67.100	Astyanax_mexicanus
ENSG00000120662	MTRF1	100	87.696	ENSBTAG00000012260	MTRF1	100	87.696	Bos_taurus
ENSG00000120662	MTRF1	100	91.480	ENSCJAG00000017739	MTRF1	100	91.480	Callithrix_jacchus
ENSG00000120662	MTRF1	100	86.353	ENSCAFG00000004795	MTRF1	100	86.353	Canis_familiaris
ENSG00000120662	MTRF1	100	86.353	ENSCAFG00020018178	MTRF1	100	86.353	Canis_lupus_dingo
ENSG00000120662	MTRF1	100	86.996	ENSCHIG00000011810	MTRF1	100	86.996	Capra_hircus
ENSG00000120662	MTRF1	100	90.359	ENSTSYG00000006976	MTRF1	100	90.359	Carlito_syrichta
ENSG00000120662	MTRF1	97	86.574	ENSCAPG00000013163	MTRF1	100	86.574	Cavia_aperea
ENSG00000120662	MTRF1	100	86.323	ENSCPOG00000005264	MTRF1	100	86.323	Cavia_porcellus
ENSG00000120662	MTRF1	100	92.152	ENSCCAG00000035116	MTRF1	100	92.152	Cebus_capucinus
ENSG00000120662	MTRF1	100	97.528	ENSCATG00000009909	MTRF1	100	97.528	Cercocebus_atys
ENSG00000120662	MTRF1	100	85.650	ENSCLAG00000000582	MTRF1	100	85.650	Chinchilla_lanigera
ENSG00000120662	MTRF1	100	97.528	ENSCSAG00000017835	MTRF1	100	97.528	Chlorocebus_sabaeus
ENSG00000120662	MTRF1	92	79.218	ENSCHOG00000011915	-	100	79.218	Choloepus_hoffmanni
ENSG00000120662	MTRF1	100	66.297	ENSCPBG00000007969	MTRF1	99	66.297	Chrysemys_picta_bellii
ENSG00000120662	MTRF1	100	98.230	ENSCANG00000040353	MTRF1	100	97.528	Colobus_angolensis_palliatus
ENSG00000120662	MTRF1	100	82.063	ENSCGRG00001003065	Mtrf1	100	82.063	Cricetulus_griseus_chok1gshd
ENSG00000120662	MTRF1	100	82.063	ENSCGRG00000002570	Mtrf1	100	82.063	Cricetulus_griseus_crigri
ENSG00000120662	MTRF1	86	56.658	ENSCSEG00000005667	mtrf1	86	56.658	Cynoglossus_semilaevis
ENSG00000120662	MTRF1	88	53.652	ENSCVAG00000021729	mtrf1	91	53.652	Cyprinodon_variegatus
ENSG00000120662	MTRF1	53	58.974	ENSDARG00000033579	mtrf1	99	58.974	Danio_rerio
ENSG00000120662	MTRF1	100	87.723	ENSDNOG00000034196	MTRF1	100	92.581	Dasypus_novemcinctus
ENSG00000120662	MTRF1	99	86.292	ENSDORG00000016429	Mtrf1	100	86.292	Dipodomys_ordii
ENSG00000120662	MTRF1	100	83.632	ENSETEG00000014811	MTRF1	100	83.632	Echinops_telfairi
ENSG00000120662	MTRF1	53	56.838	ENSEBUG00000000778	mtrf1	96	56.838	Eptatretus_burgeri
ENSG00000120662	MTRF1	100	89.462	ENSEASG00005015715	MTRF1	100	89.462	Equus_asinus_asinus
ENSG00000120662	MTRF1	100	88.341	ENSECAG00000014389	MTRF1	97	88.341	Equus_caballus
ENSG00000120662	MTRF1	91	76.800	ENSEEUG00000004450	-	100	65.324	Erinaceus_europaeus
ENSG00000120662	MTRF1	86	54.856	ENSELUG00000006544	mtrf1	88	54.856	Esox_lucius
ENSG00000120662	MTRF1	100	86.099	ENSFCAG00000031635	MTRF1	100	86.099	Felis_catus
ENSG00000120662	MTRF1	92	65.079	ENSFALG00000008036	MTRF1	96	68.831	Ficedula_albicollis
ENSG00000120662	MTRF1	100	85.426	ENSFDAG00000017881	MTRF1	100	85.426	Fukomys_damarensis
ENSG00000120662	MTRF1	85	54.090	ENSFHEG00000019043	mtrf1	87	54.090	Fundulus_heteroclitus
ENSG00000120662	MTRF1	84	52.646	ENSGMOG00000008608	mtrf1	99	52.646	Gadus_morhua
ENSG00000120662	MTRF1	98	64.509	ENSGALG00000016951	MTRF1	98	64.509	Gallus_gallus
ENSG00000120662	MTRF1	85	55.789	ENSGAFG00000007093	mtrf1	86	55.789	Gambusia_affinis
ENSG00000120662	MTRF1	84	56.878	ENSGACG00000013728	mtrf1	98	56.878	Gasterosteus_aculeatus
ENSG00000120662	MTRF1	92	64.286	ENSGAGG00000025696	MTRF1	99	74.920	Gopherus_agassizii
ENSG00000120662	MTRF1	100	99.558	ENSGGOG00000002529	MTRF1	100	99.551	Gorilla_gorilla
ENSG00000120662	MTRF1	100	86.771	ENSHGLG00000003210	MTRF1	100	86.771	Heterocephalus_glaber_female
ENSG00000120662	MTRF1	100	86.771	ENSHGLG00100011843	MTRF1	100	86.771	Heterocephalus_glaber_male
ENSG00000120662	MTRF1	86	53.806	ENSHCOG00000009449	mtrf1	86	53.806	Hippocampus_comes
ENSG00000120662	MTRF1	100	87.220	ENSSTOG00000021682	MTRF1	100	87.220	Ictidomys_tridecemlineatus
ENSG00000120662	MTRF1	100	84.753	ENSJJAG00000017590	Mtrf1	100	84.753	Jaculus_jaculus
ENSG00000120662	MTRF1	86	55.844	ENSKMAG00000003231	mtrf1	85	55.844	Kryptolebias_marmoratus
ENSG00000120662	MTRF1	52	65.948	ENSLBEG00000023151	mtrf1	93	65.948	Labrus_bergylta
ENSG00000120662	MTRF1	52	65.948	ENSLBEG00000027169	-	93	65.948	Labrus_bergylta
ENSG00000120662	MTRF1	96	61.111	ENSLACG00000010582	MTRF1	97	61.432	Latimeria_chalumnae
ENSG00000120662	MTRF1	87	58.505	ENSLOCG00000005937	MTRF1	87	58.505	Lepisosteus_oculatus
ENSG00000120662	MTRF1	99	71.719	ENSLAFG00000030499	-	99	71.719	Loxodonta_africana
ENSG00000120662	MTRF1	100	85.426	ENSLAFG00000022177	-	100	85.426	Loxodonta_africana
ENSG00000120662	MTRF1	100	97.079	ENSMFAG00000037972	MTRF1	100	97.079	Macaca_fascicularis
ENSG00000120662	MTRF1	100	97.303	ENSMNEG00000035487	MTRF1	100	97.303	Macaca_nemestrina
ENSG00000120662	MTRF1	100	97.079	ENSMLEG00000033582	MTRF1	100	97.079	Mandrillus_leucophaeus
ENSG00000120662	MTRF1	92	50.781	ENSMAMG00000022048	mtrf1	83	57.527	Mastacembelus_armatus
ENSG00000120662	MTRF1	88	55.668	ENSMZEG00005017922	mtrf1	87	55.668	Maylandia_zebra
ENSG00000120662	MTRF1	87	70.619	ENSMGAG00000014971	MTRF1	93	70.619	Meleagris_gallopavo
ENSG00000120662	MTRF1	100	82.063	ENSMAUG00000011661	Mtrf1	100	82.063	Mesocricetus_auratus
ENSG00000120662	MTRF1	100	92.584	ENSMICG00000033131	MTRF1	100	92.584	Microcebus_murinus
ENSG00000120662	MTRF1	100	80.717	ENSMOCG00000011945	Mtrf1	100	80.717	Microtus_ochrogaster
ENSG00000120662	MTRF1	51	58.515	ENSMMOG00000013394	mtrf1	94	58.515	Mola_mola
ENSG00000120662	MTRF1	100	73.378	ENSMODG00000014772	MTRF1	100	73.378	Monodelphis_domestica
ENSG00000120662	MTRF1	85	56.053	ENSMALG00000013274	mtrf1	87	56.053	Monopterus_albus
ENSG00000120662	MTRF1	100	80.269	MGP_CAROLIEiJ_G0019539	Mtrf1	99	80.269	Mus_caroli
ENSG00000120662	MTRF1	100	81.839	ENSMUSG00000022022	Mtrf1	100	81.839	Mus_musculus
ENSG00000120662	MTRF1	100	80.899	MGP_PahariEiJ_G0030557	Mtrf1	100	80.899	Mus_pahari
ENSG00000120662	MTRF1	100	80.942	MGP_SPRETEiJ_G0020435	Mtrf1	100	80.942	Mus_spretus
ENSG00000120662	MTRF1	99	85.811	ENSMPUG00000001874	MTRF1	99	85.811	Mustela_putorius_furo
ENSG00000120662	MTRF1	100	87.668	ENSMLUG00000017237	MTRF1	100	87.668	Myotis_lucifugus
ENSG00000120662	MTRF1	100	85.426	ENSNGAG00000014460	Mtrf1	100	85.426	Nannospalax_galili
ENSG00000120662	MTRF1	51	67.249	ENSNBRG00000004634	mtrf1	97	67.249	Neolamprologus_brichardi
ENSG00000120662	MTRF1	100	99.115	ENSNLEG00000001236	MTRF1	100	98.427	Nomascus_leucogenys
ENSG00000120662	MTRF1	100	67.785	ENSMEUG00000001846	MTRF1	100	67.785	Notamacropus_eugenii
ENSG00000120662	MTRF1	100	67.257	ENSOPRG00000006450	-	100	58.055	Ochotona_princeps
ENSG00000120662	MTRF1	100	84.045	ENSODEG00000005782	MTRF1	100	84.045	Octodon_degus
ENSG00000120662	MTRF1	85	56.992	ENSONIG00000012476	mtrf1	98	56.992	Oreochromis_niloticus
ENSG00000120662	MTRF1	73	72.000	ENSOANG00000003383	-	98	71.845	Ornithorhynchus_anatinus
ENSG00000120662	MTRF1	100	87.220	ENSOCUG00000025207	MTRF1	100	87.220	Oryctolagus_cuniculus
ENSG00000120662	MTRF1	87	55.556	ENSORLG00000003225	mtrf1	88	55.556	Oryzias_latipes
ENSG00000120662	MTRF1	87	55.556	ENSORLG00020021048	mtrf1	87	55.556	Oryzias_latipes_hni
ENSG00000120662	MTRF1	92	50.388	ENSORLG00015020957	mtrf1	88	55.297	Oryzias_latipes_hsok
ENSG00000120662	MTRF1	85	56.579	ENSOMEG00000002022	mtrf1	87	56.579	Oryzias_melastigma
ENSG00000120662	MTRF1	100	84.305	ENSOGAG00000009719	-	100	84.305	Otolemur_garnettii
ENSG00000120662	MTRF1	73	77.914	ENSOGAG00000026411	-	100	77.914	Otolemur_garnettii
ENSG00000120662	MTRF1	100	86.771	ENSOARG00000006994	MTRF1	100	86.771	Ovis_aries
ENSG00000120662	MTRF1	100	100.000	ENSPPAG00000000050	MTRF1	100	100.000	Pan_paniscus
ENSG00000120662	MTRF1	100	86.996	ENSPPRG00000009511	MTRF1	100	86.996	Panthera_pardus
ENSG00000120662	MTRF1	100	86.771	ENSPTIG00000006673	MTRF1	100	86.771	Panthera_tigris_altaica
ENSG00000120662	MTRF1	100	100.000	ENSPTRG00000005815	MTRF1	100	100.000	Pan_troglodytes
ENSG00000120662	MTRF1	100	97.303	ENSPANG00000010809	MTRF1	100	97.303	Papio_anubis
ENSG00000120662	MTRF1	85	54.617	ENSPKIG00000015711	mtrf1	89	54.617	Paramormyrops_kingsleyae
ENSG00000120662	MTRF1	99	64.062	ENSPSIG00000004773	MTRF1	99	64.062	Pelodiscus_sinensis
ENSG00000120662	MTRF1	53	67.373	ENSPMGG00000006724	mtrf1	96	67.373	Periophthalmus_magnuspinnatus
ENSG00000120662	MTRF1	100	82.774	ENSPEMG00000020982	Mtrf1	100	82.774	Peromyscus_maniculatus_bairdii
ENSG00000120662	MTRF1	92	40.476	ENSPMAG00000009849	mtrf1	99	52.023	Petromyzon_marinus
ENSG00000120662	MTRF1	100	72.422	ENSPCIG00000012940	MTRF1	100	72.422	Phascolarctos_cinereus
ENSG00000120662	MTRF1	85	55.000	ENSPFOG00000000254	mtrf1	87	55.000	Poecilia_formosa
ENSG00000120662	MTRF1	85	55.526	ENSPLAG00000014280	mtrf1	87	55.526	Poecilia_latipinna
ENSG00000120662	MTRF1	85	54.737	ENSPMEG00000023245	mtrf1	87	54.737	Poecilia_mexicana
ENSG00000120662	MTRF1	52	62.661	ENSPREG00000018619	mtrf1	96	62.661	Poecilia_reticulata
ENSG00000120662	MTRF1	100	98.230	ENSPPYG00000005313	MTRF1	100	98.202	Pongo_abelii
ENSG00000120662	MTRF1	100	92.377	ENSPCOG00000018133	MTRF1	100	92.377	Propithecus_coquereli
ENSG00000120662	MTRF1	100	86.771	ENSPVAG00000008573	MTRF1	100	86.771	Pteropus_vampyrus
ENSG00000120662	MTRF1	51	68.122	ENSPNYG00000004357	mtrf1	93	68.122	Pundamilia_nyererei
ENSG00000120662	MTRF1	87	53.827	ENSPNAG00000010682	mtrf1	90	53.827	Pygocentrus_nattereri
ENSG00000120662	MTRF1	100	81.208	ENSRNOG00000047106	Mtrf1	93	91.150	Rattus_norvegicus
ENSG00000120662	MTRF1	100	97.788	ENSRBIG00000007069	MTRF1	100	97.528	Rhinopithecus_bieti
ENSG00000120662	MTRF1	100	97.788	ENSRROG00000035345	MTRF1	100	97.528	Rhinopithecus_roxellana
ENSG00000120662	MTRF1	92	94.444	ENSSBOG00000004572	MTRF1	100	92.857	Saimiri_boliviensis_boliviensis
ENSG00000120662	MTRF1	91	80.000	ENSSHAG00000018109	MTRF1	100	73.966	Sarcophilus_harrisii
ENSG00000120662	MTRF1	85	56.693	ENSSFOG00015006191	mtrf1	86	56.693	Scleropages_formosus
ENSG00000120662	MTRF1	94	52.482	ENSSMAG00000015740	mtrf1	95	52.482	Scophthalmus_maximus
ENSG00000120662	MTRF1	87	57.252	ENSSDUG00000022608	mtrf1	76	57.252	Seriola_dumerili
ENSG00000120662	MTRF1	87	57.506	ENSSLDG00000013584	mtrf1	76	57.506	Seriola_lalandi_dorsalis
ENSG00000120662	MTRF1	100	82.247	ENSSARG00000002306	MTRF1	100	82.247	Sorex_araneus
ENSG00000120662	MTRF1	53	71.915	ENSSPUG00000007354	MTRF1	97	71.915	Sphenodon_punctatus
ENSG00000120662	MTRF1	86	55.699	ENSSPAG00000000881	mtrf1	87	55.699	Stegastes_partitus
ENSG00000120662	MTRF1	100	86.323	ENSSSCG00000009436	MTRF1	100	86.323	Sus_scrofa
ENSG00000120662	MTRF1	92	65.079	ENSTGUG00000012422	MTRF1	93	69.271	Taeniopygia_guttata
ENSG00000120662	MTRF1	87	55.641	ENSTRUG00000000396	mtrf1	87	55.641	Takifugu_rubripes
ENSG00000120662	MTRF1	83	57.453	ENSTNIG00000017149	-	98	57.143	Tetraodon_nigroviridis
ENSG00000120662	MTRF1	54	78.661	ENSTBEG00000004696	-	100	78.661	Tupaia_belangeri
ENSG00000120662	MTRF1	100	89.013	ENSTTRG00000010370	MTRF1	100	89.013	Tursiops_truncatus
ENSG00000120662	MTRF1	100	88.789	ENSUMAG00000014772	MTRF1	100	88.789	Ursus_maritimus
ENSG00000120662	MTRF1	100	87.696	ENSVPAG00000002565	MTRF1	100	87.696	Vicugna_pacos
ENSG00000120662	MTRF1	100	86.353	ENSVVUG00000028755	MTRF1	100	86.353	Vulpes_vulpes
ENSG00000120662	MTRF1	86	67.277	ENSXETG00000018904	mtrf1	99	67.277	Xenopus_tropicalis
ENSG00000120662	MTRF1	52	61.638	ENSXCOG00000020386	mtrf1	95	61.638	Xiphophorus_couchianus
ENSG00000120662	MTRF1	85	53.947	ENSXMAG00000009853	mtrf1	86	53.947	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003747	translation release factor activity	9838146.	TAS	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0006415	translational termination	21873635.	IBA	Process
GO:0006449	regulation of translational termination	9838146.	TAS	Process
GO:0016149	translation release factor activity, codon specific	21873635.	IBA	Function
GO:0043022	ribosome binding	21873635.	IBA	Function
GO:0070126	mitochondrial translational termination	21873635.	IBA	Process